|
| Status |
Public on Sep 01, 2017 |
| Title |
EZH2 inhibitor-mediated transcriptional profiling in prostate cancer cells [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We reported here the gene expression profiles that were mediated upon the treatment of EZH2 inhibitor in two hormone-refractory prostate cancer cell lines: the sensitive, AR-positive abl cells and the insensitive, AR-null DU145 cells.
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| |
|
| Overall design |
We treated both types of prostate cancer cells with two different EZH2 inhibitors (GSK126 or EPZ-6438) at final concentrations of 5 uM for 60-72 hrs, and then collected RNAs for gene expression profiling.
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| |
|
| Contributor(s) |
Xu K, Chen C |
| Citation(s) |
35031563 |
| |
| Submission date |
Apr 13, 2016 |
| Last update date |
Feb 08, 2022 |
| Contact name |
Kexin Xu |
| E-mail(s) |
[email protected]
|
| Organization name |
UT Health Science Center at San Antonio
|
| Department |
Molecular Medicine
|
| Street address |
7703 Floyd Curl, MC 8257
|
| City |
San Antonio |
| State/province |
TX |
| ZIP/Postal code |
78229 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE80240 |
Distinct changes in transcriptional profiles and epigenetic patterns mediated by EZH2 inhibitors in sensitive and insensitive prostate cancer cells |
|
| Relations |
| BioProject |
PRJNA318380 |
| SRA |
SRP073247 |
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