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Pulmonary sulcus neoplasm

MedGen UID:
277550
•Concept ID:
C1335574
•
Neoplastic Process
Synonyms: Pulmonary Sulcus Neoplasm; pulmonary sulcus neoplasm; Pulmonary Sulcus Tumor; pulmonary sulcus tumor; pulmonary sulcus tumour
 
Monarch Initiative: MONDO:0024813

Definition

A neoplasm originating from the apical lung. Most superior sulcus neoplasms are bronchogenic carcinomas. This tumor may be associated with Pancoast syndrome. It is also known as Pancoast tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary sulcus neoplasm

Professional guidelines

PubMed

Surgical Management of Lung Cancer Involving the Chest Wall.
Lanuti M
Thorac Surg Clin 2017 May;27(2):195-199. doi: 10.1016/j.thorsurg.2017.01.013. PMID: 28363374
Management of Pancoast tumours.
Rusch VW
Lancet Oncol 2006 Dec;7(12):997-1005. doi: 10.1016/S1470-2045(06)70974-3. PMID: 17138221
Changes in the treatment of Pancoast tumors.
Detterbeck FC
Ann Thorac Surg 2003 Jun;75(6):1990-7. doi: 10.1016/s0003-4975(03)00134-6. PMID: 12822662

Recent clinical studies

Etiology

Study protocol for JCOG1807C (DEEP OCEAN): a interventional prospective trial to evaluate the efficacy and safety of durvalumab before and after operation or durvalumab as maintenance therapy after chemoradiotherapy against superior sulcus non-small cell lung cancer.
Aokage K, Tsuboi M, Zenke Y, Horinouchi H, Nakamura N, Ishikura S, Nishikawa H, Kumagai S, Koyama S, Kanato K, Kataoka T, Wakabayashi M, Fukutani M, Fukuda H, Ohe Y, Watanabe SI; Lung Cancer Surgical Study Group of the Japan Clinical Oncology Group
Jpn J Clin Oncol 2022 Apr 6;52(4):383-387. doi: 10.1093/jjco/hyab208. PMID: 34999817Free PMC Article
Surgery for Locally Advanced and Oligometastatic Non-Small Cell Lung Cancer.
Coster JN, Groth SS
Surg Oncol Clin N Am 2020 Oct;29(4):543-554. doi: 10.1016/j.soc.2020.07.001. PMID: 32883457
How to evaluate the risk/benefit of trimodality therapy in locally advanced non-small-cell lung cancer.
Kunitoh H, Suzuki K
Br J Cancer 2007 May 21;96(10):1498-503. Epub 2007 May 1 doi: 10.1038/sj.bjc.6603751. PMID: 17473830Free PMC Article
Induction chemoradiation and surgical resection for superior sulcus non-small-cell lung carcinomas: long-term results of Southwest Oncology Group Trial 9416 (Intergroup Trial 0160).
Rusch VW, Giroux DJ, Kraut MJ, Crowley J, Hazuka M, Winton T, Johnson DH, Shulman L, Shepherd F, Deschamps C, Livingston RB, Gandara D
J Clin Oncol 2007 Jan 20;25(3):313-8. doi: 10.1200/JCO.2006.08.2826. PMID: 17235046
Resection of superior sulcus tumors (posterior approach).
Kent MS, Bilsky MH, Rusch VW
Thorac Surg Clin 2004 May;14(2):217-28. doi: 10.1016/S1547-4127(04)00013-1. PMID: 15382298

Diagnosis

Management of Lung Cancer Invading the Superior Sulcus.
Kratz JR, Woodard G, Jablons DM
Thorac Surg Clin 2017 May;27(2):149-157. doi: 10.1016/j.thorsurg.2017.01.008. PMID: 28363369
Management of Pancoast tumours.
Rusch VW
Lancet Oncol 2006 Dec;7(12):997-1005. doi: 10.1016/S1470-2045(06)70974-3. PMID: 17138221
Superior sulcus tumors and Pancoast's syndrome.
Jett JR
Lung Cancer 2003 Dec;42 Suppl 2:S17-21. doi: 10.1016/j.lungcan.2003.08.006. PMID: 14644531
Superior pulmonary sulcus tumors and Pancoast's syndrome.
Arcasoy SM, Jett JR
N Engl J Med 1997 Nov 6;337(19):1370-6. doi: 10.1056/NEJM199711063371907. PMID: 9358132
Pancoast (superior sulcus) tumors.
Detterbeck FC
Ann Thorac Surg 1997 Jun;63(6):1810-8. doi: 10.1016/s0003-4975(97)00360-3. PMID: 9205202

Therapy

Prospective Feasibility and Phase 1/2 Trial of Preoperative Proton Beam Therapy With Concurrent Chemotherapy for Resectable Stage IIIA or Superior Sulcus Non-Small Cell Lung Cancer.
Simone CB 2nd, Yegya-Raman N, Manjunath S, Verma V, Shabason JE, Xu L, Cengel KA, Levin WP, Berman AT, Christodouleas JP, Aggarwal C, Cohen RB, Langer CJ, Pechet TT, Singhal S, Kucharczuk JC, Rengan R, Feigenberg SJ
Int J Radiat Oncol Biol Phys 2023 Nov 1;117(3):683-689. Epub 2023 May 17 doi: 10.1016/j.ijrobp.2023.05.016. PMID: 37201756
Hybrid robotic lobectomy with thoracic wall resection for superior sulcus tumor.
Uchida S, Suzuki K, Fukui M, Hattori A, Matsunaga T, Takamochi K
Gen Thorac Cardiovasc Surg 2022 Aug;70(8):756-758. Epub 2022 Jun 6 doi: 10.1007/s11748-022-01839-x. PMID: 35666358
Trimodality therapy for superior sulcus tumours: evolution and evaluation of a treatment protocol.
Vos CG, Hartemink KJ, Blaauwgeers JL, Oosterhuis JW, Senan S, Smit EF, Thunnissen E, Paul MA
Eur J Surg Oncol 2013 Feb;39(2):197-203. Epub 2012 Oct 11 doi: 10.1016/j.ejso.2012.09.002. PMID: 23062624
How to evaluate the risk/benefit of trimodality therapy in locally advanced non-small-cell lung cancer.
Kunitoh H, Suzuki K
Br J Cancer 2007 May 21;96(10):1498-503. Epub 2007 May 1 doi: 10.1038/sj.bjc.6603751. PMID: 17473830Free PMC Article
Induction chemoradiation and surgical resection for superior sulcus non-small-cell lung carcinomas: long-term results of Southwest Oncology Group Trial 9416 (Intergroup Trial 0160).
Rusch VW, Giroux DJ, Kraut MJ, Crowley J, Hazuka M, Winton T, Johnson DH, Shulman L, Shepherd F, Deschamps C, Livingston RB, Gandara D
J Clin Oncol 2007 Jan 20;25(3):313-8. doi: 10.1200/JCO.2006.08.2826. PMID: 17235046

Prognosis

Management of Pancoast tumours.
Rusch VW
Lancet Oncol 2006 Dec;7(12):997-1005. doi: 10.1016/S1470-2045(06)70974-3. PMID: 17138221
Resection of superior sulcus tumors (posterior approach).
Kent MS, Bilsky MH, Rusch VW
Thorac Surg Clin 2004 May;14(2):217-28. doi: 10.1016/S1547-4127(04)00013-1. PMID: 15382298
Superior sulcus tumors and Pancoast's syndrome.
Jett JR
Lung Cancer 2003 Dec;42 Suppl 2:S17-21. doi: 10.1016/j.lungcan.2003.08.006. PMID: 14644531
Pancoast tumors of the lung.
Jones DR, Detterbeck FC
Curr Opin Pulm Med 1998 Jul;4(4):191-7. doi: 10.1097/00063198-199807000-00001. PMID: 10813231
Superior pulmonary sulcus tumors and Pancoast's syndrome.
Arcasoy SM, Jett JR
N Engl J Med 1997 Nov 6;337(19):1370-6. doi: 10.1056/NEJM199711063371907. PMID: 9358132

Clinical prediction guides

Influence of anterior tumor location on survival after resection of lung cancer invading the thoracic inlet (Pancoast tumors).
Tsitsias T, Yasufuku K, Pierre A, Leighl N, Cho J, Waddell TK, Darling G, Cypel M, Donahoe L, Yeung J, Keshavjee S, de Perrot M
J Thorac Cardiovasc Surg 2023 May;165(5):1710-1719.e3. Epub 2022 Nov 2 doi: 10.1016/j.jtcvs.2022.10.033. PMID: 36481062
Prognostic value of adjuvant therapy in T4 non-small cell lung cancer: An inverse probability of treatment weighting analysis.
Song YT, Yang SL, Fu Z, Liu XH, Yan SY, Wang ZH, Qin TT, Jiang HW, Jin Y, Yin P
Thorac Cancer 2019 Mar;10(3):472-482. Epub 2019 Jan 9 doi: 10.1111/1759-7714.12960. PMID: 30628189Free PMC Article
Clinical Prediction of Pathologic Complete Response in Superior Sulcus Non-Small Cell Lung Cancer.
Antonoff MB, Hofstetter WL, Correa AM, Bell JM, Sepesi B, Rice DC, Vaporciyan AA, Walsh GL, Mehran RJ, Swisher SG, Meyers BF
Ann Thorac Surg 2016 Jan;101(1):211-7. Epub 2015 Aug 14 doi: 10.1016/j.athoracsur.2015.06.019. PMID: 26279367
Complete pathological response is predictive for clinical outcome after tri-modality therapy for carcinomas of the superior pulmonary sulcus.
Blaauwgeers JL, Kappers I, Klomp HM, Belderbos JS, Dijksman LM, Smit EF, Postmus PE, Paul MA, Oosterhuis JW, Hartemink KJ, Vos CG, Burgers JA, Dahele M, Phernambucq EC, Witte BI, Thunnissen E
Virchows Arch 2013 May;462(5):547-56. Epub 2013 Apr 3 doi: 10.1007/s00428-013-1404-6. PMID: 23549732
Pancoast tumor: use of MRI for tumor staging.
Beale R, Slater R, Hennington M, Keagy B
South Med J 1992 Dec;85(12):1260-3. doi: 10.1097/00007611-199212000-00027. PMID: 1470977

Recent systematic reviews

En Bloc Resection of Pulmonary Sulcus Non-small Cell Lung Cancer Invading the Spine: A Systematic Literature Review and Pooled Data Analysis.
Collaud S, Fadel E, Schirren J, Yokomise H, Bolukbas S, Dartevelle P, Keshavjee S, Waddell TK, de Perrot M
Ann Surg 2015 Jul;262(1):184-8. doi: 10.1097/SLA.0000000000000797. PMID: 25072427
Management of locally advanced pancoast (superior sulcus) tumors with spine involvement.
Setzer M, Robinson LA, Vrionis FD
Cancer Control 2014 Apr;21(2):158-67. doi: 10.1177/107327481402100209. PMID: 24667403

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