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Hyperplasia of the endometrium

MedGen UID:
41787
•Concept ID:
C0014173
•
Disease or Syndrome
Synonyms: Endometrial Hyperplasia; Endometrial Hyperplasias; Hyperplasia, Endometrial; Hyperplasias, Endometrial
SNOMED CT: Endometrial hyperplasia (237072009)
 
HPO: HP:0040298

Definition

A proliferation of the endometrial cells resulting in glandular enlargement and budding. The proliferation may or may not be associated with atypia of the endometrial cells. When the hyperplastic changes are excessive, there is formation of complex epithelial structures (complex endometrial hyperplasia). [from NCI]

Professional guidelines

PubMed

Fertility preserving management of early endometrial cancer in a patient cohort at the department of women's health at the university of Tuebingen.
Andress J, Pasternak J, Walter C, Kommoss S, Krämer B, Hartkopf A, Brucker SY, Schönfisch B, Steinmacher S
Arch Gynecol Obstet 2021 Jul;304(1):215-221. Epub 2021 Feb 19 doi: 10.1007/s00404-020-05905-8. PMID: 33606091Free PMC Article
Complex atypical hyperplasia of the endometrium: differences in outcome following conservative management of pre- and postmenopausal women.
Brownfoot FC, Hickey M, Ang WC, Arora V, McNally O
Reprod Sci 2014 Oct;21(10):1244-8. Epub 2014 Feb 10 doi: 10.1177/1933719114522517. PMID: 24516039
Treatment for complex atypical hyperplasia of the endometrium.
Jobo T, Kawaguchi M, Imai M, Kuramoto H
Eur J Gynaecol Oncol 2001;22(5):365-8. PMID: 11766742

Recent clinical studies

Etiology

The value of magnetic resonance imaging in investigating complex atypical hyperplasia of the endometrium.
Ofinran O, Balega J
Minerva Ginecol 2016 Aug;68(4):400-4. Epub 2016 Mar 22 PMID: 27002383
Complex atypical hyperplasia of the endometrium: differences in outcome following conservative management of pre- and postmenopausal women.
Brownfoot FC, Hickey M, Ang WC, Arora V, McNally O
Reprod Sci 2014 Oct;21(10):1244-8. Epub 2014 Feb 10 doi: 10.1177/1933719114522517. PMID: 24516039
Patients with atypical hyperplasia of the endometrium should be treated in oncological centers.
Antonsen SL, Ulrich L, Høgdall C
Gynecol Oncol 2012 Apr;125(1):124-8. Epub 2011 Dec 20 doi: 10.1016/j.ygyno.2011.12.436. PMID: 22198048
Tamoxifen-induced hyperplasia of the endometrium.
Neis KJ, Brandner P, Schlenker M
Contrib Gynecol Obstet 2000;20:60-8. doi: 10.1159/000060285. PMID: 11791286
Progestins.
Hirvonen E
Maturitas 1996 May;23 Suppl:S13-8. doi: 10.1016/0378-5122(96)01005-5. PMID: 8865133

Diagnosis

Endometriosis in a post-laparoscopic scar--case report and literature review.
Chmaj-Wierzchowska K, Pieta B, Czerniak T, Opala T
Ginekol Pol 2014 May;85(5):386-9. doi: 10.17772/gp/1737. PMID: 25011222
Complex atypical hyperplasia of the endometrium: differences in outcome following conservative management of pre- and postmenopausal women.
Brownfoot FC, Hickey M, Ang WC, Arora V, McNally O
Reprod Sci 2014 Oct;21(10):1244-8. Epub 2014 Feb 10 doi: 10.1177/1933719114522517. PMID: 24516039
Patients with atypical hyperplasia of the endometrium should be treated in oncological centers.
Antonsen SL, Ulrich L, Høgdall C
Gynecol Oncol 2012 Apr;125(1):124-8. Epub 2011 Dec 20 doi: 10.1016/j.ygyno.2011.12.436. PMID: 22198048
Endometrial hyperplasia/adenocarcinoma. a conventional approach.
Mazur MT
Ann Diagn Pathol 2005 Jun;9(3):174-81. doi: 10.1016/j.anndiagpath.2005.03.001. PMID: 15944963
Nodular histiocytic hyperplasia of the endometrium.
Fukunaga M, Iwaki S
Arch Pathol Lab Med 2004 Sep;128(9):1032-4. doi: 10.5858/2004-128-1032-NHHOTE. PMID: 15335251

Therapy

Endometriosis in a post-laparoscopic scar--case report and literature review.
Chmaj-Wierzchowska K, Pieta B, Czerniak T, Opala T
Ginekol Pol 2014 May;85(5):386-9. doi: 10.17772/gp/1737. PMID: 25011222
Complex atypical hyperplasia of the endometrium: differences in outcome following conservative management of pre- and postmenopausal women.
Brownfoot FC, Hickey M, Ang WC, Arora V, McNally O
Reprod Sci 2014 Oct;21(10):1244-8. Epub 2014 Feb 10 doi: 10.1177/1933719114522517. PMID: 24516039
Patients with atypical hyperplasia of the endometrium should be treated in oncological centers.
Antonsen SL, Ulrich L, Høgdall C
Gynecol Oncol 2012 Apr;125(1):124-8. Epub 2011 Dec 20 doi: 10.1016/j.ygyno.2011.12.436. PMID: 22198048
Tamoxifen-induced hyperplasia of the endometrium.
Neis KJ, Brandner P, Schlenker M
Contrib Gynecol Obstet 2000;20:60-8. doi: 10.1159/000060285. PMID: 11791286
Progestins.
Hirvonen E
Maturitas 1996 May;23 Suppl:S13-8. doi: 10.1016/0378-5122(96)01005-5. PMID: 8865133

Prognosis

Hysteroscopic Resection in Fertility-Sparing Surgery for Atypical Hyperplasia and Endometrial Cancer: Safety and Efficacy.
De Marzi P, Bergamini A, Luchini S, Petrone M, Taccagni GL, Mangili G, Colombo G, Candiani M
J Minim Invasive Gynecol 2015 Nov-Dec;22(7):1178-82. Epub 2015 Jun 16 doi: 10.1016/j.jmig.2015.06.004. PMID: 26092080
Complex atypical hyperplasia of the endometrium: differences in outcome following conservative management of pre- and postmenopausal women.
Brownfoot FC, Hickey M, Ang WC, Arora V, McNally O
Reprod Sci 2014 Oct;21(10):1244-8. Epub 2014 Feb 10 doi: 10.1177/1933719114522517. PMID: 24516039
Nodular histiocytic hyperplasia of the endometrium.
Kim KR, Lee YH, Ro JY
Int J Gynecol Pathol 2002 Apr;21(2):141-6. doi: 10.1097/00004347-200204000-00006. PMID: 11917223
Clinical significance of histiocytes in the detection of endometrial adenocarcinoma and hyperplasia.
Nguyen TN, Bourdeau JL, Ferenczy A, Franco EL
Diagn Cytopathol 1998 Aug;19(2):89-93. doi: 10.1002/(sici)1097-0339(199808)19:2<89::aid-dc3>3.0.co;2-i. PMID: 9702482
Complex hyperplasia of the endometrium. Predictive value of curettage vs. hysterectomy specimens.
Lambert B, Muteganya D, Lepage Y, Boivin Y
J Reprod Med 1994 Aug;39(8):639-42. PMID: 7996530

Clinical prediction guides

Selective vs Complete Sampling in Hysterectomy Specimens Performed for Atypical Hyperplasia.
Bryant BH, Doughty E, Kalof AN
Am J Clin Pathol 2019 Oct 7;152(5):666-674. doi: 10.1093/ajcp/aqz098. PMID: 31332427
Tamoxifen-induced hyperplasia of the endometrium.
Neis KJ, Brandner P, Schlenker M
Contrib Gynecol Obstet 2000;20:60-8. doi: 10.1159/000060285. PMID: 11791286
Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.
Sakurada A, Hamada H, Fukushige S, Yokoyama T, Yoshinaga K, Furukawa T, Sato S, Yajima A, Sato M, Fujimura S, Horii A
Int J Oncol 1999 Dec;15(6):1069-74. doi: 10.3892/ijo.15.6.1069. PMID: 10568810
Clinical significance of histiocytes in the detection of endometrial adenocarcinoma and hyperplasia.
Nguyen TN, Bourdeau JL, Ferenczy A, Franco EL
Diagn Cytopathol 1998 Aug;19(2):89-93. doi: 10.1002/(sici)1097-0339(199808)19:2<89::aid-dc3>3.0.co;2-i. PMID: 9702482
Complex hyperplasia of the endometrium. Predictive value of curettage vs. hysterectomy specimens.
Lambert B, Muteganya D, Lepage Y, Boivin Y
J Reprod Med 1994 Aug;39(8):639-42. PMID: 7996530

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