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T-cell leukemia

MedGen UID:
6064
•Concept ID:
C0023492
•
Neoplastic Process
Synonyms: Leukemia, Lymphocytic, T Cell; Leukemia, Lymphocytic, T-Cell; Leukemia, T Cell; Leukemia, T Lymphocytic; Leukemia, T-Cell; Leukemia, T-Cell Lymphocytic; Leukemia, T-Lymphocytic; Leukemias, T Lymphocytic; Leukemias, T-Cell; Leukemias, T-Cell Lymphocytic; Leukemias, T-Lymphocytic; Lymphocytic Leukemia, T; Lymphocytic Leukemia, T Cell; Lymphocytic Leukemia, T-Cell; Lymphocytic Leukemias, T; Lymphocytic Leukemias, T-Cell; T Cell Leukemia; T Lymphocytic Leukemia; T Lymphocytic Leukemias; T-Cell Leukemia; T-Cell Leukemias; T-Cell Lymphocytic Leukemia; T-Cell Lymphocytic Leukemias; T-Lymphocytic Leukemia; T-Lymphocytic Leukemias
 
Monarch Initiative: MONDO:0005525

Definition

A malignant disease of the T-lymphocytes in the bone marrow, thymus, and/or blood. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT-cell leukemia

Professional guidelines

PubMed

T-Cell Prolymphocytic Leukemia: Diagnosis, Pathogenesis, and Treatment.
Gutierrez M, Bladek P, Goksu B, Murga-Zamalloa C, Bixby D, Wilcox R
Int J Mol Sci 2023 Jul 28;24(15) doi: 10.3390/ijms241512106. PMID: 37569479Free PMC Article
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
LGL leukemia: from pathogenesis to treatment.
Lamy T, Moignet A, Loughran TP Jr
Blood 2017 Mar 2;129(9):1082-1094. Epub 2017 Jan 23 doi: 10.1182/blood-2016-08-692590. PMID: 28115367

Recent clinical studies

Etiology

What is new in mature T-cell leukemias?
Bailey NG, Elenitoba-Johnson KSJ
Semin Diagn Pathol 2020 Jan;37(1):72-78. Epub 2019 Dec 17 doi: 10.1053/j.semdp.2019.12.001. PMID: 31917110
An "off-the-shelf" fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies.
Cooper ML, Choi J, Staser K, Ritchey JK, Devenport JM, Eckardt K, Rettig MP, Wang B, Eissenberg LG, Ghobadi A, Gehrs LN, Prior JL, Achilefu S, Miller CA, Fronick CC, O'Neal J, Gao F, Weinstock DM, Gutierrez A, Fulton RS, DiPersio JF
Leukemia 2018 Sep;32(9):1970-1983. Epub 2018 Feb 20 doi: 10.1038/s41375-018-0065-5. PMID: 29483708Free PMC Article
Mature T-cell leukemias: Molecular and Clinical Aspects.
Bailey NG, Elenitoba-Johnson KS
Curr Hematol Malig Rep 2015 Dec;10(4):421-8. doi: 10.1007/s11899-015-0288-8. PMID: 26433891
Mature T-cell leukemias.
Ravandi F, Kantarjian H, Jones D, Dearden C, Keating M, O'Brien S
Cancer 2005 Nov 1;104(9):1808-18. doi: 10.1002/cncr.21405. PMID: 16136598
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Diagnosis

Flow Cytometry of T cells and T-cell Neoplasms.
Craig JW, Dorfman DM
Clin Lab Med 2017 Dec;37(4):725-751. Epub 2017 Oct 3 doi: 10.1016/j.cll.2017.07.002. PMID: 29128066
Kikuchi-Fujimoto disease: a diagnostic dilemma.
Mathew LM, Kapila R, Schwartz RA
Int J Dermatol 2016 Oct;55(10):1069-75. Epub 2016 May 21 doi: 10.1111/ijd.13314. PMID: 27207311
Mature T-cell leukemias.
Ravandi F, Kantarjian H, Jones D, Dearden C, Keating M, O'Brien S
Cancer 2005 Nov 1;104(9):1808-18. doi: 10.1002/cncr.21405. PMID: 16136598
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
The molecular basis of leukemia.
Cline MJ
N Engl J Med 1994 Feb 3;330(5):328-36. doi: 10.1056/NEJM199402033300507. PMID: 8277954

Therapy

TRBC1-targeting antibody-drug conjugates for the treatment of T cell cancers.
Nichakawade TD, Ge J, Mog BJ, Lee BS, Pearlman AH, Hwang MS, DiNapoli SR, Wyhs N, Marcou N, Glavaris S, Konig MF, Gabelli SB, Watson E, Sterling C, Wagner-Johnston N, Rozati S, Swinnen L, Fuchs E, Pardoll DM, Gabrielson K, Papadopoulos N, Bettegowda C, Kinzler KW, Zhou S, Sur S, Vogelstein B, Paul S
Nature 2024 Apr;628(8007):416-423. Epub 2024 Mar 27 doi: 10.1038/s41586-024-07233-2. PMID: 38538786Free PMC Article
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.
Maciocia PM, Wawrzyniecka PA, Philip B, Ricciardelli I, Akarca AU, Onuoha SC, Legut M, Cole DK, Sewell AK, Gritti G, Somja J, Piris MA, Peggs KS, Linch DC, Marafioti T, Pule MA
Nat Med 2017 Dec;23(12):1416-1423. Epub 2017 Nov 13 doi: 10.1038/nm.4444. PMID: 29131157
Prolymphocytic leukemia.
Absi A, Hsi E, Kalaycio M
Curr Treat Options Oncol 2005 May;6(3):197-208. doi: 10.1007/s11864-005-0003-4. PMID: 15869731
Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency.
McCormack MP, Rabbitts TH
N Engl J Med 2004 Feb 26;350(9):913-22. doi: 10.1056/NEJMra032207. PMID: 14985489
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Prognosis

What is new in mature T-cell leukemias?
Bailey NG, Elenitoba-Johnson KSJ
Semin Diagn Pathol 2020 Jan;37(1):72-78. Epub 2019 Dec 17 doi: 10.1053/j.semdp.2019.12.001. PMID: 31917110
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.
Maciocia PM, Wawrzyniecka PA, Philip B, Ricciardelli I, Akarca AU, Onuoha SC, Legut M, Cole DK, Sewell AK, Gritti G, Somja J, Piris MA, Peggs KS, Linch DC, Marafioti T, Pule MA
Nat Med 2017 Dec;23(12):1416-1423. Epub 2017 Nov 13 doi: 10.1038/nm.4444. PMID: 29131157
Kikuchi-Fujimoto disease: a diagnostic dilemma.
Mathew LM, Kapila R, Schwartz RA
Int J Dermatol 2016 Oct;55(10):1069-75. Epub 2016 May 21 doi: 10.1111/ijd.13314. PMID: 27207311
Mature T-cell leukemias: Molecular and Clinical Aspects.
Bailey NG, Elenitoba-Johnson KS
Curr Hematol Malig Rep 2015 Dec;10(4):421-8. doi: 10.1007/s11899-015-0288-8. PMID: 26433891
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Clinical prediction guides

Recent advances in T-cell lymphoid neoplasms.
Bigas A, Rodriguez-Sevilla JJ, Espinosa L, Gallardo F
Exp Hematol 2022 Feb;106:3-18. Epub 2021 Dec 5 doi: 10.1016/j.exphem.2021.12.191. PMID: 34879258
The Production, Quality Control, and Characterization of ZED8, a CD8-Specific (89)Zr-Labeled Immuno-PET Clinical Imaging Agent.
Gill H, Seipert R, Carroll VM, Gouasmat A, Yin J, Ogasawara A, de Jong I, Phan MM, Wang X, Yang J, Ilovich O, Marik J, Williams SP
AAPS J 2020 Jan 3;22(2):22. doi: 10.1208/s12248-019-0392-0. PMID: 31900688
Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.
Baum C, von Kalle C, Staal FJ, Li Z, Fehse B, Schmidt M, Weerkamp F, Karlsson S, Wagemaker G, Williams DA
Mol Ther 2004 Jan;9(1):5-13. doi: 10.1016/j.ymthe.2003.10.013. PMID: 14741772
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
The NF-kappa B p65 promoter.
Ueberla K, Lu Y, Chung E, Haseltine WA
J Acquir Immune Defic Syndr (1988) 1993 Mar;6(3):227-30. PMID: 8450395

Recent systematic reviews

Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa.
Oloumbou EF, Engone-Ondo JD, Mamimandjiami Idam I, Moussavou-Boudzanga P, Mfouo-Tynga I, Mouinga-Ondeme A
Viruses 2022 Dec 16;14(12) doi: 10.3390/v14122808. PMID: 36560812Free PMC Article
The efficacy of anti-CD19 chimeric antigen receptor T cells for B-cell malignancies.
Cao JX, Gao WJ, You J, Wu LH, Liu JL, Wang ZX
Cytotherapy 2019 Jul;21(7):769-781. Epub 2019 May 31 doi: 10.1016/j.jcyt.2019.04.005. PMID: 31160157
Thyroid cancer and T lymphoblastic leukemia in Crohn disease: a case report and literature review.
Byun JM, Baek SK, Yoon HJ, Kim SY, Maeng CH, Park TS, Kim HJ, Choi YY, Um YJ
Lab Med 2015 Spring;46(2):140-5. doi: 10.1309/LMU4KMJDRM3AD6FQ. PMID: 25918193
Diseases of large granular lymphocytes.
Alekshun TJ, Sokol L
Cancer Control 2007 Apr;14(2):141-50. doi: 10.1177/107327480701400207. PMID: 17387299

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