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Simple Endometrial Hyperplasia without Atypia

MedGen UID:
233444
•Concept ID:
C1335967
•
Pathologic Function

Definition

A proliferation of endometrial cells resulting in glandular enlargement and budding without changes in the basic structure of the endometrium. Epithelial atypia is absent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSimple Endometrial Hyperplasia without Atypia

Professional guidelines

PubMed

A diagnostic dilemma for solid ovarian masses: the clinical and radiological aspects with differential diagnosis of 23 cases.
Genç M, Solak A, Genç B, Sivrikoz ON, Kurtulmuş S, Turan A, Sahin N, Gür EB
Eur J Gynaecol Oncol 2015;36(2):186-91. PMID: 26050358
Cytological criteria of endometrial lesions with emphasis on stromal and epithelial cell clusters: result of 8 years of experience with intrauterine sampling.
Kobayashi H, Otsuki Y, Simizu S, Yamada M, Mukai R, Sawaki Y, Nakayama S, Torii Y
Cytopathology 2008 Feb;19(1):19-27. Epub 2007 Oct 3 doi: 10.1111/j.1365-2303.2007.00493.x. PMID: 17916089

Recent clinical studies

Etiology

Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding.
Van Den Bosch T, Verbakel JY, Valentin L, Wynants L, De Cock B, Pascual MA, Leone FPG, Sladkevicius P, Alcazar JL, Votino A, Fruscio R, Lanzani C, Van Holsbeke C, Rossi A, Jokubkiene L, Kudla M, Jakab A, Domali E, Epstein E, Van Pachterbeke C, Bourne T, Van Calster B, Timmerman D
Ultrasound Obstet Gynecol 2021 Jan;57(1):164-172. doi: 10.1002/uog.22109. PMID: 32484286
New concepts for an old problem: the diagnosis of endometrial hyperplasia.
Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT
Hum Reprod Update 2017 Mar 1;23(2):232-254. doi: 10.1093/humupd/dmw042. PMID: 27920066Free PMC Article
Endometrial hyperplasia.
Mills AM, Longacre TA
Semin Diagn Pathol 2010 Nov;27(4):199-214. doi: 10.1053/j.semdp.2010.09.002. PMID: 21309256
Endometrial cancer.
Sorosky JI
Obstet Gynecol 2008 Feb;111(2 Pt 1):436-47. doi: 10.1097/AOG.0b013e318162f690. PMID: 18238985

Diagnosis

Ultrasound features of endometrial pathology in women without abnormal uterine bleeding: results from the International Endometrial Tumor Analysis study (IETA3).
Heremans R, Van Den Bosch T, Valentin L, Wynants L, Pascual MA, Fruscio R, Testa AC, Buonomo F, Guerriero S, Epstein E, Bourne T, Timmerman D, Leone FPG; IETA Consortium
Ultrasound Obstet Gynecol 2022 Aug;60(2):243-255. doi: 10.1002/uog.24910. PMID: 35385178
Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding.
Van Den Bosch T, Verbakel JY, Valentin L, Wynants L, De Cock B, Pascual MA, Leone FPG, Sladkevicius P, Alcazar JL, Votino A, Fruscio R, Lanzani C, Van Holsbeke C, Rossi A, Jokubkiene L, Kudla M, Jakab A, Domali E, Epstein E, Van Pachterbeke C, Bourne T, Van Calster B, Timmerman D
Ultrasound Obstet Gynecol 2021 Jan;57(1):164-172. doi: 10.1002/uog.22109. PMID: 32484286
New concepts for an old problem: the diagnosis of endometrial hyperplasia.
Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT
Hum Reprod Update 2017 Mar 1;23(2):232-254. doi: 10.1093/humupd/dmw042. PMID: 27920066Free PMC Article
Endometrial hyperplasia.
Mills AM, Longacre TA
Semin Diagn Pathol 2010 Nov;27(4):199-214. doi: 10.1053/j.semdp.2010.09.002. PMID: 21309256
Endometrial cancer.
Sorosky JI
Obstet Gynecol 2008 Feb;111(2 Pt 1):436-47. doi: 10.1097/AOG.0b013e318162f690. PMID: 18238985

Therapy

Metformin for endometrial hyperplasia.
Shiwani H, Clement NS, Daniels JP, Atiomo W
Cochrane Database Syst Rev 2024 May 2;5(5):CD012214. doi: 10.1002/14651858.CD012214.pub3. PMID: 38695827Free PMC Article
Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Metformin for endometrial hyperplasia.
Clement NS, Oliver TR, Shiwani H, Sanner JR, Mulvaney CA, Atiomo W
Cochrane Database Syst Rev 2017 Oct 27;10(10):CD012214. doi: 10.1002/14651858.CD012214.pub2. PMID: 29077194Free PMC Article
Triple negative endometrial cancer.
Bulsa M, Urasińska E
Ginekol Pol 2017;88(4):212-214. doi: 10.5603/GP.a2017.0040. PMID: 28509323
Diagnosis and management of endometrial hyperplasia.
Armstrong AJ, Hurd WW, Elguero S, Barker NM, Zanotti KM
J Minim Invasive Gynecol 2012 Sep-Oct;19(5):562-71. Epub 2012 Aug 3 doi: 10.1016/j.jmig.2012.05.009. PMID: 22863972

Prognosis

Triple negative endometrial cancer.
Bulsa M, Urasińska E
Ginekol Pol 2017;88(4):212-214. doi: 10.5603/GP.a2017.0040. PMID: 28509323
Diagnosis and management of endometrial hyperplasia.
Armstrong AJ, Hurd WW, Elguero S, Barker NM, Zanotti KM
J Minim Invasive Gynecol 2012 Sep-Oct;19(5):562-71. Epub 2012 Aug 3 doi: 10.1016/j.jmig.2012.05.009. PMID: 22863972
Endometrial cancer.
Sorosky JI
Obstet Gynecol 2012 Aug;120(2 Pt 1):383-97. doi: 10.1097/AOG.0b013e3182605bf1. PMID: 22825101
Endometrial cancer.
Sorosky JI
Obstet Gynecol 2008 Feb;111(2 Pt 1):436-47. doi: 10.1097/AOG.0b013e318162f690. PMID: 18238985
Pathophysiology and management of endometrial hyperplasia and carcinoma.
Fu YS, Gambone JC, Berek JS
West J Med 1990 Jul;153(1):50-61. PMID: 2202159Free PMC Article

Clinical prediction guides

Ultrasound features of endometrial pathology in women without abnormal uterine bleeding: results from the International Endometrial Tumor Analysis study (IETA3).
Heremans R, Van Den Bosch T, Valentin L, Wynants L, Pascual MA, Fruscio R, Testa AC, Buonomo F, Guerriero S, Epstein E, Bourne T, Timmerman D, Leone FPG; IETA Consortium
Ultrasound Obstet Gynecol 2022 Aug;60(2):243-255. doi: 10.1002/uog.24910. PMID: 35385178
Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding.
Van Den Bosch T, Verbakel JY, Valentin L, Wynants L, De Cock B, Pascual MA, Leone FPG, Sladkevicius P, Alcazar JL, Votino A, Fruscio R, Lanzani C, Van Holsbeke C, Rossi A, Jokubkiene L, Kudla M, Jakab A, Domali E, Epstein E, Van Pachterbeke C, Bourne T, Van Calster B, Timmerman D
Ultrasound Obstet Gynecol 2021 Jan;57(1):164-172. doi: 10.1002/uog.22109. PMID: 32484286
Management of endometrial precancers.
Trimble CL, Method M, Leitao M, Lu K, Ioffe O, Hampton M, Higgins R, Zaino R, Mutter GL; Society of Gynecologic Oncology Clinical Practice Committee
Obstet Gynecol 2012 Nov;120(5):1160-75. doi: 10.1097/aog.0b013e31826bb121. PMID: 23090535Free PMC Article
Endometrial cancer.
Sorosky JI
Obstet Gynecol 2012 Aug;120(2 Pt 1):383-97. doi: 10.1097/AOG.0b013e3182605bf1. PMID: 22825101
Endometrial cancer.
Sorosky JI
Obstet Gynecol 2008 Feb;111(2 Pt 1):436-47. doi: 10.1097/AOG.0b013e318162f690. PMID: 18238985

Recent systematic reviews

Metformin for endometrial hyperplasia.
Shiwani H, Clement NS, Daniels JP, Atiomo W
Cochrane Database Syst Rev 2024 May 2;5(5):CD012214. doi: 10.1002/14651858.CD012214.pub3. PMID: 38695827Free PMC Article
Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Oral and intrauterine progestogens for atypical endometrial hyperplasia.
Luo L, Luo B, Zheng Y, Zhang H, Li J, Sidell N
Cochrane Database Syst Rev 2018 Dec 4;12(12):CD009458. doi: 10.1002/14651858.CD009458.pub3. PMID: 30521671Free PMC Article
Metformin for endometrial hyperplasia.
Clement NS, Oliver TR, Shiwani H, Sanner JR, Mulvaney CA, Atiomo W
Cochrane Database Syst Rev 2017 Oct 27;10(10):CD012214. doi: 10.1002/14651858.CD012214.pub2. PMID: 29077194Free PMC Article
Atypical Endometrial Polyps and Concurrent Endometrial Cancer: A Systematic Review.
de Rijk SR, Steenbergen ME, Nieboer TE, Coppus SF
Obstet Gynecol 2016 Sep;128(3):519-525. doi: 10.1097/AOG.0000000000001566. PMID: 27500332

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