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Recurrent Chordoma

MedGen UID:
1670910
•Concept ID:
C4744483
•
Neoplastic Process

Definition

The reemergence of chordoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Chordoma

Professional guidelines

PubMed

Longitudinal treatment outcomes of recurrent clival chordomas: a single-center retrospective study.
Hong S, Mahajan A, Shinya Y, Laack NN, Link MJ, O'Brien EK, Stokken JK, Janus JR, Ho TP, Choby G, Van Gompel JJ
J Neurosurg 2024 Apr 1;140(4):920-928. Epub 2023 Oct 13 doi: 10.3171/2023.7.JNS231196. PMID: 37856417
Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group.
Stacchiotti S, Gronchi A, Fossati P, Akiyama T, Alapetite C, Baumann M, Blay JY, Bolle S, Boriani S, Bruzzi P, Capanna R, Caraceni A, Casadei R, Colia V, Debus J, Delaney T, Desai A, Dileo P, Dijkstra S, Doglietto F, Flanagan A, Froelich S, Gardner PA, Gelderblom H, Gokaslan ZL, Haas R, Heery C, Hindi N, Hohenberger P, Hornicek F, Imai R, Jeys L, Jones RL, Kasper B, Kawai A, Krengli M, Leithner A, Logowska I, Martin Broto J, Mazzatenta D, Morosi C, Nicolai P, Norum OJ, Patel S, Penel N, Picci P, Pilotti S, Radaelli S, Ricchini F, Rutkowski P, Scheipl S, Sen C, Tamborini E, Thornton KA, Timmermann B, Torri V, Tunn PU, Uhl M, Yamada Y, Weber DC, Vanel D, Varga PP, Vleggeert-Lankamp CLA, Casali PG, Sommer J
Ann Oncol 2017 Jun 1;28(6):1230-1242. doi: 10.1093/annonc/mdx054. PMID: 28184416Free PMC Article
Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.
Ailon T, Torabi R, Fisher CG, Rhines LD, Clarke MJ, Bettegowda C, Boriani S, Yamada YJ, Kawahara N, Varga PP, Shin JH, Saghal A, Gokaslan ZL
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S193-S198. doi: 10.1097/BRS.0000000000001812. PMID: 27753782Free PMC Article

Recent clinical studies

Etiology

Activity of pemetrexed in pre-clinical chordoma models and humans.
Kesari S, Wang F, Juarez T, Ashili S, Patro CPK, Carrillo J, Nguyen M, Truong J, Levy J, Sommer J, Freed DM, Xiu J, Takasumi Y, Bouffet E, Gill JM
Sci Rep 2023 May 5;13(1):7317. doi: 10.1038/s41598-023-34404-4. PMID: 37147496Free PMC Article
Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group.
Stacchiotti S, Gronchi A, Fossati P, Akiyama T, Alapetite C, Baumann M, Blay JY, Bolle S, Boriani S, Bruzzi P, Capanna R, Caraceni A, Casadei R, Colia V, Debus J, Delaney T, Desai A, Dileo P, Dijkstra S, Doglietto F, Flanagan A, Froelich S, Gardner PA, Gelderblom H, Gokaslan ZL, Haas R, Heery C, Hindi N, Hohenberger P, Hornicek F, Imai R, Jeys L, Jones RL, Kasper B, Kawai A, Krengli M, Leithner A, Logowska I, Martin Broto J, Mazzatenta D, Morosi C, Nicolai P, Norum OJ, Patel S, Penel N, Picci P, Pilotti S, Radaelli S, Ricchini F, Rutkowski P, Scheipl S, Sen C, Tamborini E, Thornton KA, Timmermann B, Torri V, Tunn PU, Uhl M, Yamada Y, Weber DC, Vanel D, Varga PP, Vleggeert-Lankamp CLA, Casali PG, Sommer J
Ann Oncol 2017 Jun 1;28(6):1230-1242. doi: 10.1093/annonc/mdx054. PMID: 28184416Free PMC Article
Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.
Ailon T, Torabi R, Fisher CG, Rhines LD, Clarke MJ, Bettegowda C, Boriani S, Yamada YJ, Kawahara N, Varga PP, Shin JH, Saghal A, Gokaslan ZL
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S193-S198. doi: 10.1097/BRS.0000000000001812. PMID: 27753782Free PMC Article
Multidisciplinary management of recurrent chordomas.
Yamada Y, Gounder M, Laufer I
Curr Treat Options Oncol 2013 Sep;14(3):442-53. doi: 10.1007/s11864-013-0247-3. PMID: 23860859
Propofol lipemia mimicking chyle leak during neck dissection.
Vokes DE, Linskey ME, Armstrong WB
Head Neck 2006 Dec;28(12):1147-9. doi: 10.1002/hed.20472. PMID: 16983690

Diagnosis

Longitudinal treatment outcomes of recurrent clival chordomas: a single-center retrospective study.
Hong S, Mahajan A, Shinya Y, Laack NN, Link MJ, O'Brien EK, Stokken JK, Janus JR, Ho TP, Choby G, Van Gompel JJ
J Neurosurg 2024 Apr 1;140(4):920-928. Epub 2023 Oct 13 doi: 10.3171/2023.7.JNS231196. PMID: 37856417
Diffuse skeletal muscle metastases from sacral chordoma.
Carey K, Bestic J, Attia S, Cortese C, Jain M
Skeletal Radiol 2014 Jul;43(7):985-9. Epub 2014 Jan 10 doi: 10.1007/s00256-013-1794-1. PMID: 24407557
Propofol lipemia mimicking chyle leak during neck dissection.
Vokes DE, Linskey ME, Armstrong WB
Head Neck 2006 Dec;28(12):1147-9. doi: 10.1002/hed.20472. PMID: 16983690
Computer aided tumor resection in the pelvis.
Krettek C, Geerling J, Bastian L, Citak M, Rücker F, Kendoff D, Hüfner T
Injury 2004 Jun;35 Suppl 1:S-A79-83. doi: 10.1016/j.injury.2004.05.014. PMID: 15183707
Recurrence of clival chordoma along the surgical pathway.
Fischbein NJ, Kaplan MJ, Holliday RA, Dillon WP
AJNR Am J Neuroradiol 2000 Mar;21(3):578-83. PMID: 10730655Free PMC Article

Therapy

Activity of pemetrexed in pre-clinical chordoma models and humans.
Kesari S, Wang F, Juarez T, Ashili S, Patro CPK, Carrillo J, Nguyen M, Truong J, Levy J, Sommer J, Freed DM, Xiu J, Takasumi Y, Bouffet E, Gill JM
Sci Rep 2023 May 5;13(1):7317. doi: 10.1038/s41598-023-34404-4. PMID: 37147496Free PMC Article
Immune Checkpoint Inhibitors Have Clinical Activity in Patients With Recurrent Chordoma.
Bishop AJ, Amini B, Lin H, Raza SM, Patel S, Grosshans DR, Ghia A, Farooqi A, Guadagnolo BA, Mitra D, Akdemir KC, Lazar AJ, Wang WL, Alvarez-Breckenridge C, Bird J, Rhines LD, Somaiah N, Conley AP
J Immunother 2022 Oct 1;45(8):374-378. Epub 2022 Aug 4 doi: 10.1097/CJI.0000000000000431. PMID: 35943386Free PMC Article
Outcomes, Prognostic Factors and Salvage Treatment for Recurrent Chordoma After Pencil Beam Scanning Proton Therapy at the Paul Scherrer Institute.
Beer J, Kountouri M, Kole AJ, Murray FR, Leiser D, Kliebsch U, Combescure C, Pica A, Bachtiary B, Bolsi A, Lomax AJ, Walser M, Weber DC
Clin Oncol (R Coll Radiol) 2020 Aug;32(8):537-544. Epub 2020 Mar 26 doi: 10.1016/j.clon.2020.03.002. PMID: 32222414
Safety and Local Control of Radiation Therapy for Chordoma of the Spine and Sacrum: A Systematic Review.
Pennicooke B, Laufer I, Sahgal A, Varga PP, Gokaslan ZL, Bilsky MH, Yamada YJ
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S186-S192. doi: 10.1097/BRS.0000000000001831. PMID: 27509195Free PMC Article
Proton therapy for reirradiation of progressive or recurrent chordoma.
McDonald MW, Linton OR, Shah MV
Int J Radiat Oncol Biol Phys 2013 Dec 1;87(5):1107-14. doi: 10.1016/j.ijrobp.2013.09.038. PMID: 24267972

Prognosis

Longitudinal treatment outcomes of recurrent clival chordomas: a single-center retrospective study.
Hong S, Mahajan A, Shinya Y, Laack NN, Link MJ, O'Brien EK, Stokken JK, Janus JR, Ho TP, Choby G, Van Gompel JJ
J Neurosurg 2024 Apr 1;140(4):920-928. Epub 2023 Oct 13 doi: 10.3171/2023.7.JNS231196. PMID: 37856417
Activity of pemetrexed in pre-clinical chordoma models and humans.
Kesari S, Wang F, Juarez T, Ashili S, Patro CPK, Carrillo J, Nguyen M, Truong J, Levy J, Sommer J, Freed DM, Xiu J, Takasumi Y, Bouffet E, Gill JM
Sci Rep 2023 May 5;13(1):7317. doi: 10.1038/s41598-023-34404-4. PMID: 37147496Free PMC Article
Loss of SMARCB1 promotes autophagy and facilitates tumour progression in chordoma by transcriptionally activating ATG5.
Li M, Shen Y, Xiong Y, Wang S, Li C, Bai J, Zhang Y
Cell Prolif 2021 Dec;54(12):e13136. Epub 2021 Oct 20 doi: 10.1111/cpr.13136. PMID: 34668612Free PMC Article
Outcomes, Prognostic Factors and Salvage Treatment for Recurrent Chordoma After Pencil Beam Scanning Proton Therapy at the Paul Scherrer Institute.
Beer J, Kountouri M, Kole AJ, Murray FR, Leiser D, Kliebsch U, Combescure C, Pica A, Bachtiary B, Bolsi A, Lomax AJ, Walser M, Weber DC
Clin Oncol (R Coll Radiol) 2020 Aug;32(8):537-544. Epub 2020 Mar 26 doi: 10.1016/j.clon.2020.03.002. PMID: 32222414
MTNR1B loss promotes chordoma recurrence by abrogating melatonin-mediated β-catenin signaling repression.
Liu L, Wang T, Yang X, Xu C, Liao Z, Wang X, Su D, Li Y, Zhou H, Qiu X, Chen Y, Huang D, Lian C, Su P
J Pineal Res 2019 Sep;67(2):e12588. Epub 2019 Jun 28 doi: 10.1111/jpi.12588. PMID: 31140197

Clinical prediction guides

Activity of pemetrexed in pre-clinical chordoma models and humans.
Kesari S, Wang F, Juarez T, Ashili S, Patro CPK, Carrillo J, Nguyen M, Truong J, Levy J, Sommer J, Freed DM, Xiu J, Takasumi Y, Bouffet E, Gill JM
Sci Rep 2023 May 5;13(1):7317. doi: 10.1038/s41598-023-34404-4. PMID: 37147496Free PMC Article
Immune Checkpoint Inhibitors Have Clinical Activity in Patients With Recurrent Chordoma.
Bishop AJ, Amini B, Lin H, Raza SM, Patel S, Grosshans DR, Ghia A, Farooqi A, Guadagnolo BA, Mitra D, Akdemir KC, Lazar AJ, Wang WL, Alvarez-Breckenridge C, Bird J, Rhines LD, Somaiah N, Conley AP
J Immunother 2022 Oct 1;45(8):374-378. Epub 2022 Aug 4 doi: 10.1097/CJI.0000000000000431. PMID: 35943386Free PMC Article
Loss of SMARCB1 promotes autophagy and facilitates tumour progression in chordoma by transcriptionally activating ATG5.
Li M, Shen Y, Xiong Y, Wang S, Li C, Bai J, Zhang Y
Cell Prolif 2021 Dec;54(12):e13136. Epub 2021 Oct 20 doi: 10.1111/cpr.13136. PMID: 34668612Free PMC Article
MTNR1B loss promotes chordoma recurrence by abrogating melatonin-mediated β-catenin signaling repression.
Liu L, Wang T, Yang X, Xu C, Liao Z, Wang X, Su D, Li Y, Zhou H, Qiu X, Chen Y, Huang D, Lian C, Su P
J Pineal Res 2019 Sep;67(2):e12588. Epub 2019 Jun 28 doi: 10.1111/jpi.12588. PMID: 31140197
Propofol lipemia mimicking chyle leak during neck dissection.
Vokes DE, Linskey ME, Armstrong WB
Head Neck 2006 Dec;28(12):1147-9. doi: 10.1002/hed.20472. PMID: 16983690

Recent systematic reviews

Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.
Ailon T, Torabi R, Fisher CG, Rhines LD, Clarke MJ, Bettegowda C, Boriani S, Yamada YJ, Kawahara N, Varga PP, Shin JH, Saghal A, Gokaslan ZL
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S193-S198. doi: 10.1097/BRS.0000000000001812. PMID: 27753782Free PMC Article
Safety and Local Control of Radiation Therapy for Chordoma of the Spine and Sacrum: A Systematic Review.
Pennicooke B, Laufer I, Sahgal A, Varga PP, Gokaslan ZL, Bilsky MH, Yamada YJ
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S186-S192. doi: 10.1097/BRS.0000000000001831. PMID: 27509195Free PMC Article

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