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Acute monoblastic leukemia

MedGen UID:
141597
•Concept ID:
C0457334
•
Neoplastic Process
Synonyms: Acute Monoblastic Leukemia; Acute Monoblastic Leukemia (FAB M5a); FAB M5A; FAB type M5a; French-American-British type M5a
SNOMED CT: French-American-British type M5a (278170009); FAB M5A (22331004); FAB type M5a (278170009)

Definition

An acute myeloid leukemia in which the monoblasts represent 80% or more of the total cellular population. (WHO, 2001) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Acute monoblastic leukemia

Professional guidelines

PubMed

Biologic characteristics and treatment of acute nonlymphocytic leukemia in children. Report of the ANLL Strategy Group of the Childrens Cancer Study Group.
Lampkin BC, Lange B, Bernstein I, Woods W, Odom L, Wells R, Ruymann F, Feig S, Miller L, Chard R
Pediatr Clin North Am 1988 Aug;35(4):743-64. doi: 10.1016/s0031-3955(16)36508-7. PMID: 3047652
Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin.
Odom LF, Gordon EM
Blood 1984 Oct;64(4):875-82. PMID: 6592009
Acute monoblastic leukemia: diagnosis and treatment of ten cases.
McKenna RW, Bloomfield CD, Dick F, Nesbit ME, Brunning RD
Blood 1975 Oct;46(4):481-94. PMID: 169929

Recent clinical studies

Etiology

Hemophagocytic syndrome in children with acute monoblastic leukemia-another cause of fever of unknown origin.
Lackner H, Seidel MG, Strenger V, Sovinz P, Schwinger W, Benesch M, Sperl D, Urban C
Support Care Cancer 2013 Dec;21(12):3519-23. Epub 2013 Aug 24 doi: 10.1007/s00520-013-1937-x. PMID: 23975227
Congenital monoblastic leukemia presenting as jaundice, pleural effusion, and ascites: case report and literature review.
Wu X, Du L, Wang X
Fetal Pediatr Pathol 2011;30(1):27-31. doi: 10.3109/15513815.2010.494701. PMID: 21204663
Teniposide in lymphomas and leukemias.
Sonneveld P
Semin Oncol 1992 Apr;19(2 Suppl 6):59-64. PMID: 1411640
Acute monoblastic leukemia: a unique subtype--a review from the Childrens Cancer Study Group.
Odom LF, Lampkin BC, Tannous R, Buckley JD, Hammond GD
Leuk Res 1990;14(1):1-10. doi: 10.1016/0145-2126(90)90140-5. PMID: 2406511
Acute monoblastic leukemia: a clinical and biologic study of 74 cases.
Tobelem G, Jacquillat C, Chastang C, Auclerc MF, Lechevallier T, Weil M, Daniel MT, Flandrin G, Harrousseau JL, Schaison G, Boiron M, Bernard J
Blood 1980 Jan;55(1):71-6. PMID: 6927957

Diagnosis

Acute Monoblastic Leukemia with Erythrophagocytosis and Absence of KAT6A Rearrangement.
Sánchez CM, de Castro DR, de Viñaspre AVG, Zilaurren AU, Abad AM, de Castro JMG
Turk J Haematol 2020 Nov 19;37(4):282-283. Epub 2020 Jun 10 doi: 10.4274/tjh.galenos.2020.2020.0237. PMID: 32519830Free PMC Article
Congenital monoblastic leukemia presenting as jaundice, pleural effusion, and ascites: case report and literature review.
Wu X, Du L, Wang X
Fetal Pediatr Pathol 2011;30(1):27-31. doi: 10.3109/15513815.2010.494701. PMID: 21204663
Neuroblastoma presenting as acute monoblastic leukemia.
Boyd JE, Parmley RT, Langevin AM, Saldívar VA
J Pediatr Hematol Oncol 1996 May;18(2):206-12. doi: 10.1097/00043426-199605000-00024. PMID: 8846141
Acute monoblastic leukemia: a clinical and biologic study of 74 cases.
Tobelem G, Jacquillat C, Chastang C, Auclerc MF, Lechevallier T, Weil M, Daniel MT, Flandrin G, Harrousseau JL, Schaison G, Boiron M, Bernard J
Blood 1980 Jan;55(1):71-6. PMID: 6927957
Acute monoblastic leukemia: diagnosis and treatment of ten cases.
McKenna RW, Bloomfield CD, Dick F, Nesbit ME, Brunning RD
Blood 1975 Oct;46(4):481-94. PMID: 169929

Therapy

Acute monoblastic leukemia with t(10;11)(p12;q23) presenting with pulmonary involvement: a case report and literature review.
Prayongratana K, Kulpraneet M, Panichchob P, Tantisiriwat W
J Med Assoc Thai 2008 Apr;91(4):559-63. PMID: 18556867
Simultaneous presentation of acute monoblastic leukemia and mantle cell lymphoma: case report and review of the literature.
Pawarode A, Baer MR, Padmanabhan S, Wallace PK, Barcos M, Sait SN, Block AW, Wetzler M, Battiwalla M
Leuk Lymphoma 2005 Dec;46(12):1813-8. doi: 10.1080/10428190500244258. PMID: 16263586
Acute monoblastic leukemia: a unique subtype--a review from the Childrens Cancer Study Group.
Odom LF, Lampkin BC, Tannous R, Buckley JD, Hammond GD
Leuk Res 1990;14(1):1-10. doi: 10.1016/0145-2126(90)90140-5. PMID: 2406511
Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin.
Odom LF, Gordon EM
Blood 1984 Oct;64(4):875-82. PMID: 6592009
Acute monoblastic leukemia: diagnosis and treatment of ten cases.
McKenna RW, Bloomfield CD, Dick F, Nesbit ME, Brunning RD
Blood 1975 Oct;46(4):481-94. PMID: 169929

Prognosis

CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition.
Galland A, Gourain V, Habbas K, Güler Y, Martin E, Ebel C, Tavian M, Vallat L, Chenard MP, Mauvieux L, Freund JN, Duluc I, Domon-Dell C
Mol Oncol 2021 Sep;15(9):2318-2329. Epub 2021 Jun 26 doi: 10.1002/1878-0261.12982. PMID: 33960108Free PMC Article
Bone Marrow Necrosis in Acute Monoblastic Leukemia.
Terao T, Matsue K
N Engl J Med 2021 Feb 18;384(7):650. doi: 10.1056/NEJMicm2026508. PMID: 33596359
Congenital monoblastic leukemia presenting as jaundice, pleural effusion, and ascites: case report and literature review.
Wu X, Du L, Wang X
Fetal Pediatr Pathol 2011;30(1):27-31. doi: 10.3109/15513815.2010.494701. PMID: 21204663
Acute monoblastic leukemia: a unique subtype--a review from the Childrens Cancer Study Group.
Odom LF, Lampkin BC, Tannous R, Buckley JD, Hammond GD
Leuk Res 1990;14(1):1-10. doi: 10.1016/0145-2126(90)90140-5. PMID: 2406511
Acute monoblastic leukemia: a clinical and biologic study of 74 cases.
Tobelem G, Jacquillat C, Chastang C, Auclerc MF, Lechevallier T, Weil M, Daniel MT, Flandrin G, Harrousseau JL, Schaison G, Boiron M, Bernard J
Blood 1980 Jan;55(1):71-6. PMID: 6927957

Clinical prediction guides

Clonal dynamics in a case of acute monoblastic leukemia that later developed myeloproliferative neoplasm.
Sato S, Itonaga H, Taguchi M, Sawayama Y, Imanishi D, Tsushima H, Hata T, Moriuchi Y, Mishima H, Kinoshita A, Yoshiura KI, Miyazaki Y
Int J Hematol 2018 Aug;108(2):213-217. Epub 2018 Feb 7 doi: 10.1007/s12185-018-2419-1. PMID: 29417354
mRNA expression profiling of histone modifying enzymes in pediatric acute monoblastic leukemia.
Xiao PF, Tao YF, Hu SY, Cao L, Lu J, Wang J, Feng X, Pan J, Chai YH
Pharmazie 2017 Mar 1;72(3):177-186. doi: 10.1691/ph.2017.6768. PMID: 29442054
Hemophagocytic syndrome in children with acute monoblastic leukemia-another cause of fever of unknown origin.
Lackner H, Seidel MG, Strenger V, Sovinz P, Schwinger W, Benesch M, Sperl D, Urban C
Support Care Cancer 2013 Dec;21(12):3519-23. Epub 2013 Aug 24 doi: 10.1007/s00520-013-1937-x. PMID: 23975227
Translocation (5;10)(q13;q26) in acute monoblastic leukemia.
Pernice F, Musolino C, Mazza G, Puglisi D, Squadrito G, Frisina N, Squadrito G
Cancer Genet Cytogenet 1998 Mar;101(2):152-5. doi: 10.1016/s0165-4608(97)00264-1. PMID: 9494619
Chromosome clues to acute leukemia in Down's syndrome.
Hecht F, Hecht BK, Morgan R, Sandberg AA, Link MP
Cancer Genet Cytogenet 1986 Mar 15;21(2):93-8. doi: 10.1016/0165-4608(86)90034-8. PMID: 2936445

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