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Stage IA2 Cervical Cancer FIGO 2018

MedGen UID:
1688055
•Concept ID:
C5206438
•
Neoplastic Process
Synonym: Stage IA2 Cervical Carcinoma FIGO 2018

Definition

Cervical carcinoma with measured stromal invasion equal or more than 3 mm and less than 5 mm in depth. (FIGO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage IA2 Cervical Cancer FIGO 2018

Professional guidelines

PubMed

Comparative study of tumor-free laparoscopic and open surgery in the treatment of early-stage cervical cancer.
Zhao J, Liu Q, Jiang D, Chen T, Meng S, Shu C
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2023 Nov 28;48(11):1686-1695. doi: 10.11817/j.issn.1672-7347.2023.230334. PMID: 38432859Free PMC Article
Exploring a Better Adjuvant Treatment for Surgically Treated High-Grade Neuroendocrine Carcinoma of the Cervix.
Wang R, Xiao Y, Ma L, Wu Z, Xia H
Gynecol Obstet Invest 2022;87(6):398-405. Epub 2022 Oct 21 doi: 10.1159/000527661. PMID: 36273460Free PMC Article
Individualization of surgical management of cervical cancer stages IA1, IA2.
Pichlík T, Rob L, Robová H, Halaška MJ, Drozenová J, Hruda M, Drochýtek V
Ceska Gynekol 2019 Spring;84(3):172-176. PMID: 31324105

Recent clinical studies

Etiology

Comparative study of tumor-free laparoscopic and open surgery in the treatment of early-stage cervical cancer.
Zhao J, Liu Q, Jiang D, Chen T, Meng S, Shu C
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2023 Nov 28;48(11):1686-1695. doi: 10.11817/j.issn.1672-7347.2023.230334. PMID: 38432859Free PMC Article
Prognostic value of the 2018 FIGO staging system for cervical cancer.
Mohamud A, Høgdall C, Schnack T
Gynecol Oncol 2022 Jun;165(3):506-513. Epub 2022 Mar 26 doi: 10.1016/j.ygyno.2022.02.017. PMID: 35346512
Characteristics, complications, and outcomes of early-stage cervical stump carcinoma: laparoscopy versus laparotomy.
Lu Z, Guo C, Wang T, Qiu J, Hua K
J Int Med Res 2021 Feb;49(2):300060521992247. doi: 10.1177/0300060521992247. PMID: 33641455Free PMC Article
Does a pre-operative conization improve disease-free survival in early-stage cervical cancer?
Benoit L, Koual M, Nguyen-Xuan HT, Balaya V, Nos C, Montero-Macías R, Bats AS
Arch Gynecol Obstet 2021 Jan;303(1):231-239. Epub 2020 Sep 22 doi: 10.1007/s00404-020-05798-7. PMID: 32964259
Individualization of surgical management of cervical cancer stages IA1, IA2.
Pichlík T, Rob L, Robová H, Halaška MJ, Drozenová J, Hruda M, Drochýtek V
Ceska Gynekol 2019 Spring;84(3):172-176. PMID: 31324105

Diagnosis

Comparison between laparoscopic and abdominal radical hysterectomy for cervical adenosquamous carcinoma at stage IA2 to IIA2: A multicenter retrospective study.
Teng X, Kang S, Li W, Ding H, Ling B, Zhu L, Wang D, Lang J, Liu P, Chen C
J Obstet Gynaecol Res 2023 Jun;49(6):1592-1610. Epub 2023 Mar 14 doi: 10.1111/jog.15633. PMID: 36919234
Prognostic value of the 2018 FIGO staging system for cervical cancer.
Mohamud A, Høgdall C, Schnack T
Gynecol Oncol 2022 Jun;165(3):506-513. Epub 2022 Mar 26 doi: 10.1016/j.ygyno.2022.02.017. PMID: 35346512
Comparison of Postoperative Adjuvant Chemotherapy and Concurrent Chemoradiotherapy for FIGO2018 Stage IIIC1 Cervical Cancer: A Retrospective Study.
Kagabu M, Nagasawa T, Tatsuki S, Fukagawa Y, Tomabechi H, Takatori E, Kaido Y, Shoji T, Baba T
Medicina (Kaunas) 2021 May 29;57(6) doi: 10.3390/medicina57060548. PMID: 34072478Free PMC Article
Individualization of surgical management of cervical cancer stages IA1, IA2.
Pichlík T, Rob L, Robová H, Halaška MJ, Drozenová J, Hruda M, Drochýtek V
Ceska Gynekol 2019 Spring;84(3):172-176. PMID: 31324105
Long-term results of fertility-sparing treatment for early-stage cervical cancer.
Bogani G, Chiappa V, Vinti D, Somigliana E, Filippi F, Murru G, Murgia F, Martinelli F, Ditto A, Raspagliesi F
Gynecol Oncol 2019 Jul;154(1):89-94. Epub 2019 Apr 16 doi: 10.1016/j.ygyno.2019.04.007. PMID: 31000470

Therapy

An update of oncologic and obstetric outcomes after abdominal trachelectomy using the FIGO 2018 staging system for cervical cancer: a single-institution retrospective analysis.
Okugawa K, Yahata H, Ohgami T, Yasunaga M, Asanoma K, Kobayashi H, Kato K
J Gynecol Oncol 2023 May;34(3):e41. Epub 2023 Jan 31 doi: 10.3802/jgo.2023.34.e41. PMID: 36807744Free PMC Article
Proof-of-concept randomized phase II non-inferiority trial of simple versus type B2 hysterectomy in early-stage cervical cancer ≤2 cm (LESSER).
Carneiro VCG, Batista TP, Andrade MR, Barros AV, Câmara LHLD, Ramalho NM, Lucena MA, Fontão DFS, Tancredi R, Silva Júnior TC, Bezerra ALR, Baiocchi G
Int J Gynecol Cancer 2023 Apr 3;33(4):498-503. doi: 10.1136/ijgc-2022-004092. PMID: 36696980
Exploring a Better Adjuvant Treatment for Surgically Treated High-Grade Neuroendocrine Carcinoma of the Cervix.
Wang R, Xiao Y, Ma L, Wu Z, Xia H
Gynecol Obstet Invest 2022;87(6):398-405. Epub 2022 Oct 21 doi: 10.1159/000527661. PMID: 36273460Free PMC Article
Characteristics, complications, and outcomes of early-stage cervical stump carcinoma: laparoscopy versus laparotomy.
Lu Z, Guo C, Wang T, Qiu J, Hua K
J Int Med Res 2021 Feb;49(2):300060521992247. doi: 10.1177/0300060521992247. PMID: 33641455Free PMC Article
The Selection of Time Interval Between Surgery and Adjuvant Therapy in Early Stage Cervical Cancer.
You KY, Zhou XH, Jiang YH, Bi ZF, Liu YM, Qiu XS
Int J Gynecol Cancer 2018 Sep;28(7):1325-1332. doi: 10.1097/IGC.0000000000001307. PMID: 30074519Free PMC Article

Prognosis

Comparative study of tumor-free laparoscopic and open surgery in the treatment of early-stage cervical cancer.
Zhao J, Liu Q, Jiang D, Chen T, Meng S, Shu C
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2023 Nov 28;48(11):1686-1695. doi: 10.11817/j.issn.1672-7347.2023.230334. PMID: 38432859Free PMC Article
Comparison between laparoscopic and abdominal radical hysterectomy for cervical adenosquamous carcinoma at stage IA2 to IIA2: A multicenter retrospective study.
Teng X, Kang S, Li W, Ding H, Ling B, Zhu L, Wang D, Lang J, Liu P, Chen C
J Obstet Gynaecol Res 2023 Jun;49(6):1592-1610. Epub 2023 Mar 14 doi: 10.1111/jog.15633. PMID: 36919234
Prognostic value of the 2018 FIGO staging system for cervical cancer.
Mohamud A, Høgdall C, Schnack T
Gynecol Oncol 2022 Jun;165(3):506-513. Epub 2022 Mar 26 doi: 10.1016/j.ygyno.2022.02.017. PMID: 35346512
Prognostic value of lymphovascular space invasion in early-stage cervical cancer.
Weyl A, Illac C, Lusque A, Leray H, Vaysse C, Martinez A, Chantalat E, Motton S
Int J Gynecol Cancer 2020 Oct;30(10):1493-1499. Epub 2020 Jun 21 doi: 10.1136/ijgc-2020-001274. PMID: 32565486
Comparison of laparoscopic and open radical hysterectomy in cervical cancer patients with tumor size ≤2 cm.
Chen X, Zhao N, Ye P, Chen J, Nan X, Zhao H, Zhou K, Zhang Y, Xue J, Zhou H, Shang H, Zhu H, Leanne VM, Yan X
Int J Gynecol Cancer 2020 May;30(5):564-571. Epub 2020 Apr 9 doi: 10.1136/ijgc-2019-000994. PMID: 32276941

Clinical prediction guides

Reproductive, obstetrical and oncological outcomes of fertility-sparing treatment for cervical cancer according to the FIGO 2018 staging system: A systematic review.
Taliento C, Scutiero G, Battello G, Sala A, Pellecchia G, Trozzi R, Arcieri M, Pavone M, Bizzarri N, Greco P, Driul L, Amant F, Fagotti A, Scambia G, Vizzielli G, Restaino S
Eur J Surg Oncol 2025 Jan;51(1):109359. Epub 2024 Nov 7 doi: 10.1016/j.ejso.2024.109359. PMID: 39531915
Comparison between laparoscopic and abdominal radical hysterectomy for cervical adenosquamous carcinoma at stage IA2 to IIA2: A multicenter retrospective study.
Teng X, Kang S, Li W, Ding H, Ling B, Zhu L, Wang D, Lang J, Liu P, Chen C
J Obstet Gynaecol Res 2023 Jun;49(6):1592-1610. Epub 2023 Mar 14 doi: 10.1111/jog.15633. PMID: 36919234
Prognostic value of the 2018 FIGO staging system for cervical cancer.
Mohamud A, Høgdall C, Schnack T
Gynecol Oncol 2022 Jun;165(3):506-513. Epub 2022 Mar 26 doi: 10.1016/j.ygyno.2022.02.017. PMID: 35346512
Carcinomatosis in Early-Stage Cervical Cancer Treated with Robotic Radical Hysterectomy: Recurrence Patterns, Risk Factors, and Survival.
Fitzsimmons CK, Stephens AJ, Kennard JA, Manyam M, Pepe JW, Ahmad S, McKenzie ND, Kendrick JE, Holloway RW
Ann Surg Oncol 2022 Mar;29(3):2006-2013. Epub 2021 Nov 10 doi: 10.1245/s10434-021-11052-4. PMID: 34757549
Comparison between laparoscopic and abdominal radical hysterectomy for low-risk cervical cancer: a multicentre retrospective study.
Li Z, Chen C, Liu P, Lu A, Zhao H, Zhan X, Duan H, Li P, Zhao W, Yao J, Li D, Jiang H, Liu M, Bin X, Lang J
Arch Gynecol Obstet 2022 Feb;305(2):449-458. Epub 2021 Aug 18 doi: 10.1007/s00404-021-06185-6. PMID: 34406459

Recent systematic reviews

Reproductive, obstetrical and oncological outcomes of fertility-sparing treatment for cervical cancer according to the FIGO 2018 staging system: A systematic review.
Taliento C, Scutiero G, Battello G, Sala A, Pellecchia G, Trozzi R, Arcieri M, Pavone M, Bizzarri N, Greco P, Driul L, Amant F, Fagotti A, Scambia G, Vizzielli G, Restaino S
Eur J Surg Oncol 2025 Jan;51(1):109359. Epub 2024 Nov 7 doi: 10.1016/j.ejso.2024.109359. PMID: 39531915

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