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Childhood Acute Monoblastic Leukemia

MedGen UID:
124640
•Concept ID:
C0279645
•
Neoplastic Process
Synonyms: Childhood Acute M5a Leukemia; Childhood Acute Monoblastic Leukemia without Differentiation; M5a Childhood Acute Monoblastic Leukemia without Differentiation; M5a Pediatric Acute Monoblastic Leukemia without Differentiation; Pediatric Acute M5a Leukemia; Pediatric Acute Monoblastic Leukemia without Differentiation

Definition

An acute monoblastic leukemia occurring in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Acute Monoblastic Leukemia

Professional guidelines

PubMed

Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia.
Loh ML
Br J Haematol 2011 Mar;152(6):677-87. doi: 10.1111/j.1365-2141.2010.08525.x. PMID: 21623760
Childhood myelodysplastic syndrome: focus on the approach to diagnosis and treatment of juvenile myelomonocytic leukemia.
Loh ML
Hematology Am Soc Hematol Educ Program 2010;2010:357-62. doi: 10.1182/asheducation-2010.1.357. PMID: 21239819
Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin.
Odom LF, Gordon EM
Blood 1984 Oct;64(4):875-82. PMID: 6592009

Recent clinical studies

Etiology

Pediatric acute myeloid leukemia and hyperleukocytosis with WBC count greater than 50 × 10(9)/L.
Zhang A, Liu L, Zong S, Chang L, Chen X, Yang W, Guo Y, Zhang L, Zou Y, Chen Y, Zhang Y, Ruan M, Zhu X
Int J Hematol 2023 Dec;118(6):737-744. Epub 2023 Sep 21 doi: 10.1007/s12185-023-03665-0. PMID: 37733171
miR-9 is a tumor suppressor in pediatric AML with t(8;21).
Emmrich S, Katsman-Kuipers JE, Henke K, Khatib ME, Jammal R, Engeland F, Dasci F, Zwaan CM, den Boer ML, Verboon L, Stary J, Baruchel A, de Haas V, Danen-van Oorschot AA, Fornerod M, Pieters R, Reinhardt D, Klusmann JH, van den Heuvel-Eibrink MM
Leukemia 2014 May;28(5):1022-32. Epub 2013 Nov 25 doi: 10.1038/leu.2013.357. PMID: 24270738
Epidemiology of childhood acute myelogenous leukemia.
Bhatia S, Neglia JP
J Pediatr Hematol Oncol 1995 May;17(2):94-100. doi: 10.1097/00043426-199505000-00002. PMID: 7749772
Teniposide in lymphomas and leukemias.
Sonneveld P
Semin Oncol 1992 Apr;19(2 Suppl 6):59-64. PMID: 1411640
Myeloproliferative diseases in childhood.
Nix WL, Fernbach DJ
Am J Pediatr Hematol Oncol 1981 Winter;3(4):397-407. PMID: 6174053

Diagnosis

CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216.
Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard É, Thibault P, Bonneil É, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith MA, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm BT, Cellot S
Blood Adv 2024 Jan 9;8(1):112-129. doi: 10.1182/bloodadvances.2022008899. PMID: 37729615Free PMC Article
Pediatric acute myeloid leukemia and hyperleukocytosis with WBC count greater than 50 × 10(9)/L.
Zhang A, Liu L, Zong S, Chang L, Chen X, Yang W, Guo Y, Zhang L, Zou Y, Chen Y, Zhang Y, Ruan M, Zhu X
Int J Hematol 2023 Dec;118(6):737-744. Epub 2023 Sep 21 doi: 10.1007/s12185-023-03665-0. PMID: 37733171
Lineage switch in childhood acute leukemia: an unusual event with poor outcome.
Rossi JG, Bernasconi AR, Alonso CN, Rubio PL, Gallego MS, Carrara CA, Guitter MR, Eberle SE, Cocce M, Zubizarreta PA, Felice MS
Am J Hematol 2012 Sep;87(9):890-7. Epub 2012 Jun 8 doi: 10.1002/ajh.23266. PMID: 22685031
Childhood myelodysplastic syndrome: focus on the approach to diagnosis and treatment of juvenile myelomonocytic leukemia.
Loh ML
Hematology Am Soc Hematol Educ Program 2010;2010:357-62. doi: 10.1182/asheducation-2010.1.357. PMID: 21239819
Myeloproliferative diseases in childhood.
Nix WL, Fernbach DJ
Am J Pediatr Hematol Oncol 1981 Winter;3(4):397-407. PMID: 6174053

Therapy

Novel therapies for children with acute myeloid leukaemia.
Moore AS, Kearns PR, Knapper S, Pearson AD, Zwaan CM
Leukemia 2013 Jul;27(7):1451-60. Epub 2013 Apr 8 doi: 10.1038/leu.2013.106. PMID: 23563239
Myelodysplastic syndrome and acute myeloid leukemia after treatment for solid tumors of childhood.
Farhi DC, Odell CA, Shurin SB
Am J Clin Pathol 1993 Sep;100(3):270-5. doi: 10.1093/ajcp/100.3.270. PMID: 8379535
Teniposide in lymphomas and leukemias.
Sonneveld P
Semin Oncol 1992 Apr;19(2 Suppl 6):59-64. PMID: 1411640
Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin.
Odom LF, Gordon EM
Blood 1984 Oct;64(4):875-82. PMID: 6592009
Myeloproliferative diseases in childhood.
Nix WL, Fernbach DJ
Am J Pediatr Hematol Oncol 1981 Winter;3(4):397-407. PMID: 6174053

Prognosis

Pediatric acute myeloid leukemia and hyperleukocytosis with WBC count greater than 50 × 10(9)/L.
Zhang A, Liu L, Zong S, Chang L, Chen X, Yang W, Guo Y, Zhang L, Zou Y, Chen Y, Zhang Y, Ruan M, Zhu X
Int J Hematol 2023 Dec;118(6):737-744. Epub 2023 Sep 21 doi: 10.1007/s12185-023-03665-0. PMID: 37733171
Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia.
Loh ML
Br J Haematol 2011 Mar;152(6):677-87. doi: 10.1111/j.1365-2141.2010.08525.x. PMID: 21623760
Childhood myelodysplastic syndrome: focus on the approach to diagnosis and treatment of juvenile myelomonocytic leukemia.
Loh ML
Hematology Am Soc Hematol Educ Program 2010;2010:357-62. doi: 10.1182/asheducation-2010.1.357. PMID: 21239819
Acute myeloid leukemias expressing lymphoid-associated antigens: diagnostic incidence and prognostic significance.
Drexler HG, Thiel E, Ludwig WD
Leukemia 1993 Apr;7(4):489-98. PMID: 7681917
Acute myeloid leukaemia in childhood: clinical features and prognosis.
Chessells JM, O'Callaghan U, Hardisty RM
Br J Haematol 1986 Jul;63(3):555-64. doi: 10.1111/j.1365-2141.1986.tb07533.x. PMID: 3460625

Clinical prediction guides

IL-1 signaling pathway molecules as key markers in childhood asthma.
Wei W, Huang J, Ma Y, Ma X, Fang L, Fang W, Hao C
Pediatr Allergy Immunol 2021 Feb;32(2):305-313. Epub 2020 Nov 4 doi: 10.1111/pai.13388. PMID: 33025692
Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia.
Tartaglia M, Martinelli S, Cazzaniga G, Cordeddu V, Iavarone I, Spinelli M, Palmi C, Carta C, Pession A, Aricò M, Masera G, Basso G, Sorcini M, Gelb BD, Biondi A
Blood 2004 Jul 15;104(2):307-13. Epub 2004 Feb 24 doi: 10.1182/blood-2003-11-3876. PMID: 14982869
Cutaneous involvement in children with acute lymphoblastic leukemia or lymphoblastic lymphoma. The Children's Leukemia Cooperative Group of the European Organization of Research and Treatment of Cancer (EORTC).
Millot F, Robert A, Bertrand Y, Mechinaud F, Laureys G, Ferster A, Brock P, Rohrlich P, Mazingue F, Plantaz D, Plouvier E, Pacquement H, Behar C, Rialland X, Chantraine JM, Guilhot F, Otten J
Pediatrics 1997 Jul;100(1):60-4. doi: 10.1542/peds.100.1.60. PMID: 9200360
Prognostic factors in childhood acute myelogenous leukemia.
Grier HE, Gelber RD, Camitta BM, Delorey MJ, Link MP, Price KN, Leavitt PR, Weinstein HJ
J Clin Oncol 1987 Jul;5(7):1026-32. doi: 10.1200/JCO.1987.5.7.1026. PMID: 3474356
Acute myeloid leukaemia in childhood: clinical features and prognosis.
Chessells JM, O'Callaghan U, Hardisty RM
Br J Haematol 1986 Jul;63(3):555-64. doi: 10.1111/j.1365-2141.1986.tb07533.x. PMID: 3460625

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