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Heavy-chain paraproteinemia

MedGen UID:
1393831
Concept ID:
C4476930
Finding
HPO: HP:0031049

Definition

An abnormal immunoglobulin heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeavy-chain paraproteinemia

Professional guidelines

PubMed

Gertz MA
Am J Hematol 2024 Feb;99(2):309-324. Epub 2023 Dec 14 doi: 10.1002/ajh.27177. PMID: 38095141
Gertz MA
Am J Hematol 2022 Jun 1;97(6):818-829. Epub 2022 Apr 25 doi: 10.1002/ajh.26569. PMID: 35429180
Ryšavá R
Nephrol Dial Transplant 2019 Sep 1;34(9):1460-1466. doi: 10.1093/ndt/gfy291. PMID: 30299492

Recent clinical studies

Etiology

Gertz MA
Am J Hematol 2022 Jun 1;97(6):818-829. Epub 2022 Apr 25 doi: 10.1002/ajh.26569. PMID: 35429180
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Ryšavá R
Nephrol Dial Transplant 2019 Sep 1;34(9):1460-1466. doi: 10.1093/ndt/gfy291. PMID: 30299492
Chan NC, Chan NP
Methods Mol Biol 2017;1541:295-302. doi: 10.1007/978-1-4939-6703-2_23. PMID: 27910031
Isaacson PG
Hum Pathol 1994 Oct;25(10):1020-9. doi: 10.1016/0046-8177(94)90060-4. PMID: 7927306

Diagnosis

Gertz MA
Am J Hematol 2024 Feb;99(2):309-324. Epub 2023 Dec 14 doi: 10.1002/ajh.27177. PMID: 38095141
Gertz MA
Am J Hematol 2022 Jun 1;97(6):818-829. Epub 2022 Apr 25 doi: 10.1002/ajh.26569. PMID: 35429180
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Ryšavá R
Nephrol Dial Transplant 2019 Sep 1;34(9):1460-1466. doi: 10.1093/ndt/gfy291. PMID: 30299492
Fermand JP, Brouet JC
Hematol Oncol Clin North Am 1999 Dec;13(6):1281-94. doi: 10.1016/s0889-8588(05)70127-1. PMID: 10626151

Therapy

Bai Y, Sun B, Su J
J Stroke Cerebrovasc Dis 2025 Feb;34(2):108181. Epub 2024 Dec 7 doi: 10.1016/j.jstrokecerebrovasdis.2024.108181. PMID: 39653298
Hambach J, Mann AM, Bannas P, Koch-Nolte F
Front Immunol 2022;13:1005800. Epub 2022 Nov 2 doi: 10.3389/fimmu.2022.1005800. PMID: 36405759Free PMC Article
Gertz MA
Am J Hematol 2022 Jun 1;97(6):818-829. Epub 2022 Apr 25 doi: 10.1002/ajh.26569. PMID: 35429180
Alexanian R
CA Cancer J Clin 1976 Jan-Feb;26(1):38-49. doi: 10.3322/canjclin.26.1.38. PMID: 812592
Lee SL, Rosner F, Ruberman W, Glasberg S
Ann Intern Med 1971 Sep;75(3):407-14. doi: 10.7326/0003-4819-75-3-407. PMID: 5568152

Prognosis

Gertz MA
Am J Hematol 2024 Feb;99(2):309-324. Epub 2023 Dec 14 doi: 10.1002/ajh.27177. PMID: 38095141
Gertz MA
Am J Hematol 2022 Jun 1;97(6):818-829. Epub 2022 Apr 25 doi: 10.1002/ajh.26569. PMID: 35429180
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Ryšavá R
Nephrol Dial Transplant 2019 Sep 1;34(9):1460-1466. doi: 10.1093/ndt/gfy291. PMID: 30299492
Isaacson PG
Hum Pathol 1994 Oct;25(10):1020-9. doi: 10.1016/0046-8177(94)90060-4. PMID: 7927306

Clinical prediction guides

Bandy A, Kobayashi Y, Stein AC
Gastroenterology 2021 Nov;161(5):e1-e3. Epub 2018 Feb 1 doi: 10.1053/j.gastro.2018.01.051. PMID: 29408577
Sharma S, Gupta P, Aggarwal R, Malhotra P, Minz RW, Bansal F
Lab Med 2019 Oct 10;50(4):357-363. doi: 10.1093/labmed/lmz006. PMID: 30915470
Walker BA, Boyle EM, Wardell CP, Murison A, Begum DB, Dahir NM, Proszek PZ, Johnson DC, Kaiser MF, Melchor L, Aronson LI, Scales M, Pawlyn C, Mirabella F, Jones JR, Brioli A, Mikulasova A, Cairns DA, Gregory WM, Quartilho A, Drayson MT, Russell N, Cook G, Jackson GH, Leleu X, Davies FE, Morgan GJ
J Clin Oncol 2015 Nov 20;33(33):3911-20. Epub 2015 Aug 17 doi: 10.1200/JCO.2014.59.1503. PMID: 26282654Free PMC Article
Caers J, Vekemans MC, Bries G, Beel K, Delrieu V, Deweweire A, Demuynck H, De Prijck B, De Samblanx H, Kentos A, Meuleman N, Mineur P, Offner F, Vande Broek I, Van Droogenbroeck J, Vande Velde A, Wu KL, Delforge M, Schots R, Doyen C; Multiple Myeloma Study Group of the Belgian Hematological Society
Ann Med 2013 Sep;45(5-6):413-22. Epub 2013 Jun 14 doi: 10.3109/07853890.2013.801562. PMID: 23767978
Kyle RA, Rajkumar SV
Br J Haematol 2006 Sep;134(6):573-89. doi: 10.1111/j.1365-2141.2006.06235.x. PMID: 16938117

Recent systematic reviews

Cárdenas MC, García-Sanz R, Puig N, Pérez-Surribas D, Flores-Montero J, Ortiz-Espejo M, de la Rubia J, Cruz-Iglesias E
Clin Chem Lab Med 2023 Nov 27;61(12):2115-2130. Epub 2023 Jul 24 doi: 10.1515/cclm-2023-0326. PMID: 37477188

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