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Colon neuroendocrine tumor G1

MedGen UID:
234158
•Concept ID:
C1333084
•
Neoplastic Process
Synonyms: carcinoid tumor of colon; carcinoid tumor of the colon; carcinoid tumour of colon; carcinoid tumour of the colon; colon carcinoid tumor; colon carcinoid tumor (disease); colon carcinoid tumour; colon carcinoid tumour (disease); Colon NET G1; colon NET G1; colon neuroendocrine neoplasm G1; Colon Neuroendocrine Tumor G1; colon neuroendocrine tumor G1; colon neuroendocrine tumor, well differentiated, low grade; colonic carcinoid tumor; colonic carcinoid tumour; grade 1 neuroendocrine neoplasm of colon
 
Monarch Initiative: MONDO:0006155

Definition

A well differentiated, low grade neuroendocrine neoplasm that arises from the colon. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. [from NCI]

Professional guidelines

PubMed

Characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre.
Bazarbashi S, Aseafan M, Elgazzar T, Alkhayat M, Alghabban A, Abdelgawad MI, Alshamsan B, Alshibany A, Elhassan T, Aljubran A, Alzahrani A, Alhindi H, Raef H
BMC Endocr Disord 2023 Apr 7;23(1):74. doi: 10.1186/s12902-023-01326-1. PMID: 37029347Free PMC Article
Gastroenteropancreatic Well-Differentiated Grade 3 Neuroendocrine Tumors: Review and Position Statement.
Coriat R, Walter T, Terris B, Couvelard A, Ruszniewski P
Oncologist 2016 Oct;21(10):1191-1199. Epub 2016 Jul 8 doi: 10.1634/theoncologist.2015-0476. PMID: 27401895Free PMC Article

Recent clinical studies

Etiology

Site-specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany.
Grundmann N, Voigtländer S, Hakimhashemi A, Pape UF, Meyer M, Müller-Nordhorn J
Cancer Med 2023 Oct;12(19):19949-19958. Epub 2023 Sep 22 doi: 10.1002/cam4.6510. PMID: 37737059Free PMC Article
European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours.
Rinke A, Ambrosini V, Dromain C, Garcia-Carbonero R, Haji A, Koumarianou A, van Dijkum EN, O'Toole D, Rindi G, Scoazec JY, Ramage J
J Neuroendocrinol 2023 Jun;35(6):e13309. Epub 2023 Jun 22 doi: 10.1111/jne.13309. PMID: 37345509
Prognostic factors of patients with gastroenteropancreatic neuroendocrine neoplasms.
Huang PY, Tsai KL, Liang CM, Tai WC, Rau KM, Wu KL, Huang CC, Chuah SK
Kaohsiung J Med Sci 2018 Nov;34(11):650-656. Epub 2018 Jun 20 doi: 10.1016/j.kjms.2018.05.009. PMID: 30392572
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Maryański J, Cyran-Chlebicka A, Szczepankiewicz B, Cebulski W, Słodkowski M, Wroński M
Pol Przegl Chir 2018 May 16;90(3):7-12. doi: 10.5604/01.3001.0011.8164. PMID: 30015320
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Diagnosis

Site-specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany.
Grundmann N, Voigtländer S, Hakimhashemi A, Pape UF, Meyer M, Müller-Nordhorn J
Cancer Med 2023 Oct;12(19):19949-19958. Epub 2023 Sep 22 doi: 10.1002/cam4.6510. PMID: 37737059Free PMC Article
European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours.
Rinke A, Ambrosini V, Dromain C, Garcia-Carbonero R, Haji A, Koumarianou A, van Dijkum EN, O'Toole D, Rindi G, Scoazec JY, Ramage J
J Neuroendocrinol 2023 Jun;35(6):e13309. Epub 2023 Jun 22 doi: 10.1111/jne.13309. PMID: 37345509
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Maryański J, Cyran-Chlebicka A, Szczepankiewicz B, Cebulski W, Słodkowski M, Wroński M
Pol Przegl Chir 2018 May 16;90(3):7-12. doi: 10.5604/01.3001.0011.8164. PMID: 30015320
Gastroenteropancreatic Well-Differentiated Grade 3 Neuroendocrine Tumors: Review and Position Statement.
Coriat R, Walter T, Terris B, Couvelard A, Ruszniewski P
Oncologist 2016 Oct;21(10):1191-1199. Epub 2016 Jul 8 doi: 10.1634/theoncologist.2015-0476. PMID: 27401895Free PMC Article
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Therapy

Clinicopathologic characteristics and prognosis of gastroenteropancreatic neuroendocrine neoplasms: a multicenter study in South China.
Fang C, Wang W, Zhang Y, Feng X, Sun J, Zeng Y, Chen Y, Li Y, Chen M, Zhou Z, Chen J
Chin J Cancer 2017 Jun 21;36(1):51. doi: 10.1186/s40880-017-0218-3. PMID: 28637502Free PMC Article
Inhibition of histone deacetylases in melanoma-a perspective from bench to bedside.
Hornig E, Heppt MV, Graf SA, Ruzicka T, Berking C
Exp Dermatol 2016 Nov;25(11):831-838. doi: 10.1111/exd.13089. PMID: 27792246
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650
Identification of the BRAF V600E mutation in gastroenteropancreatic neuroendocrine tumors.
Park C, Ha SY, Kim ST, Kim HC, Heo JS, Park YS, Lauwers G, Lee J, Kim KM
Oncotarget 2016 Jan 26;7(4):4024-35. doi: 10.18632/oncotarget.6602. PMID: 26684240Free PMC Article
Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids.
Mo H, Elson CE
J Nutr 1999 Apr;129(4):804-13. doi: 10.1093/jn/129.4.804. PMID: 10203554

Prognosis

Prognostic factors of patients with gastroenteropancreatic neuroendocrine neoplasms.
Huang PY, Tsai KL, Liang CM, Tai WC, Rau KM, Wu KL, Huang CC, Chuah SK
Kaohsiung J Med Sci 2018 Nov;34(11):650-656. Epub 2018 Jun 20 doi: 10.1016/j.kjms.2018.05.009. PMID: 30392572
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Maryański J, Cyran-Chlebicka A, Szczepankiewicz B, Cebulski W, Słodkowski M, Wroński M
Pol Przegl Chir 2018 May 16;90(3):7-12. doi: 10.5604/01.3001.0011.8164. PMID: 30015320
Clinicopathologic characteristics and prognosis of gastroenteropancreatic neuroendocrine neoplasms: a multicenter study in South China.
Fang C, Wang W, Zhang Y, Feng X, Sun J, Zeng Y, Chen Y, Li Y, Chen M, Zhou Z, Chen J
Chin J Cancer 2017 Jun 21;36(1):51. doi: 10.1186/s40880-017-0218-3. PMID: 28637502Free PMC Article
Gastroenteropancreatic Well-Differentiated Grade 3 Neuroendocrine Tumors: Review and Position Statement.
Coriat R, Walter T, Terris B, Couvelard A, Ruszniewski P
Oncologist 2016 Oct;21(10):1191-1199. Epub 2016 Jul 8 doi: 10.1634/theoncologist.2015-0476. PMID: 27401895Free PMC Article
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Clinical prediction guides

Development of novel prediction models for nodal and distant metastasis in G1 and G2 colorectal neuroendocrine tumors.
Wang Z, Liu Q
Int J Colorectal Dis 2023 Feb 13;38(1):37. doi: 10.1007/s00384-023-04331-x. PMID: 36781493
Biodistribution of (18)F-AlF-NOTA-octreotide in Different Organs and Characterization of Uptake in Neuroendocrine Neoplasms.
Hou J, Long T, Yang N, Chen D, Zeng S, Zheng K, Liao G, Hu S
Mol Imaging Biol 2021 Dec;23(6):827-835. Epub 2021 Jul 6 doi: 10.1007/s11307-021-01628-7. PMID: 34231107
Gastrointestinal neuro-endocrine tumors: retrospective study of 36 cases.
Zehani A, Aloui S, Chelly I, Haouet S, Kchir N
Tunis Med 2017 Jun;95(6):393-400. PMID: 29512793
Enhancing circadian clock function in cancer cells inhibits tumor growth.
Kiessling S, Beaulieu-Laroche L, Blum ID, Landgraf D, Welsh DK, Storch KF, Labrecque N, Cermakian N
BMC Biol 2017 Feb 14;15(1):13. doi: 10.1186/s12915-017-0349-7. PMID: 28196531Free PMC Article
Clinical characteristics and prognostic factors of gastroenteropancreatic neuroendocrine tumors: a single center experience in China.
Hu HK, Ke NW, Li A, Du XJ, Guo Q, Hu WM
Hepatogastroenterology 2015 Jan-Feb;62(137):178-83. PMID: 25911892

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