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| Status |
Public on Mar 01, 2020 |
| Title |
Genome reprogramming in Saccharomyces cerevisiae upon nonylphenol exposure |
| Platform organisms |
Schizosaccharomyces pombe; Saccharomyces cerevisiae |
| Sample organism |
Saccharomyces cerevisiae |
| Experiment type |
Expression profiling by array
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| Summary |
We analyzed genome-wide transcriptional changes in the S. cerevisiae strain BY4742 upon exposure to NP to identify differentially expressed genes, biological processes, metabolic pathways, and cellular compartments affected by this compound. For these analyses, we focused on two NP exposure scenarios: (1) exposure to a low inhibitory concentration (resulting in <15% reduction in cell number), and (2) exposure to a high inhibitory concentration (resulting in >65% reduction in cell number).
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| Overall design |
Yeast cells were exposed to nonylphenol (NP) at mid-exponential phase for 120 and 180 minutes and then were harvested for RNA extraction and hybridization on Affymetrix microarrays. We aimed to investigate the transcriptional profiles of Saccharomyces ceresivisae genome upon exposure to two different concentrations of NP.
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| Contributor(s) |
Bereketoglu C, Mertoglu B, Arga KY, Eraslan S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Mar 15, 2017 |
| Last update date |
Mar 02, 2020 |
| Contact name |
Ceyhun Bereketoglu |
| E-mail(s) |
[email protected]
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| Organization name |
Marmara University
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| Street address |
Goztepe
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| City |
Istanbul |
| ZIP/Postal code |
34722 |
| Country |
Turkey |
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| Platforms (1) |
| GPL2529 |
[Yeast_2] Affymetrix Yeast Genome 2.0 Array |
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| Samples (18)
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| GSM2537194 |
control RNA for 120 min treatment, biological rep1 |
| GSM2537195 |
control RNA for 120 min treatment, biological rep2 |
| GSM2537196 |
control RNA for 120 min treatment, biological rep3 |
| GSM2537197 |
RNA of 1 mg/L NP for 120 min treatment, biological rep1 |
| GSM2537198 |
RNA of 1 mg/L NP for 120 min treatment, biological rep2 |
| GSM2537199 |
RNA of 1 mg/L NP for 120 min treatment, biological rep3 |
| GSM2537200 |
RNA of 5 mg/L NP for 120 min treatment, biological rep1 |
| GSM2537201 |
RNA of 5 mg/L NP for 120 min treatment, biological rep2 |
| GSM2537202 |
RNA of 5 mg/L NP for 120 min treatment, biological rep3 |
| GSM2537203 |
control RNA for 180 min treatment, biological rep1 |
| GSM2537204 |
control RNA for 180 min treatment, biological rep2 |
| GSM2537205 |
control RNA for 180 min treatment, biological rep3 |
| GSM2537206 |
RNA of 1 mg/L NP for 180 min treatment, biological rep1 |
| GSM2537207 |
RNA of 1 mg/L NP for 180 min treatment, biological rep2 |
| GSM2537208 |
RNA of 1 mg/L NP for 180 min treatment, biological rep3 |
| GSM2537209 |
RNA of 5 mg/L NP for 180 min treatment, biological rep1 |
| GSM2537210 |
RNA of 5 mg/L NP for 180 min treatment, biological rep2 |
| GSM2537211 |
RNA of 5 mg/L NP for 180 min treatment, biological rep3 |
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| Relations |
| BioProject |
PRJNA379290 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE96651_RAW.tar |
14.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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