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Constitutional symptom

MedGen UID:
3593
•Concept ID:
C0009812
•
Sign or Symptom
Synonyms: Constitutional Finding; Constitutional Symptom
 
HPO: HP:0025142

Definition

A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConstitutional symptom

Professional guidelines

PubMed

Novel agents for the treatment of polycythemia vera: an insight into preclinical research and early phase clinical trials.
Padrnos L, Mesa R
Expert Opin Investig Drugs 2020 Aug;29(8):809-817. Epub 2020 Jul 16 doi: 10.1080/13543784.2020.1782886. PMID: 32552220Free PMC Article
Impact of influenza treatment with oseltamivir on health, sleep and daily activities of otherwise healthy adults and adolescents.
Bettis R, Iacuzio D, Jung T, Fuchs R, Aultman R, Gyldmark M
Clin Drug Investig 2006;26(6):329-40. doi: 10.2165/00044011-200626060-00004. PMID: 17163267

Recent clinical studies

Etiology

Fever in systemic lupus erythematosus: associated clinical features and genetic factors.
Olivieri G, Ceccarelli F, Perricone C, Ciccacci C, Pirone C, Natalucci F, Spinelli FR, Alessandri C, Borgiani P, Conti F
Clin Exp Rheumatol 2022 Nov;40(11):2141-2146. Epub 2022 Mar 23 doi: 10.55563/clinexprheumatol/7x37pf. PMID: 35349414
Diagnosis and Therapy of Infectious Encephalitis in Children: A Ten-Years Retrospective Study.
Pata D, Buonsenso D, Frasca G, Lazzareschi I, Salerno G, Turriziani Colonna A, Mariotti P, Valentini P
Pediatr Infect Dis J 2021 Jun 1;40(6):513-517. doi: 10.1097/INF.0000000000003070. PMID: 33902074
Novel agents for the treatment of polycythemia vera: an insight into preclinical research and early phase clinical trials.
Padrnos L, Mesa R
Expert Opin Investig Drugs 2020 Aug;29(8):809-817. Epub 2020 Jul 16 doi: 10.1080/13543784.2020.1782886. PMID: 32552220Free PMC Article
Outbreak of Human Metapneumovirus in a Nursing Home: A Clinical Perspective.
Seynaeve D, Augusseau-Rivière B, Couturier P, Morel-Baccard C, Landelle C, Bosson JL, Gavazzi G, Mallaret MR
J Am Med Dir Assoc 2020 Jan;21(1):104-109.e1. Epub 2019 May 14 doi: 10.1016/j.jamda.2019.03.015. PMID: 31101588Free PMC Article
Correlates of the rate of decline of CD4+ lymphocytes among injection drug users infected with the human immunodeficiency virus.
Alcabes P, Schoenbaum EE, Klein RS
Am J Epidemiol 1993 May 1;137(9):989-1000. doi: 10.1093/oxfordjournals.aje.a116771. PMID: 8100395

Diagnosis

Fever in systemic lupus erythematosus: associated clinical features and genetic factors.
Olivieri G, Ceccarelli F, Perricone C, Ciccacci C, Pirone C, Natalucci F, Spinelli FR, Alessandri C, Borgiani P, Conti F
Clin Exp Rheumatol 2022 Nov;40(11):2141-2146. Epub 2022 Mar 23 doi: 10.55563/clinexprheumatol/7x37pf. PMID: 35349414
Development and validation of a simple risk score for diagnosing COVID-19 in the emergency room.
Sung J, Choudry N, Bachour R
Epidemiol Infect 2020 Nov 13;148:e273. doi: 10.1017/S0950268820002769. PMID: 33183384Free PMC Article
Outbreak of Human Metapneumovirus in a Nursing Home: A Clinical Perspective.
Seynaeve D, Augusseau-Rivière B, Couturier P, Morel-Baccard C, Landelle C, Bosson JL, Gavazzi G, Mallaret MR
J Am Med Dir Assoc 2020 Jan;21(1):104-109.e1. Epub 2019 May 14 doi: 10.1016/j.jamda.2019.03.015. PMID: 31101588Free PMC Article
Impetigo herpetiformis in a primigravida: successful treatment with etretinate.
Bukhari IA
J Drugs Dermatol 2004 Jul-Aug;3(4):449-51. PMID: 15303793
Correlates of the rate of decline of CD4+ lymphocytes among injection drug users infected with the human immunodeficiency virus.
Alcabes P, Schoenbaum EE, Klein RS
Am J Epidemiol 1993 May 1;137(9):989-1000. doi: 10.1093/oxfordjournals.aje.a116771. PMID: 8100395

Therapy

Differences between aquagenic and non-aquagenic pruritus in myeloproliferative neoplasms: An observational study of 500 patients.
Le Gall-Ianotto C, Ficheux AS, Lippert E, Herbreteau L, Rio L, Pan-Petesch B, Misery L, Ianotto JC
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1175-1183. Epub 2023 Mar 9 doi: 10.1111/jdv.18990. PMID: 36808754
Novel agents for the treatment of polycythemia vera: an insight into preclinical research and early phase clinical trials.
Padrnos L, Mesa R
Expert Opin Investig Drugs 2020 Aug;29(8):809-817. Epub 2020 Jul 16 doi: 10.1080/13543784.2020.1782886. PMID: 32552220Free PMC Article
Effect of nitazoxanide in adults and adolescents with acute uncomplicated influenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial.
Haffizulla J, Hartman A, Hoppers M, Resnick H, Samudrala S, Ginocchio C, Bardin M, Rossignol JF; US Nitazoxanide Influenza Clinical Study Group
Lancet Infect Dis 2014 Jul;14(7):609-18. Epub 2014 May 19 doi: 10.1016/S1473-3099(14)70717-0. PMID: 24852376Free PMC Article
Impetigo herpetiformis in a primigravida: successful treatment with etretinate.
Bukhari IA
J Drugs Dermatol 2004 Jul-Aug;3(4):449-51. PMID: 15303793
Correlates of the rate of decline of CD4+ lymphocytes among injection drug users infected with the human immunodeficiency virus.
Alcabes P, Schoenbaum EE, Klein RS
Am J Epidemiol 1993 May 1;137(9):989-1000. doi: 10.1093/oxfordjournals.aje.a116771. PMID: 8100395

Prognosis

Diagnosis and Therapy of Infectious Encephalitis in Children: A Ten-Years Retrospective Study.
Pata D, Buonsenso D, Frasca G, Lazzareschi I, Salerno G, Turriziani Colonna A, Mariotti P, Valentini P
Pediatr Infect Dis J 2021 Jun 1;40(6):513-517. doi: 10.1097/INF.0000000000003070. PMID: 33902074
Development and validation of a simple risk score for diagnosing COVID-19 in the emergency room.
Sung J, Choudry N, Bachour R
Epidemiol Infect 2020 Nov 13;148:e273. doi: 10.1017/S0950268820002769. PMID: 33183384Free PMC Article
Neurological phenotypes in patients with NLRP3-, MEFV-, and TNFRSF1A low-penetrance variants.
Mulazzani E, Wagner D, Havla J, Schlüter M, Meinl I, Gerdes LA, Kümpfel T
J Neuroinflammation 2020 Jun 20;17(1):196. doi: 10.1186/s12974-020-01867-5. PMID: 32563262Free PMC Article
Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT.
McLornan DP, Malpassuti V, Lippinkhof-Kozijn A, Potter V, Beelen D, Bunjes D, Sengeloev H, Radujkovic A, Passweg J, Chalandon Y, Kröger N, Wulf GG, Johansson JE, Ciceri F, Bornhäuser M, Holler E, Guffroy B, Martin S, Neubauer A, Gramatski M, Robin M, Iacobelli S, Hayden P, Hernández Boluda JC, Czerw T, Yakoub-Agha I
Br J Haematol 2020 Aug;190(3):437-441. Epub 2020 Feb 28 doi: 10.1111/bjh.16537. PMID: 32108327
Correlates of the rate of decline of CD4+ lymphocytes among injection drug users infected with the human immunodeficiency virus.
Alcabes P, Schoenbaum EE, Klein RS
Am J Epidemiol 1993 May 1;137(9):989-1000. doi: 10.1093/oxfordjournals.aje.a116771. PMID: 8100395

Clinical prediction guides

Clinical and Radiological Presentation of Patients with Smear Positive Pulmonary Tuberculosis.
Noor SM, Ahmad MM, Anwar KMR, Chowdhury MF, Sultana M, Kader MA, Khan MAS
Mymensingh Med J 2024 Oct;33(4):1211-1218. PMID: 39351745
Differences between aquagenic and non-aquagenic pruritus in myeloproliferative neoplasms: An observational study of 500 patients.
Le Gall-Ianotto C, Ficheux AS, Lippert E, Herbreteau L, Rio L, Pan-Petesch B, Misery L, Ianotto JC
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1175-1183. Epub 2023 Mar 9 doi: 10.1111/jdv.18990. PMID: 36808754
Fever in systemic lupus erythematosus: associated clinical features and genetic factors.
Olivieri G, Ceccarelli F, Perricone C, Ciccacci C, Pirone C, Natalucci F, Spinelli FR, Alessandri C, Borgiani P, Conti F
Clin Exp Rheumatol 2022 Nov;40(11):2141-2146. Epub 2022 Mar 23 doi: 10.55563/clinexprheumatol/7x37pf. PMID: 35349414
Development and validation of a simple risk score for diagnosing COVID-19 in the emergency room.
Sung J, Choudry N, Bachour R
Epidemiol Infect 2020 Nov 13;148:e273. doi: 10.1017/S0950268820002769. PMID: 33183384Free PMC Article
Correlates of the rate of decline of CD4+ lymphocytes among injection drug users infected with the human immunodeficiency virus.
Alcabes P, Schoenbaum EE, Klein RS
Am J Epidemiol 1993 May 1;137(9):989-1000. doi: 10.1093/oxfordjournals.aje.a116771. PMID: 8100395

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