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Uterine Corpus Smooth Muscle Neoplasm

MedGen UID:
311427
•Concept ID:
C1519863
•
Neoplastic Process

Definition

A benign, intermediate, or malignant neoplasm that arises from the uterine corpus and is composed of neoplastic cells with smooth muscle differentiation. [from NCI]

Professional guidelines

PubMed

POTENTIAL DIAGNOSTIC BIOMARKERS FOR HUMAN MESENCHYMAL TUMORS, ESPECIALLY LMP2/Β1I AND CYCLIN E1/MIB1 DIFFERENTIAL EXPRESSION: PRUM-IBIO STUDY.
Tanabe Y, Hayashi T, Okada M, Aburatani H, Tonegawa S, Abiko K, Konishi I
Georgian Med News 2024 May;(350):42-48. PMID: 39089269
TFE3 translocation-associated perivascular epithelioid cell neoplasm (PEComa) of the gynecologic tract: morphology, immunophenotype, differential diagnosis.
Schoolmeester JK, Dao LN, Sukov WR, Wang L, Park KJ, Murali R, Hameed MR, Soslow RA
Am J Surg Pathol 2015 Mar;39(3):394-404. doi: 10.1097/PAS.0000000000000349. PMID: 25517951Free PMC Article

Recent clinical studies

Etiology

ALK Immunoexpression is Specific for Inflammatory Myofibroblastic Tumor Among Vulvovaginal Mesenchymal Neoplasms.
Bowman CJ, Medeiros F, Fadare O, Sangoi AR, Horvai AE, Devine WP, McCluggage WG, Rabban JT
Int J Gynecol Pathol 2023 Jan 1;42(1):1-10. Epub 2022 Feb 18 doi: 10.1097/PGP.0000000000000858. PMID: 35180768
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Patterns of bone morphogenetic protein-2 expression in smooth muscle tumors of the uterine corpus and other uterine tissues.
Fadare O, Renshaw IL, Liang SX
Appl Immunohistochem Mol Morphol 2011 Jul;19(4):352-9. doi: 10.1097/PAI.0b013e3182013441. PMID: 21285872
Perivascular epithelioid cell tumor (PEComa) of the uterus: an outcome-based clinicopathologic analysis of 41 reported cases.
Fadare O
Adv Anat Pathol 2008 Mar;15(2):63-75. doi: 10.1097/PAP.0b013e31816613b0. PMID: 18418088
Lipoleiomyomatous tumors of the uterus: a heterogeneous group? Histopathological study of five cases.
Shintaku M
Pathol Int 1996 Jul;46(7):498-502. doi: 10.1111/j.1440-1827.1996.tb03644.x. PMID: 8870005

Diagnosis

Pan-TRK immunohistochemistry in gynaecological mesenchymal tumours: diagnostic implications and pitfalls.
Moura MS, Costa J, Velasco V, Kommoss F, Oliva E, Le Loarer F, McCluggage WG, Razack R, Treilleux I, Mills A, Longacre T, Devouassoux-Shisheboran M, Hostein I, Azmani R, Blanchard L, Hartog C, Soubeyran I, Khalifa E, Croce S
Histopathology 2024 Feb;84(3):451-462. Epub 2023 Nov 21 doi: 10.1111/his.15082. PMID: 37988282
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Unusual types of smooth muscle tumors of uterine corpus: case reports and literature review.
Makharoblidze E, Goishvili N, Mchedlishvili M, Khakhutaishvili I, Jangavadze M
Georgian Med News 2013 Mar;(216):7-11. PMID: 23567300
Uterine adenomyoma: a clinicopathologic review of 26 cases and a review of the literature.
Tahlan A, Nanda A, Mohan H
Int J Gynecol Pathol 2006 Oct;25(4):361-5. doi: 10.1097/01.pgp.0000209570.08716.b3. PMID: 16990713
Pure mesenchymal neoplasms of the uterine corpus: selected problems.
Kempson RL, Hendrickson MR
Semin Diagn Pathol 1988 May;5(2):172-98. PMID: 3041510

Therapy

Large cell neuroendocrine carcinoma with sarcomatous changes of the endometrium: a case report with immunohistochemical studies and molecular genetic study of KIT and PDGFRA.
Terada T
Pathol Res Pract 2010 Jun 15;206(6):420-5. Epub 2010 Feb 26 doi: 10.1016/j.prp.2009.12.008. PMID: 20189318
Unexpected borderline malignant and malignant smooth muscle cell tumors of the uterine corpus in women treated with LH-RH analogues.
Wauters CC, Ter Harmsel BW, Hermans MP, Smedts F
Eur J Obstet Gynecol Reprod Biol 1995 Oct;62(2):257-9. doi: 10.1016/0301-2115(95)02192-a. PMID: 8582508

Prognosis

Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Mixed endometrial stromal and smooth muscle tumor of the uterus in a postmenopausal woman: morphologic and immunohistochemical features.
Yun KY, Kim YH, Suh DS, Lee NK, Choi KU, Kim KH
Eur J Gynaecol Oncol 2017;38(2):319-322. PMID: 29953805
Recognition of parametrial invasion, an important landmark when treating cervical cancer.
Shin SJ, Kim KR, Song DE, Ro JY, Kong KY, Lee SW, Nam JH
Gynecol Oncol 2012 Mar;124(3):502-7. Epub 2011 Nov 19 doi: 10.1016/j.ygyno.2011.11.015. PMID: 22108255
Primary osteosarcoma of the uterine corpus: case report and review of the literature.
Su M, Tokairin T, Nishikawa Y, Yoshioka T, Takahashi O, Watanabe H, Doi Y, Omori Y, Yoshioka T, Sageshima M, Tanaka T, Enomoto K
Pathol Int 2002 Feb;52(2):158-63. doi: 10.1046/j.1440-1827.2002.01325.x. PMID: 11940222
Pure mesenchymal neoplasms of the uterine corpus: selected problems.
Kempson RL, Hendrickson MR
Semin Diagn Pathol 1988 May;5(2):172-98. PMID: 3041510

Clinical prediction guides

ALK Is a Specific Diagnostic Marker for Inflammatory Myofibroblastic Tumor of the Uterus.
Mohammad N, Haimes JD, Mishkin S, Kudlow BA, Leong MY, Chew SH, Koay E, Whitehouse A, Cope N, Ali RH, Köbel M, Stewart CJR, McCluggage WG, Lee CH
Am J Surg Pathol 2018 Oct;42(10):1353-1359. doi: 10.1097/PAS.0000000000001120. PMID: 30015720
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Endometrial stromal sarcoma: clinicopathological and immunophenotype study of 18 cases.
Vera AA, Guadarrama MB
Ann Diagn Pathol 2011 Oct;15(5):312-7. Epub 2011 Jun 8 doi: 10.1016/j.anndiagpath.2011.01.008. PMID: 21652246
Uterine adenomyoma: a clinicopathologic review of 26 cases and a review of the literature.
Tahlan A, Nanda A, Mohan H
Int J Gynecol Pathol 2006 Oct;25(4):361-5. doi: 10.1097/01.pgp.0000209570.08716.b3. PMID: 16990713
Pure mesenchymal neoplasms of the uterine corpus: selected problems.
Kempson RL, Hendrickson MR
Semin Diagn Pathol 1988 May;5(2):172-98. PMID: 3041510

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