U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SHORT SLEEP, FAMILIAL NATURAL, 2(FNSS2)

MedGen UID:
1684839
Concept ID:
C5231420
Disease or Syndrome
Synonym: FNSS2
 
Gene (location): ADRB1 (10q25.3)
 
OMIM®: 618591

Definition

Individuals with familial natural short sleep-2 (FNSS2) have a sleep requirement of 4 to 6 hours per night (Shi et al., 2019). For a discussion of genetic heterogeneity of FNSS, see FNSS1 (612975). [from OMIM]

Clinical features

From HPO
Shortened sleep phase
MedGen UID:
1774915
Concept ID:
C5421580
Finding
A tendency to sleep fewer hours than usual while feeling well-rested.

Professional guidelines

PubMed

Bizaoui V, Michot C, Baujat G, Amouroux C, Baron S, Capri Y, Cohen-Solal M, Collet C, Dieux A, Geneviève D, Isidor B, Monnot S, Rossi M, Rothenbuhler A, Schaefer E, Cormier-Daire V
Clin Genet 2019 Oct;96(4):309-316. Epub 2019 Jun 25 doi: 10.1111/cge.13591. PMID: 31237352
Lehmann KJ, Nelson R, MacLellan D, Anderson P, Romao RLP
J Pediatr Urol 2018 Feb;14(1):53.e1-53.e8. Epub 2017 Sep 6 doi: 10.1016/j.jpurol.2017.07.016. PMID: 28986091
NIH Consens State Sci Statements 2005 Jun 13-15;22(2):1-30. PMID: 17308547

Recent clinical studies

Etiology

Cui Y, Li J, Li L, Zhao Q, Chen S, Xia L, Fu T, Ji J, Gu Z
Int J Rheum Dis 2020 Mar;23(3):367-373. Epub 2019 Nov 25 doi: 10.1111/1756-185X.13678. PMID: 31763772
Bizaoui V, Michot C, Baujat G, Amouroux C, Baron S, Capri Y, Cohen-Solal M, Collet C, Dieux A, Geneviève D, Isidor B, Monnot S, Rossi M, Rothenbuhler A, Schaefer E, Cormier-Daire V
Clin Genet 2019 Oct;96(4):309-316. Epub 2019 Jun 25 doi: 10.1111/cge.13591. PMID: 31237352
Lehmann KJ, Nelson R, MacLellan D, Anderson P, Romao RLP
J Pediatr Urol 2018 Feb;14(1):53.e1-53.e8. Epub 2017 Sep 6 doi: 10.1016/j.jpurol.2017.07.016. PMID: 28986091
Cooijmans KHM, Beijers R, Rovers AC, de Weerth C
BMC Pediatr 2017 Jul 6;17(1):154. doi: 10.1186/s12887-017-0906-9. PMID: 28683833Free PMC Article
Martinez SM, Tschann JM, Butte NF, Gregorich SE, Penilla C, Flores E, Greenspan LC, Pasch LA, Deardorff J
Sleep 2017 Feb 1;40(2) doi: 10.1093/sleep/zsw057. PMID: 28364488Free PMC Article

Diagnosis

Bizaoui V, Michot C, Baujat G, Amouroux C, Baron S, Capri Y, Cohen-Solal M, Collet C, Dieux A, Geneviève D, Isidor B, Monnot S, Rossi M, Rothenbuhler A, Schaefer E, Cormier-Daire V
Clin Genet 2019 Oct;96(4):309-316. Epub 2019 Jun 25 doi: 10.1111/cge.13591. PMID: 31237352
Lehmann KJ, Nelson R, MacLellan D, Anderson P, Romao RLP
J Pediatr Urol 2018 Feb;14(1):53.e1-53.e8. Epub 2017 Sep 6 doi: 10.1016/j.jpurol.2017.07.016. PMID: 28986091
Cooijmans KHM, Beijers R, Rovers AC, de Weerth C
BMC Pediatr 2017 Jul 6;17(1):154. doi: 10.1186/s12887-017-0906-9. PMID: 28683833Free PMC Article
Rychnovsky J, Hunter LP
Womens Health Issues 2009 Jan-Feb;19(1):38-44. doi: 10.1016/j.whi.2008.07.015. PMID: 19111786
NIH Consens State Sci Statements 2005 Jun 13-15;22(2):1-30. PMID: 17308547

Therapy

Li J, Hao Y, Tian D, He S, Sun X, Yang H
BMC Public Health 2019 Apr 3;19(1):373. doi: 10.1186/s12889-019-6712-6. PMID: 30943937Free PMC Article
Lehmann KJ, Nelson R, MacLellan D, Anderson P, Romao RLP
J Pediatr Urol 2018 Feb;14(1):53.e1-53.e8. Epub 2017 Sep 6 doi: 10.1016/j.jpurol.2017.07.016. PMID: 28986091
Cooijmans KHM, Beijers R, Rovers AC, de Weerth C
BMC Pediatr 2017 Jul 6;17(1):154. doi: 10.1186/s12887-017-0906-9. PMID: 28683833Free PMC Article
Martinez SM, Tschann JM, Butte NF, Gregorich SE, Penilla C, Flores E, Greenspan LC, Pasch LA, Deardorff J
Sleep 2017 Feb 1;40(2) doi: 10.1093/sleep/zsw057. PMID: 28364488Free PMC Article
NIH Consens State Sci Statements 2005 Jun 13-15;22(2):1-30. PMID: 17308547

Prognosis

Cui Y, Li J, Li L, Zhao Q, Chen S, Xia L, Fu T, Ji J, Gu Z
Int J Rheum Dis 2020 Mar;23(3):367-373. Epub 2019 Nov 25 doi: 10.1111/1756-185X.13678. PMID: 31763772
Bizaoui V, Michot C, Baujat G, Amouroux C, Baron S, Capri Y, Cohen-Solal M, Collet C, Dieux A, Geneviève D, Isidor B, Monnot S, Rossi M, Rothenbuhler A, Schaefer E, Cormier-Daire V
Clin Genet 2019 Oct;96(4):309-316. Epub 2019 Jun 25 doi: 10.1111/cge.13591. PMID: 31237352
Lehmann KJ, Nelson R, MacLellan D, Anderson P, Romao RLP
J Pediatr Urol 2018 Feb;14(1):53.e1-53.e8. Epub 2017 Sep 6 doi: 10.1016/j.jpurol.2017.07.016. PMID: 28986091
Cooijmans KHM, Beijers R, Rovers AC, de Weerth C
BMC Pediatr 2017 Jul 6;17(1):154. doi: 10.1186/s12887-017-0906-9. PMID: 28683833Free PMC Article
NIH Consens State Sci Statements 2005 Jun 13-15;22(2):1-30. PMID: 17308547

Clinical prediction guides

Qi X, Pan C, Yang J, Liu L, Hao J, Wen Y, Zhang N, Wei W, Cheng B, Cheng S, Zhang F
Sleep Health 2024 Aug;10(4):402-409. Epub 2024 May 21 doi: 10.1016/j.sleh.2024.03.003. PMID: 38772848
Solmi M, Estradé A, Thompson T, Agorastos A, Radua J, Cortese S, Dragioti E, Leisch F, Vancampfort D, Thygesen LC, Aschauer H, Schloegelhofer M, Akimova E, Schneeberger A, Huber CG, Hasler G, Conus P, Cuénod KQD, von Känel R, Arrondo G, Fusar-Poli P, Gorwood P, Llorca PM, Krebs MO, Scanferla E, Kishimoto T, Rabbani G, Skonieczna-Żydecka K, Brambilla P, Favaro A, Takamiya A, Zoccante L, Colizzi M, Bourgin J, Kamiński K, Moghadasin M, Seedat S, Matthews E, Wells J, Vassilopoulou E, Gadelha A, Su KP, Kwon JS, Kim M, Lee TY, Papsuev O, Manková D, Boscutti A, Gerunda C, Saccon D, Righi E, Monaco F, Croatto G, Cereda G, Demurtas J, Brondino N, Veronese N, Enrico P, Politi P, Ciappolino V, Pfennig A, Bechdolf A, Meyer-Lindenberg A, Kahl KG, Domschke K, Bauer M, Koutsouleris N, Winter S, Borgwardt S, Bitter I, Balazs J, Czobor P, Unoka Z, Mavridis D, Tsamakis K, Bozikas VP, Tunvirachaisakul C, Maes M, Rungnirundorn T, Supasitthumrong T, Haque A, Brunoni AR, Costardi CG, Schuch FB, Polanczyk G, Luiz JM, Fonseca L, Aparicio LV, Valvassori SS, Nordentoft M, Vendsborg P, Hoffmann SH, Sehli J, Sartorius N, Heuss S, Guinart D, Hamilton J, Kane J, Rubio J, Sand M, Koyanagi A, Solanes A, Andreu-Bernabeu A, Cáceres ASJ, Arango C, Díaz-Caneja CM, Hidalgo-Mazzei D, Vieta E, Gonzalez-Peñas J, Fortea L, Parellada M, Fullana MA, Verdolini N, Fárková E, Janků K, Millan M, Honciuc M, Moniuszko-Malinowska A, Łoniewski I, Samochowiec J, Kiszkiel Ł, Marlicz M, Sowa P, Marlicz W, Spies G, Stubbs B, Firth J, Sullivan S, Darcin AE, Aksu H, Dilbaz N, Noyan O, Kitazawa M, Kurokawa S, Tazawa Y, Anselmi A, Cracco C, Machado AI, Estrade N, De Leo D, Curtis J, Berk M, Ward P, Teasdale S, Rosenbaum S, Marx W, Horodnic AV, Oprea L, Alexinschi O, Ifteni P, Turliuc S, Ciuhodaru T, Bolos A, Matei V, Nieman DH, Sommer I, van Os J, van Amelsvoort T, Sun CF, Guu TW, Jiao C, Zhang J, Fan J, Zou L, Yu X, Chi X, de Timary P, van Winke R, Ng B, Pena E, Arellano R, Roman R, Sanchez T, Movina L, Morgado P, Brissos S, Aizberg O, Mosina A, Krinitski D, Mugisha J, Sadeghi-Bahmani D, Sadeghi M, Hadi S, Brand S, Errazuriz A, Crossley N, Ristic DI, López-Jaramillo C, Efthymiou D, Kuttichira P, Kallivayalil RA, Javed A, Afridi MI, James B, Seb-Akahomen OJ, Fiedorowicz J, Carvalho AF, Daskalakis J, Yatham LN, Yang L, Okasha T, Dahdouh A, Gerdle B, Tiihonen J, Shin JI, Lee J, Mhalla A, Gaha L, Brahim T, Altynbekov K, Negay N, Nurmagambetova S, Jamei YA, Weiser M, Correll CU
J Affect Disord 2022 Feb 15;299:393-407. Epub 2021 Jul 19 doi: 10.1016/j.jad.2021.07.048. PMID: 34949568Free PMC Article
Cui Y, Li J, Li L, Zhao Q, Chen S, Xia L, Fu T, Ji J, Gu Z
Int J Rheum Dis 2020 Mar;23(3):367-373. Epub 2019 Nov 25 doi: 10.1111/1756-185X.13678. PMID: 31763772
Li J, Hao Y, Tian D, He S, Sun X, Yang H
BMC Public Health 2019 Apr 3;19(1):373. doi: 10.1186/s12889-019-6712-6. PMID: 30943937Free PMC Article
Lehmann KJ, Nelson R, MacLellan D, Anderson P, Romao RLP
J Pediatr Urol 2018 Feb;14(1):53.e1-53.e8. Epub 2017 Sep 6 doi: 10.1016/j.jpurol.2017.07.016. PMID: 28986091

Recent systematic reviews

Lehmann KJ, Nelson R, MacLellan D, Anderson P, Romao RLP
J Pediatr Urol 2018 Feb;14(1):53.e1-53.e8. Epub 2017 Sep 6 doi: 10.1016/j.jpurol.2017.07.016. PMID: 28986091
NIH Consens State Sci Statements 2005 Jun 13-15;22(2):1-30. PMID: 17308547

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...