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Recurrent Dedifferentiated Chordoma

MedGen UID:
1695315
•Concept ID:
C5206776
•
Neoplastic Process

Definition

The reemergence of dedifferentiated chordoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Dedifferentiated Chordoma

Professional guidelines

PubMed

Chordoma: Genetics and Contemporary Management.
Desai R, Pelargos PE, Dunn IF
Int J Mol Sci 2024 May 28;25(11) doi: 10.3390/ijms25115877. PMID: 38892063Free PMC Article
Treatment of dedifferentiated chordoma: a retrospective study from a large volume cancer center.
Nachwalter RN, Rothrock RJ, Katsoulakis E, Gounder MM, Boland PJ, Bilsky MH, Laufer I, Schmitt AM, Yamada Y, Higginson DS
J Neurooncol 2019 Sep;144(2):369-376. Epub 2019 Jul 23 doi: 10.1007/s11060-019-03239-3. PMID: 31338785Free PMC Article
Surgical Treatment of Sacral Chordoma: En Bloc Resection with Negative Margins is a Determinant of the Long-Term Outcome.
Colangeli S, Muratori F, Bettini L, Frenos F, Totti F, D'Arienzo A, Campo FR, Scoccianti G, Beltrami G, Campanacci DA, Capanna R
Surg Technol Int 2018 Nov 11;33:343-348. PMID: 30204925

Recent clinical studies

Etiology

Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes.
Denu RA, Yang RK, Lazar AJ, Patel SS, Lewis VO, Roszik J, Livingston JA, Wang WL, Shaw KR, Ratan R, Zarzour MA, Bird J, Raza S, Akdemir KC, Rodon Ahnert J, Subbiah V, Patel S, Conley AP
Clin Cancer Res 2023 Dec 1;29(23):4844-4852. doi: 10.1158/1078-0432.CCR-23-1703. PMID: 37747813Free PMC Article
Local Control After Proton Therapy for Pediatric Chordoma.
Indelicato DJ, Rotondo RL, Mailhot Vega RB, Holtzman AL, Looi WS, Morris CG, Sandler ES, Aldana PR, Bradley JA
Int J Radiat Oncol Biol Phys 2021 Apr 1;109(5):1406-1413. Epub 2020 Nov 27 doi: 10.1016/j.ijrobp.2020.11.051. PMID: 33253819
Treatment of dedifferentiated chordoma: a retrospective study from a large volume cancer center.
Nachwalter RN, Rothrock RJ, Katsoulakis E, Gounder MM, Boland PJ, Bilsky MH, Laufer I, Schmitt AM, Yamada Y, Higginson DS
J Neurooncol 2019 Sep;144(2):369-376. Epub 2019 Jul 23 doi: 10.1007/s11060-019-03239-3. PMID: 31338785Free PMC Article
Chordoma: a systematic review of the epidemiology and clinical prognostic factors predicting progression-free and overall survival.
Bakker SH, Jacobs WCH, Pondaag W, Gelderblom H, Nout RA, Dijkstra PDS, Peul WC, Vleggeert-Lankamp CLA
Eur Spine J 2018 Dec;27(12):3043-3058. Epub 2018 Sep 15 doi: 10.1007/s00586-018-5764-0. PMID: 30220042
A review of the surgical management of sacral chordoma.
Kayani B, Hanna SA, Sewell MD, Saifuddin A, Molloy S, Briggs TW
Eur J Surg Oncol 2014 Nov;40(11):1412-20. Epub 2014 Apr 25 doi: 10.1016/j.ejso.2014.04.008. PMID: 24793103

Diagnosis

Chordoma: Genetics and Contemporary Management.
Desai R, Pelargos PE, Dunn IF
Int J Mol Sci 2024 May 28;25(11) doi: 10.3390/ijms25115877. PMID: 38892063Free PMC Article
Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes.
Denu RA, Yang RK, Lazar AJ, Patel SS, Lewis VO, Roszik J, Livingston JA, Wang WL, Shaw KR, Ratan R, Zarzour MA, Bird J, Raza S, Akdemir KC, Rodon Ahnert J, Subbiah V, Patel S, Conley AP
Clin Cancer Res 2023 Dec 1;29(23):4844-4852. doi: 10.1158/1078-0432.CCR-23-1703. PMID: 37747813Free PMC Article
Chordoma.
Ulici V, Hart J
Arch Pathol Lab Med 2022 Mar 1;146(3):386-395. doi: 10.5858/arpa.2020-0258-RA. PMID: 34319396
Skull Base Chordomas and Chondrosarcomas.
Kremenevski N, Schlaffer SM, Coras R, Kinfe TM, Graillon T, Buchfelder M
Neuroendocrinology 2020;110(9-10):836-847. Epub 2020 Jun 15 doi: 10.1159/000509386. PMID: 32541136
Dedifferentiated Chordoma: Clinicopathologic and Molecular Characteristics With Integrative Analysis.
Hung YP, Diaz-Perez JA, Cote GM, Wejde J, Schwab JH, Nardi V, Chebib IA, Deshpande V, Selig MK, Bredella MA, Rosenberg AE, Nielsen GP
Am J Surg Pathol 2020 Sep;44(9):1213-1223. doi: 10.1097/PAS.0000000000001501. PMID: 32427623

Therapy

Local Control After Proton Therapy for Pediatric Chordoma.
Indelicato DJ, Rotondo RL, Mailhot Vega RB, Holtzman AL, Looi WS, Morris CG, Sandler ES, Aldana PR, Bradley JA
Int J Radiat Oncol Biol Phys 2021 Apr 1;109(5):1406-1413. Epub 2020 Nov 27 doi: 10.1016/j.ijrobp.2020.11.051. PMID: 33253819
Dedifferentiated chordoma arising in irradiated sacral chordoma.
Ikeda H, Honjo J, Sakurai H, Mitsuhashi N, Fukuda T, Niibe H
Radiat Med 1997 Mar-Apr;15(2):109-11. PMID: 9192436
Dedifferentiated chordoma. Response to aggressive chemotherapy in two cases.
Fleming GF, Heimann PS, Stephens JK, Simon MA, Ferguson MK, Benjamin RS, Samuels BL
Cancer 1993 Aug 1;72(3):714-8. doi: 10.1002/1097-0142(19930801)72:3<714::aid-cncr2820720314>3.0.co;2-1. PMID: 8334623

Prognosis

Chordoma: Genetics and Contemporary Management.
Desai R, Pelargos PE, Dunn IF
Int J Mol Sci 2024 May 28;25(11) doi: 10.3390/ijms25115877. PMID: 38892063Free PMC Article
Chordoma.
Ulici V, Hart J
Arch Pathol Lab Med 2022 Mar 1;146(3):386-395. doi: 10.5858/arpa.2020-0258-RA. PMID: 34319396
Skull Base Chordomas and Chondrosarcomas.
Kremenevski N, Schlaffer SM, Coras R, Kinfe TM, Graillon T, Buchfelder M
Neuroendocrinology 2020;110(9-10):836-847. Epub 2020 Jun 15 doi: 10.1159/000509386. PMID: 32541136
Chordoma: a systematic review of the epidemiology and clinical prognostic factors predicting progression-free and overall survival.
Bakker SH, Jacobs WCH, Pondaag W, Gelderblom H, Nout RA, Dijkstra PDS, Peul WC, Vleggeert-Lankamp CLA
Eur Spine J 2018 Dec;27(12):3043-3058. Epub 2018 Sep 15 doi: 10.1007/s00586-018-5764-0. PMID: 30220042
A review of the surgical management of sacral chordoma.
Kayani B, Hanna SA, Sewell MD, Saifuddin A, Molloy S, Briggs TW
Eur J Surg Oncol 2014 Nov;40(11):1412-20. Epub 2014 Apr 25 doi: 10.1016/j.ejso.2014.04.008. PMID: 24793103

Clinical prediction guides

Local Control After Proton Therapy for Pediatric Chordoma.
Indelicato DJ, Rotondo RL, Mailhot Vega RB, Holtzman AL, Looi WS, Morris CG, Sandler ES, Aldana PR, Bradley JA
Int J Radiat Oncol Biol Phys 2021 Apr 1;109(5):1406-1413. Epub 2020 Nov 27 doi: 10.1016/j.ijrobp.2020.11.051. PMID: 33253819
Chordomas: A review with emphasis on their pathophysiology, pathology, molecular biology, and genetics.
Karpathiou G, Dumollard JM, Dridi M, Dal Col P, Barral FG, Boutonnat J, Peoc'h M
Pathol Res Pract 2020 Sep;216(9):153089. Epub 2020 Jun 29 doi: 10.1016/j.prp.2020.153089. PMID: 32825957
Chordoma: a systematic review of the epidemiology and clinical prognostic factors predicting progression-free and overall survival.
Bakker SH, Jacobs WCH, Pondaag W, Gelderblom H, Nout RA, Dijkstra PDS, Peul WC, Vleggeert-Lankamp CLA
Eur Spine J 2018 Dec;27(12):3043-3058. Epub 2018 Sep 15 doi: 10.1007/s00586-018-5764-0. PMID: 30220042
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients.
Zhou J, Sun J, Bai HX, Huang X, Zou Y, Tan X, Zhang Z, Tang X, Tao Y, Xiao B, Zhang PJ, Yang L
Neurosurgery 2017 Nov 1;81(5):812-823. doi: 10.1093/neuros/nyx081. PMID: 28368502
Clinical features and prognostic factors of patients with chordoma in the spine: a retrospective analysis of 153 patients in a single center.
Meng T, Yin H, Li B, Li Z, Xu W, Zhou W, Cheng M, Wang J, Zhou L, Yang X, Liu T, Yan W, Song D, Xiao J
Neuro Oncol 2015 May;17(5):725-32. Epub 2014 Dec 8 doi: 10.1093/neuonc/nou331. PMID: 25488908Free PMC Article

Recent systematic reviews

Chordoma: a systematic review of the epidemiology and clinical prognostic factors predicting progression-free and overall survival.
Bakker SH, Jacobs WCH, Pondaag W, Gelderblom H, Nout RA, Dijkstra PDS, Peul WC, Vleggeert-Lankamp CLA
Eur Spine J 2018 Dec;27(12):3043-3058. Epub 2018 Sep 15 doi: 10.1007/s00586-018-5764-0. PMID: 30220042

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