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| Status |
Public on Apr 12, 2015 |
| Title |
Expression array from SIRT6WT and SIRT6KO muscle |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
SIRT6 is a member of a highly conserved family of NAD+-dependent deacetylases with various roles in metabolism, stress resistance, and life span. SIRT6- deficient mice develop normally but succumb to a lethal hypoglycemia early in life; however, the mechanism underlying this hypoglycemia remained unclear. Here, we demonstrate that SIRT6 functions as a histone H3K9 deacetylase to control the expres- sion of multiple glycolytic genes. Specifically, SIRT6 appears to function as a corepressor of the transcrip- tion factor Hif1a, a critical regulator of nutrient stress responses. Consistent with this notion, SIRT6-defi- cient cells exhibit increased Hif1a activity and show increased glucose uptake with upregulation of glycolysis and diminished mitochondrial respiration. Our studies uncover a role for the chromatin factor SIRT6 as a master regulator of glucose homeostasis and may provide the basis for novel therapeutic approaches against metabolic diseases, such as diabetes and obesity.
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| Overall design |
RNA was prepared from muscle of three SIRT6 wild type and KO mice, and hybridized onto an Affymetrix GeneChip Mouse Genome 430 2.0 Array.
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| Contributor(s) |
Zhong L, Mostoslavsky R |
| Citation(s) |
20141841 |
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| Submission date |
Apr 11, 2015 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Raul Mostoslavsky |
| Organization name |
Massachusetts General Hospital
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| Street address |
185 Cambridge Street, CPZN 4100
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02114 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA280883 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE67780_RAW.tar |
19.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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