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Uterine leiomyosarcoma

MedGen UID:
83679
Concept ID:
C0280631
Neoplastic Process
Synonyms: Body of Uterus Leiomyosarcoma; body of uterus leiomyosarcoma; Corpus Uteri Leiomyosarcoma; corpus uteri leiomyosarcoma; leiomyosarcoma - uterus; Leiomyosarcoma of body of uterus; Leiomyosarcoma of Body of Uterus; leiomyosarcoma of body of uterus; Leiomyosarcoma of corpus uteri; Leiomyosarcoma of Corpus Uteri; leiomyosarcoma of corpus uteri; Leiomyosarcoma of the Body of Uterus; leiomyosarcoma of the body of uterus; Leiomyosarcoma of the Corpus Uteri; leiomyosarcoma of the corpus uteri; Leiomyosarcoma of the corpus uteri; Leiomyosarcoma of the Uterine Body; leiomyosarcoma of the uterine body; Leiomyosarcoma of the Uterine Corpus; leiomyosarcoma of the uterine corpus; Leiomyosarcoma of the Uterus; leiomyosarcoma of the uterus; Leiomyosarcoma of Uterine Body; leiomyosarcoma of uterine body; Leiomyosarcoma of Uterine Corpus; leiomyosarcoma of uterine corpus; Leiomyosarcoma of uterus; Leiomyosarcoma of Uterus; leiomyosarcoma of uterus; Uterine Body Leiomyosarcoma; uterine body leiomyosarcoma; Uterine Corpus Leiomyosarcoma; uterine corpus leiomyosarcoma; uterine leiomyosarcoma; Uterine Leiomyosarcoma; uterus leiomyosarcoma
SNOMED CT: Leiomyosarcoma of uterus (447389009); Leiomyosarcoma of body of uterus (770559003); Leiomyosarcoma of corpus uteri (770559003)
 
HPO: HP:0002891
Monarch Initiative: MONDO:0016262
Orphanet: ORPHA213625

Definition

The presence of a leiomyosarcoma of the uterus. [from HPO]

Conditions with this feature

Colorectal cancer
MedGen UID:
83428
Concept ID:
C0346629
Neoplastic Process
Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.
Hereditary leiomyomatosis and renal cell cancer
MedGen UID:
353771
Concept ID:
C1708350
Neoplastic Process
FH tumor predisposition syndrome is characterized by cutaneous leiomyomata, uterine leiomyomata (fibroids), and/or renal tumors. Pheochromocytoma and paraganglioma have also been described in a small number of families. Cutaneous leiomyomata appear as skin-colored to light brown papules or nodules distributed over the trunk and extremities, and occasionally on the face, and appear at a mean age of 30 years, increasing in size and number with age. Uterine leiomyomata tend to be numerous and large; age at diagnosis ranges from 18 to 53 years, with most women experiencing irregular or heavy menstruation and pelvic pain. Renal tumors are usually unilateral, solitary, and aggressive. They are associated with poor survival due to clinical aggressiveness and propensity to metastasize despite small primary tumor size. The median age of detection is approximately age 40 years.

Professional guidelines

PubMed

Hindman N, Kang S, Fournier L, Lakhman Y, Nougaret S, Reinhold C, Sadowski E, Huang JQ, Ascher S
Radiology 2023 Feb;306(2):e211658. Epub 2022 Oct 4 doi: 10.1148/radiol.211658. PMID: 36194109Free PMC Article
Bobiński M, Kraczkowski JJ, Witt E, Wertel I, Polak G, Kotarski J, Bednarek W
Wiad Lek 2016;69(6):799-803. PMID: 28214818
Serrano C, Mackintosh C, Herrero D, Martins AS, de Alava E, Hernández T, Pérez-Fontán J, Abad M, Pérez A, Serrano E, Bullón A, Orfao A
Clin Cancer Res 2005 Jul 1;11(13):4977-9; author reply 4979-80. doi: 10.1158/1078-0432.CCR-04-2461. PMID: 16000598

Recent clinical studies

Etiology

Hindman N, Kang S, Fournier L, Lakhman Y, Nougaret S, Reinhold C, Sadowski E, Huang JQ, Ascher S
Radiology 2023 Feb;306(2):e211658. Epub 2022 Oct 4 doi: 10.1148/radiol.211658. PMID: 36194109Free PMC Article
Li Y, Gong Q, Peng J, Liu Y, Jiang Y, Zhang S
Eur J Obstet Gynecol Reprod Biol 2022 Dec;279:94-101. Epub 2022 Oct 21 doi: 10.1016/j.ejogrb.2022.10.013. PMID: 36308940
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
Bobiński M, Kraczkowski JJ, Witt E, Wertel I, Polak G, Kotarski J, Bednarek W
Wiad Lek 2016;69(6):799-803. PMID: 28214818
Van Dinh T, Woodruff JD
Am J Obstet Gynecol 1982 Dec 1;144(7):817-23. doi: 10.1016/0002-9378(82)90358-1. PMID: 7148905

Diagnosis

Momeni-Boroujeni A, Yousefi E, Balakrishnan R, Riviere S, Kertowidjojo E, Hensley ML, Ladanyi M, Ellenson LH, Chiang S
Mod Pathol 2023 Apr;36(4):100084. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100084. PMID: 36788080Free PMC Article
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Sun S, Bonaffini PA, Nougaret S, Fournier L, Dohan A, Chong J, Smith J, Addley H, Reinhold C
Diagn Interv Imaging 2019 Oct;100(10):619-634. Epub 2019 Aug 16 doi: 10.1016/j.diii.2019.07.007. PMID: 31427216
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
George S, Serrano C, Hensley ML, Ray-Coquard I
J Clin Oncol 2018 Jan 10;36(2):144-150. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.75.9845. PMID: 29220301Free PMC Article

Therapy

Ingham M, Allred JB, Chen L, Das B, Kochupurakkal B, Gano K, George S, Attia S, Burgess MA, Seetharam M, Boikos SA, Bui N, Chen JL, Close JL, Cote GM, Thaker PH, Ivy SP, Bose S, D'Andrea A, Marino-Enriquez A, Shapiro GI, Schwartz GK
J Clin Oncol 2023 Sep 1;41(25):4154-4163. Epub 2023 Jul 19 doi: 10.1200/JCO.23.00402. PMID: 37467452Free PMC Article
Hindman N, Kang S, Fournier L, Lakhman Y, Nougaret S, Reinhold C, Sadowski E, Huang JQ, Ascher S
Radiology 2023 Feb;306(2):e211658. Epub 2022 Oct 4 doi: 10.1148/radiol.211658. PMID: 36194109Free PMC Article
Li Y, Gong Q, Peng J, Liu Y, Jiang Y, Zhang S
Eur J Obstet Gynecol Reprod Biol 2022 Dec;279:94-101. Epub 2022 Oct 21 doi: 10.1016/j.ejogrb.2022.10.013. PMID: 36308940
Kalinsky K, Hong F, McCourt CK, Sachdev JC, Mitchell EP, Zwiebel JA, Doyle LA, McShane LM, Li S, Gray RJ, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Conley BA, O'Dwyer PJ, Harris LN, Arteaga CL, Chen AP, Flaherty KT
JAMA Oncol 2021 Feb 1;7(2):271-278. doi: 10.1001/jamaoncol.2020.6741. PMID: 33377972Free PMC Article
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869

Prognosis

Ganjoo KN
Curr Probl Cancer 2019 Aug;43(4):283-288. Epub 2019 Jun 14 doi: 10.1016/j.currproblcancer.2019.06.001. PMID: 31235185
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
Bobiński M, Kraczkowski JJ, Witt E, Wertel I, Polak G, Kotarski J, Bednarek W
Wiad Lek 2016;69(6):799-803. PMID: 28214818
Ducie JA, Leitao MM Jr
Expert Rev Anticancer Ther 2016;16(1):45-55. Epub 2015 Nov 26 doi: 10.1586/14737140.2016.1115724. PMID: 26558647Free PMC Article
Van Dinh T, Woodruff JD
Am J Obstet Gynecol 1982 Dec 1;144(7):817-23. doi: 10.1016/0002-9378(82)90358-1. PMID: 7148905

Clinical prediction guides

Dall G, Vandenberg CJ, Nesic K, Ratnayake G, Zhu W, Vissers JHA, Bedő J, Penington J, Wakefield MJ, Kee D, Carmagnac A, Lim R, Shield-Artin K, Milesi B, Lobley A, Kyran EL, O'Grady E, Tram J, Zhou W, Nugawela D, Stewart KP, Caldwell R, Papadopoulos L, Ng AP, Dobrovic A, Fox SB, McNally O, Power JD, Meniawy T, Tan TH, Collins IM, Klein O, Barnett S, Olesen I, Hamilton A, Hofmann O, Grimmond S, Papenfuss AT, Scott CL, Barker HE
J Exp Clin Cancer Res 2023 May 4;42(1):112. doi: 10.1186/s13046-023-02687-0. PMID: 37143137Free PMC Article
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
Ricci S, Stone RL, Fader AN
Gynecol Oncol 2017 Apr;145(1):208-216. Epub 2017 Feb 13 doi: 10.1016/j.ygyno.2017.02.019. PMID: 28209496
Hayashi T, Kawano M, Ichimura T, Ida K, Ando H, Zharhary D, Kanai Y, Aburatani H, Tonegawa S, Shiozawa T, Yaegashi N, Konishi I
Anticancer Res 2016 Oct;36(10):4997-5007. doi: 10.21873/anticanres.11068. PMID: 27798858
O'Cearbhaill R, Hensley ML
Expert Rev Anticancer Ther 2010 Feb;10(2):153-69. doi: 10.1586/era.09.187. PMID: 20131992

Recent systematic reviews

Travaglino A, Raffone A, Raimondo D, Gencarelli A, Esposito I, Gallo C, Improda FP, Vitale SG, Mollo A, Casadio P, Seracchioli R, Zullo F, Insabato L
Arch Gynecol Obstet 2023 Feb;307(2):379-386. Epub 2022 Mar 28 doi: 10.1007/s00404-022-06531-2. PMID: 35344084Free PMC Article
Li Y, Gong Q, Peng J, Liu Y, Jiang Y, Zhang S
Eur J Obstet Gynecol Reprod Biol 2022 Dec;279:94-101. Epub 2022 Oct 21 doi: 10.1016/j.ejogrb.2022.10.013. PMID: 36308940
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Travaglino A, Raffone A, Catena U, De Luca M, Toscano P, Del Prete E, Vecchione ML, Lionetti R, Zullo F, Insabato L
Eur J Obstet Gynecol Reprod Biol 2021 Nov;266:119-124. Epub 2021 Sep 28 doi: 10.1016/j.ejogrb.2021.09.026. PMID: 34624740
Wen KC, Horng HC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Aug;55(4):463-71. doi: 10.1016/j.tjog.2016.04.033. PMID: 27590365

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