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Panophthalmitis

MedGen UID:
10561
•Concept ID:
C0030332
•
Disease or Syndrome
Synonym: Panophthalmitides
SNOMED CT: Panophthalmitis (33382000)
 
Monarch Initiative: MONDO:0006884

Definition

Acute suppurative inflammation of the inner eye with necrosis of the sclera (and sometimes the cornea) and extension of the inflammation into the orbit. Pain may be severe and the globe may rupture. In endophthalmitis the globe does not rupture. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPanophthalmitis

Professional guidelines

PubMed

Microbial Keratitis in Thyroid Eye Disease: Clinical Features, Microbiological Profile, and Treatment Outcome.
Naik MN, Vasanthapuram VH, Joseph J, Murthy SI
Ophthalmic Plast Reconstr Surg 2019 Nov/Dec;35(6):543-548. doi: 10.1097/IOP.0000000000001361. PMID: 30844912
Demograhic pattern, clinical features and treatment outcome of patients with infective keratitis in the eastern region of Nepal.
Lavaju P, Arya SK, Khanal B, Amatya R, Patel S
Nepal J Ophthalmol 2009 Jul-Dec;1(2):101-6. doi: 10.3126/nepjoph.v1i2.3683. PMID: 21141001

Recent clinical studies

Etiology

MRI findings in endophthalmitis and panophthalmitis.
Sharma V, Sharma R, Tiwari T, Goyal S
BMJ Case Rep 2022 Feb 28;15(2) doi: 10.1136/bcr-2021-246856. PMID: 35228230Free PMC Article
Ocular Tuberculosis in HIV-infected Individuals.
Mehta S, Peters RP, Smit DP, Gupta V
Ocul Immunol Inflamm 2020 Nov 16;28(8):1251-1258. Epub 2020 Aug 18 doi: 10.1080/09273948.2020.1776882. PMID: 32809898
Fulminant Sphingomonas paucimobilis keratitis: case study and review of literature.
Agarwal R, Gagrani M, Mahajan A, Sharma N
BMJ Case Rep 2019 Dec 3;12(12) doi: 10.1136/bcr-2019-231642. PMID: 31801779Free PMC Article
Bacterial endophthalmitis in neonates.
Lohrer R, Belohradsky BH
Eur J Pediatr 1987 Jul;146(4):354-9. doi: 10.1007/BF00444936. PMID: 3308466
Does enucleation of the eye containing a malignant melanoma prevent or accelerate the dissemination of tumour cells.
Zimmerman LE, McLean IW, Foster WD
Br J Ophthalmol 1978 Jun;62(6):420-5. doi: 10.1136/bjo.62.6.420. PMID: 352389Free PMC Article

Diagnosis

Ocular Syphilis Causing Panophthalmitis.
Mathews B, George R, Ulrich JN
Ophthalmic Plast Reconstr Surg 2021 Mar-Apr 01;37(2):e69-e71. doi: 10.1097/IOP.0000000000001780. PMID: 32732543
Panophthalmitis in a patient with dengue fever.
Kumar V, Deorari V, Swaroop S, Biswas A
BMJ Case Rep 2019 Jun 3;12(6) doi: 10.1136/bcr-2019-229588. PMID: 31164382Free PMC Article
Intraocular blastomycosis: case report and review.
Lopez R, Mason JO, Parker JS, Pappas PG
Clin Infect Dis 1994 May;18(5):805-7. doi: 10.1093/clinids/18.5.805. PMID: 8075276
Tuberculous panophthalmitis.
McMoli TE, Mordi VP, Grange A, Abiose A
J Pediatr Ophthalmol Strabismus 1978 Nov-Dec;15(6):383-5. doi: 10.3928/0191-3913-19781101-12. PMID: 739370
Unsuspected retinoblastoma.
Andrew JM, Smith DR
Am J Ophthalmol 1965 Sep;60(3):536-40. doi: 10.1016/0002-9394(65)90728-2. PMID: 5294147

Therapy

Endogenous panophthalmitis after colonoscopy.
Yamamoto Y, Oguni K, Hagiya H, Otuska F
Intern Emerg Med 2024 Jan;19(1):241-242. Epub 2023 Jul 10 doi: 10.1007/s11739-023-03368-8. PMID: 37430068
Fulminant Sphingomonas paucimobilis keratitis: case study and review of literature.
Agarwal R, Gagrani M, Mahajan A, Sharma N
BMJ Case Rep 2019 Dec 3;12(12) doi: 10.1136/bcr-2019-231642. PMID: 31801779Free PMC Article
Ocular tuberculosis masquerading as ocular tumors.
Demirci H, Shields CL, Shields JA, Eagle RC Jr
Surv Ophthalmol 2004 Jan-Feb;49(1):78-89. doi: 10.1016/j.survophthal.2003.10.009. PMID: 14711441
Bacillus cereus endophthalmitis.
Le Saux N, Harding GK
Can J Surg 1987 Jan;30(1):28-9. PMID: 3102030
Tuberculous panophthalmitis.
McMoli TE, Mordi VP, Grange A, Abiose A
J Pediatr Ophthalmol Strabismus 1978 Nov-Dec;15(6):383-5. doi: 10.3928/0191-3913-19781101-12. PMID: 739370

Prognosis

Fulminant Sphingomonas paucimobilis keratitis: case study and review of literature.
Agarwal R, Gagrani M, Mahajan A, Sharma N
BMJ Case Rep 2019 Dec 3;12(12) doi: 10.1136/bcr-2019-231642. PMID: 31801779Free PMC Article
Bilateral endogenous bacterial panophthalmitis.
Krėpštė L, Žemaitienė R, Barzdžiukas V, Miliauskas A
Medicina (Kaunas) 2013;49(3):143-7. PMID: 23893059
Bacterial endophthalmitis in neonates.
Lohrer R, Belohradsky BH
Eur J Pediatr 1987 Jul;146(4):354-9. doi: 10.1007/BF00444936. PMID: 3308466
Bacillus cereus endophthalmitis.
Le Saux N, Harding GK
Can J Surg 1987 Jan;30(1):28-9. PMID: 3102030
Does enucleation of the eye containing a malignant melanoma prevent or accelerate the dissemination of tumour cells.
Zimmerman LE, McLean IW, Foster WD
Br J Ophthalmol 1978 Jun;62(6):420-5. doi: 10.1136/bjo.62.6.420. PMID: 352389Free PMC Article

Clinical prediction guides

Fulminant Orbital Cellulitis - A Rare Presentation of Endogenous Endophthalmitis.
Sharma U, Goel I, Chhabra S, Gupta SK, Gupta G
Nepal J Ophthalmol 2023 Jul;15(30):84-88. doi: 10.3126/nepjoph.v15i2.48720. PMID: 38976340
Elevated white blood cell count may predict risk of orbital implant exposure.
Bee YS, Lin MC, Sheu SJ, Ng JD
Can J Ophthalmol 2014 Feb;49(1):45-9. doi: 10.1016/j.jcjo.2013.08.013. PMID: 24513356
Severe Candida albicans panophthalmitis treated with all available and potentially effective antifungal drugs: fluconazole, liposomal amphotericin B, caspofungin, and voriconazole.
Manfredi R, Sabbatani S
Scand J Infect Dis 2006;38(10):950-1. doi: 10.1080/00365540600617041. PMID: 17008248
Sudden visual loss associated with clostridial bacteraemia.
Cannistra AJ, Albert DM, Frambach DA, Dreher RJ, Roberts L
Br J Ophthalmol 1988 May;72(5):380-5. doi: 10.1136/bjo.72.5.380. PMID: 3395597Free PMC Article
Bacillus laterosporus endophthalmitis.
Yabbara KF, Juffali F, Matossian RM
Arch Ophthalmol 1977 Dec;95(12):2187-9. doi: 10.1001/archopht.1977.04450120093010. PMID: 303897

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