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Noninvasive malignant thymoma

MedGen UID:: 78893
•Concept ID:: C0278847
•: Neoplastic Process

Synonyms:	Malignant Thymoma, Noninvasive; malignant thymoma, noninvasive; Noninvasive Malignant Thymoma; noninvasive malignant thymoma; Thymoma Malignant Noninvasive; thymoma malignant noninvasive

Monarch Initiative:	MONDO:0004147

Definition

A morphologically malignant thymoma that is entirely confined within the capsule. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNoninvasive malignant thymoma

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Thymoma
        Malignant Thymoma
        Noninvasive malignant thymoma

Professional guidelines

PubMed

Biomarkers Suitable for Early Detection of Intrathoracic Cancers in Primary Care: A Systematic Review.

Hamad W, Grigore B, Walford H, Peters J, Alexandris P, Bonfield S, Standen L, Boscott R, Behiyat D, Kuhn I, Neal RD, Walter FM, Calanzani N
Cancer Epidemiol Biomarkers Prev 2025 Jan 9;34(1):19-34. doi: 10.1158/1055-9965.EPI-24-0713. PMID: 39400573 Free PMC Article

Differential diagnosis of thymic tumors using a combination of 11C-methionine PET and FDG PET.

Sasaki M, Kuwabara Y, Ichiya Y, Akashi Y, Yoshida T, Nakagawa M, Murayama S, Masuda K
J Nucl Med 1999 Oct;40(10):1595-601. PMID: 10520697

Thymoma: a clinico-pathologic study based on newly developed morphologic criteria.

Rendina EA, Pescarmona EO, Venuta F, Nardi S, De Rosa G, Martelli M, Ricci C
Tumori 1988 Feb 29;74(1):79-84. doi: 10.1177/030089168807400114. PMID: 3354066

See all (3)

Recent clinical studies

Etiology

Advanced biomedical imaging for accurate discrimination and prognostication of mediastinal masses.

Mahmoudi S, Gruenewald LD, Eichler K, Martin SS, Booz C, Bernatz S, Lahrsow M, Yel I, Gotta J, Biciusca T, Mohammed H, Ziegengeist NS, Torgashov K, Hammerstingl RM, Sommer CM, Weber C, Almansour H, Bucolo G, D'Angelo T, Scholtz JE, Gruber-Rouh T, Vogl TJ, Koch V
Eur J Clin Invest 2023 Dec;53(12):e14075. Epub 2023 Aug 12 doi: 10.1111/eci.14075. PMID: 37571983

Myasthenic crisis.

Claytor B, Cho SM, Li Y
Muscle Nerve 2023 Jul;68(1):8-19. Epub 2023 Apr 28 doi: 10.1002/mus.27832. PMID: 37114503

Overview of the 2022 WHO Classification of Thyroid Neoplasms.

Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841

Predictors of outcome in patients with myasthenic crisis undergoing non-invasive mechanical ventilation: A retrospective 20 year longitudinal cohort study from a single Italian center.

Iori E, Mazzoli M, Ariatti A, Bastia E, Agnoletto V, Gozzi M, Marchioni A, Galassi G
Neuromuscul Disord 2021 Dec;31(12):1241-1250. Epub 2021 Aug 20 doi: 10.1016/j.nmd.2021.08.008. PMID: 34782245

Type AB thymoma with brain metastasis: Report of a case.

Ohata N, Usami N, Kawaguchi K, Tateyama H, Yokoi K
Surg Today 2011 Oct;41(10):1436-8. Epub 2011 Sep 16 doi: 10.1007/s00595-010-4442-6. PMID: 21922373

See all (58)

Diagnosis

Multifocal primary intrapulmonary thymoma successfully resected via robotic-assisted thoracoscopic surgery.

Shell D, Malone J, Kho J, Yap CH
BMJ Case Rep 2023 Nov 24;16(11) doi: 10.1136/bcr-2023-257789. PMID: 38000810 Free PMC Article

Myasthenic crisis.

Claytor B, Cho SM, Li Y
Muscle Nerve 2023 Jul;68(1):8-19. Epub 2023 Apr 28 doi: 10.1002/mus.27832. PMID: 37114503

Overview of the 2022 WHO Classification of Thyroid Neoplasms.

Imaging of the thymus.

Mendelson DS
Chest Surg Clin N Am 2001 May;11(2):269-93, x. PMID: 11413756

A thymoma associated with hyperparathyroidism.

Suzuki T, Suzuki S, Kitami A, Hori G, Inoue T, Suzuki S, Kubota T
Thorac Cardiovasc Surg 1997 Aug;45(4):211-2. doi: 10.1055/s-2007-1013728. PMID: 9323828

See all (68)

Therapy

Development and validation of a contrast-enhanced CT-based radiomics nomogram for differentiating mass-like thymic hyperplasia and low-risk thymoma.

Dong W, Xiong S, Wang X, Hu S, Liu Y, Liu H, Wang X, Chen J, Qiu Y, Fan B
J Cancer Res Clin Oncol 2023 Nov;149(16):14901-14910. Epub 2023 Aug 21 doi: 10.1007/s00432-023-05263-3. PMID: 37604939

Thymoma and thymic carcinoma.

Venuta F, Anile M, Diso D, Vitolo D, Rendina EA, De Giacomo T, Francioni F, Coloni GF
Eur J Cardiothorac Surg 2010 Jan;37(1):13-25. Epub 2009 Jul 16 doi: 10.1016/j.ejcts.2009.05.038. PMID: 19615917

Optimal therapy for thymoma.

Kondo K
J Med Invest 2008 Feb;55(1-2):17-28. doi: 10.2152/jmi.55.17. PMID: 18319541

Incidental discovery of an anterior mediastinal angiomyolipoma.

Watts KA, Watts JR Jr
J Thorac Imaging 2007 May;22(2):180-1. doi: 10.1097/01.rti.0000213571.09280.f8. PMID: 17527125

Acetylcholine receptor autoantibody secretion by thymocytes: relationship to myasthenia gravis.

Yoshikawa H, Lennon VA
Neurology 1997 Aug;49(2):562-7. doi: 10.1212/wnl.49.2.562. PMID: 9270597

See all (17)

Prognosis

Myasthenic crisis.

Claytor B, Cho SM, Li Y
Muscle Nerve 2023 Jul;68(1):8-19. Epub 2023 Apr 28 doi: 10.1002/mus.27832. PMID: 37114503

Overview of the 2022 WHO Classification of Thyroid Neoplasms.

Predictors of outcome in patients with myasthenic crisis undergoing non-invasive mechanical ventilation: A retrospective 20 year longitudinal cohort study from a single Italian center.

Iori E, Mazzoli M, Ariatti A, Bastia E, Agnoletto V, Gozzi M, Marchioni A, Galassi G
Neuromuscul Disord 2021 Dec;31(12):1241-1250. Epub 2021 Aug 20 doi: 10.1016/j.nmd.2021.08.008. PMID: 34782245

Noninvasive thymoma in the middle mediastinum.

Kanzaki M, Oyama K, Ikeda T, Yoshida T, Murasugi M, Onuki T
Ann Thorac Surg 2004 Jun;77(6):2209-10. doi: 10.1016/S0003-4975(03)01392-4. PMID: 15172308

A thymoma associated with hyperparathyroidism.

Suzuki T, Suzuki S, Kitami A, Hori G, Inoue T, Suzuki S, Kubota T
Thorac Cardiovasc Surg 1997 Aug;45(4):211-2. doi: 10.1055/s-2007-1013728. PMID: 9323828

See all (66)

Clinical prediction guides

Advanced biomedical imaging for accurate discrimination and prognostication of mediastinal masses.

Predictors of outcome in patients with myasthenic crisis undergoing non-invasive mechanical ventilation: A retrospective 20 year longitudinal cohort study from a single Italian center.

Iori E, Mazzoli M, Ariatti A, Bastia E, Agnoletto V, Gozzi M, Marchioni A, Galassi G
Neuromuscul Disord 2021 Dec;31(12):1241-1250. Epub 2021 Aug 20 doi: 10.1016/j.nmd.2021.08.008. PMID: 34782245

Thymoma calcification: is it clinically meaningful?

Harris K, Elsayegh D, Azab B, Alkaied H, Chalhoub M
World J Surg Oncol 2011 Aug 23;9:95. doi: 10.1186/1477-7819-9-95. PMID: 21861913 Free PMC Article

Acetylcholine receptor autoantibody secretion by thymocytes: relationship to myasthenia gravis.

Yoshikawa H, Lennon VA
Neurology 1997 Aug;49(2):562-7. doi: 10.1212/wnl.49.2.562. PMID: 9270597

Thymoma: a clinical and pathological study of 65 cases.

Salyer WR, Eggleston JC
Cancer 1976 Jan;37(1):229-49. doi: 10.1002/1097-0142(197601)37:1<229::aid-cncr2820370133>3.0.co;2-2. PMID: 1247958

See all (51)