U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IgA heavy chain paraproteinemia

MedGen UID:
1705867
Concept ID:
C5209276
Finding
Synonym: Alpha heavy chain disease
 
HPO: HP:0020194

Definition

An abnormal IgA heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIgA heavy chain paraproteinemia

Professional guidelines

PubMed

Chae H, Han E, Yoo J, Lee J, Lee JJ, Cha K, Kim M, Kim Y, Lee SE, Min CK
Clin Chim Acta 2018 Apr;479:7-13. Epub 2018 Jan 8 doi: 10.1016/j.cca.2018.01.010. PMID: 29324245
Ermak N, Nguyen-Khoa T, Alyanakian MA
Ann Biol Clin (Paris) 2016 Oct 1;74(5):597-605. doi: 10.1684/abc.2016.1180. PMID: 27707674
van de Donk NW, Palumbo A, Johnsen HE, Engelhardt M, Gay F, Gregersen H, Hajek R, Kleber M, Ludwig H, Morgan G, Musto P, Plesner T, Sezer O, Terpos E, Waage A, Zweegman S, Einsele H, Sonneveld P, Lokhorst HM; European Myeloma Network
Haematologica 2014 Jun;99(6):984-96. Epub 2014 Mar 21 doi: 10.3324/haematol.2013.100552. PMID: 24658815Free PMC Article

Recent clinical studies

Etiology

Wang Y, Chen D, Hu R, Zhang Y, Liang D, Xu F, Liu F, Zhu X, Lin Y, Yang X, Liu X, Xing G, Liang S, Zeng C
Am J Kidney Dis 2024 Oct;84(4):447-456.e1. Epub 2024 May 14 doi: 10.1053/j.ajkd.2024.03.021. PMID: 38750878
Lakhwani S, Rosiñol L, Puig N, Pico-Picos MA, Medina-González L, Martínez-López J, Paiva B, Cedena MT, Oriol A, Ríos-Tamayo R, Blanchard MJ, Jarque I, Bargay J, Moraleda JM, Carrillo-Cruz E, Sureda A, Krsnik I, González E, Casado LF, Martí JM, Encinas C, De Arriba F, Palomera L, Sampol A, González-Montes Y, Motlló C, De La Cruz J, Alonso R, Mateos MV, Bladé J, Lahuerta JJ, San-Miguel J, Hernández MT
Haematologica 2024 Jun 1;109(6):1909-1917. doi: 10.3324/haematol.2023.284154. PMID: 38031761Free PMC Article
Chae H, Han E, Yoo J, Lee J, Lee JJ, Cha K, Kim M, Kim Y, Lee SE, Min CK
Clin Chim Acta 2018 Apr;479:7-13. Epub 2018 Jan 8 doi: 10.1016/j.cca.2018.01.010. PMID: 29324245
Ermak N, Nguyen-Khoa T, Alyanakian MA
Ann Biol Clin (Paris) 2016 Oct 1;74(5):597-605. doi: 10.1684/abc.2016.1180. PMID: 27707674
Witzig TE, Wahner-Roedler DL
Curr Treat Options Oncol 2002 Jun;3(3):247-54. doi: 10.1007/s11864-002-0014-3. PMID: 12057070

Diagnosis

Wang Y, Chen D, Hu R, Zhang Y, Liang D, Xu F, Liu F, Zhu X, Lin Y, Yang X, Liu X, Xing G, Liang S, Zeng C
Am J Kidney Dis 2024 Oct;84(4):447-456.e1. Epub 2024 May 14 doi: 10.1053/j.ajkd.2024.03.021. PMID: 38750878
Sannier A, Hanouna G, Daugas E, Vrtovsnik F, Goujon JM, Chemouny JM
Br J Haematol 2018 Oct;183(1):13. Epub 2018 May 29 doi: 10.1111/bjh.15420. PMID: 29808912
Chae H, Han E, Yoo J, Lee J, Lee JJ, Cha K, Kim M, Kim Y, Lee SE, Min CK
Clin Chim Acta 2018 Apr;479:7-13. Epub 2018 Jan 8 doi: 10.1016/j.cca.2018.01.010. PMID: 29324245
Stankowski-Drengler T, Gertz MA, Katzmann JA, Lacy MQ, Kumar S, Leung N, Hayman SR, Buadi F, Kyle RA, Rajkumar SV, Dispenzieri A
Am J Hematol 2010 Jun;85(6):431-4. doi: 10.1002/ajh.21707. PMID: 20513121Free PMC Article
Witzig TE, Wahner-Roedler DL
Curr Treat Options Oncol 2002 Jun;3(3):247-54. doi: 10.1007/s11864-002-0014-3. PMID: 12057070

Therapy

Lakhwani S, Rosiñol L, Puig N, Pico-Picos MA, Medina-González L, Martínez-López J, Paiva B, Cedena MT, Oriol A, Ríos-Tamayo R, Blanchard MJ, Jarque I, Bargay J, Moraleda JM, Carrillo-Cruz E, Sureda A, Krsnik I, González E, Casado LF, Martí JM, Encinas C, De Arriba F, Palomera L, Sampol A, González-Montes Y, Motlló C, De La Cruz J, Alonso R, Mateos MV, Bladé J, Lahuerta JJ, San-Miguel J, Hernández MT
Haematologica 2024 Jun 1;109(6):1909-1917. doi: 10.3324/haematol.2023.284154. PMID: 38031761Free PMC Article
Wechalekar AD, Chakraborty R, Lentzsch S
Hematol Oncol Clin North Am 2020 Dec;34(6):1027-1039. Epub 2020 Oct 1 doi: 10.1016/j.hoc.2020.08.016. PMID: 33099421
Kurimoto M, Sonoki T, Nakamura Y, Yamamoto Y, Maeda Y, Kuriyama K, Mushino T, Hosoi H, Murata S, Shimanuki M, Hatanaka K, Hanaoka N, Kato J, Nakakuma H
Intern Med 2014;53(6):581-5. doi: 10.2169/internalmedicine.53.1625. PMID: 24633028
Ögmundsdóttir HM, Valgeirsdóttir S, Schiffhauer HR, Óskarsdóttir LB, Steingrímsdóttir H, Haraldsdóttir V
Clin Lymphoma Myeloma Leuk 2013 Apr;13(2):191-3. Epub 2013 Mar 13 doi: 10.1016/j.clml.2013.02.017. PMID: 23490993
Demeule B, Gurny R, Arvinte T
Eur J Pharm Biopharm 2006 Feb;62(2):121-30. Epub 2005 Oct 10 doi: 10.1016/j.ejpb.2005.08.008. PMID: 16221544

Prognosis

Lakhwani S, Rosiñol L, Puig N, Pico-Picos MA, Medina-González L, Martínez-López J, Paiva B, Cedena MT, Oriol A, Ríos-Tamayo R, Blanchard MJ, Jarque I, Bargay J, Moraleda JM, Carrillo-Cruz E, Sureda A, Krsnik I, González E, Casado LF, Martí JM, Encinas C, De Arriba F, Palomera L, Sampol A, González-Montes Y, Motlló C, De La Cruz J, Alonso R, Mateos MV, Bladé J, Lahuerta JJ, San-Miguel J, Hernández MT
Haematologica 2024 Jun 1;109(6):1909-1917. doi: 10.3324/haematol.2023.284154. PMID: 38031761Free PMC Article
Chae H, Han E, Yoo J, Lee J, Lee JJ, Cha K, Kim M, Kim Y, Lee SE, Min CK
Clin Chim Acta 2018 Apr;479:7-13. Epub 2018 Jan 8 doi: 10.1016/j.cca.2018.01.010. PMID: 29324245
Ermak N, Nguyen-Khoa T, Alyanakian MA
Ann Biol Clin (Paris) 2016 Oct 1;74(5):597-605. doi: 10.1684/abc.2016.1180. PMID: 27707674
Boyle EM, Fouquet G, Guidez S, Bonnet S, Demarquette H, Dulery R, Herbaux C, Noel MP, Manier S, Schraen S, Onraed B, Faucompré JL, Hennache B, Petillon MO, Mathiot C, Avet-Loiseau H, Facon T, Harding SJ, Moreau P, Leleu X
Cancer 2014 Dec 15;120(24):3952-7. Epub 2014 Aug 12 doi: 10.1002/cncr.28946. PMID: 25116271
Witzig TE, Wahner-Roedler DL
Curr Treat Options Oncol 2002 Jun;3(3):247-54. doi: 10.1007/s11864-002-0014-3. PMID: 12057070

Clinical prediction guides

Lakhwani S, Rosiñol L, Puig N, Pico-Picos MA, Medina-González L, Martínez-López J, Paiva B, Cedena MT, Oriol A, Ríos-Tamayo R, Blanchard MJ, Jarque I, Bargay J, Moraleda JM, Carrillo-Cruz E, Sureda A, Krsnik I, González E, Casado LF, Martí JM, Encinas C, De Arriba F, Palomera L, Sampol A, González-Montes Y, Motlló C, De La Cruz J, Alonso R, Mateos MV, Bladé J, Lahuerta JJ, San-Miguel J, Hernández MT
Haematologica 2024 Jun 1;109(6):1909-1917. doi: 10.3324/haematol.2023.284154. PMID: 38031761Free PMC Article
Boyle EM, Fouquet G, Guidez S, Bonnet S, Demarquette H, Dulery R, Herbaux C, Noel MP, Manier S, Schraen S, Onraed B, Faucompré JL, Hennache B, Petillon MO, Mathiot C, Avet-Loiseau H, Facon T, Harding SJ, Moreau P, Leleu X
Cancer 2014 Dec 15;120(24):3952-7. Epub 2014 Aug 12 doi: 10.1002/cncr.28946. PMID: 25116271
van de Donk NW, Palumbo A, Johnsen HE, Engelhardt M, Gay F, Gregersen H, Hajek R, Kleber M, Ludwig H, Morgan G, Musto P, Plesner T, Sezer O, Terpos E, Waage A, Zweegman S, Einsele H, Sonneveld P, Lokhorst HM; European Myeloma Network
Haematologica 2014 Jun;99(6):984-96. Epub 2014 Mar 21 doi: 10.3324/haematol.2013.100552. PMID: 24658815Free PMC Article
Stankowski-Drengler T, Gertz MA, Katzmann JA, Lacy MQ, Kumar S, Leung N, Hayman SR, Buadi F, Kyle RA, Rajkumar SV, Dispenzieri A
Am J Hematol 2010 Jun;85(6):431-4. doi: 10.1002/ajh.21707. PMID: 20513121Free PMC Article
Parkhouse RM, Virella G, Dourmashkin RR
Clin Exp Immunol 1971 Apr;8(4):581-91. PMID: 4995936Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...