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Central Nervous System B-Cell Non-Hodgkin Lymphoma

MedGen UID:
1632151
•Concept ID:
C4688312
•
Neoplastic Process
Synonyms: B-Cell Primary Central Nervous System Non-Hodgkin Lymphoma; Primary Central Nervous System B-Cell Non-Hodgkin's Lymphoma

Definition

A B-cell non-Hodgkin lymphoma that arises from the brain, meninges, or spinal cord. [from NCI]

Professional guidelines

PubMed

Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616

Recent clinical studies

Etiology

How I treat secondary CNS involvement by aggressive lymphomas.
Alderuccio JP, Nayak L, Cwynarski K
Blood 2023 Nov 23;142(21):1771-1783. doi: 10.1182/blood.2023020168. PMID: 37702537Free PMC Article
CAR T-cell therapy in large B cell lymphoma.
Boardman AP, Salles G
Hematol Oncol 2023 Jun;41 Suppl 1(Suppl 1):112-118. doi: 10.1002/hon.3153. PMID: 37294963Free PMC Article
How I treat diffuse large B-cell lymphoma.
Melchardt T, Egle A, Greil R
ESMO Open 2023 Feb;8(1):100750. Epub 2023 Jan 10 doi: 10.1016/j.esmoop.2022.100750. PMID: 36634531Free PMC Article
Prevention and management of secondary central nervous system lymphoma.
Bobillo S, Khwaja J, Ferreri AJM, Cwynarski K
Haematologica 2023 Mar 1;108(3):673-689. doi: 10.3324/haematol.2022.281457. PMID: 36384246Free PMC Article
CNS prophylaxis for diffuse large B-cell lymphoma.
Eyre TA, Savage KJ, Cheah CY, El-Galaly TC, Lewis KL, McKay P, Wilson MR, Evens AM, Bobillo S, Villa D, Maurer MJ, Cwynarski K, Ferreri AJM
Lancet Oncol 2022 Sep;23(9):e416-e426. doi: 10.1016/S1470-2045(22)00371-0. PMID: 36055310

Diagnosis

Prevention and management of secondary central nervous system lymphoma.
Bobillo S, Khwaja J, Ferreri AJM, Cwynarski K
Haematologica 2023 Mar 1;108(3):673-689. doi: 10.3324/haematol.2022.281457. PMID: 36384246Free PMC Article
How we treat primary central nervous system lymphoma.
Calimeri T, Steffanoni S, Gagliardi F, Chiara A, Ferreri AJM
ESMO Open 2021 Aug;6(4):100213. Epub 2021 Jul 13 doi: 10.1016/j.esmoop.2021.100213. PMID: 34271311Free PMC Article
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Extranodal lymphomas.
Chiappella A, Benevolo G, Vitolo U
Rinsho Ketsueki 2013 Oct;54(10):1843-9. PMID: 24064835

Therapy

How I treat diffuse large B-cell lymphoma.
Melchardt T, Egle A, Greil R
ESMO Open 2023 Feb;8(1):100750. Epub 2023 Jan 10 doi: 10.1016/j.esmoop.2022.100750. PMID: 36634531Free PMC Article
Prevention and management of secondary central nervous system lymphoma.
Bobillo S, Khwaja J, Ferreri AJM, Cwynarski K
Haematologica 2023 Mar 1;108(3):673-689. doi: 10.3324/haematol.2022.281457. PMID: 36384246Free PMC Article
CNS prophylaxis for diffuse large B-cell lymphoma.
Eyre TA, Savage KJ, Cheah CY, El-Galaly TC, Lewis KL, McKay P, Wilson MR, Evens AM, Bobillo S, Villa D, Maurer MJ, Cwynarski K, Ferreri AJM
Lancet Oncol 2022 Sep;23(9):e416-e426. doi: 10.1016/S1470-2045(22)00371-0. PMID: 36055310
How we treat primary central nervous system lymphoma.
Calimeri T, Steffanoni S, Gagliardi F, Chiara A, Ferreri AJM
ESMO Open 2021 Aug;6(4):100213. Epub 2021 Jul 13 doi: 10.1016/j.esmoop.2021.100213. PMID: 34271311Free PMC Article
The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490

Prognosis

The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma.
Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, Batchelor TT
Neuro Oncol 2019 Feb 19;21(3):296-305. doi: 10.1093/neuonc/noy192. PMID: 30418592Free PMC Article
Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks.
Ponzoni M, Campo E, Nakamura S
Blood 2018 Oct 11;132(15):1561-1567. Epub 2018 Aug 15 doi: 10.1182/blood-2017-04-737445. PMID: 30111607
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article

Clinical prediction guides

High-Dose Methotrexate as CNS Prophylaxis in High-Risk Aggressive B-Cell Lymphoma.
Lewis KL, Jakobsen LH, Villa D, Smedby KE, Savage KJ, Eyre TA, Cwynarski K, Bishton MJ, Fox CP, Hawkes EA, Maurer MJ, El-Galaly TC, Cheah CY; International CNS Prophylaxis Study Group
J Clin Oncol 2023 Dec 10;41(35):5376-5387. Epub 2023 Oct 5 doi: 10.1200/JCO.23.00365. PMID: 37797284
How I treat secondary CNS involvement by aggressive lymphomas.
Alderuccio JP, Nayak L, Cwynarski K
Blood 2023 Nov 23;142(21):1771-1783. doi: 10.1182/blood.2023020168. PMID: 37702537Free PMC Article
Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients.
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks.
Ponzoni M, Campo E, Nakamura S
Blood 2018 Oct 11;132(15):1561-1567. Epub 2018 Aug 15 doi: 10.1182/blood-2017-04-737445. PMID: 30111607
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article

Recent systematic reviews

Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients.
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
The prevention of central nervous system relapse in diffuse large B-cell lymphoma: a British Society for Haematology good practice paper.
McKay P, Wilson MR, Chaganti S, Smith J, Fox CP, Cwynarski K; British Society of Haematology
Br J Haematol 2020 Sep;190(5):708-714. Epub 2020 Jul 15 doi: 10.1111/bjh.16866. PMID: 32433789
Eye involvement in primary central nervous system lymphoma.
Farrall AL, Smith JR
Surv Ophthalmol 2020 Sep-Oct;65(5):548-561. Epub 2020 Feb 11 doi: 10.1016/j.survophthal.2020.02.001. PMID: 32057762
Rituximab in primary central nervous system lymphoma-A systematic review and meta-analysis.
Schmitt AM, Herbrand AK, Fox CP, Bakunina K, Bromberg JEC, Cwynarski K, Doorduijn JK, Ferreri AJM, Illerhaus G, Issa S, Schorb E, Zucca E, Hemkens LG, Schandelmaier S, Kasenda B
Hematol Oncol 2019 Dec;37(5):548-557. Epub 2019 Oct 9 doi: 10.1002/hon.2666. PMID: 31418878
Guidelines for the diagnosis and management of primary central nervous system diffuse large B-cell lymphoma.
Fox CP, Phillips EH, Smith J, Linton K, Gallop-Evans E, Hemmaway C, Auer DP, Fuller C, Davies AJ, McKay P, Cwynarski K; British Society for Haematology
Br J Haematol 2019 Feb;184(3):348-363. Epub 2018 Nov 23 doi: 10.1111/bjh.15661. PMID: 30467845

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