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Urinary bladder small cell neuroendocrine carcinoma

MedGen UID:
231950
•Concept ID:
C1332564
•
Neoplastic Process
Synonyms: Bladder Small Cell Carcinoma; bladder small cell neuroendocrine cancer; Bladder Small Cell Neuroendocrine Carcinoma; bladder small cell neuroendocrine carcinoma; Poorly differentiated neuroendocrine carcinoma of the bladder; poorly differentiated neuroendocrine carcinoma of the bladder; SCCB; Small cell bladder cancer; small cell bladder cancer; Small cell bladder carcinoma; small cell bladder carcinoma; small cell carcinoma of the bladder; Small cell carcinoma of the bladder; Small cell carcinoma of the urinary bladder; small cell carcinoma of the urinary bladder; small cell carcinoma of urinary bladder; Small cell neuroendocrine carcinoma of bladder; Small Cell Neuroendocrine Carcinoma of the Urinary Bladder; small cell neuroendocrine carcinoma of the urinary bladder; Small Cell Neuroendocrine Carcinoma of Urinary Bladder; Small cell neuroendocrine carcinoma of urinary bladder; small cell neuroendocrine carcinoma of urinary bladder; small cell/neuroendocrine carcinoma of urinary bladder; urinary bladder small cell carcinoma; urinary bladder small cell neuroendocrine carcinoma
SNOMED CT: Small cell neuroendocrine carcinoma of bladder (718604008); Small cell neuroendocrine carcinoma of urinary bladder (718604008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0004114
Orphanet: ORPHA284400

Definition

Small cell carcinoma of the bladder (SCCB) is a very rare, poorly differentiated neuroendocrine epithelial bladder tumor characterized clinically by hematuria and/or dysuria and a highly aggressive course. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUrinary bladder small cell neuroendocrine carcinoma

Professional guidelines

PubMed

Diagnosis and treatment in primary bladder small cell carcinoma: Literature review.
Celik O, Ekin G, Ipekci T, Budak S, Ilbey YO
Arch Ital Urol Androl 2016 Mar 31;88(1):52-5. doi: 10.4081/aiua.2016.1.52. PMID: 27072176
Bladder cancer.
Montie JE, Clark PE, Eisenberger MA, El-Galley R, Greenberg RE, Herr HW, Hudes GR, Kuban DA, Kuzel TM, Lange PH, Lele SM, Michalski J, Patterson A, Pohar KS, Richie JP, Sexton WJ, Shipley WU, Small EJ, Trump DL, Walther PJ, Wilson TG; National Comprehensive Cancer Network
J Natl Compr Canc Netw 2009 Jan;7(1):8-39. doi: 10.6004/jnccn.2009.0002. PMID: 19176203
Management of patients with metastatic cancer of unknown primary.
Ghosh L, Dahut W, Kakar S, Posadas EM, Torres CG, Cancel-Santiago R, Ghosh BC
Curr Probl Surg 2005 Jan;42(1):12-66. doi: 10.1067/j.cpsurg.2004.10.002. PMID: 15711508

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

Photodynamic Diagnosis-Assisted Transurethral Resection - Lights Out?
Dahm P, Narayan VM
NEJM Evid 2022 Oct;1(10):EVIDe2200194. Epub 2022 Sep 27 doi: 10.1056/EVIDe2200194. PMID: 38319828
Expression of Nectin-4 in Bladder Urothelial Carcinoma, in Morphologic Variants, and Nonurothelial Histotypes.
Hoffman-Censits JH, Lombardo KA, Parimi V, Kamanda S, Choi W, Hahn NM, McConkey DJ, McGuire BM, Bivalacqua TJ, Kates M, Matoso A
Appl Immunohistochem Mol Morphol 2021 Sep 1;29(8):619-625. doi: 10.1097/PAI.0000000000000938. PMID: 33901032Free PMC Article
COUNTERPOINT: Is Cystectomy Needed for Small-Cell Bladder Cancer?
Kollmeier MA
Oncology (Williston Park) 2015 Sep;29(9):645, 648-9. PMID: 26384801
POINT: Is Cystectomy Needed for Small-Cell Bladder Cancer?
Raghavan D
Oncology (Williston Park) 2015 Sep;29(9):645-7. PMID: 26384800
Small cell carcinoma of the urinary bladder. A clinicopathologic analysis of 64 patients.
Montie JE
J Urol 2005 Jun;173(6):1920-1. doi: 10.1097/01.ju.0000161245.95285.b2. PMID: 15879778

Diagnosis

Molecular profile of bladder cancer progression to clinically aggressive subtypes.
Guo CC, Lee S, Lee JG, Chen H, Zaleski M, Choi W, McConkey DJ, Wei P, Czerniak B
Nat Rev Urol 2024 Jul;21(7):391-405. Epub 2024 Feb 6 doi: 10.1038/s41585-023-00847-7. PMID: 38321289
Photodynamic Diagnosis-Assisted Transurethral Resection - Lights Out?
Dahm P, Narayan VM
NEJM Evid 2022 Oct;1(10):EVIDe2200194. Epub 2022 Sep 27 doi: 10.1056/EVIDe2200194. PMID: 38319828
Squamous carcinoma of the ovary.
Roxburgh P, Glasspool R
Curr Oncol Rep 2014 Dec;16(12):413. doi: 10.1007/s11912-014-0413-1. PMID: 25344339
Crushing artifacts resulting in small blue cellular clusters that simulate small cell carcinoma.
Flamminio F, Tosi AL, Fellegara G
Int J Surg Pathol 2011 Aug;19(4):487-91. Epub 2011 Jun 1 doi: 10.1177/1066896911411187. PMID: 21632632
Small cell carcinoma of the bladder and prostate.
Abbas F, Civantos F, Benedetto P, Soloway MS
Urology 1995 Nov;46(5):617-30. doi: 10.1016/S0090-4295(99)80290-8. PMID: 7495110

Therapy

FGFR-targeted therapeutics: clinical activity, mechanisms of resistance and new directions.
Katoh M, Loriot Y, Brandi G, Tavolari S, Wainberg ZA, Katoh M
Nat Rev Clin Oncol 2024 Apr;21(4):312-329. Epub 2024 Feb 29 doi: 10.1038/s41571-024-00869-z. PMID: 38424198
Photodynamic Diagnosis-Assisted Transurethral Resection - Lights Out?
Dahm P, Narayan VM
NEJM Evid 2022 Oct;1(10):EVIDe2200194. Epub 2022 Sep 27 doi: 10.1056/EVIDe2200194. PMID: 38319828
Molecular determinants of response to PD-L1 blockade across tumor types.
Banchereau R, Leng N, Zill O, Sokol E, Liu G, Pavlick D, Maund S, Liu LF, Kadel E 3rd, Baldwin N, Jhunjhunwala S, Nickles D, Assaf ZJ, Bower D, Patil N, McCleland M, Shames D, Molinero L, Huseni M, Sanjabi S, Cummings C, Mellman I, Mariathasan S, Hegde P, Powles T
Nat Commun 2021 Jun 25;12(1):3969. doi: 10.1038/s41467-021-24112-w. PMID: 34172722Free PMC Article
Serotonin Pathway in Cancer.
Balakrishna P, George S, Hatoum H, Mukherjee S
Int J Mol Sci 2021 Jan 28;22(3) doi: 10.3390/ijms22031268. PMID: 33525332Free PMC Article
A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer.
Ott PA, Hu-Lieskovan S, Chmielowski B, Govindan R, Naing A, Bhardwaj N, Margolin K, Awad MM, Hellmann MD, Lin JJ, Friedlander T, Bushway ME, Balogh KN, Sciuto TE, Kohler V, Turnbull SJ, Besada R, Curran RR, Trapp B, Scherer J, Poran A, Harjanto D, Barthelme D, Ting YS, Dong JZ, Ware Y, Huang Y, Huang Z, Wanamaker A, Cleary LD, Moles MA, Manson K, Greshock J, Khondker ZS, Fritsch E, Rooney MS, DeMario M, Gaynor RB, Srinivasan L
Cell 2020 Oct 15;183(2):347-362.e24. doi: 10.1016/j.cell.2020.08.053. PMID: 33064988

Prognosis

Mutational signature and prognosis in adenocarcinoma of the bladder.
Yang G, Shahatiaili A, Bai S, Wang L, Jin D, Cao M, Su P, Liu Q, Tao K, Long Q, Shi Y, Xiao J, Tian F, Zhang L, Chen H, Su X
J Pathol 2024 Mar;262(3):334-346. Epub 2024 Jan 5 doi: 10.1002/path.6239. PMID: 38180342
Basaloid squamous cell carcinoma in the urinary bladder with small-cell carcinoma.
Neves TR, Soares MJ, Monteiro PG, Lima MS, Monteiro HG
J Clin Oncol 2011 May 20;29(15):e440-2. Epub 2011 Mar 14 doi: 10.1200/JCO.2010.33.8152. PMID: 21402607
Chemotherapy for metastatic bladder cancer.
Roberts JT
Clin Oncol (R Coll Radiol) 2005 Oct;17(7):514-23. doi: 10.1016/j.clon.2005.07.007. PMID: 16238139
Small cell carcinoma of the urinary bladder. A clinicopathologic analysis of 64 patients.
Montie JE
J Urol 2005 Jun;173(6):1920-1. doi: 10.1097/01.ju.0000161245.95285.b2. PMID: 15879778
Small cell carcinoma of the bladder and prostate.
Abbas F, Civantos F, Benedetto P, Soloway MS
Urology 1995 Nov;46(5):617-30. doi: 10.1016/S0090-4295(99)80290-8. PMID: 7495110

Clinical prediction guides

Optimizing Upper-Tract Imaging for Non-Visible Haematuria.
Michael KGFT, Ravindranath N, Michael S, German A, Riley T, Calleary JG, Bourdoumis A, Surange R
Urol Int 2023;107(1):23-28. Epub 2022 Aug 30 doi: 10.1159/000525458. PMID: 36041410
Molecular determinants of response to PD-L1 blockade across tumor types.
Banchereau R, Leng N, Zill O, Sokol E, Liu G, Pavlick D, Maund S, Liu LF, Kadel E 3rd, Baldwin N, Jhunjhunwala S, Nickles D, Assaf ZJ, Bower D, Patil N, McCleland M, Shames D, Molinero L, Huseni M, Sanjabi S, Cummings C, Mellman I, Mariathasan S, Hegde P, Powles T
Nat Commun 2021 Jun 25;12(1):3969. doi: 10.1038/s41467-021-24112-w. PMID: 34172722Free PMC Article
Expression of Nectin-4 in Bladder Urothelial Carcinoma, in Morphologic Variants, and Nonurothelial Histotypes.
Hoffman-Censits JH, Lombardo KA, Parimi V, Kamanda S, Choi W, Hahn NM, McConkey DJ, McGuire BM, Bivalacqua TJ, Kates M, Matoso A
Appl Immunohistochem Mol Morphol 2021 Sep 1;29(8):619-625. doi: 10.1097/PAI.0000000000000938. PMID: 33901032Free PMC Article
A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer.
Ott PA, Hu-Lieskovan S, Chmielowski B, Govindan R, Naing A, Bhardwaj N, Margolin K, Awad MM, Hellmann MD, Lin JJ, Friedlander T, Bushway ME, Balogh KN, Sciuto TE, Kohler V, Turnbull SJ, Besada R, Curran RR, Trapp B, Scherer J, Poran A, Harjanto D, Barthelme D, Ting YS, Dong JZ, Ware Y, Huang Y, Huang Z, Wanamaker A, Cleary LD, Moles MA, Manson K, Greshock J, Khondker ZS, Fritsch E, Rooney MS, DeMario M, Gaynor RB, Srinivasan L
Cell 2020 Oct 15;183(2):347-362.e24. doi: 10.1016/j.cell.2020.08.053. PMID: 33064988
Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer.
Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, Castro MAA, Gibb EA, Kanchi RS, Gordenin DA, Shukla SA, Sanchez-Vega F, Hansel DE, Czerniak BA, Reuter VE, Su X, de Sa Carvalho B, Chagas VS, Mungall KL, Sadeghi S, Pedamallu CS, Lu Y, Klimczak LJ, Zhang J, Choo C, Ojesina AI, Bullman S, Leraas KM, Lichtenberg TM, Wu CJ, Schultz N, Getz G, Meyerson M, Mills GB, McConkey DJ; TCGA Research Network, Weinstein JN, Kwiatkowski DJ, Lerner SP
Cell 2017 Oct 19;171(3):540-556.e25. Epub 2017 Oct 5 doi: 10.1016/j.cell.2017.09.007. PMID: 28988769Free PMC Article

Recent systematic reviews

A Systematic Review on the Diagnostic Value of Fibroblast Activation Protein Inhibitor PET/CT in Genitourinary Cancers.
Hagens MJ, van Leeuwen PJ, Wondergem M, Boellaard TN, Sanguedolce F, Oprea-Lager DE, Bex A, Vis AN, van der Poel HG, Mertens LS; EAU Section of Urological Imaging
J Nucl Med 2024 Jun 3;65(6):888-896. doi: 10.2967/jnumed.123.267260. PMID: 38637140
Do proton pump inhibitors alter the response to immune checkpoint inhibitors in cancer patients? A meta-analysis.
Lopes S, Pabst L, Dory A, Klotz M, Gourieux B, Michel B, Mascaux C
Front Immunol 2023;14:1070076. Epub 2023 Jan 26 doi: 10.3389/fimmu.2023.1070076. PMID: 36776847Free PMC Article
Adjuvant Radiotherapy for Upper Tract Urothelial Carcinoma: Systematic Review and Meta-Analysis.
Zalay O, Yan M, Sigurdson S, Malone S, Vera-Badillo FE, Mahmud A
Curr Oncol 2022 Dec 20;30(1):19-36. doi: 10.3390/curroncol30010002. PMID: 36661651Free PMC Article
Chemoablation in Urothelial Carcinoma: A Systematic Review and Future Perspectives.
Alsyouf M, Pierorazio P, Groegler J, Hu B
Urology 2020 Oct;144:28-37. Epub 2020 Jun 12 doi: 10.1016/j.urology.2020.05.066. PMID: 32540302
The economics of bladder cancer: costs and considerations of caring for this disease.
Svatek RS, Hollenbeck BK, Holmäng S, Lee R, Kim SP, Stenzl A, Lotan Y
Eur Urol 2014 Aug;66(2):253-62. Epub 2014 Jan 21 doi: 10.1016/j.eururo.2014.01.006. PMID: 24472711

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

    Reviews

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    • PMC Articles
      Related information in PubMed Central Links
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