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Benign vaginal neoplasm

MedGen UID:
57810
•Concept ID:
C0154002
•
Neoplastic Process
Synonyms: Benign Neoplasm of the Vagina; benign neoplasm of the vagina; Benign neoplasm of vagina; Benign Neoplasm of Vagina; benign neoplasm of vagina; Benign Tumor of the Vagina; benign tumor of the vagina; Benign tumor of vagina; Benign Tumor of Vagina; benign tumor of vagina; benign tumour of the vagina; benign tumour of vagina; Benign Vaginal Neoplasm; benign vaginal neoplasm; Benign Vaginal Neoplasms; benign vaginal neoplasms; Benign Vaginal Tumor; benign vaginal tumor; benign vaginal tumour; vagina benign neoplasm; vagina female reproductive organ benign neoplasm; vaginal benign neoplasm
SNOMED CT: Benign tumor of vagina (92473001); Benign neoplasm of vagina (92473001)
 
Monarch Initiative: MONDO:0000647

Definition

A neoplasm that arises from the vagina and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Evaluation and management of urethral and periurethral masses in women.
Zuo SW, Napoe GS
Curr Opin Obstet Gynecol 2023 Dec 1;35(6):517-524. Epub 2023 Aug 29 doi: 10.1097/GCO.0000000000000914. PMID: 37678190
Diagnosis and management of uterine fibroids: current trends and future strategies.
Ahmad A, Kumar M, Bhoi NR, Badruddeen, Akhtar J, Khan MI, Ajmal M, Ahmad M
J Basic Clin Physiol Pharmacol 2023 May 1;34(3):291-310. Epub 2023 Mar 30 doi: 10.1515/jbcpp-2022-0219. PMID: 36989026
Advances in diagnostics and management of gestational trophoblastic disease.
Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620Free PMC Article

Recent clinical studies

Etiology

Advances in diagnostics and management of gestational trophoblastic disease.
Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620Free PMC Article
Nerve-sparing in Gynecologic Surgery: A Perspective.
Magrina J, Yang J, Yi J, Wasson M
J Minim Invasive Gynecol 2021 Mar;28(3):475-480. Epub 2020 Jul 20 doi: 10.1016/j.jmig.2020.07.009. PMID: 32702513
Uterine Leiomyosarcoma.
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
Potential contribution of the uterine microbiome in the development of endometrial cancer.
Walther-António MR, Chen J, Multinu F, Hokenstad A, Distad TJ, Cheek EH, Keeney GL, Creedon DJ, Nelson H, Mariani A, Chia N
Genome Med 2016 Nov 25;8(1):122. doi: 10.1186/s13073-016-0368-y. PMID: 27884207Free PMC Article
Geriatric gynecology.
Perkins KE, King MC
Emerg Med Clin North Am 2012 Nov;30(4):1007-19. doi: 10.1016/j.emc.2012.08.011. PMID: 23137409

Diagnosis

Gynecologic cancer in pregnancy.
Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Uterine Leiomyosarcoma.
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
Geriatric gynecology.
Perkins KE, King MC
Emerg Med Clin North Am 2012 Nov;30(4):1007-19. doi: 10.1016/j.emc.2012.08.011. PMID: 23137409
Paraurethral leiomyoma.
Perugia G, Ciccariello M, Pirolli F, Chinazzi A, Teodonio S, Borgoni G, Croce F, Liberti M
Urology 2012 Apr;79(4):e51-2. Epub 2011 Oct 19 doi: 10.1016/j.urology.2011.08.004. PMID: 22014968
Cervical tumors.
Sahdev A
Semin Ultrasound CT MR 2010 Oct;31(5):399-413. doi: 10.1053/j.sult.2010.07.004. PMID: 20974359

Therapy

Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics.
Wolf J, Kist LF, Pereira SB, Quessada MA, Petek H, Pille A, Maccari JG, Mutlaq MP, Nasi LA
Rev Med Virol 2024 May;34(3):e2537. doi: 10.1002/rmv.2537. PMID: 38666757
Nerve-sparing in Gynecologic Surgery: A Perspective.
Magrina J, Yang J, Yi J, Wasson M
J Minim Invasive Gynecol 2021 Mar;28(3):475-480. Epub 2020 Jul 20 doi: 10.1016/j.jmig.2020.07.009. PMID: 32702513
Uterine Leiomyosarcoma.
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
Vaginal route: a gynaecological route for much more than hysterectomy.
Sheth SS, Paghdiwalla KP, Hajari AR
Best Pract Res Clin Obstet Gynaecol 2011 Apr;25(2):115-32. Epub 2011 Feb 23 doi: 10.1016/j.bpobgyn.2010.12.005. PMID: 21349773
Tumorigenic aspects.
Kirk ME
Int J Gynaecol Obstet 1978-1979;16(6):473-8. doi: 10.1002/j.1879-3479.1979.tb00952.x. PMID: 39811

Prognosis

Detection of endometrial cancer using tampon-based collection and methylated DNA markers.
Bakkum-Gamez JN, Sherman ME, Slettedahl SW, Mahoney DW, Lemens MA, Laughlin-Tommaso SK, Hopkins MR, VanOosten A, Shridhar V, Staub JK, Cao X, Foote PH, Clarke MA, Burger KN, Berger CK, O'Connell MC, Doering KA, Podratz KC, DeStephano CC, Schoolmeester JK, Kerr SE, Wentzensen N, Taylor WR, Kisiel JB
Gynecol Oncol 2023 Jul;174:11-20. Epub 2023 May 2 doi: 10.1016/j.ygyno.2023.04.014. PMID: 37141817Free PMC Article
Gynecologic cancer in pregnancy.
Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Uterine Leiomyosarcoma.
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
Uterine hemangioma: a rare pathologic entity.
Chou WY, Chang HW
Arch Pathol Lab Med 2012 May;136(5):567-71. doi: 10.5858/arpa.2011-0078-RS. PMID: 22540306
Post-irradiation cytology of cervical cancer patients.
Shield PW, Daunter B, Wright RG
Cytopathology 1992;3(3):167-82. doi: 10.1111/j.1365-2303.1992.tb00043.x. PMID: 1511122

Clinical prediction guides

Detection of endometrial cancer using tampon-based collection and methylated DNA markers.
Bakkum-Gamez JN, Sherman ME, Slettedahl SW, Mahoney DW, Lemens MA, Laughlin-Tommaso SK, Hopkins MR, VanOosten A, Shridhar V, Staub JK, Cao X, Foote PH, Clarke MA, Burger KN, Berger CK, O'Connell MC, Doering KA, Podratz KC, DeStephano CC, Schoolmeester JK, Kerr SE, Wentzensen N, Taylor WR, Kisiel JB
Gynecol Oncol 2023 Jul;174:11-20. Epub 2023 May 2 doi: 10.1016/j.ygyno.2023.04.014. PMID: 37141817Free PMC Article
Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Clinical and ultrasound characteristics of vaginal lesions.
Pozzati F, Moro F, Leombroni M, Bertoldo V, Trivellizzi N, Mascilini F, Bolomini G, Ciccarone F, Garganese G, Scambia G, Testa AC
Int J Gynecol Cancer 2021 Jan;31(1):45-51. Epub 2020 Nov 23 doi: 10.1136/ijgc-2020-001651. PMID: 33229406
Uterine Leiomyosarcoma.
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
Dysregulated expression of long noncoding RNAs in gynecologic cancers.
Hosseini ES, Meryet-Figuiere M, Sabzalipoor H, Kashani HH, Nikzad H, Asemi Z
Mol Cancer 2017 Jun 21;16(1):107. doi: 10.1186/s12943-017-0671-2. PMID: 28637507Free PMC Article

Recent systematic reviews

Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen.
Romero SA, Young K, Hickey M, Su HI
Cochrane Database Syst Rev 2020 Dec 21;12(12):CD007245. doi: 10.1002/14651858.CD007245.pub4. PMID: 33348436Free PMC Article
WITHDRAWN: Robotic assisted surgery for gynaecological cancer.
Shi G, Lu D, Liu Z, Liu D, Zhou X
Cochrane Database Syst Rev 2014;2014(12):CD008640. Epub 2014 Dec 11 doi: 10.1002/14651858.CD008640.pub3. PMID: 25502432Free PMC Article
A systematic review and cost analysis of robot-assisted hysterectomy in malignant and benign conditions.
Tapper AM, Hannola M, Zeitlin R, Isojärvi J, Sintonen H, Ikonen TS
Eur J Obstet Gynecol Reprod Biol 2014 Jun;177:1-10. Epub 2014 Mar 15 doi: 10.1016/j.ejogrb.2014.03.010. PMID: 24703710
Systematic review of robotic surgery in gynecology: robotic techniques compared with laparoscopy and laparotomy.
Gala RB, Margulies R, Steinberg A, Murphy M, Lukban J, Jeppson P, Aschkenazi S, Olivera C, South M, Lowenstein L, Schaffer J, Balk EM, Sung V; Society of Gynecologic Surgeons Systematic Review Group
J Minim Invasive Gynecol 2014 May-Jun;21(3):353-61. Epub 2013 Dec 1 doi: 10.1016/j.jmig.2013.11.010. PMID: 24295923
Atypical glandular cells and cervical cancer: systematic review.
Marques JP, Costa LB, Pinto AP, Lima AF, Duarte ME, Barbosa AP, Medeiros PL
Rev Assoc Med Bras (1992) 2011 Mar-Apr;57(2):234-8. doi: 10.1590/s0104-42302011000200024. PMID: 21537713

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