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Refractory Acute Leukemia

MedGen UID:
1662593
Concept ID:
C4725027
Neoplastic Process

Definition

Acute leukemia that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Marit G, Cony P, Duclos F, Puntous M, Broustet A, Reiffers J
Haematol Blood Transfus 1990;33:614-8. doi: 10.1007/978-3-642-74643-7_112. PMID: 2323662
Liu MC, Chen YC, Tsay W, Shen MC, Wang CH, Liu CH
Taiwan Yi Xue Hui Za Zhi 1987 Jun;86(6):628-33. PMID: 3655707
Kramer BS, Appelbaum FR, Herzig GP, Graw RG Jr, Levine AS
Cancer Treat Rep 1977 Oct;61(7):1397-8. PMID: 271045

Recent clinical studies

Etiology

Dai Y, Luo L, Wei Z, Cheng P, Luo J, Li J
Ann Hematol 2024 Oct;103(10):4057-4063. Epub 2024 Jul 24 doi: 10.1007/s00277-024-05892-9. PMID: 39046511Free PMC Article
Nath K, Lee J, Elko TA, Levy L, Preston E, Devlin SM, Ponce DM, Lin RJ, Shaffer BC, Cho C, Politikos I, Jakubowski AA, Park JH, Rampal R, Perales MA, Tallman MS, Barker JN, Berman E, Tamari R, Stein E, Giralt SA, Gyurkocza B
Am J Hematol 2023 Dec;98(12):1869-1876. Epub 2023 Sep 9 doi: 10.1002/ajh.27084. PMID: 37688521Free PMC Article
Moiseev I, Bondarenko S, Morozova E, Vlasova Y, Dotsenko A, Epifanovskaya O, Babenko E, Botina A, Baykov V, Surkova E, Lapin S, Beynarovich A, Borzenkova E, Golosgchapov O, Kanunnikov M, Kudyasheva O, Ovechkina V, Pirogova O, Porunova V, Rudakova T, Smikova O, Smirnova A, Afansyev B
Transplant Cell Ther 2021 Jul;27(7):601.e1-601.e7. Epub 2021 May 7 doi: 10.1016/j.jtct.2021.03.032. PMID: 33845259
Willemze R, Archimbaud E, Muus P
Leukemia 1993 May;7 Suppl 1:49-50. PMID: 7683357
Fülle HH, Hellriegel KP
Onkologie 1986 Jun;9(3):152-3. doi: 10.1159/000215992. PMID: 3528962

Diagnosis

Di Mambro A, Arroyo-Berdugo Y, Fioretti T, Randles M, Cozzuto L, Rajeeve V, Cevenini A, Austin MJ, Esposito G, Ponomarenko J, Lucas CM, Cutillas P, Gribben J, Williams O, Calle Y, Patel B, Esposito MT
Oncogene 2023 Dec;42(50):3670-3683. Epub 2023 Oct 27 doi: 10.1038/s41388-023-02840-1. PMID: 37891368Free PMC Article
Nath K, Lee J, Elko TA, Levy L, Preston E, Devlin SM, Ponce DM, Lin RJ, Shaffer BC, Cho C, Politikos I, Jakubowski AA, Park JH, Rampal R, Perales MA, Tallman MS, Barker JN, Berman E, Tamari R, Stein E, Giralt SA, Gyurkocza B
Am J Hematol 2023 Dec;98(12):1869-1876. Epub 2023 Sep 9 doi: 10.1002/ajh.27084. PMID: 37688521Free PMC Article
Sun Q, Wu B, Meng F, Yao Q, Huang Z, Xu J, Zhu Z
Hematology 2023 Dec;28(1):2204620. doi: 10.1080/16078454.2023.2204620. PMID: 37199372
Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S
Mod Pathol 2018 Jul;31(7):1141-1154. Epub 2018 Feb 14 doi: 10.1038/s41379-018-0014-x. PMID: 29449681
Seiter K, Katragadda S, Ponce D, Rasul M, Ahmed N
J Hematol Oncol 2009 May 22;2:21. doi: 10.1186/1756-8722-2-21. PMID: 19463179Free PMC Article

Therapy

Issa GC, Aldoss I, Thirman MJ, DiPersio J, Arellano M, Blachly JS, Mannis GN, Perl A, Dickens DS, McMahon CM, Traer E, Zwaan CM, Grove CS, Stone R, Shami PJ, Mantzaris I, Greenwood M, Shukla N, Cuglievan B, Kovacsovics T, Gu Y, Bagley RG, Madigan K, Chudnovsky Y, Nguyen HV, McNeer N, Stein EM
J Clin Oncol 2025 Jan;43(1):75-84. Epub 2024 Aug 9 doi: 10.1200/JCO.24.00826. PMID: 39121437Free PMC Article
Dai Y, Luo L, Wei Z, Cheng P, Luo J, Li J
Ann Hematol 2024 Oct;103(10):4057-4063. Epub 2024 Jul 24 doi: 10.1007/s00277-024-05892-9. PMID: 39046511Free PMC Article
Kwon MC, Thuring JW, Querolle O, Dai X, Verhulst T, Pande V, Marien A, Goffin D, Wenge DV, Yue H, Cutler JA, Jin C, Perner F, Hogeling SM, Shaffer PL, Jacobs F, Vinken P, Cai W, Keersmaekers V, Eyassu F, Bhogal B, Verstraeten K, El Ashkar S, Perry JA, Jayaguru P, Barreyro L, Kuchnio A, Darville N, Krosky D, Urbanietz G, Verbist B, Edwards JP, Cowley GS, Kirkpatrick R, Steele R, Ferrante L, Guttke C, Daskalakis N, Pietsch EC, Wilson DM, Attar R, Elsayed Y, Fischer ES, Schuringa JJ, Armstrong SA, Packman K, Philippar U
Blood 2024 Sep 12;144(11):1206-1220. doi: 10.1182/blood.2023022480. PMID: 38905635Free PMC Article
Di Mambro A, Arroyo-Berdugo Y, Fioretti T, Randles M, Cozzuto L, Rajeeve V, Cevenini A, Austin MJ, Esposito G, Ponomarenko J, Lucas CM, Cutillas P, Gribben J, Williams O, Calle Y, Patel B, Esposito MT
Oncogene 2023 Dec;42(50):3670-3683. Epub 2023 Oct 27 doi: 10.1038/s41388-023-02840-1. PMID: 37891368Free PMC Article
Habringer S, Lapa C, Herhaus P, Schottelius M, Istvanffy R, Steiger K, Slotta-Huspenina J, Schirbel A, Hänscheid H, Kircher S, Buck AK, Götze K, Vick B, Jeremias I, Schwaiger M, Peschel C, Oostendorp R, Wester HJ, Grigoleit GU, Keller U
Theranostics 2018;8(2):369-383. Epub 2018 Jan 1 doi: 10.7150/thno.21397. PMID: 29290814Free PMC Article

Prognosis

Issa GC, Aldoss I, Thirman MJ, DiPersio J, Arellano M, Blachly JS, Mannis GN, Perl A, Dickens DS, McMahon CM, Traer E, Zwaan CM, Grove CS, Stone R, Shami PJ, Mantzaris I, Greenwood M, Shukla N, Cuglievan B, Kovacsovics T, Gu Y, Bagley RG, Madigan K, Chudnovsky Y, Nguyen HV, McNeer N, Stein EM
J Clin Oncol 2025 Jan;43(1):75-84. Epub 2024 Aug 9 doi: 10.1200/JCO.24.00826. PMID: 39121437Free PMC Article
Dai Y, Luo L, Wei Z, Cheng P, Luo J, Li J
Ann Hematol 2024 Oct;103(10):4057-4063. Epub 2024 Jul 24 doi: 10.1007/s00277-024-05892-9. PMID: 39046511Free PMC Article
Di Mambro A, Arroyo-Berdugo Y, Fioretti T, Randles M, Cozzuto L, Rajeeve V, Cevenini A, Austin MJ, Esposito G, Ponomarenko J, Lucas CM, Cutillas P, Gribben J, Williams O, Calle Y, Patel B, Esposito MT
Oncogene 2023 Dec;42(50):3670-3683. Epub 2023 Oct 27 doi: 10.1038/s41388-023-02840-1. PMID: 37891368Free PMC Article
Ogasawara M, Miyashita M, Yamagishi Y, Ota S
Ther Apher Dial 2022 Jun;26(3):537-547. Epub 2022 Mar 10 doi: 10.1111/1744-9987.13828. PMID: 35249263
Fülle HH, Hellriegel KP
Onkologie 1986 Jun;9(3):152-3. doi: 10.1159/000215992. PMID: 3528962

Clinical prediction guides

Issa GC, Aldoss I, Thirman MJ, DiPersio J, Arellano M, Blachly JS, Mannis GN, Perl A, Dickens DS, McMahon CM, Traer E, Zwaan CM, Grove CS, Stone R, Shami PJ, Mantzaris I, Greenwood M, Shukla N, Cuglievan B, Kovacsovics T, Gu Y, Bagley RG, Madigan K, Chudnovsky Y, Nguyen HV, McNeer N, Stein EM
J Clin Oncol 2025 Jan;43(1):75-84. Epub 2024 Aug 9 doi: 10.1200/JCO.24.00826. PMID: 39121437Free PMC Article
Dai Y, Luo L, Wei Z, Cheng P, Luo J, Li J
Ann Hematol 2024 Oct;103(10):4057-4063. Epub 2024 Jul 24 doi: 10.1007/s00277-024-05892-9. PMID: 39046511Free PMC Article
Chen Z, Xue Q, Yao S
Mini Rev Med Chem 2023;23(7):787-803. doi: 10.2174/1389557523666221216095821. PMID: 36529918
Ogasawara M, Miyashita M, Yamagishi Y, Ota S
Ther Apher Dial 2022 Jun;26(3):537-547. Epub 2022 Mar 10 doi: 10.1111/1744-9987.13828. PMID: 35249263
Grupp SA, Kalos M, Barrett D, Aplenc R, Porter DL, Rheingold SR, Teachey DT, Chew A, Hauck B, Wright JF, Milone MC, Levine BL, June CH
N Engl J Med 2013 Apr 18;368(16):1509-1518. Epub 2013 Mar 25 doi: 10.1056/NEJMoa1215134. PMID: 23527958Free PMC Article

Recent systematic reviews

Soliman R, Heneghan C, Bolous NS, Sidhom I, Ahmed S, Roberts N, Oke J, Elhaddad A
Expert Rev Hematol 2022 Apr;15(4):345-357. Epub 2022 May 4 doi: 10.1080/17474086.2022.2069096. PMID: 35485262

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