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Renal tubular epithelial cell cytoplasmic vacuolization

MedGen UID:
1717347
•Concept ID:
C5397618
•
Finding
HPO: HP:0032596

Definition

Tubular cross section with intracytoplasmic vacuoles in at least one tubular epithelial cell. This feature is classified as isometric when vacuoles are round and similar in size and coarse when vacuoles were not round in shape or varied in size. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal tubular epithelial cell cytoplasmic vacuolization

Professional guidelines

PubMed

Delayed treatment with an autophagy inhibitor 3-MA alleviates the progression of hyperuricemic nephropathy.
Shi Y, Tao M, Ma X, Hu Y, Huang G, Qiu A, Zhuang S, Liu N
Cell Death Dis 2020 Jun 17;11(6):467. doi: 10.1038/s41419-020-2673-z. PMID: 32555189Free PMC Article
Cytopathologic features of clear cell papillary renal cell carcinoma: A recently described variant to be considered in the differential diagnosis of clear cell renal epithelial neoplasms.
Sayeed S, Lindsey KG, Baras AS, Jackson C, Powers CN, Uram-Tuculescu C, Smith SC
Cancer Cytopathol 2016 Aug;124(8):565-72. Epub 2016 Apr 7 doi: 10.1002/cncy.21721. PMID: 27062008

Recent clinical studies

Etiology

TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney.
Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Minami S, Takahashi A, Matsuda J, Sakai S, Yonishi H, Maeda S, Matsui S, Matsui I, Hamano T, Takahashi M, Goto M, Izumi Y, Bamba T, Sasai M, Yamamoto M, Matsusaka T, Niimura F, Yanagita M, Nakamura S, Yoshimori T, Ballabio A, Isaka Y
JCI Insight 2023 Feb 22;8(4) doi: 10.1172/jci.insight.162498. PMID: 36649084Free PMC Article
Renal tubular epithelial cells injury induced by mannitol and its potential mechanism.
Shi J, Qian J, Li H, Luo H, Luo W, Lin Z
Ren Fail 2018 Nov;40(1):85-91. doi: 10.1080/0886022X.2017.1419973. PMID: 29299951Free PMC Article
Basal Vacuolization in Renal Tubular Epithelial Cells at Autopsy and Their Relation to Ketoacidosis.
Zhou C, Yool AJ, Byard RW
J Forensic Sci 2017 May;62(3):681-685. Epub 2017 Jan 30 doi: 10.1111/1556-4029.13311. PMID: 28133737
Renal tubular epithelial vacuoles-a marker for both hyperlipidemia and ketoacidosis at autopsy.
Zhou C, Moore L, Yool A, Jaunzems A, Byard RW
J Forensic Sci 2015 May;60(3):638-41. Epub 2015 Feb 12 doi: 10.1111/1556-4029.12711. PMID: 25684621
Basal renal tubular epithelial cell vacuolization and alcoholic ketoacidosis.
Zhou C, Byard RW
J Forensic Sci 2012 Jan;57(1):126-8. Epub 2011 Nov 10 doi: 10.1111/j.1556-4029.2011.01957.x. PMID: 22074296

Diagnosis

Subnuclear renal tubular vacuoles in alcohol use disorder.
Auld FM, Parai JL, Milroy CM
J Forensic Sci 2023 Sep;68(5):1759-1767. Epub 2023 Jul 6 doi: 10.1111/1556-4029.15321. PMID: 37409637
Basal Vacuolization in Renal Tubular Epithelial Cells at Autopsy and Their Relation to Ketoacidosis.
Zhou C, Yool AJ, Byard RW
J Forensic Sci 2017 May;62(3):681-685. Epub 2017 Jan 30 doi: 10.1111/1556-4029.13311. PMID: 28133737
Renal tubular epithelial vacuoles-a marker for both hyperlipidemia and ketoacidosis at autopsy.
Zhou C, Moore L, Yool A, Jaunzems A, Byard RW
J Forensic Sci 2015 May;60(3):638-41. Epub 2015 Feb 12 doi: 10.1111/1556-4029.12711. PMID: 25684621
Basal renal tubular epithelial cell vacuolization and alcoholic ketoacidosis.
Zhou C, Byard RW
J Forensic Sci 2012 Jan;57(1):126-8. Epub 2011 Nov 10 doi: 10.1111/j.1556-4029.2011.01957.x. PMID: 22074296
How useful is basal renal tubular epithelial cell vacuolization as a marker for significant hyperglycemia at autopsy?
Zhou C, Gilbert JD, Byard RW
J Forensic Sci 2011 Nov;56(6):1531-3. Epub 2011 Aug 9 doi: 10.1111/j.1556-4029.2011.01865.x. PMID: 21827461

Therapy

Human umbilical cord mesenchymal stem cell exosomes alleviate acute kidney injury by inhibiting pyroptosis in rats and NRK-52E cells.
Wan Y, Yu Y, Yu C, Luo J, Wen S, Shen L, Wei G, Hua Y
Ren Fail 2023 Dec;45(1):2221138. doi: 10.1080/0886022X.2023.2221138. PMID: 37293812Free PMC Article
TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney.
Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Minami S, Takahashi A, Matsuda J, Sakai S, Yonishi H, Maeda S, Matsui S, Matsui I, Hamano T, Takahashi M, Goto M, Izumi Y, Bamba T, Sasai M, Yamamoto M, Matsusaka T, Niimura F, Yanagita M, Nakamura S, Yoshimori T, Ballabio A, Isaka Y
JCI Insight 2023 Feb 22;8(4) doi: 10.1172/jci.insight.162498. PMID: 36649084Free PMC Article
Delayed treatment with an autophagy inhibitor 3-MA alleviates the progression of hyperuricemic nephropathy.
Shi Y, Tao M, Ma X, Hu Y, Huang G, Qiu A, Zhuang S, Liu N
Cell Death Dis 2020 Jun 17;11(6):467. doi: 10.1038/s41419-020-2673-z. PMID: 32555189Free PMC Article
Osmotic nephrosis: acute kidney injury with accumulation of proximal tubular lysosomes due to administration of exogenous solutes.
Dickenmann M, Oettl T, Mihatsch MJ
Am J Kidney Dis 2008 Mar;51(3):491-503. doi: 10.1053/j.ajkd.2007.10.044. PMID: 18295066
Light and electron microscopical changes seen in acute tubular necrosis in renal allografts.
Wakabayashi T
Acta Pathol Jpn 1988 Apr;38(4):435-44. doi: 10.1111/j.1440-1827.1988.tb02317.x. PMID: 3041736

Prognosis

Death following extreme temperature exposure: Histological, biochemical and immunohistochemical markers.
Natanti A, Mazzanti R, Palpacelli M, Turchi C, Tagliabracci A, Pesaresi M
Med Sci Law 2021 Jan;61(1_suppl):36-41. doi: 10.1177/0025802420942423. PMID: 33591877
Xp11.2 translocation renal cell carcinoma with NONO-TFE3 gene fusion: morphology, prognosis, and potential pitfall in detecting TFE3 gene rearrangement.
Xia QY, Wang Z, Chen N, Gan HL, Teng XD, Shi SS, Wang X, Wei X, Ye SB, Li R, Ma HH, Lu ZF, Zhou XJ, Rao Q
Mod Pathol 2017 Mar;30(3):416-426. Epub 2016 Dec 9 doi: 10.1038/modpathol.2016.204. PMID: 27934879
Septic Ketoacidosis-A Potentially Lethal Entity with Renal Tubular Epithelial Vacuolization.
Zhou C, Byard RW
J Forensic Sci 2017 Jan;62(1):122-125. Epub 2016 Dec 8 doi: 10.1111/1556-4029.13245. PMID: 27930814
Subnuclear lipid-containing vacuolization in cases of ketoacidosis - correlation of morphological findings and ketone body concentrations.
Wollner K, Hess C, Madea B
Arch Kriminol 2016 Aug;238(1-2):57-63. PMID: 29894604
Cytopathologic features of clear cell papillary renal cell carcinoma: A recently described variant to be considered in the differential diagnosis of clear cell renal epithelial neoplasms.
Sayeed S, Lindsey KG, Baras AS, Jackson C, Powers CN, Uram-Tuculescu C, Smith SC
Cancer Cytopathol 2016 Aug;124(8):565-72. Epub 2016 Apr 7 doi: 10.1002/cncy.21721. PMID: 27062008

Clinical prediction guides

Effect of autophagy on oxalate-induced toxicity of human proximal renal tubular epithelial cell.
Liu D, Lei J, Huang K, Yin G
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Mar 28;46(3):221-226. doi: 10.11817/j.issn.1672-7347.2021.190299. PMID: 33927067Free PMC Article
Renal tubular epithelial cells injury induced by mannitol and its potential mechanism.
Shi J, Qian J, Li H, Luo H, Luo W, Lin Z
Ren Fail 2018 Nov;40(1):85-91. doi: 10.1080/0886022X.2017.1419973. PMID: 29299951Free PMC Article
Basal Vacuolization in Renal Tubular Epithelial Cells at Autopsy and Their Relation to Ketoacidosis.
Zhou C, Yool AJ, Byard RW
J Forensic Sci 2017 May;62(3):681-685. Epub 2017 Jan 30 doi: 10.1111/1556-4029.13311. PMID: 28133737
Renal tubular epithelial vacuoles-a marker for both hyperlipidemia and ketoacidosis at autopsy.
Zhou C, Moore L, Yool A, Jaunzems A, Byard RW
J Forensic Sci 2015 May;60(3):638-41. Epub 2015 Feb 12 doi: 10.1111/1556-4029.12711. PMID: 25684621
Autophagy activation reduces renal tubular injury induced by urinary proteins.
Liu WJ, Luo MN, Tan J, Chen W, Huang LZ, Yang C, Pan Q, Li B, Liu HF
Autophagy 2014 Feb;10(2):243-56. Epub 2013 Nov 26 doi: 10.4161/auto.27004. PMID: 24345797Free PMC Article

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