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Vaginitis

MedGen UID:
21815
•Concept ID:
C0042267
•
Disease or Syndrome
Synonym: Vaginitides
SNOMED CT: Inflammation of vagina (30800001); Vaginitis (30800001)
 
HPO: HP:0030683
Monarch Initiative: MONDO:0002234

Definition

Inflammation of the vagina that can result from a spectrum of conditions that cause vaginal and sometimes vulvar symptoms, such as itching, burning, irritation, odor, and vaginal discharge. [from HPO]

Professional guidelines

PubMed

Evaluation and Treatment of Vulvodynia: State of the Science.
Schlaeger JM, Glayzer JE, Villegas-Downs M, Li H, Glayzer EJ, He Y, Takayama M, Yajima H, Takakura N, Kobak WH, McFarlin BL
J Midwifery Womens Health 2023 Jan;68(1):9-34. Epub 2022 Dec 19 doi: 10.1111/jmwh.13456. PMID: 36533637Free PMC Article
Evaluation and Management of Vaginitis.
Marnach ML, Wygant JN, Casey PM
Mayo Clin Proc 2022 Feb;97(2):347-358. doi: 10.1016/j.mayocp.2021.09.022. PMID: 35120697
Vaginitis: Diagnosis and Treatment.
Paladine HL, Desai UA
Am Fam Physician 2018 Mar 1;97(5):321-329. PMID: 29671516

Recent clinical studies

Etiology

Infectious Vaginitis, Cervicitis, and Pelvic Inflammatory Disease.
Shroff S
Med Clin North Am 2023 Mar;107(2):299-315. Epub 2022 Dec 26 doi: 10.1016/j.mcna.2022.10.009. PMID: 36759099
Infections During Pregnancy.
Leeper C, Lutzkanin A 3rd
Prim Care 2018 Sep;45(3):567-586. Epub 2018 Jul 9 doi: 10.1016/j.pop.2018.05.013. PMID: 30115342
Vaginitis: Diagnosis and Treatment.
Paladine HL, Desai UA
Am Fam Physician 2018 Mar 1;97(5):321-329. PMID: 29671516
Dysuria: Evaluation and Differential Diagnosis in Adults.
Michels TC, Sands JE
Am Fam Physician 2015 Nov 1;92(9):778-86. PMID: 26554471
Vulvitis and vaginitis.
Foster DC
Curr Opin Obstet Gynecol 1993 Dec;5(6):726-32. PMID: 8286682

Diagnosis

Trichomoniasis.
Van Gerwen OT, Opsteen SA, Graves KJ, Muzny CA
Infect Dis Clin North Am 2023 Jun;37(2):245-265. Epub 2023 Mar 31 doi: 10.1016/j.idc.2023.02.001. PMID: 37005163Free PMC Article
Infectious Vaginitis, Cervicitis, and Pelvic Inflammatory Disease.
Shroff S
Med Clin North Am 2023 Mar;107(2):299-315. Epub 2022 Dec 26 doi: 10.1016/j.mcna.2022.10.009. PMID: 36759099
Recent Advances in Presentation, Diagnosis and Treatment for Mixed Vaginitis.
Qi W, Li H, Wang C, Li H, Zhang B, Dong M, Fan A, Han C, Xue F
Front Cell Infect Microbiol 2021;11:759795. Epub 2021 Nov 2 doi: 10.3389/fcimb.2021.759795. PMID: 34796129Free PMC Article
Vaginitis in Nonpregnant Patients: ACOG Practice Bulletin, Number 215.
Obstet Gynecol 2020 Jan;135(1):e1-e17. doi: 10.1097/AOG.0000000000003604. PMID: 31856123
Vaginitis: Diagnosis and Treatment.
Paladine HL, Desai UA
Am Fam Physician 2018 Mar 1;97(5):321-329. PMID: 29671516

Therapy

Diagnosis and Management of Trichomonas vaginalis: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Kissinger PJ, Gaydos CA, Seña AC, Scott McClelland R, Soper D, Secor WE, Legendre D, Workowski KA, Muzny CA
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S152-S161. doi: 10.1093/cid/ciac030. PMID: 35416973Free PMC Article
Vaginitis in Nonpregnant Patients: ACOG Practice Bulletin, Number 215.
Obstet Gynecol 2020 Jan;135(1):e1-e17. doi: 10.1097/AOG.0000000000003604. PMID: 31856123
Vaginitis: Diagnosis and Treatment.
Paladine HL, Desai UA
Am Fam Physician 2018 Mar 1;97(5):321-329. PMID: 29671516
Local oestrogen for vaginal atrophy in postmenopausal women.
Lethaby A, Ayeleke RO, Roberts H
Cochrane Database Syst Rev 2016 Aug 31;2016(8):CD001500. doi: 10.1002/14651858.CD001500.pub3. PMID: 27577677Free PMC Article
Vaginal estrogen for genitourinary syndrome of menopause: a systematic review.
Rahn DD, Carberry C, Sanses TV, Mamik MM, Ward RM, Meriwether KV, Olivera CK, Abed H, Balk EM, Murphy M; Society of Gynecologic Surgeons Systematic Review Group
Obstet Gynecol 2014 Dec;124(6):1147-1156. doi: 10.1097/AOG.0000000000000526. PMID: 25415166Free PMC Article

Prognosis

Assessment and Treatment of Vaginitis.
Mitchell CM
Obstet Gynecol 2024 Dec 1;144(6):765-781. Epub 2024 Jul 11 doi: 10.1097/AOG.0000000000005673. PMID: 38991218
Genital diseases in the mature woman.
Matthews N, Wong V, Brooks J, Kroumpouzos G
Clin Dermatol 2018 Mar-Apr;36(2):208-221. Epub 2017 Oct 3 doi: 10.1016/j.clindermatol.2017.10.012. PMID: 29566925
Vaginitis: Beyond the Basics.
Mills BB
Obstet Gynecol Clin North Am 2017 Jun;44(2):159-177. doi: 10.1016/j.ogc.2017.02.010. PMID: 28499528
Vulvovaginitis: screening for and management of trichomoniasis, vulvovaginal candidiasis, and bacterial vaginosis.
van Schalkwyk J, Yudin MH; INFECTIOUS DISEASE COMMITTEE
J Obstet Gynaecol Can 2015 Mar;37(3):266-274. doi: 10.1016/S1701-2163(15)30316-9. PMID: 26001874
Topical antifungal agents.
Ernest JM
Obstet Gynecol Clin North Am 1992 Sep;19(3):587-607. PMID: 1436934

Clinical prediction guides

Diagnosis and Treatment of Sexually Transmitted Infections: A Review.
Tuddenham S, Hamill MM, Ghanem KG
JAMA 2022 Jan 11;327(2):161-172. doi: 10.1001/jama.2021.23487. PMID: 35015033
Aerobic vaginitis: no longer a stranger.
Donders GGG, Bellen G, Grinceviciene S, Ruban K, Vieira-Baptista P
Res Microbiol 2017 Nov-Dec;168(9-10):845-858. Epub 2017 May 11 doi: 10.1016/j.resmic.2017.04.004. PMID: 28502874
Vulvovaginitis: screening for and management of trichomoniasis, vulvovaginal candidiasis, and bacterial vaginosis.
van Schalkwyk J, Yudin MH; INFECTIOUS DISEASE COMMITTEE
J Obstet Gynaecol Can 2015 Mar;37(3):266-274. doi: 10.1016/S1701-2163(15)30316-9. PMID: 26001874
Metronidazole for the treatment of vaginal infections.
Sobel R, Sobel JD
Expert Opin Pharmacother 2015 May;16(7):1109-15. doi: 10.1517/14656566.2015.1035255. PMID: 25887246
Vaginal infection.
Eschenbach DA
Clin Obstet Gynecol 1983 Mar;26(1):186-202. doi: 10.1097/00003081-198303000-00023. PMID: 6340892

Recent systematic reviews

Hyaluronic Acid in Postmenopause Vaginal Atrophy: A Systematic Review.
Dos Santos CCM, Uggioni MLR, Colonetti T, Colonetti L, Grande AJ, Da Rosa MI
J Sex Med 2021 Jan;18(1):156-166. Epub 2020 Dec 5 doi: 10.1016/j.jsxm.2020.10.016. PMID: 33293236
Clinical Recommendation: Vulvovaginitis.
Zuckerman A, Romano M
J Pediatr Adolesc Gynecol 2016 Dec;29(6):673-679. Epub 2016 Sep 21 doi: 10.1016/j.jpag.2016.08.002. PMID: 27969009
Local oestrogen for vaginal atrophy in postmenopausal women.
Lethaby A, Ayeleke RO, Roberts H
Cochrane Database Syst Rev 2016 Aug 31;2016(8):CD001500. doi: 10.1002/14651858.CD001500.pub3. PMID: 27577677Free PMC Article
Candidiasis (vulvovaginal).
Martin Lopez JE
BMJ Clin Evid 2015 Mar 16;2015 PMID: 25775428Free PMC Article
Vaginal estrogen for genitourinary syndrome of menopause: a systematic review.
Rahn DD, Carberry C, Sanses TV, Mamik MM, Ward RM, Meriwether KV, Olivera CK, Abed H, Balk EM, Murphy M; Society of Gynecologic Surgeons Systematic Review Group
Obstet Gynecol 2014 Dec;124(6):1147-1156. doi: 10.1097/AOG.0000000000000526. PMID: 25415166Free PMC Article

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