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Refractory Spinal Cord Neoplasm

MedGen UID:
389571
•Concept ID:
C2347926
•
Neoplastic Process
Synonym: Refractory Spinal Cord Tumor

Definition

Spinal cord neoplasm resistant to treatment. [from NCI]

Professional guidelines

PubMed

Clinical features, pathophysiology, and management of acute myelopathy following CAR T-cell therapy.
Deschênes-Simard X, Santomasso BD, Dahi PB
Blood 2024 Nov 14;144(20):2083-2094. doi: 10.1182/blood.2024025679. PMID: 39226460
Neuromodulation techniques for cancer pain management.
Magee DJ, Schutzer-Weissmann J, Pereira EAC, Brown MRD
Curr Opin Support Palliat Care 2021 Jun 1;15(2):77-83. doi: 10.1097/SPC.0000000000000549. PMID: 33843762
Diagnosis and management of primary central nervous system lymphoma.
Han CH, Batchelor TT
Cancer 2017 Nov 15;123(22):4314-4324. Epub 2017 Sep 26 doi: 10.1002/cncr.30965. PMID: 28950405

Recent clinical studies

Etiology

Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing.
Hu J, Zhang L, Xia H, Yan Y, Zhu X, Sun F, Sun L, Li S, Li D, Wang J, Han Y, Zhang J, Bian D, Yu H, Chen Y, Fan P, Ma Q, Jiang G, Wang C, Zhang P
Genome Med 2023 Mar 3;15(1):14. doi: 10.1186/s13073-023-01164-9. PMID: 36869384Free PMC Article
Exceptional Cases of Spinal Cord Stimulation for the Treatment of Refractory Cancer-Related Pain.
Bulat E, Chakravarthy V, Crowther J, Rakesh N, Barzilai O, Gulati A
Neuromodulation 2023 Jul;26(5):1051-1058. Epub 2022 Aug 6 doi: 10.1016/j.neurom.2022.06.002. PMID: 35941017Free PMC Article
Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial.
Kato K, Cho BC, Takahashi M, Okada M, Lin CY, Chin K, Kadowaki S, Ahn MJ, Hamamoto Y, Doki Y, Yen CC, Kubota Y, Kim SB, Hsu CH, Holtved E, Xynos I, Kodani M, Kitagawa Y
Lancet Oncol 2019 Nov;20(11):1506-1517. Epub 2019 Sep 30 doi: 10.1016/S1470-2045(19)30626-6. PMID: 31582355
Updates on Primary Central Nervous System Lymphoma.
Schaff LR, Grommes C
Curr Oncol Rep 2018 Feb 28;20(2):11. doi: 10.1007/s11912-018-0666-1. PMID: 29492682Free PMC Article
Long-Term Complications of the Neurogenic Bladder.
Nseyo U, Santiago-Lastra Y
Urol Clin North Am 2017 Aug;44(3):355-366. doi: 10.1016/j.ucl.2017.04.003. PMID: 28716317

Diagnosis

Refractory Primary Vitreoretinal Lymphoma Involving the Spinal Cord with a Temporary Complete Response to Tirabrutinib.
Iizuka-Honma H, Takizawa H, Mitsumori T, Okura H, Ishii H, Noguchi M
Intern Med 2023 Feb 1;62(3):459-463. Epub 2022 Jul 5 doi: 10.2169/internalmedicine.9591-22. PMID: 35793963Free PMC Article
Primary central nervous system lymphoma.
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
Central Nervous System Lymphomas.
Grommes C
Continuum (Minneap Minn) 2020 Dec;26(6):1476-1494. doi: 10.1212/CON.0000000000000936. PMID: 33273169
Long-Term Complications of the Neurogenic Bladder.
Nseyo U, Santiago-Lastra Y
Urol Clin North Am 2017 Aug;44(3):355-366. doi: 10.1016/j.ucl.2017.04.003. PMID: 28716317
Cranial and spinal oligodendrogliomatosis: a case report and review of the literature.
Lee SL, Wong A, Stadler JA 3rd, McClendon J Jr, Smith TR, Wadhwani NR, Tomita T
Childs Nerv Syst 2015 Jan;31(1):147-53. Epub 2014 Aug 26 doi: 10.1007/s00381-014-2506-4. PMID: 25155447

Therapy

Novel Therapies for Primary Central Nervous System Lymphomas.
Aquilanti E, Herrity E, Nayak L
Curr Neurol Neurosci Rep 2024 Dec;24(12):621-629. Epub 2024 Oct 11 doi: 10.1007/s11910-024-01376-5. PMID: 39390309
Primary central nervous system lymphoma.
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
Central Nervous System Lymphomas.
Grommes C
Continuum (Minneap Minn) 2020 Dec;26(6):1476-1494. doi: 10.1212/CON.0000000000000936. PMID: 33273169
Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial.
Kato K, Cho BC, Takahashi M, Okada M, Lin CY, Chin K, Kadowaki S, Ahn MJ, Hamamoto Y, Doki Y, Yen CC, Kubota Y, Kim SB, Hsu CH, Holtved E, Xynos I, Kodani M, Kitagawa Y
Lancet Oncol 2019 Nov;20(11):1506-1517. Epub 2019 Sep 30 doi: 10.1016/S1470-2045(19)30626-6. PMID: 31582355
Updates on Primary Central Nervous System Lymphoma.
Schaff LR, Grommes C
Curr Oncol Rep 2018 Feb 28;20(2):11. doi: 10.1007/s11912-018-0666-1. PMID: 29492682Free PMC Article

Prognosis

Novel Therapies for Primary Central Nervous System Lymphomas.
Aquilanti E, Herrity E, Nayak L
Curr Neurol Neurosci Rep 2024 Dec;24(12):621-629. Epub 2024 Oct 11 doi: 10.1007/s11910-024-01376-5. PMID: 39390309
Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing.
Hu J, Zhang L, Xia H, Yan Y, Zhu X, Sun F, Sun L, Li S, Li D, Wang J, Han Y, Zhang J, Bian D, Yu H, Chen Y, Fan P, Ma Q, Jiang G, Wang C, Zhang P
Genome Med 2023 Mar 3;15(1):14. doi: 10.1186/s13073-023-01164-9. PMID: 36869384Free PMC Article
Refractory Primary Vitreoretinal Lymphoma Involving the Spinal Cord with a Temporary Complete Response to Tirabrutinib.
Iizuka-Honma H, Takizawa H, Mitsumori T, Okura H, Ishii H, Noguchi M
Intern Med 2023 Feb 1;62(3):459-463. Epub 2022 Jul 5 doi: 10.2169/internalmedicine.9591-22. PMID: 35793963Free PMC Article
Primary central nervous system lymphoma.
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
Cranial and spinal oligodendrogliomatosis: a case report and review of the literature.
Lee SL, Wong A, Stadler JA 3rd, McClendon J Jr, Smith TR, Wadhwani NR, Tomita T
Childs Nerv Syst 2015 Jan;31(1):147-53. Epub 2014 Aug 26 doi: 10.1007/s00381-014-2506-4. PMID: 25155447

Clinical prediction guides

Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing.
Hu J, Zhang L, Xia H, Yan Y, Zhu X, Sun F, Sun L, Li S, Li D, Wang J, Han Y, Zhang J, Bian D, Yu H, Chen Y, Fan P, Ma Q, Jiang G, Wang C, Zhang P
Genome Med 2023 Mar 3;15(1):14. doi: 10.1186/s13073-023-01164-9. PMID: 36869384Free PMC Article
Exceptional Cases of Spinal Cord Stimulation for the Treatment of Refractory Cancer-Related Pain.
Bulat E, Chakravarthy V, Crowther J, Rakesh N, Barzilai O, Gulati A
Neuromodulation 2023 Jul;26(5):1051-1058. Epub 2022 Aug 6 doi: 10.1016/j.neurom.2022.06.002. PMID: 35941017Free PMC Article
Central Nervous System Lymphomas.
Grommes C
Continuum (Minneap Minn) 2020 Dec;26(6):1476-1494. doi: 10.1212/CON.0000000000000936. PMID: 33273169
Update on Mechanism and Therapeutic Implications of Spinal Cord Stimulation and Cerebral Hemodynamics: A Narrative Review.
Peppucci E, Di Bonaventura R, Esposito V, Zhong J, Iacopino G, Barbagallo G, Visocchi M
Acta Neurochir Suppl 2017;124:27-36. doi: 10.1007/978-3-319-39546-3_5. PMID: 28120049
Bacillus Calmette-Guérin osteomyelitis mimicking spinal metastasis from urothelial cell carcinoma of the bladder.
Patel AR, Sabanegh ES, Jones JS, Gordon SM, Ballin M, Ruggieri PM, Stephenson AJ
Eur Urol 2010 Dec;58(6):934-7. Epub 2009 Jun 3 doi: 10.1016/j.eururo.2009.05.045. PMID: 19501456

Recent systematic reviews

Intrathecal Drug Delivery Systems for Cancer Pain: A Health Technology Assessment.
Ontario Health
Ont Health Technol Assess Ser 2024;24(2):1-162. Epub 2024 Jan 11 PMID: 38344326Free PMC Article
What is the effectiveness of radiofrequency ablation in the management of patients with spinal metastases? A systematic review and meta-analysis.
Murali N, Turmezei T, Bhatti S, Patel P, Marshall T, Smith T
J Orthop Surg Res 2021 Nov 6;16(1):659. doi: 10.1186/s13018-021-02775-x. PMID: 34742319Free PMC Article
Spinal cord stimulation for cancer-related pain in adults.
Peng L, Min S, Zejun Z, Wei K, Bennett MI
Cochrane Database Syst Rev 2015 Jun 29;2015(6):CD009389. doi: 10.1002/14651858.CD009389.pub3. PMID: 26121600Free PMC Article
Spinal cord stimulation for cancer-related pain in adults.
Lihua P, Su M, Zejun Z, Ke W, Bennett MI
Cochrane Database Syst Rev 2013 Feb 28;(2):CD009389. doi: 10.1002/14651858.CD009389.pub2. PMID: 23450600
Bisphosphonates for advanced prostate cancer.
Yuen KK, Shelley M, Sze WM, Wilt T, Mason MD
Cochrane Database Syst Rev 2006 Oct 18;(4):CD006250. doi: 10.1002/14651858.CD006250. PMID: 17054286

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