U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Allergic reaction

MedGen UID:
287129
•Concept ID:
C1527304
•
Pathologic Function
Synonyms: Allergic Reaction; Allergic Reactions; Reaction, Allergic; Reactions, Allergic
SNOMED CT: Allergic reaction (419076005)

Definition

A pathological immune process generally directed towards a foreign antigen, which results in tissue injury, which is usually transient. It is the realization of the allergic disposition. It is most often applied to type I hypersensitivity but other hypersensitivity types especially type IV (e.g. allergic contact dermatitis) may be involved. [from SNOMEDCT_US]

Professional guidelines

PubMed

Management of Anaphylaxis.
Navalpakam A, Thanaputkaiporn N, Poowuttikul P
Immunol Allergy Clin North Am 2022 Feb;42(1):65-76. doi: 10.1016/j.iac.2021.09.005. PMID: 34823751
Anaphylaxis: Emergency Department Treatment.
McHugh K, Repanshek Z
Emerg Med Clin North Am 2022 Feb;40(1):19-32. Epub 2021 Oct 29 doi: 10.1016/j.emc.2021.08.004. PMID: 34782088
Evaluation and Management of Penicillin Allergy: A Review.
Shenoy ES, Macy E, Rowe T, Blumenthal KG
JAMA 2019 Jan 15;321(2):188-199. doi: 10.1001/jama.2018.19283. PMID: 30644987

Recent clinical studies

Etiology

Hyaluronic Acid Basics and Rheology.
Wu GT, Kam J, Bloom JD
Clin Plast Surg 2023 Jul;50(3):391-398. doi: 10.1016/j.cps.2022.12.004. PMID: 37169405
Hyaluronic Acid Basics and Rheology.
Wu GT, Kam J, Bloom JD
Facial Plast Surg Clin North Am 2022 Aug;30(3):301-308. doi: 10.1016/j.fsc.2022.03.004. PMID: 35934432
Anaphylaxis: Emergency Department Treatment.
McHugh K, Repanshek Z
Emerg Med Clin North Am 2022 Feb;40(1):19-32. Epub 2021 Oct 29 doi: 10.1016/j.emc.2021.08.004. PMID: 34782088
Improving Diagnostic Accuracy in Food Allergy.
Foong RX, Dantzer JA, Wood RA, Santos AF
J Allergy Clin Immunol Pract 2021 Jan;9(1):71-80. doi: 10.1016/j.jaip.2020.09.037. PMID: 33429723Free PMC Article
Food Allergy: A Review.
Seth D, Poowutikul P, Pansare M, Kamat D
Pediatr Ann 2020 Jan 1;49(1):e50-e58. doi: 10.3928/19382359-20191206-01. PMID: 31930423

Diagnosis

Anaphylaxis: Emergency Department Treatment.
McHugh K, Repanshek Z
Immunol Allergy Clin North Am 2023 Aug;43(3):453-466. doi: 10.1016/j.iac.2022.10.002. PMID: 37394252
Management of Anaphylaxis.
Navalpakam A, Thanaputkaiporn N, Poowuttikul P
Immunol Allergy Clin North Am 2022 Feb;42(1):65-76. doi: 10.1016/j.iac.2021.09.005. PMID: 34823751
Improving Diagnostic Accuracy in Food Allergy.
Foong RX, Dantzer JA, Wood RA, Santos AF
J Allergy Clin Immunol Pract 2021 Jan;9(1):71-80. doi: 10.1016/j.jaip.2020.09.037. PMID: 33429723Free PMC Article
Food Allergy: A Review.
Seth D, Poowutikul P, Pansare M, Kamat D
Pediatr Ann 2020 Jan 1;49(1):e50-e58. doi: 10.3928/19382359-20191206-01. PMID: 31930423
Anaphylaxis in Children and Adolescents.
Poowuttikul P, Seth D
Pediatr Clin North Am 2019 Oct;66(5):995-1005. Epub 2019 Aug 5 doi: 10.1016/j.pcl.2019.06.005. PMID: 31466687

Therapy

Management of Anaphylaxis.
Navalpakam A, Thanaputkaiporn N, Poowuttikul P
Immunol Allergy Clin North Am 2022 Feb;42(1):65-76. doi: 10.1016/j.iac.2021.09.005. PMID: 34823751
Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial.
PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group, Young PJ, Bagshaw SM, Forbes AB, Nichol AD, Wright SE, Bailey M, Bellomo R, Beasley R, Brickell K, Eastwood GM, Gattas DJ, van Haren F, Litton E, Mackle DM, McArthur CJ, McGuinness SP, Mouncey PR, Navarra L, Opgenorth D, Pilcher D, Saxena MK, Webb SA, Wiley D, Rowan KM
JAMA 2020 Feb 18;323(7):616-626. doi: 10.1001/jama.2019.22190. PMID: 31950977Free PMC Article
Antibiotic regimens for postpartum endometritis.
Mackeen AD, Packard RE, Ota E, Speer L
Cochrane Database Syst Rev 2015 Feb 2;2015(2):CD001067. doi: 10.1002/14651858.CD001067.pub3. PMID: 25922861Free PMC Article
A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis.
Polman CH, O'Connor PW, Havrdova E, Hutchinson M, Kappos L, Miller DH, Phillips JT, Lublin FD, Giovannoni G, Wajgt A, Toal M, Lynn F, Panzara MA, Sandrock AW; AFFIRM Investigators
N Engl J Med 2006 Mar 2;354(9):899-910. doi: 10.1056/NEJMoa044397. PMID: 16510744
Cephalosporins can be prescribed safely for penicillin-allergic patients.
Pichichero ME
J Fam Pract 2006 Feb;55(2):106-12. PMID: 16451776

Prognosis

Anaphylaxis: Emergency Department Treatment.
McHugh K, Repanshek Z
Immunol Allergy Clin North Am 2023 Aug;43(3):453-466. doi: 10.1016/j.iac.2022.10.002. PMID: 37394252
Vancomycin-Associated Acute Kidney Injury: A Narrative Review from Pathophysiology to Clinical Application.
Kan WC, Chen YC, Wu VC, Shiao CC
Int J Mol Sci 2022 Feb 12;23(4) doi: 10.3390/ijms23042052. PMID: 35216167Free PMC Article
Anaphylaxis: Emergency Department Treatment.
McHugh K, Repanshek Z
Emerg Med Clin North Am 2022 Feb;40(1):19-32. Epub 2021 Oct 29 doi: 10.1016/j.emc.2021.08.004. PMID: 34782088
Improving Diagnostic Accuracy in Food Allergy.
Foong RX, Dantzer JA, Wood RA, Santos AF
J Allergy Clin Immunol Pract 2021 Jan;9(1):71-80. doi: 10.1016/j.jaip.2020.09.037. PMID: 33429723Free PMC Article
Vaccination and allergy: EAACI position paper, practical aspects.
Nilsson L, Brockow K, Alm J, Cardona V, Caubet JC, Gomes E, Jenmalm MC, Lau S, Netterlid E, Schwarze J, Sheikh A, Storsaeter J, Skevaki C, Terreehorst I, Zanoni G
Pediatr Allergy Immunol 2017 Nov;28(7):628-640. Epub 2017 Oct 10 doi: 10.1111/pai.12762. PMID: 28779496

Clinical prediction guides

Anaphylaxis: Emergency Department Treatment.
McHugh K, Repanshek Z
Immunol Allergy Clin North Am 2023 Aug;43(3):453-466. doi: 10.1016/j.iac.2022.10.002. PMID: 37394252
Anaphylaxis: Emergency Department Treatment.
McHugh K, Repanshek Z
Emerg Med Clin North Am 2022 Feb;40(1):19-32. Epub 2021 Oct 29 doi: 10.1016/j.emc.2021.08.004. PMID: 34782088
Improving Diagnostic Accuracy in Food Allergy.
Foong RX, Dantzer JA, Wood RA, Santos AF
J Allergy Clin Immunol Pract 2021 Jan;9(1):71-80. doi: 10.1016/j.jaip.2020.09.037. PMID: 33429723Free PMC Article
Stinging Insect Allergens.
Cui L, Xu YY, Wang XJ, Guan K
Curr Protein Pept Sci 2020;21(2):142-152. doi: 10.2174/1389203720666191120130209. PMID: 31752653
Vaccination and allergy: EAACI position paper, practical aspects.
Nilsson L, Brockow K, Alm J, Cardona V, Caubet JC, Gomes E, Jenmalm MC, Lau S, Netterlid E, Schwarze J, Sheikh A, Storsaeter J, Skevaki C, Terreehorst I, Zanoni G
Pediatr Allergy Immunol 2017 Nov;28(7):628-640. Epub 2017 Oct 10 doi: 10.1111/pai.12762. PMID: 28779496

Recent systematic reviews

Autologous platelet-rich plasma for assisted reproduction.
Vaidakis D, Papapanou M, Siristatidis CS
Cochrane Database Syst Rev 2024 Apr 29;4(4):CD013875. doi: 10.1002/14651858.CD013875.pub2. PMID: 38682756Free PMC Article
Food Proteins in Human Breast Milk and Probability of IgE-Mediated Allergic Reaction in Children During Breastfeeding: A Systematic Review.
Gamirova A, Berbenyuk A, Levina D, Peshko D, Simpson MR, Azad MB, Järvinen KM, Brough HA, Genuneit J, Greenhawt M, Verhasselt V, Peroni DG, Perkin MR, Warner JO, Palmer DJ, Boyle RJ, Munblit D
J Allergy Clin Immunol Pract 2022 May;10(5):1312-1324.e8. Epub 2022 Feb 2 doi: 10.1016/j.jaip.2022.01.028. PMID: 35123103
Anaphylaxis-a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis.
Shaker MS, Wallace DV, Golden DBK, Oppenheimer J, Bernstein JA, Campbell RL, Dinakar C, Ellis A, Greenhawt M, Khan DA, Lang DM, Lang ES, Lieberman JA, Portnoy J, Rank MA, Stukus DR, Wang J; Collaborators, Riblet N, Bobrownicki AMP, Bontrager T, Dusin J, Foley J, Frederick B, Fregene E, Hellerstedt S, Hassan F, Hess K, Horner C, Huntington K, Kasireddy P, Keeler D, Kim B, Lieberman P, Lindhorst E, McEnany F, Milbank J, Murphy H, Pando O, Patel AK, Ratliff N, Rhodes R, Robertson K, Scott H, Snell A, Sullivan R, Trivedi V, Wickham A; Chief Editors, Shaker MS, Wallace DV; Workgroup Contributors, Shaker MS, Wallace DV, Bernstein JA, Campbell RL, Dinakar C, Ellis A, Golden DBK, Greenhawt M, Lieberman JA, Rank MA, Stukus DR, Wang J; Joint Task Force on Practice Parameters Reviewers, Shaker MS, Wallace DV, Golden DBK, Bernstein JA, Dinakar C, Ellis A, Greenhawt M, Horner C, Khan DA, Lieberman JA, Oppenheimer J, Rank MA, Shaker MS, Stukus DR, Wang J
J Allergy Clin Immunol 2020 Apr;145(4):1082-1123. Epub 2020 Jan 28 doi: 10.1016/j.jaci.2020.01.017. PMID: 32001253
Fluoride mouthrinses for preventing dental caries in children and adolescents.
Marinho VC, Chong LY, Worthington HV, Walsh T
Cochrane Database Syst Rev 2016 Jul 29;7(7):CD002284. doi: 10.1002/14651858.CD002284.pub2. PMID: 27472005Free PMC Article
Antibiotic regimens for postpartum endometritis.
Mackeen AD, Packard RE, Ota E, Speer L
Cochrane Database Syst Rev 2015 Feb 2;2015(2):CD001067. doi: 10.1002/14651858.CD001067.pub3. PMID: 25922861Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...