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| Status |
Public on Jan 01, 2008 |
| Title |
Sex-specific early response to pressure overload in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Pressure overload (PO) leads first to cardiac hypertrophy and later to heart failure. In mice, PO leads to sex differences in cardiac morphology and function. However, early sex differences in gene regulation that precede sex differences in function have not yet been identified.
To identify such changes, we developed a model of PO that is characterized by compensated hypertrophy without sex differences after 2 weeks and by heart failure with sex differences after 9 weeks. We used transverse aortic constriction (TAC) or sham-operation in male and female mice and analyzed gene expression by microarray experiments.
Keywords: the influence of gender on hypertrophic gene expression
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| Overall design |
The gene expression induced by pressure overload in female and male mice in comparison to sham operated control mice was investigated. For each of these four conditions four biological replicates were performed and the individual samples were hybridized seperately on Affymetrix RAE 430A GeneChip Arrays.
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| Contributor(s) |
Brokat S, Witt H, Ruiz Noppinger P, Grohe C, Regitz-Zagrosek V |
| Citation(s) |
18665344 |
| |
| Submission date |
Feb 06, 2007 |
| Last update date |
Jan 08, 2019 |
| Contact name |
Henning Witt |
| E-mail(s) |
[email protected]
|
| Phone |
++49-30-450578727
|
| Organization name |
Max Planck Institute for Molecular Genetics
|
| Department |
Hans Lehrach
|
| Lab |
Patricia Ruiz
|
| Street address |
Ihnestrasse 65
|
| City |
Berlin |
| ZIP/Postal code |
14195 |
| Country |
Germany |
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| Platforms (1) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA99313 |
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