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Abnormal renal tubular epithelial morphology

MedGen UID:
1717573
•Concept ID:
C5397621
•
Anatomical Abnormality
HPO: HP:0032599

Definition

Any structural anomaly of the renal tubular epithelial cells (RTEC), a layer of cells in the outer layer of the renal tubule. These cells play a role in the absorption of substances such as glucose and amino from the primary urine. [from HPO]

Professional guidelines

PubMed

Bone morphogenetic protein 7: a novel treatment for chronic renal and bone disease.
Li T, Surendran K, Zawaideh MA, Mathew S, Hruska KA
Curr Opin Nephrol Hypertens 2004 Jul;13(4):417-22. doi: 10.1097/01.mnh.0000133974.24935.fe. PMID: 15199292

Recent clinical studies

Etiology

Renal intrinsic cells remodeling in diabetic kidney disease and the regulatory effects of SGLT2 Inhibitors.
Guo W, Li H, Li Y, Kong W
Biomed Pharmacother 2023 Sep;165:115025. Epub 2023 Jun 28 doi: 10.1016/j.biopha.2023.115025. PMID: 37385209
Mechanistic insights into hyperuricemia-associated renal abnormalities with special emphasis on epithelial-to-mesenchymal transition: Pathologic implications and putative pharmacologic targets.
Balakumar P, Alqahtani A, Khan NA, Mahadevan N, Dhanaraj SA
Pharmacol Res 2020 Nov;161:105209. Epub 2020 Sep 23 doi: 10.1016/j.phrs.2020.105209. PMID: 32979505
Sodium glucose cotransporter (SGLT)-2 inhibitors alleviate the renal stress responsible for sympathetic activation.
Sano M
Ther Adv Cardiovasc Dis 2020 Jan-Dec;14:1753944720939383. doi: 10.1177/1753944720939383. PMID: 32715944Free PMC Article
Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease.
Rajani R, Pastor-Soler NM, Hallows KR
Curr Opin Nephrol Hypertens 2017 Sep;26(5):375-383. doi: 10.1097/MNH.0000000000000349. PMID: 28614117
Pathophysiology of ischaemic acute kidney injury.
Kanagasundaram NS
Ann Clin Biochem 2015 Mar;52(Pt 2):193-205. Epub 2014 Oct 7 doi: 10.1177/0004563214556820. PMID: 25293591

Diagnosis

Mechanistic insights into hyperuricemia-associated renal abnormalities with special emphasis on epithelial-to-mesenchymal transition: Pathologic implications and putative pharmacologic targets.
Balakumar P, Alqahtani A, Khan NA, Mahadevan N, Dhanaraj SA
Pharmacol Res 2020 Nov;161:105209. Epub 2020 Sep 23 doi: 10.1016/j.phrs.2020.105209. PMID: 32979505
Cell Cycle Arrest as a Therapeutic Target of Acute Kidney Injury.
Wang WG, Sun WX, Gao BS, Lian X, Zhou HL
Curr Protein Pept Sci 2017;18(12):1224-1231. doi: 10.2174/1389203717666160915162238. PMID: 27634440
2004 WHO classification of the renal tumors of the adults.
Lopez-Beltran A, Scarpelli M, Montironi R, Kirkali Z
Eur Urol 2006 May;49(5):798-805. Epub 2006 Jan 17 doi: 10.1016/j.eururo.2005.11.035. PMID: 16442207
Pax2 in development and renal disease.
Dressler GR, Woolf AS
Int J Dev Biol 1999;43(5):463-8. PMID: 10535325
Renal epithelial hyperplastic and neoplastic proliferation in autosomal dominant polycystic kidney disease.
Gregoire JR, Torres VE, Holley KE, Farrow GM
Am J Kidney Dis 1987 Jan;9(1):27-38. doi: 10.1016/s0272-6386(87)80158-0. PMID: 3812480

Therapy

Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway.
Lu J, Li XQ, Chen PP, Zhang JX, Li L, Wang GH, Liu XQ, Jiang CM, Ma KL
Acta Pharmacol Sin 2024 Feb;45(2):366-377. Epub 2023 Sep 28 doi: 10.1038/s41401-023-01160-0. PMID: 37770579Free PMC Article
Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis.
Wang B, Yang LN, Yang LT, Liang Y, Guo F, Fu P, Ma L
Acta Pharmacol Sin 2024 Jan;45(1):150-165. Epub 2023 Sep 11 doi: 10.1038/s41401-023-01156-w. PMID: 37696989Free PMC Article
Renal intrinsic cells remodeling in diabetic kidney disease and the regulatory effects of SGLT2 Inhibitors.
Guo W, Li H, Li Y, Kong W
Biomed Pharmacother 2023 Sep;165:115025. Epub 2023 Jun 28 doi: 10.1016/j.biopha.2023.115025. PMID: 37385209
Sodium glucose cotransporter (SGLT)-2 inhibitors alleviate the renal stress responsible for sympathetic activation.
Sano M
Ther Adv Cardiovasc Dis 2020 Jan-Dec;14:1753944720939383. doi: 10.1177/1753944720939383. PMID: 32715944Free PMC Article
AT1 and AT2 receptors modulate renal tubular cell necroptosis in angiotensin II-infused renal injury mice.
Zhu Y, Cui H, Lv J, Liang H, Zheng Y, Wang S, Wang M, Wang H, Ye F
Sci Rep 2019 Dec 19;9(1):19450. doi: 10.1038/s41598-019-55550-8. PMID: 31857626Free PMC Article

Prognosis

Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis.
Caza T, Wijewardena C, Al-Rabadi L, Perl A
Transl Res 2022 Jul;245:55-81. Epub 2022 Mar 12 doi: 10.1016/j.trsl.2022.03.004. PMID: 35288362Free PMC Article
Mechanistic insights into hyperuricemia-associated renal abnormalities with special emphasis on epithelial-to-mesenchymal transition: Pathologic implications and putative pharmacologic targets.
Balakumar P, Alqahtani A, Khan NA, Mahadevan N, Dhanaraj SA
Pharmacol Res 2020 Nov;161:105209. Epub 2020 Sep 23 doi: 10.1016/j.phrs.2020.105209. PMID: 32979505
Cell Cycle Arrest as a Therapeutic Target of Acute Kidney Injury.
Wang WG, Sun WX, Gao BS, Lian X, Zhou HL
Curr Protein Pept Sci 2017;18(12):1224-1231. doi: 10.2174/1389203717666160915162238. PMID: 27634440
Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis.
Anders HJ, Ryu M
Kidney Int 2011 Nov;80(9):915-925. Epub 2011 Aug 3 doi: 10.1038/ki.2011.217. PMID: 21814171
The pathogenesis of polycystic kidney disease.
Carone FA, Bacallao R, Kanwar YS
Histol Histopathol 1995 Jan;10(1):213-21. PMID: 7756739

Clinical prediction guides

Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis.
Caza T, Wijewardena C, Al-Rabadi L, Perl A
Transl Res 2022 Jul;245:55-81. Epub 2022 Mar 12 doi: 10.1016/j.trsl.2022.03.004. PMID: 35288362Free PMC Article
Cabin1 involves in renal tubular epithelial cells mitochondrial dysfunction through SIRT1/p53 pathway.
Wen Y, Chen J, Liu L, Guo G, Zeng Y, Zhang Y, Zeng Z, Wang Z, Peng X, Liang J
J Recept Signal Transduct Res 2020 Apr;40(2):141-147. Epub 2020 Jan 31 doi: 10.1080/10799893.2020.1719518. PMID: 32000560
New insights into the role of HNF-1β in kidney (patho)physiology.
Ferrè S, Igarashi P
Pediatr Nephrol 2019 Aug;34(8):1325-1335. Epub 2018 Jul 1 doi: 10.1007/s00467-018-3990-7. PMID: 29961928Free PMC Article
Cell Proliferation and Apoptosis in ADPKD.
Lee EJ
Adv Exp Med Biol 2016;933:25-34. doi: 10.1007/978-981-10-2041-4_3. PMID: 27730432
Pathophysiology of ischaemic acute kidney injury.
Kanagasundaram NS
Ann Clin Biochem 2015 Mar;52(Pt 2):193-205. Epub 2014 Oct 7 doi: 10.1177/0004563214556820. PMID: 25293591

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