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SUDDEN INFANT DEATH SYNDROME(SIDS)

MedGen UID:
52548
•Concept ID:
C0038644
•
Disease or Syndrome
Synonyms: CAV3-Related Sudden Infant Death Syndrome; SIDS; Sudden Infant Death
SNOMED CT: SIDS - sudden infant death syndrome (51178009); Sudden infant death syndrome (51178009); Unexpected sudden death of infant (51178009); Crib death (51178009); Cot death (51178009)
 
Gene (location): SCN5A (3p22.2)
 
OMIM®: 272120

Definition

Sudden infant death syndrome (SIDS) is a diagnosis of exclusion which should be made only after a thorough autopsy without identification of a specific cause of death (Mage and Donner, 2004). Weese-Mayer et al. (2007) provided a detailed review of genetic factors that have been implicated in SIDS. The authors concluded that SIDS represents more than 1 entity and has a heterogeneous etiology most likely involving several different genetically controlled metabolic pathways. [from OMIM]

Clinical features

From HPO
Sudden death
MedGen UID:
8257
•Concept ID:
C0011071
•
Pathologic Function
Rapid and unexpected death.
See: Feature record | Search on this feature
Apneic episodes in infancy
MedGen UID:
814310
•Concept ID:
C3807980
•
Finding
Recurrent episodes of apnea occurring during infancy.
See: Feature record | Search on this feature
Malignant hyperthermia
MedGen UID:
1830388
•Concept ID:
C5779784
•
Pathologic Function
Malignant hyperthermia is characterized by a rapid increase in temperature to 39-42 degrees C. Malignant hyperthermia may occur in response to either inhalational anesthetics such as halothane, to muscle relaxants such as succinylcholine, or to exercise.
See: Feature record | Search on this feature
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Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSUDDEN INFANT DEATH SYNDROME

Professional guidelines

PubMed

How to use genetic testing after sudden infant death syndrome.
Bryson LJ, Joss S
Arch Dis Child Educ Pract Ed 2022 Oct;107(5):383-385. Epub 2021 Jan 12 doi: 10.1136/archdischild-2020-320835. PMID: 33436404
Interventions for Tobacco Smoking Cessation in Adults, Including Pregnant Persons: US Preventive Services Task Force Recommendation Statement.
US Preventive Services Task Force, Krist AH, Davidson KW, Mangione CM, Barry MJ, Cabana M, Caughey AB, Donahue K, Doubeni CA, Epling JW Jr, Kubik M, Ogedegbe G, Pbert L, Silverstein M, Simon MA, Tseng CW, Wong JB
JAMA 2021 Jan 19;325(3):265-279. doi: 10.1001/jama.2020.25019. PMID: 33464343
Sudden infant death syndrome.
Gelfer P, Tatum M
J Pediatr Health Care 2014 Sep-Oct;28(5):470-4. Epub 2014 Jun 16 doi: 10.1016/j.pedhc.2014.04.007. PMID: 24944089

Recent clinical studies

Etiology

Inflammation in sudden infant death syndrome.
MacFarlane PM
Pediatr Res 2024 Mar;95(4):885-886. Epub 2023 Dec 15 doi: 10.1038/s41390-023-02966-8. PMID: 38097722
Sudden infant death syndrome prevention.
Jullien S
BMC Pediatr 2021 Sep 8;21(Suppl 1):320. doi: 10.1186/s12887-021-02536-z. PMID: 34496779Free PMC Article
Parent-infant co-sleeping and the implications for sudden infant death syndrome.
Straw J, Jones P
Nurs Child Young People 2017 Dec 5;29(10):24-29. doi: 10.7748/ncyp.2017.e945. PMID: 29206359
Sudden infant death syndrome.
Creery D, Mikrogianakis A
Am Fam Physician 2003 Oct 1;68(7):1375-6. PMID: 14567492
Sudden infant death syndrome.
Nagler J
Curr Opin Pediatr 2002 Apr;14(2):247-50. doi: 10.1097/00008480-200204000-00018. PMID: 11981299

Diagnosis

Positional Plagiocephaly and Craniosynostosis.
Santiago GS, Santiago CN, Chwa ES, Purnell CA
Pediatr Ann 2023 Jan;52(1):e10-e17. Epub 2023 Jan 1 doi: 10.3928/19382359-20221114-03. PMID: 36625797
Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome.
Harrington CT, Hafid NA, Waters KA
EBioMedicine 2022 Jun;80:104041. Epub 2022 May 6 doi: 10.1016/j.ebiom.2022.104041. PMID: 35533499Free PMC Article
SIDS and Other Sleep-Related Infant Deaths: Evidence Base for 2016 Updated Recommendations for a Safe Infant Sleeping Environment.
Moon RY; TASK FORCE ON SUDDEN INFANT DEATH SYNDROME
Pediatrics 2016 Nov;138(5) doi: 10.1542/peds.2016-2940. PMID: 27940805
Sudden infant death syndrome.
Moon RY, Fu LY
Pediatr Rev 2007 Jun;28(6):209-14. doi: 10.1542/pir.28-6-209. PMID: 17545332
Infant botulism.
Polin RA, Brown LW
Pediatr Clin North Am 1979 May;26(2):345-54. doi: 10.1016/s0031-3955(16)33710-5. PMID: 379778

Therapy

Vosoritide therapy in children with achondroplasia aged 3-59 months: a multinational, randomised, double-blind, placebo-controlled, phase 2 trial.
Savarirayan R, Wilcox WR, Harmatz P, Phillips J 3rd, Polgreen LE, Tofts L, Ozono K, Arundel P, Irving M, Bacino CA, Basel D, Bober MB, Charrow J, Mochizuki H, Kotani Y, Saal HM, Army C, Jeha G, Qi Y, Han L, Fisheleva E, Huntsman-Labed A, Day J
Lancet Child Adolesc Health 2024 Jan;8(1):40-50. Epub 2023 Nov 18 doi: 10.1016/S2352-4642(23)00265-1. PMID: 37984383
Parent-infant co-sleeping and the implications for sudden infant death syndrome.
Straw J, Jones P
Nurs Child Young People 2017 Dec 5;29(10):24-29. doi: 10.7748/ncyp.2017.e945. PMID: 29206359
Sudden infant death syndrome and advice for safe sleeping.
Horne RS, Hauck FR, Moon RY
BMJ 2015 Apr 28;350:h1989. doi: 10.1136/bmj.h1989. PMID: 25921604
Sudden infant death syndrome.
Moon RY, Fu LY
Pediatr Rev 2007 Jun;28(6):209-14. doi: 10.1542/pir.28-6-209. PMID: 17545332
Infant botulism.
Polin RA, Brown LW
Pediatr Clin North Am 1979 May;26(2):345-54. doi: 10.1016/s0031-3955(16)33710-5. PMID: 379778

Prognosis

SIDS and Other Sleep-Related Infant Deaths: Evidence Base for 2016 Updated Recommendations for a Safe Infant Sleeping Environment.
Moon RY; TASK FORCE ON SUDDEN INFANT DEATH SYNDROME
Pediatrics 2016 Nov;138(5) doi: 10.1542/peds.2016-2940. PMID: 27940805
Sudden infant death syndrome and advice for safe sleeping.
Horne RS, Hauck FR, Moon RY
BMJ 2015 Apr 28;350:h1989. doi: 10.1136/bmj.h1989. PMID: 25921604
Sudden infant death syndrome.
Creery D, Mikrogianakis A
Am Fam Physician 2003 Oct 1;68(7):1375-6. PMID: 14567492
Sudden infant death syndrome and subsequent siblings.
Carbone MT
N J Med 1992 Sep;89(9):684-6. PMID: 1436732
Sudden-infant-death syndrome.
Meyer RJ
N Engl J Med 1973 Feb 8;288(6):324. doi: 10.1056/NEJM197302082880621. PMID: 4682681

Clinical prediction guides

Neonatal respiratory inhibition.
Minowa H
J Matern Fetal Neonatal Med 2022 Dec;35(25):7132-7138. Epub 2021 Jun 28 doi: 10.1080/14767058.2021.1944094. PMID: 34182876
Sudden infant death syndrome prevention.
Jullien S
BMC Pediatr 2021 Sep 8;21(Suppl 1):320. doi: 10.1186/s12887-021-02536-z. PMID: 34496779Free PMC Article
Sids.
Hauck FR, Tanabe KO
BMJ Clin Evid 2009 Jun 5;2009 PMID: 21726486Free PMC Article
Sudden infant death syndrome: a critical review of approaches to research.
Goldwater PN
Arch Dis Child 2003 Dec;88(12):1095-100. doi: 10.1136/adc.88.12.1095. PMID: 14670779Free PMC Article
Prolonged apnea and the sudden infant death syndrome: clinical and laboratory observations.
Steinschneider A
Pediatrics 1972 Oct;50(4):646-54. PMID: 4342142

Recent systematic reviews

Burden of disease attributable to second-hand smoke exposure: A systematic review.
Carreras G, Lugo A, Gallus S, Cortini B, Fernández E, López MJ, Soriano JB, López-Nicolás A, Semple S, Gorini G; TackSHS Project Investigators
Prev Med 2019 Dec;129:105833. Epub 2019 Sep 7 doi: 10.1016/j.ypmed.2019.105833. PMID: 31505203
Parent-child bed-sharing: The good, the bad, and the burden of evidence.
Mileva-Seitz VR, Bakermans-Kranenburg MJ, Battaini C, Luijk MP
Sleep Med Rev 2017 Apr;32:4-27. Epub 2016 Mar 15 doi: 10.1016/j.smrv.2016.03.003. PMID: 27107752
Short and long term health effects of parental tobacco smoking during pregnancy and lactation: a descriptive review.
Banderali G, Martelli A, Landi M, Moretti F, Betti F, Radaelli G, Lassandro C, Verduci E
J Transl Med 2015 Oct 15;13:327. doi: 10.1186/s12967-015-0690-y. PMID: 26472248Free PMC Article
Sids.
Hauck FR, Tanabe KO
BMJ Clin Evid 2009 Jun 5;2009 PMID: 21726486Free PMC Article
Swaddling: a systematic review.
van Sleuwen BE, Engelberts AC, Boere-Boonekamp MM, Kuis W, Schulpen TW, L'Hoir MP
Pediatrics 2007 Oct;120(4):e1097-106. doi: 10.1542/peds.2006-2083. PMID: 17908730

Supplemental Content

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    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
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      Related literature resources in PubMed
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      Related literature resources in PubMed

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