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| Status |
Public on Nov 01, 2017 |
| Title |
High number of chromosomal copy number aberrations inversely relates to t(11;19)(q21;p13) translocation status in Mucoepidermoid Carcinoma of the Salivary Glands |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
genomic analysis using arrayCGH to gain insight into chromosomal copy number in mucoepidermoid carcinoma (MEC). Results suggest that two types of MECs can be distinguished: (i) a group of MECs without t(11;19)(q21;p13) translocation with many copy number aberrations (> 6), independent of histological grade, and (ii) a group of MECs with the t(11;19)(q21;p13) translocation with no or a few copy number aberrations (<6 ) with two exceptions classified as low and intermediate grade.
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| Overall design |
Tumor DNA vs Normal DNA from surrounding tumor tissue. 27 parrafine embedded MEC samples of which 17 low grade, 6 intermediate grade and 4 high grade MEC samples were compared to normal surrounding tissue.
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| Contributor(s) |
Matse JH, Veerman EI, Bolscher JM, Leemans CR, Ylstra B, Bloemena E |
| Citation(s) |
29050216 |
| |
| Submission date |
Sep 26, 2016 |
| Last update date |
Nov 01, 2017 |
| Contact name |
Johannes Hendrikus Muatse |
| E-mail(s) |
[email protected]
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| Organization name |
VU University medical center
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| Department |
Department of Oral and Maxillofacial Surgery and Oral Pathology
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| Street address |
Gustav Mahlerlaan 81
|
| City |
Amsterdam |
| ZIP/Postal code |
1081 LA |
| Country |
Netherlands |
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| Platforms (1) |
| GPL8687 |
Agilent SurePrint G3 CGH array (4X180K) CCA_VUMC design AMADID#022522 |
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| Samples (27)
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| Relations |
| BioProject |
PRJNA344477 |
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