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HLA B27 Disease Association
Clinical Genetic Test
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offered by
Laboratory Corporation of America Holdings
View lab's test page
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GTR Test Accession: Help GTR000570852.3
CAP
INHERITED DISEASEINHERITED DISEASE SUSCEPTIBILITY
Last updated in GTR: 2024-08-27
View version history
Last annual review date for the lab: 2024-08-27 LinkOut
At a Glance
Test purpose: Help
Diagnosis
Conditions (1): Help
Spondyloarthropathy, susceptibility to, 1
Genes (1): Help
HLA-B (6p21.33)
Methods (1): Help
Molecular Genetics - Sequence analysis of select exons: sequence-specific oligonucleotide probes (SSOP)
Target population: Help
HLA-B27 is strongly associated with ankylosing spondylitis (Marie-Strumpell disease). A …
Clinical validity: Help
Not provided
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
Laboratory Corporation of America Holdings
View lab's website
View lab's test page
Specimen Source: Help
Test Order Code: Help
006924
View other test codes
Lab contact: Help
Ruth Koester, PhD, D(ABHI), Lab Director
[email protected]
3364367310
How to Order: Help
Follow direction at https://www.labcorp.com/tests/006924/hla-b27-disease-association
Order URL
Informed consent required: Help
No
Pre-test genetic counseling required: Help
No
Post-test genetic counseling required: Help
No
Recommended fields not provided:
Contact policy, Test strategy, Test development
Conditions Help
Total conditions: 1
Condition/Phenotype Identifier
Test Targets
Genes Help
Total genes: 1
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Methodology
Total methods: 1
Method Category Help
Test method Help
Instrument *
Sequence analysis of select exons
sequence-specific oligonucleotide probes (SSOP)
* Instrument: Not provided
Clinical Information
Test purpose: Help
Diagnosis
Target population: Help
HLA-B27 is strongly associated with ankylosing spondylitis (Marie-Strumpell disease). A patient with consistent clinical and radiographic findings who is B27-positive has a greater chance of having or developing ankylosing spondylitis than a negative patient. The antigen is not causative, however, and 10% of normal subjects are B27-positive. This test should … View more
View citations (6)
  • Striking prevalence of ankylosing spondylitis in "healthy" w27 positive males and females. Calin A, et al. N Engl J Med. 1975;293(17):835-9. doi:10.1056/NEJM197510232931701. PMID: 126380.
  • The Second International Simmons Center Conference on HLA-B27-Related Disorders. Lipsky PE, et al. Arthritis Rheum. 1991;34(11):1476-82. doi:10.1002/art.1780341120. PMID: 1953825.
  • Molecular mimicry in HLA-B27-related arthritis. Yu DT, et al. Ann Intern Med. 1989;111(7):581-91. doi:10.7326/0003-4819-111-7-581. PMID: 2672931.
  • The HLA histocompatibility system in autoimmune states. Braun WE, et al. Clin Lab Med. 1988;8(2):351-72. PMID: 3284701.
  • Reiter's syndrome and reactive arthritis in perspective. Keat A, et al. N Engl J Med. 1983;309(26):1606-15. doi:10.1056/NEJM198312293092604. PMID: 6358890.
  • Diagnostic value of HLA-B27 testing ankylosing spondylitis and Reiter's syndrome. Khan MA, et al. Ann Intern Med. 1982;96(1):70-6. doi:10.7326/0003-4819-96-1-70. PMID: 7053711.
Recommended fields not provided:
Clinical validity, Clinical utility, What is the protocol for interpreting a variation as a VUS?, Are family members with defined clinical status recruited to assess significance of VUS without charge?, Will the lab re-contact the ordering physician if variant interpretation changes?, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Test Procedure: Help
Polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (SSOP). Detects B27 at an antigen level. Positive samples may be further sequenced to determine the HLA B27 allele.
Test Confirmation: Help
Positive samples may be further sequenced to determine the HLA B27 allele. All positives are reprepped and confirmed.
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
HLA-B27 is strongly associated with ankylosing spondylitis (Marie-Strumpell disease). A patient with consistent clinical and radiographic findings who is B27-positive has a greater chance of having or developing ankylosing spondylitis than a negative patient. The antigen is not causative, however, and 10% of normal subjects are B27-positive. This test should … View more
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
No

Method used for proficiency testing: Help
Formal PT program

PT Provider: Help
College of American Pathologists, CAP
Recommended fields not provided:
Assay limitations, Description of internal test validation method, Citations for Analytical validity, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Not provided
Additional Information

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