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Fetal intracranial hemorrhage

MedGen UID:
1814359
•Concept ID:
C5676795
•
Pathologic Function
HPO: HP:0034208

Definition

Abnormal bleeding inside the skull (cranium) of a fetus. [from HPO]

Professional guidelines

PubMed

Management and Neonatal Outcomes of Pregnancies with Fetal/Neonatal Alloimmune Thrombocytopenia: A Single-Center Retrospective Cohort Study.
Ronzoni S, Keunen J, Shah PS, Kelly EN, Windrim R, Seaward PG, Ryan G
Fetal Diagn Ther 2019;45(2):85-93. Epub 2018 Apr 18 doi: 10.1159/000487303. PMID: 29669341
Fetal intracranial hemorrhage: sonographic criteria and merits of prenatal diagnosis.
Abdelkader MA, Ramadan W, Gabr AA, Kamel A, Abdelrahman RW
J Matern Fetal Neonatal Med 2017 Sep;30(18):2250-2256. Epub 2016 Oct 26 doi: 10.1080/14767058.2016.1245283. PMID: 27718776
Prenatal diagnosis and postnatal outcome of fetal intracranial hemorrhage.
Kutuk MS, Yikilmaz A, Ozgun MT, Dolanbay M, Canpolat M, Uludag S, Uysal G, Tas M, Musa K
Childs Nerv Syst 2014 Mar;30(3):411-8. Epub 2013 Aug 2 doi: 10.1007/s00381-013-2243-0. PMID: 23907139

Recent clinical studies

Etiology

Bi-allelic variants in the ESAM tight-junction gene cause a neurodevelopmental disorder associated with fetal intracranial hemorrhage.
Lecca M, Pehlivan D, Suñer DH, Weiss K, Coste T, Zweier M, Oktay Y, Danial-Farran N, Rosti V, Bonasoni MP, Malara A, Contrò G, Zuntini R, Pollazzon M, Pascarella R, Neri A, Fusco C, Marafi D, Mitani T, Posey JE, Bayramoglu SE, Gezdirici A, Hernandez-Rodriguez J, Cladera EA, Miravet E, Roldan-Busto J, Ruiz MA, Bauzá CV, Ben-Sira L, Sigaudy S, Begemann A, Unger S, Güngör S, Hiz S, Sonmezler E, Zehavi Y, Jerdev M, Balduini A, Zuffardi O, Horvath R, Lochmüller H, Rauch A, Garavelli L, Tournier-Lasserve E, Spiegel R, Lupski JR, Errichiello E
Am J Hum Genet 2023 Apr 6;110(4):681-690. Epub 2023 Mar 29 doi: 10.1016/j.ajhg.2023.03.005. PMID: 36996813Free PMC Article
Pregnancy and Child Outcomes Following Fetal Intracranial Hemorrhage.
Gupta V, Schlatterer SD, Bulas DI, du Plessis AJ, Mulkey SB
Pediatr Neurol 2023 Mar;140:68-75. Epub 2023 Jan 4 doi: 10.1016/j.pediatrneurol.2022.12.014. PMID: 36696703
Perinatal and long-term outcome of fetal intracranial hemorrhage: systematic review and meta-analysis.
Sileo FG, Zöllner J, D'Antonio F, Islam S, Papageorghiou AT, Khalil A
Ultrasound Obstet Gynecol 2022 May;59(5):585-595. doi: 10.1002/uog.24766. PMID: 34529308
Fetal intracranial hemorrhage: role of fetal MRI.
Sanapo L, Whitehead MT, Bulas DI, Ahmadzia HK, Pesacreta L, Chang T, du Plessis A
Prenat Diagn 2017 Aug;37(8):827-836. Epub 2017 Jul 19 doi: 10.1002/pd.5096. PMID: 28626857
Immune thrombocytopenia in pregnancy.
Stavrou E, McCrae KR
Hematol Oncol Clin North Am 2009 Dec;23(6):1299-316. doi: 10.1016/j.hoc.2009.08.005. PMID: 19932435Free PMC Article

Diagnosis

Pregnancy and Child Outcomes Following Fetal Intracranial Hemorrhage.
Gupta V, Schlatterer SD, Bulas DI, du Plessis AJ, Mulkey SB
Pediatr Neurol 2023 Mar;140:68-75. Epub 2023 Jan 4 doi: 10.1016/j.pediatrneurol.2022.12.014. PMID: 36696703
Perinatal and long-term outcome of fetal intracranial hemorrhage: systematic review and meta-analysis.
Sileo FG, Zöllner J, D'Antonio F, Islam S, Papageorghiou AT, Khalil A
Ultrasound Obstet Gynecol 2022 May;59(5):585-595. doi: 10.1002/uog.24766. PMID: 34529308
Fetal intracranial hemorrhage at 24 weeks' gestation.
Hunt JC, Schneider C, Menticoglou S, Del Bigio MR
J Obstet Gynaecol Can 2011 Jul;33(7):691. doi: 10.1016/S1701-2163(16)34950-7. PMID: 21749744
Fetal intracranial hemorrhage and periventricular leukomalacia: complications of twin-twin transfusion.
Hurst RW, Abbitt PL
AJNR Am J Neuroradiol 1989 Sep-Oct;10(5 Suppl):S62-3. PMID: 2505573Free PMC Article
Sonography of fetal intracranial hemorrhage: unusual causes and a review of the literature.
Fogarty K, Cohen HL, Haller JO
J Clin Ultrasound 1989 Jun;17(5):366-70. doi: 10.1002/jcu.1870170510. PMID: 2499602

Therapy

Treasure to the mother and threat to the fetus: case report of warfarin-associated fetal intracranial hemorrhage and review of literature.
Shan D, Ji Y, Hu Y, Li T
J Int Med Res 2023 Aug;51(8):3000605231192773. doi: 10.1177/03000605231192773. PMID: 37572075Free PMC Article
Fetal intracranial hemorrhage and maternal vitamin K deficiency induced by total parenteral nutrition: A case report.
Lee S, Kim HM, Kang J, Seong WJ, Kim MJ
Medicine (Baltimore) 2022 Jan 7;101(1):e28434. doi: 10.1097/MD.0000000000028434. PMID: 35029889Free PMC Article
Fetal intracranial hemorrhage at 24 weeks' gestation.
Hunt JC, Schneider C, Menticoglou S, Del Bigio MR
J Obstet Gynaecol Can 2011 Jul;33(7):691. doi: 10.1016/S1701-2163(16)34950-7. PMID: 21749744
Third trimester fetal intracranial hemorrhage owing to vitamin K deficiency associated with hyperemesis gravidarum.
Eventov-Friedman S, Klinger G, Shinwell ES
J Pediatr Hematol Oncol 2009 Dec;31(12):985-8. doi: 10.1097/MPH.0b013e3181c3a8bc. PMID: 19956025
Vitamin K deficiency in hyperemesis gravidarum as a potential cause of fetal intracranial hemorrhage and hydrocephalus.
Kawamura Y, Kawamata K, Shinya M, Higashi M, Niiro M, Douchi T
Prenat Diagn 2008 Jan;28(1):59-61. doi: 10.1002/pd.1903. PMID: 18058978

Prognosis

The association between fetal intracranial hemorrhages detected on MRI and neurodevelopment.
Eldad K, Ya'ara G, Simon L, Omer BY
Eur J Radiol 2024 Apr;173:111380. Epub 2024 Feb 17 doi: 10.1016/j.ejrad.2024.111380. PMID: 38428252
Pregnancy and Child Outcomes Following Fetal Intracranial Hemorrhage.
Gupta V, Schlatterer SD, Bulas DI, du Plessis AJ, Mulkey SB
Pediatr Neurol 2023 Mar;140:68-75. Epub 2023 Jan 4 doi: 10.1016/j.pediatrneurol.2022.12.014. PMID: 36696703
Clinical analysis of eight cases of fetal intracranial hemorrhage in pregnancy.
Qi W, Luo JY, Li ZL, Zhang QJ, Liu ZD, Liao QP, Han Q, Yan JY
J Matern Fetal Neonatal Med 2021 Aug;34(16):2609-2615. Epub 2019 Oct 6 doi: 10.1080/14767058.2019.1670791. PMID: 31588836
Prenatal diagnosis and postnatal outcome of fetal intracranial hemorrhage.
Kutuk MS, Yikilmaz A, Ozgun MT, Dolanbay M, Canpolat M, Uludag S, Uysal G, Tas M, Musa K
Childs Nerv Syst 2014 Mar;30(3):411-8. Epub 2013 Aug 2 doi: 10.1007/s00381-013-2243-0. PMID: 23907139
Fetal intracranial hemorrhage at 24 weeks' gestation.
Hunt JC, Schneider C, Menticoglou S, Del Bigio MR
J Obstet Gynaecol Can 2011 Jul;33(7):691. doi: 10.1016/S1701-2163(16)34950-7. PMID: 21749744

Clinical prediction guides

The association between fetal intracranial hemorrhages detected on MRI and neurodevelopment.
Eldad K, Ya'ara G, Simon L, Omer BY
Eur J Radiol 2024 Apr;173:111380. Epub 2024 Feb 17 doi: 10.1016/j.ejrad.2024.111380. PMID: 38428252
Bi-allelic variants in the ESAM tight-junction gene cause a neurodevelopmental disorder associated with fetal intracranial hemorrhage.
Lecca M, Pehlivan D, Suñer DH, Weiss K, Coste T, Zweier M, Oktay Y, Danial-Farran N, Rosti V, Bonasoni MP, Malara A, Contrò G, Zuntini R, Pollazzon M, Pascarella R, Neri A, Fusco C, Marafi D, Mitani T, Posey JE, Bayramoglu SE, Gezdirici A, Hernandez-Rodriguez J, Cladera EA, Miravet E, Roldan-Busto J, Ruiz MA, Bauzá CV, Ben-Sira L, Sigaudy S, Begemann A, Unger S, Güngör S, Hiz S, Sonmezler E, Zehavi Y, Jerdev M, Balduini A, Zuffardi O, Horvath R, Lochmüller H, Rauch A, Garavelli L, Tournier-Lasserve E, Spiegel R, Lupski JR, Errichiello E
Am J Hum Genet 2023 Apr 6;110(4):681-690. Epub 2023 Mar 29 doi: 10.1016/j.ajhg.2023.03.005. PMID: 36996813Free PMC Article
Pregnancy and Child Outcomes Following Fetal Intracranial Hemorrhage.
Gupta V, Schlatterer SD, Bulas DI, du Plessis AJ, Mulkey SB
Pediatr Neurol 2023 Mar;140:68-75. Epub 2023 Jan 4 doi: 10.1016/j.pediatrneurol.2022.12.014. PMID: 36696703
Perinatal and long-term outcome of fetal intracranial hemorrhage: systematic review and meta-analysis.
Sileo FG, Zöllner J, D'Antonio F, Islam S, Papageorghiou AT, Khalil A
Ultrasound Obstet Gynecol 2022 May;59(5):585-595. doi: 10.1002/uog.24766. PMID: 34529308
Fetal intracranial hemorrhage. Prenatal diagnosis and postnatal outcomes.
Adiego B, Martínez-Ten P, Bermejo C, Estévez M, Recio Rodriguez M, Illescas T
J Matern Fetal Neonatal Med 2019 Jan;32(1):21-30. Epub 2017 Sep 4 doi: 10.1080/14767058.2017.1369521. PMID: 28826258

Recent systematic reviews

Perinatal and long-term outcome of fetal intracranial hemorrhage: systematic review and meta-analysis.
Sileo FG, Zöllner J, D'Antonio F, Islam S, Papageorghiou AT, Khalil A
Ultrasound Obstet Gynecol 2022 May;59(5):585-595. doi: 10.1002/uog.24766. PMID: 34529308

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