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Benign chondrogenic neoplasm

MedGen UID:: 208867
•Concept ID:: C0852519
•: Neoplastic Process

Synonyms:	Benign Cartilaginous Neoplasm; benign cartilaginous neoplasm; Benign Cartilaginous Tumor; benign cartilaginous tumor; benign cartilaginous tumour; Benign Chondrogenic Neoplasm; benign chondrogenic neoplasm; Benign chondrogenic neoplasm of bone and articular cartilage; Benign Chondrogenic Tumor; benign chondrogenic tumor; benign chondrogenic tumour; Benign Neoplasm of Cartilage; benign neoplasm of cartilage; Benign Neoplasm of the Cartilage; benign neoplasm of the cartilage; Benign Tumor of Cartilage; benign tumor of cartilage; Benign Tumor of the Cartilage; benign tumor of the cartilage; benign tumour of cartilage; benign tumour of the cartilage; chondrogenic neoplasm, benign
SNOMED CT:	Benign chondrogenic neoplasm (722690001); Benign chondrogenic neoplasm of bone and articular cartilage (722690001)

Monarch Initiative:	MONDO:0024470

Definition

A cartilaginous matrix-producing neoplasm characterized by the presence of neoplastic chondrocytes. There is no evidence of atypical or malignant cytological and architectural features, invasive features, or metastases. Representative examples include osteochondroma and chondroma. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Outcome of conservative and surgical treatment of enchondromas and atypical cartilaginous tumors of the long bones: retrospective analysis of 228 patients.

Omlor GW, Lohnherr V, Lange J, Gantz S, Mechtersheimer G, Merle C, Raiss P, Fellenberg J, Lehner B
BMC Musculoskelet Disord 2019 Mar 28;20(1):134. doi: 10.1186/s12891-019-2502-7. PMID: 30922289 Free PMC Article

The biology and management of cartilaginous tumors: a role for targeting isocitrate dehydrogenase.

Tinoco G, Wilky BA, Paz-Mejia A, Rosenberg A, Trent JC
Am Soc Clin Oncol Educ Book 2015:e648-55. doi: 10.14694/EdBook_AM.2015.35.e648. PMID: 25993236

See all (2)

Recent clinical studies

Etiology

Not every knee tumour is a ganglion - retrospective analysis of benign and malign tumour entities around the knee.

Behrendt P, Grunow T, K-H F, Krause M, Fahlbusch H, Priemel M
Arch Orthop Trauma Surg 2024 Aug;144(8):3227-3234. Epub 2024 Jun 21 doi: 10.1007/s00402-024-05401-7. PMID: 38904683 Free PMC Article

Regulatory role of human fibrocartilage stem cells in condyle osteochondroma.

Yin Q, Bi R, Li H, Li Q, Li P, Wang R, Zhu S
Cell Prolif 2023 Jan;56(1):e13342. Epub 2022 Sep 26 doi: 10.1111/cpr.13342. PMID: 36162830 Free PMC Article

Diagnostic accuracies of intraoperative frozen section and permanent section examinations for histological grades during open biopsy of bone tumors.

Miwa S, Yamamoto N, Hayashi K, Takeuchi A, Igarashi K, Tada K, Higuchi T, Yonezawa H, Morinaga S, Araki Y, Asano Y, Ikeda H, Nojima T, Tsuchiya H
Int J Clin Oncol 2021 Mar;26(3):613-619. Epub 2020 Nov 23 doi: 10.1007/s10147-020-01836-1. PMID: 33225397

Metabolic profiling of serum in patients with cartilage tumours using (1) H-NMR spectroscopy: A pilot study.

López-Garrido L, Bañuelos-Hernández AE, Pérez-Hernández E, Tecualt-Gómez R, Quiroz-Williams J, Ariza-Castolo A, Becerra-Martínez E, Pérez-Hernández N
Magn Reson Chem 2020 Jan;58(1):65-76. Epub 2019 Jul 19 doi: 10.1002/mrc.4925. PMID: 31323132

Chondrosarcoma of the jaw: a retrospective series.

Almansoori AA, Kim HY, Kim B, Kim SM, Lee JH
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Aug;128(2):106-111. Epub 2019 May 24 doi: 10.1016/j.oooo.2019.05.008. PMID: 31204208

See all (11)

Diagnosis

Molecular and immunohistochemical testing of bone tumours: review and update.

Kovacs SK, Manassaporn A, Nielsen GP, Hung YP
Histopathology 2023 May;82(6):794-811. Epub 2022 Dec 16 doi: 10.1111/his.14845. PMID: 36424903

Bone Tumors: Imaging Features of Common and Rare Benign Entities.

Naraghi AM, Mohankumar R, Linda D, White LM
Radiol Clin North Am 2022 Mar;60(2):205-219. Epub 2022 Jan 31 doi: 10.1016/j.rcl.2021.11.002. PMID: 35236589

Chondrogenic Bone Tumors: The Importance of Imaging Characteristics.

Engel H, Herget GW, Füllgraf H, Sutter R, Benndorf M, Bamberg F, Jungmann PM
Rofo 2021 Mar;193(3):262-275. Epub 2020 Nov 5 doi: 10.1055/a-1288-1209. PMID: 33152784

Benign and malignant cartilage tumors of the hand.

O'Connor MI, Bancroft LW
Hand Clin 2004 Aug;20(3):317-23, vi. doi: 10.1016/j.hcl.2004.03.019. PMID: 15275690

Pseudoanaplastic chondromyxoid fibroma.

Bahk WJ, Mirra JM, Sohn KR, Shin DS
Ann Diagn Pathol 1998 Aug;2(4):241-6. doi: 10.1016/s1092-9134(98)80013-0. PMID: 9845744

See all (26)

Therapy

Chondroblastoma's Lung Metastases Treated with Denosumab in Pediatric Patient.

Focaccia M, Gambarotti M, Hakim R, Paioli A, Cesari M, Spazzoli B, Spinnato P, Donati D, Rocca M, Longhi A
Cancer Res Treat 2021 Jan;53(1):279-282. Epub 2020 Aug 6 doi: 10.4143/crt.2020.384. PMID: 32777878 Free PMC Article

Outcome of conservative and surgical treatment of enchondromas and atypical cartilaginous tumors of the long bones: retrospective analysis of 228 patients.

The biology and management of cartilaginous tumors: a role for targeting isocitrate dehydrogenase.

Tinoco G, Wilky BA, Paz-Mejia A, Rosenberg A, Trent JC
Am Soc Clin Oncol Educ Book 2015:e648-55. doi: 10.14694/EdBook_AM.2015.35.e648. PMID: 25993236

Both a visual and a semiquantitative analysis for differentiating benign from malignant chondrogenic bone tumors using Tc-99m (V) DMSA scintigraphy: a prospective study.

Shinya T, Sato S, Kunisada T, Inai R, Yanai H, Ozaki T, Kanazawa S
Nucl Med Commun 2015 Aug;36(8):802-7. doi: 10.1097/MNM.0000000000000328. PMID: 25932541

Type X collagen expression and hypertrophic differentiation in chondrogenic neoplasias.

Aigner T, Frischholz S, Dertinger S, Beier F, Girkontaité I, von der Mark K
Histochem Cell Biol 1997 Jun;107(6):435-40. doi: 10.1007/s004180050130. PMID: 9243276

See all (5)

Prognosis

Chondroblastoma's Lung Metastases Treated with Denosumab in Pediatric Patient.

Metabolic profiling of serum in patients with cartilage tumours using (1) H-NMR spectroscopy: A pilot study.

Intracranial dural based chondroma.

Reinshagen C, Redjal N, Sajed DP, Nahed BV, Walcott BP
J Clin Neurosci 2016 Mar;25:161-3. Epub 2015 Oct 24 doi: 10.1016/j.jocn.2015.05.052. PMID: 26602798

Bone and soft tissue tumours of the foot: review of 83 cases.

Kinoshita G, Matsumoto M, Maruoka T, Shiraki T, Tsunemi K, Futani H, Maruo S
J Orthop Surg (Hong Kong) 2002 Dec;10(2):173-8. doi: 10.1177/230949900201000212. PMID: 12493931

Differentiation and proliferative activity in benign and malignant cartilage tumors of bone.

Hasegawa T, Seki K, Yang P, Hirose T, Hizawa K, Wada T, Wakabayashi J
Hum Pathol 1995 Aug;26(8):838-45. doi: 10.1016/0046-8177(95)90004-7. PMID: 7543439

See all (9)

Clinical prediction guides

Outcome of conservative and surgical treatment of enchondromas and atypical cartilaginous tumors of the long bones: retrospective analysis of 228 patients.

Both a visual and a semiquantitative analysis for differentiating benign from malignant chondrogenic bone tumors using Tc-99m (V) DMSA scintigraphy: a prospective study.

Shinya T, Sato S, Kunisada T, Inai R, Yanai H, Ozaki T, Kanazawa S
Nucl Med Commun 2015 Aug;36(8):802-7. doi: 10.1097/MNM.0000000000000328. PMID: 25932541

Non-squamous cell neoplasms of the larynx: radiologic-pathologic correlation.

Becker M, Moulin G, Kurt AM, Dulgerov P, Vukanovic S, Zbären P, Marchal F, Rüfenacht DA, Terrier F
Radiographics 1998 Sep-Oct;18(5):1189-209. doi: 10.1148/radiographics.18.5.9747615. PMID: 9747615

Type X collagen expression and hypertrophic differentiation in chondrogenic neoplasias.

Aigner T, Frischholz S, Dertinger S, Beier F, Girkontaité I, von der Mark K
Histochem Cell Biol 1997 Jun;107(6):435-40. doi: 10.1007/s004180050130. PMID: 9243276

Differentiation and proliferative activity in benign and malignant cartilage tumors of bone.

Hasegawa T, Seki K, Yang P, Hirose T, Hizawa K, Wada T, Wakabayashi J
Hum Pathol 1995 Aug;26(8):838-45. doi: 10.1016/0046-8177(95)90004-7. PMID: 7543439

See all (8)

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Benign chondrogenic neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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