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| Status |
Public on Oct 24, 2006 |
| Title |
High-resolution Global Genomic Survey of 178 Gliomas |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
SNP genotyping by SNP array
|
| Summary |
Primary brain tumors are the fourth leading cause of cancer mortality in adults under the age of 54 years and the leading cause of cancer mortality in children in the United States. Therapy for the most common type of primary brain tumors, gliomas, remains suboptimal. The development of new and more effective treatments will likely require a better understanding of the biology of these tumors. Here, we show that use of the high-density 100K single-nucleotide polymorphism arrays in a large number of primary tumor samples allows for a much higher resolution survey of the glioma genome than has been previously reported in any tumor type. We not only confirmed alterations in genomic areas previously reported to be affected in gliomas, but we also refined the location of those sites and uncovered multiple, previously unknown regions that are affected by copy number alterations (amplifications, homozygous and heterozygous deletions) as well as allelic imbalances (loss of heterozygosity/gene conversions). The wealth of genomic data produced may allow for the development of a more rational molecular classification of gliomas and serve as an important starting point in the search for new molecular therapeutic targets. (Cancer Res 2006; 66(19): 9428-36)
Keywords: survey
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| Overall design |
178 glioma samples including 82 glioblastomas, 33 astrocytomas, 52 oligodendrogliomas and 11 mixed gliomas were hybridized to 100K mapping arrays (Hind and Xba) to detect and summarize chromosomal aberations in those samples.
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| Web link |
http://rembrandt-db.nci.nih.gov
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| |
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| Contributor(s) |
Kotliarov Y, Steed ME, Christopher N, Walling J, Su Q, Center A, Heiss J, Rosenblum ML, Mikkelsen T, Zenklusen J, Fine HA |
| Citation(s) |
17018597 |
| |
| Submission date |
Oct 23, 2006 |
| Last update date |
Dec 22, 2017 |
| Contact name |
Howard Fine |
| E-mail(s) |
[email protected]
|
| Phone |
301-402-6383
|
| Fax |
301-480-2246
|
| Organization name |
National Cancer Institute
|
| Department |
Neurological Disorders and Stroke
|
| Street address |
9030 Old Georgetown Rd
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
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| Platforms (2) |
| GPL2004 |
[Mapping50K_Hind240] Affymetrix Human Mapping 50K Hind240 SNP Array |
| GPL2005 |
[Mapping50K_Xba240] Affymetrix Human Mapping 50K Xba240 SNP Array |
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| Samples (356)
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| Relations |
| BioProject |
PRJNA97715 |
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