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Bacterial infection of eye

MedGen UID:
4626
•Concept ID:
C0015404
•
Disease or Syndrome
Synonyms: Bacterial Eye Infection; Bacterial Eye Infections; Bacterial Ocular Infection; Bacterial Ocular Infections; Eye Infection, Bacterial; Eye Infections, Bacterial; Infection, Bacterial Eye; Infections, Bacterial Eye; Infections, Bacterial Ocular; Ocular Infection, Bacterial; Ocular Infections, Bacterial
SNOMED CT: Bacterial infection of eye (128984004)

Definition

Infections in the inner or external eye caused by microorganisms belonging to several families of bacteria. Some of the more common genera found are Haemophilus, Neisseria, Staphylococcus, Streptococcus, and Chlamydia. [from MeSH]

Professional guidelines

PubMed

Conjunctivitis: Diagnosis and Management.
Winters S, Frazier W, Winters J
Am Fam Physician 2024 Aug;110(2):134-144. PMID: 39172671
Update on the Management of Infectious Keratitis.
Austin A, Lietman T, Rose-Nussbaumer J
Ophthalmology 2017 Nov;124(11):1678-1689. Epub 2017 Sep 21 doi: 10.1016/j.ophtha.2017.05.012. PMID: 28942073Free PMC Article
Conjunctivitis: a systematic review of diagnosis and treatment.
Azari AA, Barney NP
JAMA 2013 Oct 23;310(16):1721-9. doi: 10.1001/jama.2013.280318. PMID: 24150468Free PMC Article

Recent clinical studies

Etiology

ASCRS clinical advisory on intracameral moxifloxacin injection for infection prophylaxis.
Myers WG, Chang DF, Shorstein NH, Mah FS, Mamalis N, Miller KM; ASCRS Cataract Clinical Committee
J Cataract Refract Surg 2023 Oct 1;49(10):1068-1070. doi: 10.1097/j.jcrs.0000000000001237. PMID: 37290753
Ocular syphilis.
Tsan GL, Claiborne RT
Clin Exp Optom 2021 Sep;104(7):756-759. Epub 2021 Apr 8 doi: 10.1080/08164622.2021.1906848. PMID: 33831337
Orbital cellulitis.
Tsirouki T, Dastiridou AI, Ibánez Flores N, Cerpa JC, Moschos MM, Brazitikos P, Androudi S
Surv Ophthalmol 2018 Jul-Aug;63(4):534-553. Epub 2017 Dec 15 doi: 10.1016/j.survophthal.2017.12.001. PMID: 29248536
Infections after keratoprosthesis.
Davies E, Chodosh J
Curr Opin Ophthalmol 2016 Jul;27(4):373-7. doi: 10.1097/ICU.0000000000000270. PMID: 27138637
Endophthalmitis after intravitreal injections.
Schwartz SG, Flynn HW, Scott IU
Expert Opin Pharmacother 2009 Sep;10(13):2119-26. doi: 10.1517/14656560903081752. PMID: 19586422

Diagnosis

Postrefractive infectious keratitis: prevention, diagnosis, management, and prognosis.
Viriya E, Mah F
Curr Opin Ophthalmol 2021 Jul 1;32(4):309-314. doi: 10.1097/ICU.0000000000000775. PMID: 33973908
Ocular syphilis.
Tsan GL, Claiborne RT
Clin Exp Optom 2021 Sep;104(7):756-759. Epub 2021 Apr 8 doi: 10.1080/08164622.2021.1906848. PMID: 33831337
Orbital cellulitis.
Tsirouki T, Dastiridou AI, Ibánez Flores N, Cerpa JC, Moschos MM, Brazitikos P, Androudi S
Surv Ophthalmol 2018 Jul-Aug;63(4):534-553. Epub 2017 Dec 15 doi: 10.1016/j.survophthal.2017.12.001. PMID: 29248536
Cat-scratch disease.
Biancardi AL, Curi AL
Ocul Immunol Inflamm 2014 Apr;22(2):148-54. Epub 2013 Oct 9 doi: 10.3109/09273948.2013.833631. PMID: 24107122
Nocardia scleritis.
Knox CM, Whitcher JP, Cevellos V, Margolis TP, Irvine AR
Am J Ophthalmol 1997 May;123(5):713-4. doi: 10.1016/s0002-9394(14)71096-7. PMID: 9152089

Therapy

Steroids in the Management of Infectious Keratitis.
Keenan JD
Cornea 2023 Nov 1;42(11):1333-1339. Epub 2023 Jul 4 doi: 10.1097/ICO.0000000000003340. PMID: 38112645Free PMC Article
ASCRS clinical advisory on intracameral moxifloxacin injection for infection prophylaxis.
Myers WG, Chang DF, Shorstein NH, Mah FS, Mamalis N, Miller KM; ASCRS Cataract Clinical Committee
J Cataract Refract Surg 2023 Oct 1;49(10):1068-1070. doi: 10.1097/j.jcrs.0000000000001237. PMID: 37290753
Orbital cellulitis.
Tsirouki T, Dastiridou AI, Ibánez Flores N, Cerpa JC, Moschos MM, Brazitikos P, Androudi S
Surv Ophthalmol 2018 Jul-Aug;63(4):534-553. Epub 2017 Dec 15 doi: 10.1016/j.survophthal.2017.12.001. PMID: 29248536
Update on the Management of Infectious Keratitis.
Austin A, Lietman T, Rose-Nussbaumer J
Ophthalmology 2017 Nov;124(11):1678-1689. Epub 2017 Sep 21 doi: 10.1016/j.ophtha.2017.05.012. PMID: 28942073Free PMC Article
Cat-scratch disease.
Biancardi AL, Curi AL
Ocul Immunol Inflamm 2014 Apr;22(2):148-54. Epub 2013 Oct 9 doi: 10.3109/09273948.2013.833631. PMID: 24107122

Prognosis

Ocular syphilis.
Furtado JM, Simões M, Vasconcelos-Santos D, Oliver GF, Tyagi M, Nascimento H, Gordon DL, Smith JR
Surv Ophthalmol 2022 Mar-Apr;67(2):440-462. Epub 2021 Jun 18 doi: 10.1016/j.survophthal.2021.06.003. PMID: 34147542
Postrefractive infectious keratitis: prevention, diagnosis, management, and prognosis.
Viriya E, Mah F
Curr Opin Ophthalmol 2021 Jul 1;32(4):309-314. doi: 10.1097/ICU.0000000000000775. PMID: 33973908
Orbital cellulitis.
Tsirouki T, Dastiridou AI, Ibánez Flores N, Cerpa JC, Moschos MM, Brazitikos P, Androudi S
Surv Ophthalmol 2018 Jul-Aug;63(4):534-553. Epub 2017 Dec 15 doi: 10.1016/j.survophthal.2017.12.001. PMID: 29248536
Trabeculectomy bleb-associated infections.
Razeghinejad MR, Havens SJ, Katz LJ
Surv Ophthalmol 2017 Sep-Oct;62(5):591-610. Epub 2017 Feb 8 doi: 10.1016/j.survophthal.2017.01.009. PMID: 28188728
Cat-scratch disease.
Biancardi AL, Curi AL
Ocul Immunol Inflamm 2014 Apr;22(2):148-54. Epub 2013 Oct 9 doi: 10.3109/09273948.2013.833631. PMID: 24107122

Clinical prediction guides

Steroids in the Management of Infectious Keratitis.
Keenan JD
Cornea 2023 Nov 1;42(11):1333-1339. Epub 2023 Jul 4 doi: 10.1097/ICO.0000000000003340. PMID: 38112645Free PMC Article
Role of surfactant protein-D in ocular bacterial infection.
Hou X, Zhang X, Zhang Z
Int Ophthalmol 2022 Nov;42(11):3611-3623. Epub 2022 May 31 doi: 10.1007/s10792-022-02354-x. PMID: 35639299Free PMC Article
Paediatric orbital and periorbital infections.
Williams KJ, Allen RC
Curr Opin Ophthalmol 2019 Sep;30(5):349-355. doi: 10.1097/ICU.0000000000000589. PMID: 31261188
Endophthalmitis Prophylaxis for Cataract Surgery.
Haripriya A, Baam ZR, Chang DF
Asia Pac J Ophthalmol (Phila) 2017 Jul-Aug;6(4):324-329. doi: 10.22608/APO.2017200. PMID: 28780782
Ocular Infection: Endophthalmitis.
Schwartz SG, Flynn HW Jr, Das T, Mieler WF
Dev Ophthalmol 2016;55:176-88. Epub 2015 Oct 26 doi: 10.1159/000431195. PMID: 26501897Free PMC Article

Recent systematic reviews

Antibiotics versus placebo for acute bacterial conjunctivitis.
Chen YY, Liu SH, Nurmatov U, van Schayck OC, Kuo IC
Cochrane Database Syst Rev 2023 Mar 13;3(3):CD001211. doi: 10.1002/14651858.CD001211.pub4. PMID: 36912752Free PMC Article
A Systematic Review of Clinical Practice Guidelines for Infectious and Non-infectious Conjunctivitis.
Chan VF, Yong AC, Azuara-Blanco A, Gordon I, Safi S, Lingham G, Evans J, Keel S
Ophthalmic Epidemiol 2022 Oct;29(5):473-482. Epub 2021 Aug 29 doi: 10.1080/09286586.2021.1971262. PMID: 34459321
Trachoma.
Lansingh VC
BMJ Clin Evid 2016 Feb 9;2016 PMID: 26860629Free PMC Article
Conjunctivitis: a systematic review of diagnosis and treatment.
Azari AA, Barney NP
JAMA 2013 Oct 23;310(16):1721-9. doi: 10.1001/jama.2013.280318. PMID: 24150468Free PMC Article
Bacterial conjunctivitis.
Epling J
BMJ Clin Evid 2012 Feb 20;2012 PMID: 22348418Free PMC Article

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