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Refractory Childhood Acute Lymphoblastic Leukemia

MedGen UID:
889646
Concept ID:
C4054085
Neoplastic Process

Definition

Acute lymphoblastic leukemia that occurs in childhood and does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Childhood Acute Lymphoblastic Leukemia

Professional guidelines

PubMed

Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Brown P, Inaba H, Annesley C, Beck J, Colace S, Dallas M, DeSantes K, Kelly K, Kitko C, Lacayo N, Larrier N, Maese L, Mahadeo K, Nanda R, Nardi V, Rodriguez V, Rossoff J, Schuettpelz L, Silverman L, Sun J, Sun W, Teachey D, Wong V, Yanik G, Johnson-Chilla A, Ogba N
J Natl Compr Canc Netw 2020 Jan;18(1):81-112. doi: 10.6004/jnccn.2020.0001. PMID: 31910389
Gregory S
Semin Oncol Nurs 2019 Dec;35(6):150951. Epub 2019 Nov 20 doi: 10.1016/j.soncn.2019.150951. PMID: 31759820

Recent clinical studies

Etiology

Tran TH, Hunger SP
Semin Cancer Biol 2022 Sep;84:144-152. Epub 2020 Nov 13 doi: 10.1016/j.semcancer.2020.10.013. PMID: 33197607
Brown PA, Ji L, Xu X, Devidas M, Hogan LE, Borowitz MJ, Raetz EA, Zugmaier G, Sharon E, Bernhardt MB, Terezakis SA, Gore L, Whitlock JA, Pulsipher MA, Hunger SP, Loh ML
JAMA 2021 Mar 2;325(9):833-842. doi: 10.1001/jama.2021.0669. PMID: 33651090Free PMC Article
DeAngelo DJ, Jabbour E, Advani A
Am Soc Clin Oncol Educ Book 2020 May;40:330-342. doi: 10.1200/EDBK_280175. PMID: 32421447
Malard F, Mohty M
Lancet 2020 Apr 4;395(10230):1146-1162. doi: 10.1016/S0140-6736(19)33018-1. PMID: 32247396
Inaba H, Pui CH
Cancer Metastasis Rev 2019 Dec;38(4):595-610. doi: 10.1007/s10555-019-09834-0. PMID: 31811553Free PMC Article

Diagnosis

Si Lim SJ, Ford JB, Hermiston ML
Blood 2023 Jun 22;141(25):3019-3030. doi: 10.1182/blood.2022016503. PMID: 37018730
Kopmar NE, Cassaday RD
Blood 2023 Mar 23;141(12):1379-1388. doi: 10.1182/blood.2022017035. PMID: 36548957Free PMC Article
Jabbour E, Short NJ, Jain N, Huang X, Montalban-Bravo G, Banerjee P, Rezvani K, Jiang X, Kim KH, Kanagal-Shamanna R, Khoury JD, Patel K, Kadia TM, Daver N, Chien K, Alvarado Y, Garcia-Manero G, Issa GC, Haddad FG, Kwari M, Thankachan J, Delumpa R, Macaron W, Garris R, Konopleva M, Ravandi F, Kantarjian H
Lancet Haematol 2023 Jan;10(1):e24-e34. Epub 2022 Nov 16 doi: 10.1016/S2352-3026(22)00319-2. PMID: 36402146
Tran TH, Hunger SP
Semin Cancer Biol 2022 Sep;84:144-152. Epub 2020 Nov 13 doi: 10.1016/j.semcancer.2020.10.013. PMID: 33197607
Malard F, Mohty M
Lancet 2020 Apr 4;395(10230):1146-1162. doi: 10.1016/S0140-6736(19)33018-1. PMID: 32247396

Therapy

Laetsch TW, Maude SL, Rives S, Hiramatsu H, Bittencourt H, Bader P, Baruchel A, Boyer M, De Moerloose B, Qayed M, Buechner J, Pulsipher MA, Myers GD, Stefanski HE, Martin PL, Nemecek E, Peters C, Yanik G, Khaw SL, Davis KL, Krueger J, Balduzzi A, Boissel N, Tiwari R, O'Donovan D, Grupp SA
J Clin Oncol 2023 Mar 20;41(9):1664-1669. Epub 2022 Nov 18 doi: 10.1200/JCO.22.00642. PMID: 36399695Free PMC Article
Brown PA, Ji L, Xu X, Devidas M, Hogan LE, Borowitz MJ, Raetz EA, Zugmaier G, Sharon E, Bernhardt MB, Terezakis SA, Gore L, Whitlock JA, Pulsipher MA, Hunger SP, Loh ML
JAMA 2021 Mar 2;325(9):833-842. doi: 10.1001/jama.2021.0669. PMID: 33651090Free PMC Article
Inaba H, Pui CH
Cancer Metastasis Rev 2019 Dec;38(4):595-610. doi: 10.1007/s10555-019-09834-0. PMID: 31811553Free PMC Article
Maude SL, Laetsch TW, Buechner J, Rives S, Boyer M, Bittencourt H, Bader P, Verneris MR, Stefanski HE, Myers GD, Qayed M, De Moerloose B, Hiramatsu H, Schlis K, Davis KL, Martin PL, Nemecek ER, Yanik GA, Peters C, Baruchel A, Boissel N, Mechinaud F, Balduzzi A, Krueger J, June CH, Levine BL, Wood P, Taran T, Leung M, Mueller KT, Zhang Y, Sen K, Lebwohl D, Pulsipher MA, Grupp SA
N Engl J Med 2018 Feb 1;378(5):439-448. doi: 10.1056/NEJMoa1709866. PMID: 29385370Free PMC Article
Kantarjian HM, DeAngelo DJ, Stelljes M, Martinelli G, Liedtke M, Stock W, Gökbuget N, O'Brien S, Wang K, Wang T, Paccagnella ML, Sleight B, Vandendries E, Advani AS
N Engl J Med 2016 Aug 25;375(8):740-53. Epub 2016 Jun 12 doi: 10.1056/NEJMoa1509277. PMID: 27292104Free PMC Article

Prognosis

Tran TH, Hunger SP
Semin Cancer Biol 2022 Sep;84:144-152. Epub 2020 Nov 13 doi: 10.1016/j.semcancer.2020.10.013. PMID: 33197607
Locatelli F, Zugmaier G, Rizzari C, Morris JD, Gruhn B, Klingebiel T, Parasole R, Linderkamp C, Flotho C, Petit A, Micalizzi C, Mergen N, Mohammad A, Kormany WN, Eckert C, Möricke A, Sartor M, Hrusak O, Peters C, Saha V, Vinti L, von Stackelberg A
JAMA 2021 Mar 2;325(9):843-854. doi: 10.1001/jama.2021.0987. PMID: 33651091Free PMC Article
Brown PA, Ji L, Xu X, Devidas M, Hogan LE, Borowitz MJ, Raetz EA, Zugmaier G, Sharon E, Bernhardt MB, Terezakis SA, Gore L, Whitlock JA, Pulsipher MA, Hunger SP, Loh ML
JAMA 2021 Mar 2;325(9):833-842. doi: 10.1001/jama.2021.0669. PMID: 33651090Free PMC Article
Malard F, Mohty M
Lancet 2020 Apr 4;395(10230):1146-1162. doi: 10.1016/S0140-6736(19)33018-1. PMID: 32247396
Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, Chew A, Gonzalez VE, Zheng Z, Lacey SF, Mahnke YD, Melenhorst JJ, Rheingold SR, Shen A, Teachey DT, Levine BL, June CH, Porter DL, Grupp SA
N Engl J Med 2014 Oct 16;371(16):1507-17. doi: 10.1056/NEJMoa1407222. PMID: 25317870Free PMC Article

Clinical prediction guides

Litzow MR, Sun Z, Mattison RJ, Paietta EM, Roberts KG, Zhang Y, Racevskis J, Lazarus HM, Rowe JM, Arber DA, Wieduwilt MJ, Liedtke M, Bergeron J, Wood BL, Zhao Y, Wu G, Chang TC, Zhang W, Pratz KW, Dinner SN, Frey N, Gore SD, Bhatnagar B, Atallah EL, Uy GL, Jeyakumar D, Lin TL, Willman CL, DeAngelo DJ, Patel SB, Elliott MA, Advani AS, Tzachanis D, Vachhani P, Bhave RR, Sharon E, Little RF, Erba HP, Stone RM, Luger SM, Mullighan CG, Tallman MS
N Engl J Med 2024 Jul 25;391(4):320-333. doi: 10.1056/NEJMoa2312948. PMID: 39047240Free PMC Article
Jabbour E, Short NJ, Jain N, Huang X, Montalban-Bravo G, Banerjee P, Rezvani K, Jiang X, Kim KH, Kanagal-Shamanna R, Khoury JD, Patel K, Kadia TM, Daver N, Chien K, Alvarado Y, Garcia-Manero G, Issa GC, Haddad FG, Kwari M, Thankachan J, Delumpa R, Macaron W, Garris R, Konopleva M, Ravandi F, Kantarjian H
Lancet Haematol 2023 Jan;10(1):e24-e34. Epub 2022 Nov 16 doi: 10.1016/S2352-3026(22)00319-2. PMID: 36402146
Locatelli F, Zugmaier G, Rizzari C, Morris JD, Gruhn B, Klingebiel T, Parasole R, Linderkamp C, Flotho C, Petit A, Micalizzi C, Mergen N, Mohammad A, Kormany WN, Eckert C, Möricke A, Sartor M, Hrusak O, Peters C, Saha V, Vinti L, von Stackelberg A
JAMA 2021 Mar 2;325(9):843-854. doi: 10.1001/jama.2021.0987. PMID: 33651091Free PMC Article
Maude SL, Laetsch TW, Buechner J, Rives S, Boyer M, Bittencourt H, Bader P, Verneris MR, Stefanski HE, Myers GD, Qayed M, De Moerloose B, Hiramatsu H, Schlis K, Davis KL, Martin PL, Nemecek ER, Yanik GA, Peters C, Baruchel A, Boissel N, Mechinaud F, Balduzzi A, Krueger J, June CH, Levine BL, Wood P, Taran T, Leung M, Mueller KT, Zhang Y, Sen K, Lebwohl D, Pulsipher MA, Grupp SA
N Engl J Med 2018 Feb 1;378(5):439-448. doi: 10.1056/NEJMoa1709866. PMID: 29385370Free PMC Article
Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, Chew A, Gonzalez VE, Zheng Z, Lacey SF, Mahnke YD, Melenhorst JJ, Rheingold SR, Shen A, Teachey DT, Levine BL, June CH, Porter DL, Grupp SA
N Engl J Med 2014 Oct 16;371(16):1507-17. doi: 10.1056/NEJMoa1407222. PMID: 25317870Free PMC Article

Recent systematic reviews

Zhai Y, Hong J, Wang J, Jiang Y, Wu W, Lv Y, Guo J, Tian L, Sun H, Li Y, Li C, Zhan H, Zhao Z
Expert Rev Hematol 2024 Jan-Mar;17(1-3):67-76. Epub 2024 Jan 4 doi: 10.1080/17474086.2023.2298732. PMID: 38135295
Jeha S, Goto H, Baruchel A, Boëlle-Le Corfec E, Geffriaud-Ricouard C, Pieters R, Shin HY
Adv Ther 2023 Dec;40(12):5447-5463. Epub 2023 Oct 11 doi: 10.1007/s12325-023-02696-7. PMID: 37819554Free PMC Article
Liu H, Xi R, Mao D, Zhao X, Wu T
Clin Lymphoma Myeloma Leuk 2023 Mar;23(3):e139-e149. Epub 2022 Dec 17 doi: 10.1016/j.clml.2022.12.009. PMID: 36593170
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914
Grigor EJM, Fergusson D, Kekre N, Montroy J, Atkins H, Seftel MD, Daugaard M, Presseau J, Thavorn K, Hutton B, Holt RA, Lalu MM
Transfus Med Rev 2019 Apr;33(2):98-110. Epub 2019 Feb 14 doi: 10.1016/j.tmrv.2019.01.005. PMID: 30948292

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