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Ovarian Fibromatosis and Massive Edema

MedGen UID:
1792203
•Concept ID:
C5555762
•
Disease or Syndrome

Definition

A rare benign lesion characterized by tumor-like enlargement of the ovaries due to fibroblastic proliferation with collagen deposition (fibromatosis) or stromal accumulation of edema fluid (massive edema). It presents in premenopausal patients, with menstrual abnormalities, abdominal pain, or androgenic manifestations. Most cases are unilateral. (WHO 2020) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Fibromatosis and Massive Edema

Professional guidelines

PubMed

Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430

Recent clinical studies

Etiology

Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430

Diagnosis

Rapidly progressing ascites in a pregnancy with a massive fibroid: A case report and review of pseudo-Meigs syndrome.
Roecker ZA, Young MR, Han C
Int J Gynaecol Obstet 2024 Oct;167(1):128-131. Epub 2024 May 12 doi: 10.1002/ijgo.15604. PMID: 38736303
Massive ovarian edema associated with a broad ligament leiomyoma: a case report and review.
Harrison BT, Berg RE, Mittal K
Int J Gynecol Pathol 2014 Jul;33(4):418-22. doi: 10.1097/PGP.0b013e31829d76ee. PMID: 24901402
Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430
Ovarian fibrothecoma with massive edema.
Sakaki M, Hirokawa M, Horiguchi H, Wakatsuki S, Sano T, Izumi Y
J Med Invest 2000 Aug;47(3-4):148-51. PMID: 11019495
Massive edema of the ovary simulating fibroma.
Kalstone CE, Jaffe RB, Abell MR
Obstet Gynecol 1969 Oct;34(4):564-71. PMID: 5822682

Therapy

Ovarian fibrothecoma with massive edema.
Sakaki M, Hirokawa M, Horiguchi H, Wakatsuki S, Sano T, Izumi Y
J Med Invest 2000 Aug;47(3-4):148-51. PMID: 11019495
Diffuse intra-abdominal fibromatosis in association with bilateral ovarian fibromatosis and oedema.
Antoniuk P, Tjandra JJ, Lavery IC
Aust N Z J Surg 1993 Apr;63(4):315-8. doi: 10.1111/j.1445-2197.1993.tb00391.x. PMID: 8311821

Prognosis

A case of ovarian fibromatosis with disseminated intra-abdominal fibromatosis.
Roche WR, du Boulay CE
Histopathology 1989 Jan;14(1):101-7. doi: 10.1111/j.1365-2559.1989.tb02119.x. PMID: 2925175

Clinical prediction guides

Ovarian fibrothecoma with massive edema.
Sakaki M, Hirokawa M, Horiguchi H, Wakatsuki S, Sano T, Izumi Y
J Med Invest 2000 Aug;47(3-4):148-51. PMID: 11019495
Ovarian myxoma: clinicopathologic and immunocytologic analysis of five cases and a review of the literature.
Eichhorn JH, Scully RE
Int J Gynecol Pathol 1991;10(2):156-69. PMID: 2032767
Fibromatosis and massive edema of the ovary, possibly related entities: a report of 14 cases of fibromatosis and 11 cases of massive edema.
Young RH, Scully RE
Int J Gynecol Pathol 1984;3(2):153-78. doi: 10.1097/00004347-198402000-00005. PMID: 6490313

Supplemental Content

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