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Recurrent pharyngitis

MedGen UID:
488936
•Concept ID:
C0747556
•
Sign or Symptom
Synonyms: Pharyngitis, recurrent; Recurrent sore throat
 
HPO: HP:0100776

Definition

An increased susceptibility to pharyngitis as manifested by a history of recurrent pharyngitis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent pharyngitis

Conditions with this feature

X-linked lymphoproliferative disease due to SH2D1A deficiency
MedGen UID:
1770239
•Concept ID:
C5399825
•
Disease or Syndrome
X-linked lymphoproliferative disease (XLP) has two recognizable subtypes, XLP1 and XLP2. XLP1 is characterized predominantly by one of three commonly recognized phenotypes: Inappropriate immune response to Epstein-Barr virus (EBV) infection leading to hemophagocytic lymphohistiocytosis (HLH) or severe mononucleosis. Dysgammaglobulinemia. Lymphoproliferative disease (malignant lymphoma). XLP2 is most often characterized by HLH (often associated with EBV), dysgammaglobulinemia, and inflammatory bowel disease. HLH resulting from EBV infection is associated with an unregulated and exaggerated immune response with widespread proliferation of cytotoxic T cells, EBV-infected B cells, and macrophages. Dysgammaglobulinemia is typically hypogammaglobulinemia of one or more immunoglobulin subclasses. The malignant lymphomas are typically B-cell lymphomas, non-Hodgkin type, often extranodal, and in particular involving the intestine.
See: Condition Record
X-linked lymphoproliferative disease due to SH2D1A deficiency

Professional guidelines

PubMed

Treatment of acute pharyngitis in children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG).
Chiappini E, Simeone G, Bergamini M, Pellegrino R, Guarino A, Staiano A, Esposito S, Gattinara GC, Vecchio AL, Stefani S, Iacono ID, Scotese I, Tezza G, Dinardo G, Riccio S, Pellizzari S, Iavarone S, Lorenzetti G, Venturini E, Donà D, Pierantoni L, Doria M, Garazzino S, Midulla F, Cricelli C, Terracciano L, Capuano A, Bruzzese E, Ghiglioni D, Fusani L, Fusco E, Biasci P, Reggiani L, Matera L, Mancino E, Barbieri E, D'Avino A, Cursi L, Sullo MG, Scotti S, Marseglia GL, Di Mauro G, Principi N, Galli L, Verga MC
Ital J Pediatr 2024 Nov 6;50(1):235. doi: 10.1186/s13052-024-01789-5. PMID: 39501298Free PMC Article
Molecular analysis of Streptococcus pyogenes strains isolated from patients with recurrent pharyngitis after oral amoxicillin treatment.
Saito M, Hirose M, Ichinose H, Villanueva SYAM, Yoshida SI
J Med Microbiol 2018 Nov;67(11):1544-1550. Epub 2018 Sep 24 doi: 10.1099/jmm.0.000833. PMID: 30247119
Pharyngeal infections. Causes, findings, and management.
Mandel JH
Postgrad Med 1985 Feb 15;77(3):187-93, 196-9. doi: 10.1080/00325481.1985.11698902. PMID: 3919374

Recent clinical studies

Etiology

Treatment of acute pharyngitis in children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG).
Chiappini E, Simeone G, Bergamini M, Pellegrino R, Guarino A, Staiano A, Esposito S, Gattinara GC, Vecchio AL, Stefani S, Iacono ID, Scotese I, Tezza G, Dinardo G, Riccio S, Pellizzari S, Iavarone S, Lorenzetti G, Venturini E, Donà D, Pierantoni L, Doria M, Garazzino S, Midulla F, Cricelli C, Terracciano L, Capuano A, Bruzzese E, Ghiglioni D, Fusani L, Fusco E, Biasci P, Reggiani L, Matera L, Mancino E, Barbieri E, D'Avino A, Cursi L, Sullo MG, Scotti S, Marseglia GL, Di Mauro G, Principi N, Galli L, Verga MC
Ital J Pediatr 2024 Nov 6;50(1):235. doi: 10.1186/s13052-024-01789-5. PMID: 39501298Free PMC Article
A comprehensive comparison between pediatric and adult patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenopathy (PFAPA) syndrome.
Rigante D, Vitale A, Natale MF, Lopalco G, Andreozzi L, Frediani B, D'Errico F, Iannone F, Cantarini L
Clin Rheumatol 2017 Feb;36(2):463-468. Epub 2016 Jun 1 doi: 10.1007/s10067-016-3317-7. PMID: 27251674
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).
Burton MJ, Pollard AJ, Ramsden JD, Chong LY, Venekamp RP
Cochrane Database Syst Rev 2014 Sep 11;(9):CD008669. doi: 10.1002/14651858.CD008669.pub2. PMID: 25209127
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).
Burton MJ, Pollard AJ, Ramsden JD
Cochrane Database Syst Rev 2010 Sep 8;(9):CD008669. doi: 10.1002/14651858.CD008669. PMID: 20824883
Pharyngeal infections. Causes, findings, and management.
Mandel JH
Postgrad Med 1985 Feb 15;77(3):187-93, 196-9. doi: 10.1080/00325481.1985.11698902. PMID: 3919374

Diagnosis

A comprehensive comparison between pediatric and adult patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenopathy (PFAPA) syndrome.
Rigante D, Vitale A, Natale MF, Lopalco G, Andreozzi L, Frediani B, D'Errico F, Iannone F, Cantarini L
Clin Rheumatol 2017 Feb;36(2):463-468. Epub 2016 Jun 1 doi: 10.1007/s10067-016-3317-7. PMID: 27251674
Family History in Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA) Syndrome.
Manthiram K, Nesbitt E, Morgan T, Edwards KM
Pediatrics 2016 Sep;138(3) doi: 10.1542/peds.2015-4572. PMID: 27565549Free PMC Article
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).
Burton MJ, Pollard AJ, Ramsden JD, Chong LY, Venekamp RP
Cochrane Database Syst Rev 2014 Sep 11;(9):CD008669. doi: 10.1002/14651858.CD008669.pub2. PMID: 25209127
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).
Burton MJ, Pollard AJ, Ramsden JD
Cochrane Database Syst Rev 2010 Sep 8;(9):CD008669. doi: 10.1002/14651858.CD008669. PMID: 20824883
Pharyngeal infections. Causes, findings, and management.
Mandel JH
Postgrad Med 1985 Feb 15;77(3):187-93, 196-9. doi: 10.1080/00325481.1985.11698902. PMID: 3919374

Therapy

Treatment of acute pharyngitis in children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG).
Chiappini E, Simeone G, Bergamini M, Pellegrino R, Guarino A, Staiano A, Esposito S, Gattinara GC, Vecchio AL, Stefani S, Iacono ID, Scotese I, Tezza G, Dinardo G, Riccio S, Pellizzari S, Iavarone S, Lorenzetti G, Venturini E, Donà D, Pierantoni L, Doria M, Garazzino S, Midulla F, Cricelli C, Terracciano L, Capuano A, Bruzzese E, Ghiglioni D, Fusani L, Fusco E, Biasci P, Reggiani L, Matera L, Mancino E, Barbieri E, D'Avino A, Cursi L, Sullo MG, Scotti S, Marseglia GL, Di Mauro G, Principi N, Galli L, Verga MC
Ital J Pediatr 2024 Nov 6;50(1):235. doi: 10.1186/s13052-024-01789-5. PMID: 39501298Free PMC Article
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).
Burton MJ, Pollard AJ, Ramsden JD, Chong LY, Venekamp RP
Cochrane Database Syst Rev 2014 Sep 11;(9):CD008669. doi: 10.1002/14651858.CD008669.pub2. PMID: 25209127
Tonsillectomy care for the pediatrician.
Isaacson G
Pediatrics 2012 Aug;130(2):324-34. Epub 2012 Jul 2 doi: 10.1542/peds.2011-3857. PMID: 22753552
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).
Burton MJ, Pollard AJ, Ramsden JD
Cochrane Database Syst Rev 2010 Sep 8;(9):CD008669. doi: 10.1002/14651858.CD008669. PMID: 20824883
Indications for tonsillectomy and adenoidectomy.
Randall DA, Parker GS, Kennedy KS
Am Fam Physician 1991 Nov;44(5):1639-46. PMID: 1950961

Prognosis

The expanding spectrum of low-penetrance TNFRSF1A gene variants in adults presenting with recurrent inflammatory attacks: clinical manifestations and long-term follow-up.
Cantarini L, Rigante D, Merlini G, Vitale A, Caso F, Lucherini OM, Sfriso P, Frediani B, Punzi L, Galeazzi M, Cimaz R, Obici L
Semin Arthritis Rheum 2014 Jun;43(6):818-23. Epub 2013 Dec 12 doi: 10.1016/j.semarthrit.2013.12.002. PMID: 24393624
Short-term outcomes of tonsillectomy in adult patients with recurrent pharyngitis: a randomized controlled trial.
Koskenkorva T, Koivunen P, Koskela M, Niemela O, Kristo A, Alho OP
CMAJ 2013 May 14;185(8):E331-6. Epub 2013 Apr 2 doi: 10.1503/cmaj.121852. PMID: 23549975Free PMC Article
Clinical evaluation of the oral probiotic Streptococcus salivarius K12 in the prevention of recurrent pharyngitis and/or tonsillitis caused by Streptococcus pyogenes in adults.
Di Pierro F, Adami T, Rapacioli G, Giardini N, Streitberger C
Expert Opin Biol Ther 2013 Mar;13(3):339-43. Epub 2013 Jan 4 doi: 10.1517/14712598.2013.758711. PMID: 23286823
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).
Burton MJ, Pollard AJ, Ramsden JD
Cochrane Database Syst Rev 2010 Sep 8;(9):CD008669. doi: 10.1002/14651858.CD008669. PMID: 20824883
PFAPA syndrome in children evaluated for tonsillectomy.
Galanakis E, Papadakis CE, Giannoussi E, Karatzanis AD, Bitsori M, Helidonis ES
Arch Dis Child 2002 Jun;86(6):434-5. doi: 10.1136/adc.86.6.434. PMID: 12023179Free PMC Article

Clinical prediction guides

Additive rates model for recurrent event data with intermittently observed time-dependent covariates.
Lyu T, Luo X, Huang CY, Sun Y
Stat Methods Med Res 2021 Oct;30(10):2239-2255. Epub 2021 Aug 26 doi: 10.1177/09622802211027593. PMID: 34445914Free PMC Article
Feasibility of Powered Intracapsular Tonsillectomy in Pediatric Patients with Tonsil Problem, Including Recurrent Tonsillitis: A Single Surgeon's Experience.
Kim H, Li SW, Park SM, Kim SK, Hong SJ, Hong SM, Kim YB, Park IS
ORL J Otorhinolaryngol Relat Spec 2020;82(6):335-342. Epub 2020 Oct 19 doi: 10.1159/000509479. PMID: 33075791
A comprehensive comparison between pediatric and adult patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenopathy (PFAPA) syndrome.
Rigante D, Vitale A, Natale MF, Lopalco G, Andreozzi L, Frediani B, D'Errico F, Iannone F, Cantarini L
Clin Rheumatol 2017 Feb;36(2):463-468. Epub 2016 Jun 1 doi: 10.1007/s10067-016-3317-7. PMID: 27251674
The expanding spectrum of low-penetrance TNFRSF1A gene variants in adults presenting with recurrent inflammatory attacks: clinical manifestations and long-term follow-up.
Cantarini L, Rigante D, Merlini G, Vitale A, Caso F, Lucherini OM, Sfriso P, Frediani B, Punzi L, Galeazzi M, Cimaz R, Obici L
Semin Arthritis Rheum 2014 Jun;43(6):818-23. Epub 2013 Dec 12 doi: 10.1016/j.semarthrit.2013.12.002. PMID: 24393624
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).
Burton MJ, Pollard AJ, Ramsden JD
Cochrane Database Syst Rev 2010 Sep 8;(9):CD008669. doi: 10.1002/14651858.CD008669. PMID: 20824883

Recent systematic reviews

Treatment of acute pharyngitis in children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG).
Chiappini E, Simeone G, Bergamini M, Pellegrino R, Guarino A, Staiano A, Esposito S, Gattinara GC, Vecchio AL, Stefani S, Iacono ID, Scotese I, Tezza G, Dinardo G, Riccio S, Pellizzari S, Iavarone S, Lorenzetti G, Venturini E, Donà D, Pierantoni L, Doria M, Garazzino S, Midulla F, Cricelli C, Terracciano L, Capuano A, Bruzzese E, Ghiglioni D, Fusani L, Fusco E, Biasci P, Reggiani L, Matera L, Mancino E, Barbieri E, D'Avino A, Cursi L, Sullo MG, Scotti S, Marseglia GL, Di Mauro G, Principi N, Galli L, Verga MC
Ital J Pediatr 2024 Nov 6;50(1):235. doi: 10.1186/s13052-024-01789-5. PMID: 39501298Free PMC Article
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).
Burton MJ, Pollard AJ, Ramsden JD, Chong LY, Venekamp RP
Cochrane Database Syst Rev 2019 Dec 30;12(12):CD008669. doi: 10.1002/14651858.CD008669.pub3. PMID: 31886897Free PMC Article
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).
Burton MJ, Pollard AJ, Ramsden JD, Chong LY, Venekamp RP
Cochrane Database Syst Rev 2014 Sep 11;(9):CD008669. doi: 10.1002/14651858.CD008669.pub2. PMID: 25209127
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).
Burton MJ, Pollard AJ, Ramsden JD
Cochrane Database Syst Rev 2010 Sep 8;(9):CD008669. doi: 10.1002/14651858.CD008669. PMID: 20824883
The role of tonsillectomy in reducing recurrent pharyngitis: a systematic review.
Blakley BW, Magit AE
Otolaryngol Head Neck Surg 2009 Mar;140(3):291-7. doi: 10.1016/j.otohns.2008.12.013. PMID: 19248931

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