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Renal tubular epithelial cell apoptosis

MedGen UID:
1709607
•Concept ID:
C5397664
•
Cell or Molecular Dysfunction
HPO: HP:0032647

Definition

Increased apoptosis (programmed cell death) of tubular epithelial cells. The cells are rounded with increased eosinophilia and contain fragmented, densely basophilic nuclear debris. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Renal tubular epithelial cell apoptosis

Professional guidelines

PubMed

Curcumin mediates repulsive guidance molecule B (RGMb) in the treatment mechanism of renal fibrosis induced by unilateral ureteral obstruction.
Chen F, Xie Y, Lv Q, Zou W, Xiong L
Ren Fail 2021 Dec;43(1):1496-1505. doi: 10.1080/0886022X.2021.1997764. PMID: 34751624Free PMC Article

Recent clinical studies

Etiology

Astaxanthin attenuates contrast-induced acute kidney injury in rats via ROS/NLRP3 inflammasome.
Song L, Yao S, Zheng D, Xuan Y, Li W
Int Urol Nephrol 2022 Jun;54(6):1355-1364. Epub 2021 Oct 15 doi: 10.1007/s11255-021-03015-1. PMID: 34652584
GPR120 Ameliorates Apoptosis and Inhibits the Production of Inflammatory Cytokines in Renal Tubular Epithelial Cells.
Zhi D, Zhang M, Lin J, Liu P, Duan M
Inflammation 2021 Apr;44(2):493-505. Epub 2020 Oct 3 doi: 10.1007/s10753-020-01346-2. PMID: 33009637
Down-regulation of LINC00667 hinders renal tubular epithelial cell apoptosis and fibrosis through miR-34c.
Huang P, Gu XJ, Huang MY, Tan JH, Wang J
Clin Transl Oncol 2021 Mar;23(3):572-581. Epub 2020 Jul 23 doi: 10.1007/s12094-020-02451-2. PMID: 32705492
Niban protein regulates apoptosis in HK-2 cells via caspase-dependent pathway.
Tang S, Wang J, Liu J, Huang Y, Zhou Y, Yang S, Zhang W, Yang M, Zhang H
Ren Fail 2019 Nov;41(1):455-466. doi: 10.1080/0886022X.2019.1619582. PMID: 31163002Free PMC Article
HIV-associated nephropathy: pathogenesis.
Medapalli RK, He JC, Klotman PE
Curr Opin Nephrol Hypertens 2011 May;20(3):306-11. doi: 10.1097/MNH.0b013e328345359a. PMID: 21358326Free PMC Article

Therapy

Quercetin prevented diabetic nephropathy by inhibiting renal tubular epithelial cell apoptosis via the PI3K/AKT pathway.
Liu F, Feng Q, Yang M, Yang Y, Nie J, Wang S
Phytother Res 2024 Jul;38(7):3594-3606. Epub 2024 May 9 doi: 10.1002/ptr.8227. PMID: 38725104
Catalytic Tunable Black Phosphorus/Ceria Nanozyme: A Versatile Oxidation Cycle Accelerator for Alleviating Cisplatin-Induced Acute Kidney Injury.
Gao X, Wang B, Li J, Niu B, Cao L, Liang XJ, Zhang J, Jin Y, Yang X
Adv Healthc Mater 2023 Dec;12(30):e2301691. Epub 2023 Sep 17 doi: 10.1002/adhm.202301691. PMID: 37677811
Astaxanthin attenuates contrast-induced acute kidney injury in rats via ROS/NLRP3 inflammasome.
Song L, Yao S, Zheng D, Xuan Y, Li W
Int Urol Nephrol 2022 Jun;54(6):1355-1364. Epub 2021 Oct 15 doi: 10.1007/s11255-021-03015-1. PMID: 34652584
The role of endoplasmic reticulum stress in renal damage caused by acute mercury chloride poisoning.
Zhong Y, Wang B, Hu S, Wang T, Zhang Y, Wang J, Liu Y, Zhang H
J Toxicol Sci 2020;45(9):589-598. doi: 10.2131/jts.45.589. PMID: 32879258
Disparate effects of roscovitine on renal tubular epithelial cell apoptosis and senescence: implications for autosomal dominant polycystic kidney disease.
Park JY, Park SH, Weiss RH
Am J Nephrol 2009;29(6):509-15. Epub 2008 Dec 10 doi: 10.1159/000184590. PMID: 19066425Free PMC Article

Prognosis

Protective Effect of CXCR7 Against Hypoxia/Reoxygenation Injury in Renal Tubular Epithelial Cells.
Meng P, Liu C, Li J, Fang P, Chen L
Cell Biochem Biophys 2024 Sep;82(3):2055-2063. Epub 2024 May 28 doi: 10.1007/s12013-024-01312-x. PMID: 38806964Free PMC Article
Suppressing Syndecan-1 Shedding to Protect Against Renal Ischemia/Reperfusion Injury by Maintaining Polarity of Tubular Epithelial Cells.
Guo M, Xu J, Zhao S, Shen D, Jiang W, Zhang L, Ding X, Xu X
Shock 2022 Feb 1;57(2):256-263. doi: 10.1097/SHK.0000000000001838. PMID: 34313252

Clinical prediction guides

Quercetin prevented diabetic nephropathy by inhibiting renal tubular epithelial cell apoptosis via the PI3K/AKT pathway.
Liu F, Feng Q, Yang M, Yang Y, Nie J, Wang S
Phytother Res 2024 Jul;38(7):3594-3606. Epub 2024 May 9 doi: 10.1002/ptr.8227. PMID: 38725104
Astaxanthin attenuates contrast-induced acute kidney injury in rats via ROS/NLRP3 inflammasome.
Song L, Yao S, Zheng D, Xuan Y, Li W
Int Urol Nephrol 2022 Jun;54(6):1355-1364. Epub 2021 Oct 15 doi: 10.1007/s11255-021-03015-1. PMID: 34652584
Suppressing Syndecan-1 Shedding to Protect Against Renal Ischemia/Reperfusion Injury by Maintaining Polarity of Tubular Epithelial Cells.
Guo M, Xu J, Zhao S, Shen D, Jiang W, Zhang L, Ding X, Xu X
Shock 2022 Feb 1;57(2):256-263. doi: 10.1097/SHK.0000000000001838. PMID: 34313252
Relationship between Renalase Expression and Kidney Disease: an Observational Study in 72 Patients Undergoing Renal Biopsy.
Huang YS, Lai JB, Li SF, Wang T, Liu YN, Zhang QX, Zhang SY, Sun CH, Hu N, Zhang XZ
Curr Med Sci 2018 Apr;38(2):268-276. Epub 2018 Apr 30 doi: 10.1007/s11596-018-1875-4. PMID: 30074185
Hepatitis B virus X protein modulates apoptosis in human renal proximal tubular epithelial cells by activating the JAK2/STAT3 signaling pathway.
He P, Zhang D, Li H, Yang X, Li D, Zhai Y, Ma L, Feng G
Int J Mol Med 2013 May;31(5):1017-29. Epub 2013 Mar 7 doi: 10.3892/ijmm.2013.1295. PMID: 23483208Free PMC Article

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