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Chondromatosis

MedGen UID:
61647
•Concept ID:
C0206636
•
Neoplastic Process
Synonym: Chondromatoses
SNOMED CT: Chondromatosis (83944004); Chondromatosis (302861008); Cartilage analog of fibromatosis (83944004)

Definition

A multifocal benign neoplasm arising from bone or soft tissue. It is characterized by the presence of chondrocytes and is composed of hyaline cartilage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChondromatosis

Professional guidelines

PubMed

Assessment and Management of Loose Bodies in the Knee Joint and Related Disease: A Narrative Review.
Zmerly H, Moscato M, Akkawi I
Curr Rheumatol Rev 2022;18(1):12-19. doi: 10.2174/1573397117666211021165807. PMID: 34674623
Diagnostic Imaging and Management of Common Intra-articular and Peri-articular Soft Tissue Tumors and Tumorlike Conditions of the Knee.
Evenski AJ, Stensby JD, Rosas S, Emory CL
J Knee Surg 2019 Apr;32(4):322-330. Epub 2018 Nov 16 doi: 10.1055/s-0038-1675609. PMID: 30449023Free PMC Article
Arthroscopic management of elbow synovial chondromatosis.
Zhu W, Wang W, Mao X, Chen Y
Medicine (Baltimore) 2018 Oct;97(40):e12402. doi: 10.1097/MD.0000000000012402. PMID: 30290596Free PMC Article

Recent clinical studies

Etiology

Intra-Articular Tumors.
Sbaraglia M, Gambarotti M, Businello G, Righi A, Fassan M, Dei Tos AP
Surg Pathol Clin 2021 Dec;14(4):665-677. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.008. PMID: 34742486
Synovial chondromatosis of the upper extremity.
Ho YY, Choueka J
J Hand Surg Am 2013 Apr;38(4):804-10. Epub 2013 Mar 6 doi: 10.1016/j.jhsa.2013.01.041. PMID: 23474166
Synovial osteochondromatosis.
Langguth DM, Klestov A, Denaro C
Intern Med J 2002 Aug;32(8):419-20. doi: 10.1046/j.1445-5994.2002.00260.x. PMID: 12162400
Synovial neoformations and tumours.
Szendrói M, Deodhar A
Baillieres Best Pract Res Clin Rheumatol 2000 Jun;14(2):363-83. doi: 10.1053/berh.1999.0070. PMID: 10925750
Extraskeletal chondromas.
Marcial-Seoane RA, Marcial-Seoane MA, Ramos E, Marcial-Rojas RA
Bol Asoc Med P R 1990 Sep;82(9):394-402. PMID: 2076144

Diagnosis

Synovial Tumors and Proliferative Diseases.
Levine BD, Motamedi K, Seeger LL
Rheum Dis Clin North Am 2016 Nov;42(4):753-768. Epub 2016 Sep 7 doi: 10.1016/j.rdc.2016.07.008. PMID: 27742025
Synovial Chondromatosis.
Neumann JA, Garrigues GE, Brigman BE, Eward WC
JBJS Rev 2016 May 10;4(5) doi: 10.2106/JBJS.RVW.O.00054. PMID: 27490219
Benign synovial disorders.
Adelani MA, Wupperman RM, Holt GE
J Am Acad Orthop Surg 2008 May;16(5):268-75. doi: 10.5435/00124635-200805000-00005. PMID: 18460687
Monoarticular arthritis.
Mohana-Borges AV, Chung CB, Resnick D
Radiol Clin North Am 2004 Jan;42(1):135-49. doi: 10.1016/S0033-8389(03)00168-4. PMID: 15049528
Synovial chondromatosis.
Maurice H, Crone M, Watt I
J Bone Joint Surg Br 1988 Nov;70(5):807-11. doi: 10.1302/0301-620X.70B5.3192585. PMID: 3192585

Therapy

Potential utility of anti-TNF drugs in synovial chondromatosis associated with ankylosing spondylitis.
Yu S, Wu M, Zhou G, Ishikawa T, Liang J, Nallapothula D, Singh RR, Wang Q, Wang M
Int J Rheum Dis 2019 Nov;22(11):2073-2079. Epub 2019 Oct 24 doi: 10.1111/1756-185X.13734. PMID: 31647182
Synovial osteochondromatosis.
Langguth DM, Klestov A, Denaro C
Intern Med J 2002 Aug;32(8):419-20. doi: 10.1046/j.1445-5994.2002.00260.x. PMID: 12162400
Pathology of the synovium.
O'Connell JX
Am J Clin Pathol 2000 Nov;114(5):773-84. doi: 10.1309/LWW3-5XK0-FKG9-HDRK. PMID: 11068553
Operative hip arthroscopy.
Kim SJ, Choi NH, Kim HJ
Clin Orthop Relat Res 1998 Aug;(353):156-65. doi: 10.1097/00003086-199808000-00018. PMID: 9728170
Craniomandibular disorders in the geriatric patient.
Iacopino AM, Wathen WF
J Orofac Pain 1993 Winter;7(1):38-53. PMID: 8467296

Prognosis

Chondro-Osseous Lesions of Soft Tissue.
Cho SJ, Horvai A
Surg Pathol Clin 2015 Sep;8(3):419-44. doi: 10.1016/j.path.2015.05.004. PMID: 26297064
Oncologic conditions that simulate common sports injuries.
Krych A, Odland A, Rose P, Dahm D, Levy B, Wenger D, Stuart M, Sim F
J Am Acad Orthop Surg 2014 Apr;22(4):223-34. doi: 10.5435/JAAOS-22-04-223. PMID: 24668352
Synovial chondromatosis of the upper extremity.
Ho YY, Choueka J
J Hand Surg Am 2013 Apr;38(4):804-10. Epub 2013 Mar 6 doi: 10.1016/j.jhsa.2013.01.041. PMID: 23474166
Synovial osteochondromatosis.
Langguth DM, Klestov A, Denaro C
Intern Med J 2002 Aug;32(8):419-20. doi: 10.1046/j.1445-5994.2002.00260.x. PMID: 12162400
Extra-articular synovial chondromatosis.
Sim FH, Dahlin DC, Ivins JC
J Bone Joint Surg Am 1977 Jun;59(4):492-5. PMID: 863944

Clinical prediction guides

Differentiation between Chondrosarcoma and Synovial Chondromatosis of the Temporomandibular Joint Using CT and MR Imaging.
Jang BG, Huh KH, Yeom HG, Kang JH, Kim JE, Yoon HJ, Yi WJ, Heo MS, Lee SS
AJNR Am J Neuroradiol 2023 Oct;44(10):1176-1183. Epub 2023 Aug 31 doi: 10.3174/ajnr.A7980. PMID: 37652584Free PMC Article
Clinical Results of Surgical Resection and Histopathological Evaluation of Synovial Chondromatosis in the Shoulder: A Retrospective Study and Literature Review.
Utashima D, Matsumura N, Suzuki T, Iwamoto T, Ogawa K
Clin Orthop Surg 2020 Mar;12(1):68-75. Epub 2020 Feb 13 doi: 10.4055/cios.2020.12.1.68. PMID: 32117541Free PMC Article
Humeral Head Reconstruction With Osteochondral Allograft Transplantation.
Saltzman BM, Riboh JC, Cole BJ, Yanke AB
Arthroscopy 2015 Sep;31(9):1827-34. Epub 2015 May 13 doi: 10.1016/j.arthro.2015.03.021. PMID: 25979686
Pseudotumors and tumors of the temporomandibular joint. A review.
Poveda-Roda R, Bagán JV, Sanchis JM, Margaix M
Med Oral Patol Oral Cir Bucal 2013 May 1;18(3):e392-402. doi: 10.4317/medoral.18799. PMID: 23385515Free PMC Article
Metachondromatosis.
Hunter AG, Kozlowski K, Hochberger O
Can Assoc Radiol J 1995 Jun;46(3):202-8. PMID: 7538882

Recent systematic reviews

Arthroscopic Management of Synovial Chondromatosis of the Ankle Joint: A Systematic Review of the Literature.
Al Farii H, Doyle-Kelly C, Marwan Y, Volesky M, Turcotte R
JBJS Rev 2020 Sep;8(9):e2000045. doi: 10.2106/JBJS.RVW.20.00045. PMID: 33151646
A systematic literature review of synovial chondromatosis and pigmented villonodular synovitis of the hip.
Startzman A, Collins D, Carreira D
Phys Sportsmed 2016 Nov;44(4):425-431. Epub 2016 Aug 2 doi: 10.1080/00913847.2016.1216238. PMID: 27462929
Humeral Head Reconstruction With Osteochondral Allograft Transplantation.
Saltzman BM, Riboh JC, Cole BJ, Yanke AB
Arthroscopy 2015 Sep;31(9):1827-34. Epub 2015 May 13 doi: 10.1016/j.arthro.2015.03.021. PMID: 25979686
Arthroscopic surgery for synovial chondromatosis of the hip: a systematic review of rates and predisposing factors for recurrence.
de Sa D, Horner NS, MacDonald A, Simunovic N, Ghert MA, Philippon MJ, Ayeni OR
Arthroscopy 2014 Nov;30(11):1499-1504.e2. Epub 2014 Jul 23 doi: 10.1016/j.arthro.2014.05.033. PMID: 25064754
Synovial chondromatosis of the temporomandibular joint: a case description with systematic literature review.
Guarda-Nardini L, Piccotti F, Ferronato G, Manfredini D
Int J Oral Maxillofac Surg 2010 Aug;39(8):745-55. doi: 10.1016/j.ijom.2010.03.028. PMID: 20434884

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