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Hyperpituitarism

MedGen UID:
43783
•Concept ID:
C0020506
•
Disease or Syndrome
Synonyms: Anterior pituitary hyperfunction; hyperpituitarism; Pituitary hyperfunction; Pituitary hyperfunction (ant.)
SNOMED CT: Pituitary hyperfunction (ant.) (10649000); Hyperpituitarism (10649000); Pituitary hyperfunction (10649000); Anterior pituitary hyperfunction (10649000)
 
HPO: HP:0010514
Monarch Initiative: MONDO:0006793

Definition

Hypersecretion of one or more pituitary hormones. This can occur in conditions in which deficiency in the target organ leads to decreased hormonal feedback, or as a primary condition most usually in connection with a pituitary adenoma. [from HPO]

Professional guidelines

PubMed

Acromegaly: pathogenesis, diagnosis, and management.
Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S
Lancet Diabetes Endocrinol 2022 Nov;10(11):804-826. Epub 2022 Oct 6 doi: 10.1016/S2213-8587(22)00244-3. PMID: 36209758
Consensus on diagnosis and management of Cushing's disease: a guideline update.
Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, Biermasz NR, Boguszewski CL, Bronstein MD, Buchfelder M, Carmichael JD, Casanueva FF, Castinetti F, Chanson P, Findling J, Gadelha M, Geer EB, Giustina A, Grossman A, Gurnell M, Ho K, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Kelly DF, Lacroix A, McCormack A, Melmed S, Molitch M, Mortini P, Newell-Price J, Nieman L, Pereira AM, Petersenn S, Pivonello R, Raff H, Reincke M, Salvatori R, Scaroni C, Shimon I, Stratakis CA, Swearingen B, Tabarin A, Takahashi Y, Theodoropoulou M, Tsagarakis S, Valassi E, Varlamov EV, Vila G, Wass J, Webb SM, Zatelli MC, Biller BMK
Lancet Diabetes Endocrinol 2021 Dec;9(12):847-875. Epub 2021 Oct 20 doi: 10.1016/S2213-8587(21)00235-7. PMID: 34687601Free PMC Article
A Pituitary Society update to acromegaly management guidelines.
Fleseriu M, Biller BMK, Freda PU, Gadelha MR, Giustina A, Katznelson L, Molitch ME, Samson SL, Strasburger CJ, van der Lely AJ, Melmed S
Pituitary 2021 Feb;24(1):1-13. Epub 2020 Oct 20 doi: 10.1007/s11102-020-01091-7. PMID: 33079318Free PMC Article

Recent clinical studies

Etiology

L-thyroxin treatment in infants with hyperthyrotropinaemia: 4-year experience.
Demirel F, Bideci A, Camurdan MO, Cinaz P
Int J Clin Pract 2007 Aug;61(8):1333-6. Epub 2007 Jun 2 doi: 10.1111/j.1742-1241.2006.00998.x. PMID: 16749910
Longitudinal imaging reveals pituitary enlargement preceding hypoplasia in two brothers with combined pituitary hormone deficiency attributable to PROP1 mutation.
Riepe FG, Partsch CJ, Blankenstein O, Mönig H, Pfäffle RW, Sippell WG
J Clin Endocrinol Metab 2001 Sep;86(9):4353-7. doi: 10.1210/jcem.86.9.7828. PMID: 11549674
Primary empty sella: differences and similarities between children and adults.
Zucchini S, Ambrosetto P, Carlà G, Tani G, Franzoni E, Cacciari E
Acta Paediatr 1995 Dec;84(12):1382-5. doi: 10.1111/j.1651-2227.1995.tb13574.x. PMID: 8645956
Hormonal changes induced by bromocriptine (CB-154) at the early stage of treatment.
Strauch G, Valcke JC, Mahoudeau JA, Bricaire H
J Clin Endocrinol Metab 1977 Mar;44(3):588-90. doi: 10.1210/jcem-44-3-588. PMID: 576425
Median neuropathy (carpal-tunnel syndrome) in acromegaly. A sign of endocrine overactivity.
O'Duffy JD, Randall RV, MacCarty CS
Ann Intern Med 1973 Mar;78(3):379-83. doi: 10.7326/0003-4819-78-3-379. PMID: 4694893

Diagnosis

Common disorders of the pituitary gland: hyposecretion versus hypersecretion.
Hanberg A
J Infus Nurs 2005 Jan-Feb;28(1):36-44. doi: 10.1097/00129804-200501000-00005. PMID: 15684903
Hyperfunction and hypofunction in the anterior pituitary.
Romeo JH
Nurs Clin North Am 1996 Dec;31(4):769-78. PMID: 8969337
The evaluation and management of subclinical pituitary disease.
Soule SG, Jacobs HS
Postgrad Med J 1996 May;72(847):258-62. doi: 10.1136/pgmj.72.847.258. PMID: 8761496Free PMC Article
Pituitary function.
Dingman JF
N Engl J Med 1971 Sep 9;285(11):617-9. doi: 10.1056/NEJM197109092851107. PMID: 4331157
The diagnosis of hypersomatotropism in man.
Daughaday WH
Med Clin North Am 1968 Mar;52(2):371-80. PMID: 4872209

Therapy

Pituitary surgery's epidemiology using a national inpatient database in Japan.
Hattori Y, Tahara S, Aso S, Matsui H, Fushimi K, Yasunaga H, Morita A
Acta Neurochir (Wien) 2020 Jun;162(6):1317-1323. Epub 2020 Mar 3 doi: 10.1007/s00701-020-04270-4. PMID: 32125502
Familial Dysalbuminemic Hyperthyroxinemia that was Inappropriately Treated with Thiamazole Due to Pseudo-thyrotoxic Symptoms.
Fukaishi T, Sekiguchi Y, Hara Y
Intern Med 2017 Aug 15;56(16):2175-2180. Epub 2017 Aug 1 doi: 10.2169/internalmedicine.8619-16. PMID: 28781323Free PMC Article
Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment.
Marazuela M, Nattero L, Moure D, García-Polo I, Figueroa-Vega N, Guijarro C
Thyroid 2008 Oct;18(10):1119-23. doi: 10.1089/thy.2007.0375. PMID: 18816177
Hyponatremia due to sulfonylurea compounds.
Hagen GA, Frawley TF
J Clin Endocrinol Metab 1970 Nov;31(5):570-6. doi: 10.1210/jcem-31-5-570. PMID: 5470213
Successful treatment of acromegaly: metabolic and clinical studies in 145 patients.
Lawrence JH, Tobias CA, Linfoot JA, Born JL, Lyman JT, Chong CY, Manougian E, Wei WC
J Clin Endocrinol Metab 1970 Aug;31(2):180-98. doi: 10.1210/jcem-31-2-180. PMID: 4912771

Prognosis

L-thyroxin treatment in infants with hyperthyrotropinaemia: 4-year experience.
Demirel F, Bideci A, Camurdan MO, Cinaz P
Int J Clin Pract 2007 Aug;61(8):1333-6. Epub 2007 Jun 2 doi: 10.1111/j.1742-1241.2006.00998.x. PMID: 16749910
Longitudinal imaging reveals pituitary enlargement preceding hypoplasia in two brothers with combined pituitary hormone deficiency attributable to PROP1 mutation.
Riepe FG, Partsch CJ, Blankenstein O, Mönig H, Pfäffle RW, Sippell WG
J Clin Endocrinol Metab 2001 Sep;86(9):4353-7. doi: 10.1210/jcem.86.9.7828. PMID: 11549674
Articular manifestations of acromegaly.
Podgorski M, Robinson B, Weissberger A, Stiel J, Wang S, Brooks PM
Aust N Z J Med 1988 Feb;18(1):28-35. doi: 10.1111/j.1445-5994.1988.tb02236.x. PMID: 3395299
Bromoergocriptine and growth hormone (GH) dynamics in health and hypersomatotropism.
Sachdev Y
J Assoc Physicians India 1983 Apr;31(4):195-9. PMID: 6417104
Median neuropathy (carpal-tunnel syndrome) in acromegaly. A sign of endocrine overactivity.
O'Duffy JD, Randall RV, MacCarty CS
Ann Intern Med 1973 Mar;78(3):379-83. doi: 10.7326/0003-4819-78-3-379. PMID: 4694893

Clinical prediction guides

Reduced sleep quality and depression associate with decreased quality of life in patients with pituitary adenomas.
Leistner SM, Klotsche J, Dimopoulou C, Athanasoulia AP, Roemmler-Zehrer J, Pieper L, Schopohl J, Wittchen HU, Stalla GK, Fulda S, Sievers C
Eur J Endocrinol 2015 Jun;172(6):733-43. Epub 2015 Mar 19 doi: 10.1530/EJE-14-0941. PMID: 25792374
Clinical differentiation of primary from secondary hyperhidrosis.
Walling HW
J Am Acad Dermatol 2011 Apr;64(4):690-5. Epub 2011 Feb 18 doi: 10.1016/j.jaad.2010.03.013. PMID: 21334095
Longitudinal imaging reveals pituitary enlargement preceding hypoplasia in two brothers with combined pituitary hormone deficiency attributable to PROP1 mutation.
Riepe FG, Partsch CJ, Blankenstein O, Mönig H, Pfäffle RW, Sippell WG
J Clin Endocrinol Metab 2001 Sep;86(9):4353-7. doi: 10.1210/jcem.86.9.7828. PMID: 11549674
Investigation of hypothalamic-pituitary disease.
Lamberton RP, Jackson IM
Clin Endocrinol Metab 1983 Nov;12(3):509-34. doi: 10.1016/s0300-595x(83)80054-1. PMID: 6323063
The renin-angiotensin-aldosterone system in primary and secondary hypertension.
del Greco F, Huang CM, Quintanilla A, Krumlovsky F, Roxe DM, Santhanam S
Ann Clin Lab Sci 1981 Nov-Dec;11(6):497-505. PMID: 6119955

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