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| Status |
Public on Sep 11, 2017 |
| Title |
REV-ERBĪ± Ameliorates Heart Failure Through Transcription Repression |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Heart failure remains a major unmet clinical need and current therapies targeting neurohomonal and hemodynamic regulation have limited efficacy. We report that pharmacological activation of the transcriptional repressor REV-ERBa prevents expression of a pathological gene program and cardiomyocyte hypertrophy. In vivo, REV-ERBa agonism prevents development and halts progression of heart failure in mouse models. Thus, modulation of gene networks by targeting REV-ERBa represents a novel approach to heart failure therapy.
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| Overall design |
We performed RNAseq on NRVM at baseline and after PE stimulation (4 hr and 48 hr) in the presence or absence of SR9009 (SR or Veh were given 24 hr prior to PE).
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| Contributor(s) |
Zhang L, Jain M |
| Citation(s) |
28878135 |
| |
| Submission date |
May 04, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Ernest R Chan |
| E-mail(s) |
[email protected]
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| Organization name |
CWRU
|
| Department |
PQHS
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| Street address |
10900 Euclid Ave, Robbins E211
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| City |
Cleveland |
| State/province |
OH |
| ZIP/Postal code |
44106 |
| Country |
USA |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA385542 |
| SRA |
SRP106502 |
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