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Salivary Gland Small Cell Neuroendocrine Carcinoma

MedGen UID:
1724410
•Concept ID:
C5421221
•
Neoplastic Process

Definition

An infrequent small cell carcinoma that arises from the salivary glands. It is characterized by the presence of neuroendocrine differentiation and a high number of mitotic figures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Small Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Current diagnosis and treatment of salivary gland-type tumors of the lung.
Horio Y, Kuroda H, Masago K, Matsushita H, Sasaki E, Fujiwara Y
Jpn J Clin Oncol 2024 Mar 9;54(3):229-247. doi: 10.1093/jjco/hyad160. PMID: 38018262
Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article

Recent clinical studies

Etiology

Mucoepidermoid Carcinomas of the Larynx.
Richards HW, Bertelsen C, Hamilton B, Sauer D, Schindler J
Ann Otol Rhinol Laryngol 2022 Dec;131(12):1398-1403. Epub 2022 Jan 6 doi: 10.1177/00034894211069459. PMID: 34991344
Small Cell Carcinoma in the Head and Neck.
Wakasaki T, Yasumatsu R, Masuda M, Matsuo M, Tamae A, Kubo K, Kogo R, Uchi R, Taura M, Nakagawa T
Ann Otol Rhinol Laryngol 2019 Nov;128(11):1006-1012. Epub 2019 Jun 4 doi: 10.1177/0003489419853601. PMID: 31161776
Primary Pulmonary Salivary Gland-type Tumors: A Review and Update.
Falk N, Weissferdt A, Kalhor N, Moran CA
Adv Anat Pathol 2016 Jan;23(1):13-23. doi: 10.1097/PAP.0000000000000099. PMID: 26645458
Salivary gland cancer: an update on present and emerging therapies.
Carlson J, Licitra L, Locati L, Raben D, Persson F, Stenman G
Am Soc Clin Oncol Educ Book 2013:257-63. doi: 10.14694/EdBook_AM.2013.33.257. PMID: 23714518
Experience with CHART.
Saunders MI, Dische S, Grosch EJ, Fermont DC, Ashford RF, Maher EJ, Makepeace AR
Int J Radiat Oncol Biol Phys 1991 Aug;21(3):871-8. doi: 10.1016/0360-3016(91)90722-g. PMID: 1651312

Diagnosis

Current diagnosis and treatment of salivary gland-type tumors of the lung.
Horio Y, Kuroda H, Masago K, Matsushita H, Sasaki E, Fujiwara Y
Jpn J Clin Oncol 2024 Mar 9;54(3):229-247. doi: 10.1093/jjco/hyad160. PMID: 38018262
Approach to small biopsies in the larynx.
Lott Limbach A
Semin Diagn Pathol 2023 Sep;40(5):333-339. Epub 2023 Jun 25 doi: 10.1053/j.semdp.2023.06.004. PMID: 37391302
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Overview of the 2022 WHO Classification of Head and Neck Neuroendocrine Neoplasms.
Mete O, Wenig BM
Head Neck Pathol 2022 Mar;16(1):123-142. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01435-8. PMID: 35312985Free PMC Article
The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology.
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626
Submandibular and sublingual spaces: diagnostic imaging and evaluation.
Agarwal AK, Kanekar SG
Otolaryngol Clin North Am 2012 Dec;45(6):1311-23. doi: 10.1016/j.otc.2012.08.005. PMID: 23153751

Therapy

Emerging tyrosine kinase inhibitors for head and neck cancer.
Long Z, Grandis JR, Johnson DE
Expert Opin Emerg Drugs 2022 Sep;27(3):333-344. Epub 2022 Sep 21 doi: 10.1080/14728214.2022.2125954. PMID: 36131561Free PMC Article
Intensity-modulated radiation therapy in head-and-neck carcinomas: Potential beyond sparing the parotid glands.
Sharma A, Bahl A
J Cancer Res Ther 2020 Apr-Jun;16(3):425-433. doi: 10.4103/jcrt.JCRT_880_18. PMID: 32719246
First case report of a curative wedge resection in epithelial-myoepithelial carcinoma of the lung.
Hagmeyer L, Tharun L, Schäfer SC, Hekmat K, Büttner R, Randerath W
Gen Thorac Cardiovasc Surg 2017 Sep;65(9):535-538. Epub 2017 Jun 26 doi: 10.1007/s11748-017-0796-7. PMID: 28653299
Salivary gland cancer: an update on present and emerging therapies.
Carlson J, Licitra L, Locati L, Raben D, Persson F, Stenman G
Am Soc Clin Oncol Educ Book 2013:257-63. doi: 10.14694/EdBook_AM.2013.33.257. PMID: 23714518
Experience with CHART.
Saunders MI, Dische S, Grosch EJ, Fermont DC, Ashford RF, Maher EJ, Makepeace AR
Int J Radiat Oncol Biol Phys 1991 Aug;21(3):871-8. doi: 10.1016/0360-3016(91)90722-g. PMID: 1651312

Prognosis

Salivary gland-like tumors of the breast: Histopathologic and genetic features with clinical implications.
Schwartz CJ, Krings G
Semin Diagn Pathol 2024 Nov;41(6):272-284. Epub 2024 Oct 5 doi: 10.1053/j.semdp.2024.10.003. PMID: 39389890
Pulmonary adenoid cystic carcinoma: molecular characteristics and literature review.
Chen Z, Jiang J, Fan Y, Lu H
Diagn Pathol 2023 May 17;18(1):65. doi: 10.1186/s13000-023-01354-4. PMID: 37198615Free PMC Article
Intraductal Carcinomas of the Salivary Gland.
Todorovic E, Weinreb I
Surg Pathol Clin 2021 Mar;14(1):1-15. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.09.003. PMID: 33526215
Small Cell Carcinoma in the Head and Neck.
Wakasaki T, Yasumatsu R, Masuda M, Matsuo M, Tamae A, Kubo K, Kogo R, Uchi R, Taura M, Nakagawa T
Ann Otol Rhinol Laryngol 2019 Nov;128(11):1006-1012. Epub 2019 Jun 4 doi: 10.1177/0003489419853601. PMID: 31161776
Small cell carcinoma of the head and neck: a review.
Renner G
Semin Oncol 2007 Feb;34(1):3-14. doi: 10.1053/j.seminoncol.2006.10.024. PMID: 17270660

Clinical prediction guides

Utility of MUC4 in the diagnosis of secretory carcinoma of salivary glands.
Fatima S, Ahmed A, Suleman S, Din NU
Ann Diagn Pathol 2023 Dec;67:152220. Epub 2023 Oct 28 doi: 10.1016/j.anndiagpath.2023.152220. PMID: 37924657
Morphologic and Ancillary Studies of Pediatric Acinic Cell Carcinoma: A Single Institute Experience.
Cole GG, Salgado CM, Vargas de Stefano D, Zambrano EV, Gómez AM, Reyes-Múgica M, Wang Q
Head Neck Pathol 2023 Mar;17(1):204-209. Epub 2022 Sep 28 doi: 10.1007/s12105-022-01492-z. PMID: 36169793Free PMC Article
Prognostic Significance of Cancer Stem Cell Markers in Patients With Salivary Gland Carcinomas.
Sadeghi H, Saffar H, Taheri P, Yazdani F, Etebarian A
Appl Immunohistochem Mol Morphol 2022 Apr 1;30(4):284-290. doi: 10.1097/PAI.0000000000001006. PMID: 35001035
Small Cell Carcinoma in the Head and Neck.
Wakasaki T, Yasumatsu R, Masuda M, Matsuo M, Tamae A, Kubo K, Kogo R, Uchi R, Taura M, Nakagawa T
Ann Otol Rhinol Laryngol 2019 Nov;128(11):1006-1012. Epub 2019 Jun 4 doi: 10.1177/0003489419853601. PMID: 31161776
The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology.
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626

Recent systematic reviews

Lung cancer metastasizing to salivary glands: Systematic review.
Gupta S, Brar SK, Shubha K, Kaur A, Basavaraju S, Kedia NB, Garewal NK, Kaur M, Singh R
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S490-S498. Epub 2023 Feb 1 doi: 10.4103/jcrt.jcrt_2699_22. PMID: 38384010
Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390
Role of Adjuvant Radiotherapy in Acinic Cell Carcinoma of the Salivary Glands: A Systematic Review.
Patil R, Uzzaman L, Kelly C, Kovarik J, Jackson M, Paterson C, Munro SP, Wilson A, Iqbal MS
Clin Oncol (R Coll Radiol) 2023 Sep;35(9):e489-e497. Epub 2023 Jun 16 doi: 10.1016/j.clon.2023.06.011. PMID: 37355414
Small cell carcinoma of the salivary gland: a systematic literature review and two case reports.
Servato JP, da Silva SJ, de Faria PR, Cardoso SV, Loyola AM
Int J Oral Maxillofac Surg 2013 Jan;42(1):89-98. Epub 2012 Nov 3 doi: 10.1016/j.ijom.2012.10.004. PMID: 23131461

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