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Closed neural tube defect

MedGen UID:: 1814386
•Concept ID:: C5676822
•: Congenital Abnormality

HPO:	HP:0034238

Definition

A type of neural tube defect that is covered by skin. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVClosed neural tube defect

Congenital Systemic Disorder
- Abnormality of the nervous system
  - Abnormal nervous system morphology
    - Morphological central nervous system abnormality
      - Abnormal neural tube morphology
        Neural tube defect
        Closed neural tube defect
        Dermal sinus tract
        Lipomyelomeningocele
        Meningocele
        Frontoethmoidal meningocele
        Lateral spinal meningocele
        Lipomeningocele
        Occipital meningocele
        Occipital myelomeningocele
        Parietal meningocele
        Myelopathy
        Amyotrophic lateral sclerosis
        Amyotrophic Lateral Sclerosis 14, With or Without Frontotemporal Dementia
        Amyotrophic lateral sclerosis type 1
        Amyotrophic lateral sclerosis type 3
        Amyotrophic lateral sclerosis type 4
        Amyotrophic lateral sclerosis type 6
        Amyotrophic lateral sclerosis type 7
        Amyotrophic lateral sclerosis type 8
        Amyotrophic lateral sclerosis type 9
        Amyotrophic lateral sclerosis type 10
        Amyotrophic lateral sclerosis type 11
        Amyotrophic lateral sclerosis type 21
        Amyotrophic lateral sclerosis type 23
        Juvenile amyotrophic lateral sclerosis
        Progressive muscular atrophy
        Cervical myelopathy
        Abnormal cervical myelogram
        Epidural abscess
        Hydromyelia
        Infarction of spinal cord
        Spinal Cord Infarct During Birth
        Myelitis
        Acute flaccid myelitis
        Acute transverse myelitis
        HTLV-1-associated myelopathy-tropical spastic paraparesis
        Poliomyelitis
        Transverse myelitis
        Myelocystocele
        Pneumorrhachis
        Spinal cord compression
        Cervical cord compression
        Spinal Cord Hamartoma
        Spinal cord tumor
        Adult Spinal Cord Neoplasm
        Benign neoplasm of spinal cord
        Cervicomedullary junction neoplasm
        Childhood spinal cord tumor
        Conus medullaris neoplasm
        Epidural spinal canal neoplasm
        Recurrent Spinal Cord Neoplasm
        Refractory Spinal Cord Neoplasm
        Spinal cord cancer
        Spinal cord glioma
        Spinal cord intramedullary teratoma
        Spinal meningioma
        Spinal Cord Vascular Diseases
        Spinal cord ischemia
        Spinal muscular atrophy
        Acute infantile spinal muscular atrophy
        Kennedy disease
        Kugelberg-Welander disease
        Progressive spinal muscular atrophy
        Proximal Hereditary Motor Neuropathy Type I
        Proximal spinal muscular atrophy
        Spinal Muscular Atrophy of Childhood
        Spinal muscular atrophy, segmental
        Spinal muscular atrophy, type II
        Spinal muscular atrophy, type IV
        Werdnig-Hoffmann disease
        spinocerebellar disease
        Early onset cerebellar ataxia with myoclonus
        Friedreich ataxia
        Olivopontocerebellar atrophy
        Spinocerebellar atrophy
        Stiff-man syndrome
        Classic stiff person syndrome
        Focal stiff limb syndrome
        Progressive encephalomyelitis with rigidity and myoclonus
        Subacute combined degeneration of spinal cord
        Syringomyelia
        Primary syringomyelia
        Secondary syringomyelia
        Syringomyelia and Hydromyelia
        Tabes dorsalis

Professional guidelines

PubMed

Neural tube defects: maternal serum screening and prenatal diagnosis.

Crandall BF, Lebherz TB, Freihube R
Pediatr Clin North Am 1978 Aug;25(3):619-29. doi: 10.1016/s0031-3955(16)33607-0. PMID: 80780

See all (1)

Recent clinical studies

Etiology

Do we need to scan the whole neuraxis for coexistent abnormalities in children with surgically treated occult spinal dysraphism?

Börcek AÖ, Aslan A, Uçar M
ANZ J Surg 2019 Jul;89(7-8):914-918. Epub 2019 May 13 doi: 10.1111/ans.15164. PMID: 31083790

A practical clinical classification of spinal neural tube defects.

McComb JG
Childs Nerv Syst 2015 Oct;31(10):1641-57. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2845-9. PMID: 26351218

Closed neural tube defects in children with caudal regression.

Jeelani Y, Mosich GM, McComb JG
Childs Nerv Syst 2013 Sep;29(9):1451-7. Epub 2013 Sep 7 doi: 10.1007/s00381-013-2119-3. PMID: 24013318

Surgical treatment for lipomyelomeningocele in children.

Huang SL, Shi W, Zhang LG
World J Pediatr 2010 Nov;6(4):361-5. Epub 2010 Jun 12 doi: 10.1007/s12519-010-0210-3. PMID: 20549411

Closed neural tube defects: neurologic, orthopedic, and gait outcomes.

Ross M, Brewer K, Wright FV, Agur A
Pediatr Phys Ther 2007 Winter;19(4):288-95. doi: 10.1097/PEP.0b013e318158cf1e. PMID: 18004196

See all (13)

Diagnosis

Fetal lipomyelomeningocele: A closed neural tube defect diagnosed at second-trimester ultrasound examination.

Sarmento-Gonçalves I, Cunha M, Loureiro T, Pinto PS, Ramalho C
J Clin Ultrasound 2019 Mar;47(3):169-171. Epub 2018 Nov 8 doi: 10.1002/jcu.22662. PMID: 30411358

Surgical histopathology of limited dorsal myeloschisis with flat skin lesion.

Morioka T, Suzuki SO, Murakami N, Mukae N, Shimogawa T, Haruyama H, Kira R, Iihara K
Childs Nerv Syst 2019 Jan;35(1):119-128. Epub 2018 Jun 22 doi: 10.1007/s00381-018-3870-2. PMID: 29934704

Neurosurgical pathology of limited dorsal myeloschisis.

Morioka T, Suzuki SO, Murakami N, Shimogawa T, Mukae N, Inoha S, Sasaguri T, Iihara K
Childs Nerv Syst 2018 Feb;34(2):293-303. Epub 2017 Oct 23 doi: 10.1007/s00381-017-3625-5. PMID: 29063264

Closed neural tube defects in children with caudal regression.

Jeelani Y, Mosich GM, McComb JG
Childs Nerv Syst 2013 Sep;29(9):1451-7. Epub 2013 Sep 7 doi: 10.1007/s00381-013-2119-3. PMID: 24013318

Closed neural tube defects: neurologic, orthopedic, and gait outcomes.

Ross M, Brewer K, Wright FV, Agur A
Pediatr Phys Ther 2007 Winter;19(4):288-95. doi: 10.1097/PEP.0b013e318158cf1e. PMID: 18004196

See all (9)

Therapy

Risk factors associated with lipomyelomeningocele: a case-control study.

Esmaeili A, Hanaei S, Fadakar K, Dadkhah S, Arjipour M, Habibi Z, Nejat F, El Khashab M
Pediatr Neurosurg 2013;49(4):202-7. Epub 2014 Jun 11 doi: 10.1159/000362883. PMID: 24924296

See all (1)

Prognosis

Avoiding the antenatal counselling faux pas: bridging the gap between prenatal prognostication and postnatal outcome of closed spina bifida.

Udayakumaran S, Elayedatt RA, Krishnan V
Childs Nerv Syst 2022 Sep;38(9):1751-1762. Epub 2022 Jun 3 doi: 10.1007/s00381-022-05562-z. PMID: 35665838

Fetal lipomyelomeningocele: A closed neural tube defect diagnosed at second-trimester ultrasound examination.

Sarmento-Gonçalves I, Cunha M, Loureiro T, Pinto PS, Ramalho C
J Clin Ultrasound 2019 Mar;47(3):169-171. Epub 2018 Nov 8 doi: 10.1002/jcu.22662. PMID: 30411358

Surgical treatment for lipomyelomeningocele in children.

Huang SL, Shi W, Zhang LG
World J Pediatr 2010 Nov;6(4):361-5. Epub 2010 Jun 12 doi: 10.1007/s12519-010-0210-3. PMID: 20549411

See all (3)

Clinical prediction guides

Avoiding the antenatal counselling faux pas: bridging the gap between prenatal prognostication and postnatal outcome of closed spina bifida.

Udayakumaran S, Elayedatt RA, Krishnan V
Childs Nerv Syst 2022 Sep;38(9):1751-1762. Epub 2022 Jun 3 doi: 10.1007/s00381-022-05562-z. PMID: 35665838

Surgical histopathology of limited dorsal myeloschisis with flat skin lesion.

Morioka T, Suzuki SO, Murakami N, Mukae N, Shimogawa T, Haruyama H, Kira R, Iihara K
Childs Nerv Syst 2019 Jan;35(1):119-128. Epub 2018 Jun 22 doi: 10.1007/s00381-018-3870-2. PMID: 29934704

See all (2)

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Closed neural tube defect

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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