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Adenoma of the Colon with Intramucosal Adenocarcinoma

MedGen UID:
272285
•Concept ID:
C1332168
•
Neoplastic Process
Synonyms: Adenoma of Colon with Intramucosal Adenocarcinoma; Colonic Adenoma with Intramucosal Adenocarcinoma

Definition

An intramucosal malignant glandular epithelial infiltrate in a colonic adenoma. There is no evidence of submucosal invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenoma of the Colon with Intramucosal Adenocarcinoma

Professional guidelines

PubMed

Warning for unprincipled colorectal endoscopic submucosal dissection: accurate diagnosis and reasonable treatment strategy.
Tanaka S, Terasaki M, Hayashi N, Oka S, Chayama K
Dig Endosc 2013 Mar;25(2):107-16. Epub 2012 Dec 20 doi: 10.1111/den.12016. PMID: 23368854Free PMC Article
Utility of MMP-1, p53, E-cadherin, and collagen IV immunohistochemical stains in the differential diagnosis of adenomas with misplaced epithelium versus adenomas with invasive adenocarcinoma.
Yantiss RK, Bosenberg MW, Antonioli DA, Odze RD
Am J Surg Pathol 2002 Feb;26(2):206-15. doi: 10.1097/00000478-200202000-00007. PMID: 11812942

Recent clinical studies

Etiology

Evaluation of recurrence and surgical complementation rates after endoscopic resection of large colorectal non-pedunculated lesions.
Azevedo AAS, Ribeiro MCDPN, Mota FL, Correa PAFP, Loureiro JFM
Rev Esp Enferm Dig 2020 Dec;112(12):898-902. doi: 10.17235/reed.2020.6695/2019. PMID: 33054283
Identification of volumetric laser endomicroscopy features of colon polyps with histologic correlation.
Trindade AJ, Rishi A, Hirten R, Inamdar S, Sejpal DV, Colombel JF
Gastrointest Endosc 2018 Jun;87(6):1558-1564. Epub 2018 Feb 23 doi: 10.1016/j.gie.2018.02.024. PMID: 29477303
Gastrointestinal Polyposis in Cowden Syndrome.
Shaco-Levy R, Jasperson KW, Martin K, Samadder NJ, Burt RW, Ying J, Bronner MP
J Clin Gastroenterol 2017 Aug;51(7):e60-e67. doi: 10.1097/MCG.0000000000000703. PMID: 27661969
Risk Factors of Advanced Adenoma in Small and Diminutive Colorectal Polyp.
Jeong YH, Kim KO, Park CS, Kim SB, Lee SH, Jang BI
J Korean Med Sci 2016 Sep;31(9):1426-30. doi: 10.3346/jkms.2016.31.9.1426. PMID: 27510386Free PMC Article
Development and progression of colorectal cancer based on follow-up analysis.
Hisabe T, Hirai F, Matsui T
Dig Endosc 2014 Apr;26 Suppl 2:73-7. doi: 10.1111/den.12276. PMID: 24750153

Diagnosis

Invasive carcinoma versus pseudoinvasion: interobserver variability in the assessment of left-sided colorectal polypectomies.
Lee M, Kudose S, Del Portillo A, Ko HM, Lee H, Pittman ME, Salomao MA, Sepulveda AR, Lagana SM
J Clin Pathol 2022 Sep;75(9):593-597. Epub 2021 Apr 12 doi: 10.1136/jclinpath-2021-207406. PMID: 33846218
Gastrointestinal Polyposis in Cowden Syndrome.
Shaco-Levy R, Jasperson KW, Martin K, Samadder NJ, Burt RW, Ying J, Bronner MP
J Clin Gastroenterol 2017 Aug;51(7):e60-e67. doi: 10.1097/MCG.0000000000000703. PMID: 27661969
Evaluation of dual-wavelength excitation autofluorescence imaging of colorectal tumours with a high-sensitivity CMOS imager: a cross-sectional study.
Kominami Y, Yoshida S, Tanaka S, Miyaki R, Sanomura Y, Seo MW, Kagawa K, Kawahito S, Arimoto H, Yamada K, Chayama K
BMC Gastroenterol 2015 Sep 2;15:110. doi: 10.1186/s12876-015-0339-6. PMID: 26330262Free PMC Article
Diagnostic accuracy of ¹⁸F-FDG PET/CT for detection of advanced colorectal adenoma.
Gollub MJ, Grewal RK, Panu N, Thipphavong S, Sohn M, Zheng J, Moskowitz CS
Clin Radiol 2014 Jun;69(6):611-8. Epub 2014 Feb 26 doi: 10.1016/j.crad.2014.01.009. PMID: 24581969
Warning for unprincipled colorectal endoscopic submucosal dissection: accurate diagnosis and reasonable treatment strategy.
Tanaka S, Terasaki M, Hayashi N, Oka S, Chayama K
Dig Endosc 2013 Mar;25(2):107-16. Epub 2012 Dec 20 doi: 10.1111/den.12016. PMID: 23368854Free PMC Article

Therapy

EMR combined with hybrid argon plasma coagulation to prevent recurrence of large nonpedunculated colorectal polyps (with videos).
Motchum L, Levenick JM, Djinbachian R, Moyer MT, Bouchard S, Taghiakbari M, Repici A, Deslandres É, von Renteln D
Gastrointest Endosc 2022 Nov;96(5):840-848.e2. Epub 2022 Jun 18 doi: 10.1016/j.gie.2022.06.018. PMID: 35724695
Evaluation of recurrence and surgical complementation rates after endoscopic resection of large colorectal non-pedunculated lesions.
Azevedo AAS, Ribeiro MCDPN, Mota FL, Correa PAFP, Loureiro JFM
Rev Esp Enferm Dig 2020 Dec;112(12):898-902. doi: 10.17235/reed.2020.6695/2019. PMID: 33054283
Successful en-bloc resection of large superficial tumors in the stomach and colon using sodium hyaluronate and small-caliber-tip transparent hood.
Yamamoto H, Kawata H, Sunada K, Sasaki A, Nakazawa K, Miyata T, Sekine Y, Yano T, Satoh K, Ido K, Sugano K
Endoscopy 2003 Aug;35(8):690-4. doi: 10.1055/s-2003-41516. PMID: 12929067
Efficacy, safety, and clinical outcomes of endoscopic mucosal resection: a study of 101 cases.
Ahmad NA, Kochman ML, Long WB, Furth EE, Ginsberg GG
Gastrointest Endosc 2002 Mar;55(3):390-6. doi: 10.1067/mge.2002.121881. PMID: 11868015
Endoscopic therapy for early colon cancer: the strip biopsy resection technique.
Karita M, Tada M, Okita K, Kodama T
Gastrointest Endosc 1991 Mar-Apr;37(2):128-32. doi: 10.1016/s0016-5107(91)70669-x. PMID: 2032596

Prognosis

Gastrointestinal Polyposis in Cowden Syndrome.
Shaco-Levy R, Jasperson KW, Martin K, Samadder NJ, Burt RW, Ying J, Bronner MP
J Clin Gastroenterol 2017 Aug;51(7):e60-e67. doi: 10.1097/MCG.0000000000000703. PMID: 27661969
Risk Factors of Advanced Adenoma in Small and Diminutive Colorectal Polyp.
Jeong YH, Kim KO, Park CS, Kim SB, Lee SH, Jang BI
J Korean Med Sci 2016 Sep;31(9):1426-30. doi: 10.3346/jkms.2016.31.9.1426. PMID: 27510386Free PMC Article
Development and progression of colorectal cancer based on follow-up analysis.
Hisabe T, Hirai F, Matsui T
Dig Endosc 2014 Apr;26 Suppl 2:73-7. doi: 10.1111/den.12276. PMID: 24750153
Clinical features and prognosis of early colorectal cancer treated by endoscopic mucosal resection.
Kim MN, Kang JM, Yang JI, Kim BK, Im JP, Kim SG, Jung HC, Song IS, Kim JS
J Gastroenterol Hepatol 2011 Nov;26(11):1619-25. doi: 10.1111/j.1440-1746.2011.06749.x. PMID: 21517966
Pathology of colorectal cancer.
Ponz de Leon M, Di Gregorio C
Dig Liver Dis 2001 May;33(4):372-88. doi: 10.1016/s1590-8658(01)80095-5. PMID: 11432519

Clinical prediction guides

Characterization of sessile serrated adenomas with dysplasia including intramucosal adenocarcinoma and colorectal carcinoma with a microsatellite instability phenotype.
Sugai T, Uesugi N, Osakabe M, Yao T, Yanagawa N, Ajioka Y
Hum Pathol 2024 Mar;145:9-15. Epub 2024 Jan 11 doi: 10.1016/j.humpath.2023.12.007. PMID: 38218351
Longitudinal micro-endoscopic monitoring of high-success intramucosal xenografts for mouse models of colorectal cancer.
Paulson B, Kim IH, Namgoong JM, Kim YG, Lee S, Moon Y, Shin DM, Choo MS, Kim JK
Int J Med Sci 2019;16(11):1453-1460. Epub 2019 Sep 20 doi: 10.7150/ijms.35666. PMID: 31673236Free PMC Article
Development and progression of colorectal cancer based on follow-up analysis.
Hisabe T, Hirai F, Matsui T
Dig Endosc 2014 Apr;26 Suppl 2:73-7. doi: 10.1111/den.12276. PMID: 24750153
Diagnostic accuracy of ¹⁸F-FDG PET/CT for detection of advanced colorectal adenoma.
Gollub MJ, Grewal RK, Panu N, Thipphavong S, Sohn M, Zheng J, Moskowitz CS
Clin Radiol 2014 Jun;69(6):611-8. Epub 2014 Feb 26 doi: 10.1016/j.crad.2014.01.009. PMID: 24581969
Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular study.
Fujita K, Yamamoto H, Matsumoto T, Hirahashi M, Gushima M, Kishimoto J, Nishiyama K, Taguchi T, Yao T, Oda Y
Am J Surg Pathol 2011 Feb;35(2):295-304. doi: 10.1097/PAS.0b013e318205df36. PMID: 21263251

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