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Tuberculoid leprosy

MedGen UID:
6050
•Concept ID:
C0023351
•
Disease or Syndrome
Synonyms: Leprosies, Tuberculoid; Leprosy, Tuberculoid; Tuberculoid Leprosies; Tuberculoid Leprosy
SNOMED CT: Tuberculoid leprosy (70143003); Type T leprosy (70143003); Full tuberculoid leprosy (70143003); Type TT leprosy (70143003); TT - Full tuberculoid leprosy (70143003); Smooth leprosy (70143003); Tuberculoid Hansen's disease (leprosy) (70143003)
 
Monarch Initiative: MONDO:0005126

Definition

A principal or polar form of leprosy in which the skin lesions are few and are sharply demarcated. Peripheral nerve involvement is pronounced and may be severe. Unlike lepromatous leprosy (leprosy, lepromatous), the lepromin test is positive. Tuberculoid leprosy is rarely a source of infection to others. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTuberculoid leprosy

Professional guidelines

PubMed

Reactions and their management.
Ganapati R, Pai VV
J Indian Med Assoc 2004 Dec;102(12):688-90, 692, 694. PMID: 15871353
Trial of high dosages of dapsone in the treatment of tuberculoid leprosy.
Prasad BN
Lepr Rev 1971 Jun;42(2):118-20. doi: 10.5935/0305-7518.19710014. PMID: 5150030
Cortisone in the treatment of reactional conditions in tuberculoid leprosy.
LEWIS RA, KYI KYI K, EDWARDS R
Int J Lepr 1957 Jul-Sep;25(3):213-6. PMID: 13524993

Recent clinical studies

Etiology

Primary neural leprosy: clinical, neurophysiological and pathological presentation and progression.
Tomaselli PJ, Dos Santos DF, Dos Santos ACJ, Antunes DE, Marques VD, Foss NT, Moreira CL, Nogueira PTB, Nascimento OJM, Neder L, Barreira AA, Frade MA, Goulart IMB, Marques W
Brain 2022 May 24;145(4):1499-1506. doi: 10.1093/brain/awab396. PMID: 34664630
Histopathology of the lepromatous skin biopsy.
Massone C, Belachew WA, Schettini A
Clin Dermatol 2015 Jan-Feb;33(1):38-45. doi: 10.1016/j.clindermatol.2014.10.003. PMID: 25432809
Clinical aspects of leprosy.
Talhari C, Talhari S, Penna GO
Clin Dermatol 2015 Jan-Feb;33(1):26-37. doi: 10.1016/j.clindermatol.2014.07.002. PMID: 25432808
Scar leishmaniasis.
Arfan-ul-Bari, Simeen-ber-Rahman
J Coll Physicians Surg Pak 2006 Apr;16(4):294-5. PMID: 16624197
Reactions and their management.
Ganapati R, Pai VV
J Indian Med Assoc 2004 Dec;102(12):688-90, 692, 694. PMID: 15871353

Diagnosis

Granulomatous slack skin.
Pai K, Rao R, Devadiga R, Shenoi S, Pai S
Int J Dermatol 2000 May;39(5):374-6. doi: 10.1046/j.1365-4362.2000.00841-4.x. PMID: 10849132
Dapsone syndrome.
Hiran S, Pande TK, Rizvi SA, Vishwanathan KA
J Assoc Physicians India 1994 Jun;42(6):497. PMID: 7852239
Infective neuropathies.
Said G
Curr Opin Neurol 1994 Oct;7(5):398-401. doi: 10.1097/00019052-199410000-00006. PMID: 7804459
The origin, morphology, and function of epithelioid cells.
Turk JL, Narayanan RB
Immunobiology 1982 Apr;161(3-4):274-82. doi: 10.1016/S0171-2985(82)80083-1. PMID: 7047374
Tuberculoid leprosy.
Jopling WH
Proc R Soc Med 1976 Jun;69(6):391. PMID: 959207Free PMC Article

Therapy

Clinical aspects of leprosy.
Talhari C, Talhari S, Penna GO
Clin Dermatol 2015 Jan-Feb;33(1):26-37. doi: 10.1016/j.clindermatol.2014.07.002. PMID: 25432808
Leprosy.
Smith WC, Saunderson P
BMJ Clin Evid 2010 Jun 28;2010 PMID: 21418690Free PMC Article
Leprosy.
Lockwood DNj
BMJ Clin Evid 2007 Apr 1;2007 PMID: 19454067Free PMC Article
Scar leishmaniasis.
Arfan-ul-Bari, Simeen-ber-Rahman
J Coll Physicians Surg Pak 2006 Apr;16(4):294-5. PMID: 16624197
Dapsone syndrome.
Hiran S, Pande TK, Rizvi SA, Vishwanathan KA
J Assoc Physicians India 1994 Jun;42(6):497. PMID: 7852239

Prognosis

Presentations, Signs of Activity, and Differential Diagnosis of Vitiligo.
Goh BK, Pandya AG
Dermatol Clin 2017 Apr;35(2):135-144. doi: 10.1016/j.det.2016.11.004. PMID: 28317523
Clinical aspects of leprosy.
Talhari C, Talhari S, Penna GO
Clin Dermatol 2015 Jan-Feb;33(1):26-37. doi: 10.1016/j.clindermatol.2014.07.002. PMID: 25432808
Scar leishmaniasis.
Arfan-ul-Bari, Simeen-ber-Rahman
J Coll Physicians Surg Pak 2006 Apr;16(4):294-5. PMID: 16624197
Bacterial infections.
Gray F
Brain Pathol 1997 Jan;7(1):629-47. doi: 10.1111/j.1750-3639.1997.tb01079.x. PMID: 9034570Free PMC Article
Schistosomiasis mekongi diagnosed by rectal biopsy.
Lorette G, Jaafar MR, Grojean MF, Duong T
Br Med J (Clin Res Ed) 1983 Jun 25;286(6383):2012-3. doi: 10.1136/bmj.286.6383.2012. PMID: 6409206Free PMC Article

Clinical prediction guides

Dermoscopy of borderline tuberculoid leprosy.
Ankad BS, Sakhare PS
Int J Dermatol 2018 Jan;57(1):74-76. Epub 2017 Aug 22 doi: 10.1111/ijd.13731. PMID: 28833001
Modified simple decompression in the treatment of cubital tunnel syndrome: avoiding ulnar nerve subluxation.
Acioly MA, Soares AM, Almeida ML, Barbosa R, Daxbacher E, Carvalho CH
Arq Neuropsiquiatr 2017 Apr;75(4):238-243. doi: 10.1590/0004-282X20170023. PMID: 28489144
Leprosy.
Smith WC, Saunderson P
BMJ Clin Evid 2010 Jun 28;2010 PMID: 21418690Free PMC Article
Leprosy.
Lockwood DNj
BMJ Clin Evid 2007 Apr 1;2007 PMID: 19454067Free PMC Article
HLA and susceptibility to leprosy.
Serjeantson SW
Immunol Rev 1983;70:89-112. doi: 10.1111/j.1600-065x.1983.tb00711.x. PMID: 6339369

Recent systematic reviews

Pure neural leprosy or amyloid neuropathy? Systematic review and clinical case report.
Santos LOD, Fernandes TRMO, Barbosa TRS, Batista JADS, Souza CDF
Rev Assoc Med Bras (1992) 2021 Jan;67(1):140-149. doi: 10.1590/1806-9282.67.01.20200422. PMID: 34161469
Primary neural leprosy: systematic review.
Garbino JA, Marques W Jr, Barreto JA, Heise CO, Rodrigues MM, Antunes SL, Soares CT, Floriano MC, Nery JA, Trindade MA, Carvalho NB, Andrada NC, Barreira AA, Virmond Mda C
Arq Neuropsiquiatr 2013 Jun;71(6):397-404. doi: 10.1590/0004-282X20130046. PMID: 23828524
Leprosy.
Smith WC, Saunderson P
BMJ Clin Evid 2010 Jun 28;2010 PMID: 21418690Free PMC Article
Leprosy.
Lockwood DNj
BMJ Clin Evid 2007 Apr 1;2007 PMID: 19454067Free PMC Article

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