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| Status |
Public on Jan 30, 2015 |
| Title |
Drug screening and genomic analyses of HER2 positive breast cancer cell lines reveal predictors for treatment response [Expression profiling] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Thirteen HER2 positive breast cancer cell lines were screened with 22 commercially available compounds, mainly targeting proteins in the ErbB2 signaling pathway, and the molecular mechanisms related to treatment response were sought. To search for response predictors, genomic and transcriptomic profiling, PIK3CA mutations and PTEN status were associated to the drug responses and several genes involved in the response of the compounds were identified.
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| Overall design |
RNA from thirteen HER2 positive breast cancer cell lines was isolated and hybridized on Affymetrix arrays.
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| Contributor(s) |
Jernström S, Hongisto V, Leivonen S, Due EU, Tadele DS, Edgren H, Kallioniemi O, Perälä M, Børresen-Dale A, Mælandsmo GM, Sahlberg KK |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jun 20, 2014 |
| Last update date |
Jan 31, 2015 |
| Contact name |
Sandra Jernström |
| E-mail(s) |
[email protected]
|
| Organization name |
OUS The Norwegian Radium hospital
|
| Department |
Genetics
|
| Street address |
Ullernchausséen 70
|
| City |
Oslo |
| ZIP/Postal code |
0310 |
| Country |
Norway |
| |
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| Platforms (1) |
| GPL18850 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [Version 14] |
|
| Samples (13)
|
| GSM1417134 |
Breast cancer cell line untreated gene expression AU565 |
| GSM1417135 |
Breast cancer cell line untreated gene expression BT474 |
| GSM1417136 |
Breast cancer cell line untreated gene expression EFM-192A |
| GSM1417137 |
Breast cancer cell line untreated gene expression HCC1419 |
| GSM1417138 |
Breast cancer cell line untreated gene expression HCC1569 |
| GSM1417139 |
Breast cancer cell line untreated gene expression HCC1954 |
| GSM1417140 |
Breast cancer cell line untreated gene expression HCC202 |
| GSM1417141 |
Breast cancer cell line untreated gene expression JIMT1 |
| GSM1417142 |
Breast cancer cell line untreated gene expression KPL4 |
| GSM1417143 |
Breast cancer cell line untreated gene expression MDA-MB-453 |
| GSM1417144 |
Breast cancer cell line untreated gene expression SKBR3 |
| GSM1417145 |
Breast cancer cell line untreated gene expression SUM190PT |
| GSM1417146 |
Breast cancer cell line untreated gene expression SUM225 |
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| This SubSeries is part of SuperSeries: |
| GSE58887 |
Drug screening and genomic analyses of HER2 positive breast cancer cell lines reveal predictors for treatment response |
|
| Relations |
| BioProject |
PRJNA253199 |
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